-
2
-
-
0036296149
-
Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response
-
Beigneux A.P., Moser A.H., Shigenaga J.K., Grunfeld C., and Feingold K.R. Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response Biochem. Biophys. Res. Commun. 293 2002 145 149
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.293
, pp. 145-149
-
-
Beigneux, A.P.1
Moser, A.H.2
Shigenaga, J.K.3
Grunfeld, C.4
Feingold, K.R.5
-
3
-
-
13144260727
-
Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction
-
Bertilsson G., Heidrich J., Svensson K., Asman M., Jendeberg L., Sydow-Backman M., Ohlsson R., Postlind H., Blomquist P., and Berkenstam A. Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction Proc. Natl. Acad. Sci. USA 95 1998 12208 12213
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 12208-12213
-
-
Bertilsson, G.1
Heidrich, J.2
Svensson, K.3
Asman, M.4
Jendeberg, L.5
Sydow-backman, M.6
Ohlsson, R.7
Postlind, H.8
Blomquist, P.9
Berkenstam, A.10
-
4
-
-
0032532134
-
SXR, a novel steroid and xenobiotic-sensing nuclear receptor
-
Blumberg B., Sabbagh W. Jr., Juguilon H., Bolado J. Jr., van Meter C.M., Ong E.S., and Evans R.M. SXR, a novel steroid and xenobiotic-sensing nuclear receptor Genes Dev. 12 1998 3195 3205
-
(1998)
Genes Dev.
, vol.12
, pp. 3195-3205
-
-
Blumberg, B.1
Sabbagh Jr., W.2
Juguilon, H.3
Bolado Jr., J.4
Van Meter, C.M.5
Ong, E.S.6
Evans, R.M.7
-
5
-
-
0038128342
-
Constitutive androstane receptor and pregnane X receptor gene expression in human liver: Interindividual variability and correlation with CYP2B6 mRNA levels
-
Chang T.K.H., Bandiera S.M., and Chen J. Constitutive androstane receptor and pregnane X receptor gene expression in human liver: Interindividual variability and correlation with CYP2B6 mRNA levels Drug Metab. Dispos. 31 2003 7 10
-
(2003)
Drug Metab. Dispos.
, vol.31
, pp. 7-10
-
-
Chang, T.K.H.1
Bandiera, S.M.2
Chen, J.3
-
6
-
-
1642498178
-
Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor
-
Chen Y., Ferguson S.S., Negishi M., and Goldstein J.A. Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor J. Pharmacol. Exp. Ther. 308 2004 495 501
-
(2004)
J. Pharmacol. Exp. Ther.
, vol.308
, pp. 495-501
-
-
Chen, Y.1
Ferguson, S.S.2
Negishi, M.3
Goldstein, J.A.4
-
7
-
-
0037112315
-
PXR-dependent induction of human CYP3A4 gene expression by organochlorine pesticides
-
Coumoul X., Diry M., and Barouki R. PXR-dependent induction of human CYP3A4 gene expression by organochlorine pesticides Biochem. Pharmacol. 64 2002 1513 1519
-
(2002)
Biochem. Pharmacol.
, vol.64
, pp. 1513-1519
-
-
Coumoul, X.1
Diry, M.2
Barouki, R.3
-
8
-
-
8344268492
-
Gene regulation for the senescence marker protein DHEA-sulfotransferase by the xenobiotic-activated nuclear pregnane X receptor (PXR)
-
Echchgadda I., Song C.S., Oh T.S., Cho S.H., Rivera O.J., and Chatterjee B. Gene regulation for the senescence marker protein DHEA-sulfotransferase by the xenobiotic-activated nuclear pregnane X receptor (PXR) Mech. Aging Dev. 125 2004 733 745
-
(2004)
Mech. Aging Dev.
, vol.125
, pp. 733-745
-
-
Echchgadda, I.1
Song, C.S.2
Oh, T.S.3
Cho, S.H.4
Rivera, O.J.5
Chatterjee, B.6
-
9
-
-
0034781795
-
Use of a reporter gene assay to predict and rank the potency and efficacy of CYP3A4 inducers
-
El-Sankary W., Gibson G.G., Ayrton A., and Plant N. Use of a reporter gene assay to predict and rank the potency and efficacy of CYP3A4 inducers Drug Metab. Dispos. 29 2001 1499 1504
-
(2001)
Drug Metab. Dispos.
, vol.29
, pp. 1499-1504
-
-
El-sankary, W.1
Gibson, G.G.2
Ayrton, A.3
Plant, N.4
-
10
-
-
0034866270
-
Regulation of the rat glutathione S-transferase A2 gene by glucocorticoids: Involvement of both the glucocorticoid and pregnane X receptors
-
Falkner K.C., Pinaire J.A., Xiao G.H., Geoghegan T.E., and Prough R.A. Regulation of the rat glutathione S-transferase A2 gene by glucocorticoids: Involvement of both the glucocorticoid and pregnane X receptors Mol. Pharmacol. 60 2001 611 619
-
(2001)
Mol. Pharmacol.
, vol.60
, pp. 611-619
-
-
Falkner, K.C.1
Pinaire, J.A.2
Xiao, G.H.3
Geoghegan, T.E.4
Prough, R.A.5
-
11
-
-
1342344703
-
Human PXR variants and their differential effects on the regulation of human UDP-glucuronosyltransferase gene expression
-
Gardner-Stephen D., Heydel J.M., Goyal A., Lu Y., Xie W., Lindblom T., Mackenzie P., and Radominska-Pandya A. Human PXR variants and their differential effects on the regulation of human UDP-glucuronosyltransferase gene expression Drug Metab. Dispos. 32 2004 340 347
-
(2004)
Drug Metab. Dispos.
, vol.32
, pp. 340-347
-
-
Gardner-stephen, D.1
Heydel, J.M.2
Goyal, A.3
Lu, Y.4
Xie, W.5
Lindblom, T.6
MacKenzie, P.7
Radominska-pandya, A.8
-
12
-
-
0033305499
-
Orphan nuclear receptors: From gene to function
-
Giguere V. Orphan nuclear receptors: From gene to function Endocr. Rev. 20 1999 689 725
-
(1999)
Endocr. Rev.
, vol.20
, pp. 689-725
-
-
Giguere, V.1
-
13
-
-
0034874393
-
Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor
-
Goodwin B., Moore L.B., Stoltz C.M., McKee D.D., and Kliewer S.A. Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor Mol. Pharmacol. 60 2001 427 431
-
(2001)
Mol. Pharmacol.
, vol.60
, pp. 427-431
-
-
Goodwin, B.1
Moore, L.B.2
Stoltz, C.M.3
McKee, D.D.4
Kliewer, S.A.5
-
15
-
-
10044229222
-
Enhanced acetaminophen toxicity by activation of the pregnane X receptor
-
Guo G.L., Moffit J.S., Nicol C.J., Ward J.M., Aleksunes L.A., Slitt A.L., Kliewer S.A., Manautou J.E., and Gonzalez F.J. Enhanced acetaminophen toxicity by activation of the pregnane X receptor Toxicol. Sci. 82 2004 374 380
-
(2004)
Toxicol. Sci.
, vol.82
, pp. 374-380
-
-
Guo, G.L.1
Moffit, J.S.2
Nicol, C.J.3
Ward, J.M.4
Aleksunes, L.A.5
Slitt, A.L.6
Kliewer, S.A.7
Manautou, J.E.8
Gonzalez, F.J.9
-
16
-
-
18144410995
-
The evolution of drug-activated nuclear receptors: One ancestral gene diverged into two xenosensor genes in mammals
-
Handschin C., Blattler S., Roth A., Looser R., Oscarson M., Kaufmann M.R., Podvinec M., Gnerre C., and Meyer C.A. The evolution of drug-activated nuclear receptors: One ancestral gene diverged into two xenosensor genes in mammals Nuclear Receptor 2 2004 7
-
(2004)
Nuclear Receptor
, vol.2
, pp. 7
-
-
Handschin, C.1
Blattler, S.2
Roth, A.3
Looser, R.4
Oscarson, M.5
Kaufmann, M.R.6
Podvinec, M.7
Gnerre, C.8
Meyer, C.A.9
-
17
-
-
0344740559
-
Induction of drug metabolism: The role of nuclear receptors
-
Handschin C., and Meyer C.A. Induction of drug metabolism: The role of nuclear receptors Pharmacol. Rev. 55 2003 649 673
-
(2003)
Pharmacol. Rev.
, vol.55
, pp. 649-673
-
-
Handschin, C.1
Meyer, C.A.2
-
18
-
-
9944265844
-
Regulatory network of lipid-sensing nuclear receptors: Roles for CAR, PXR, LXR, and FXR
-
Handschin C., and Meyer U.A. Regulatory network of lipid-sensing nuclear receptors: Roles for CAR, PXR, LXR, and FXR Arch. Biochem. Biophys. 433 2005 387 396
-
(2005)
Arch. Biochem. Biophys.
, vol.433
, pp. 387-396
-
-
Handschin, C.1
Meyer, U.A.2
-
19
-
-
4444352514
-
Environmental phthalate monoesters activate pregnane X receptor-mediated transcription
-
Hurst C.H., and Waxman D.J. Environmental phthalate monoesters activate pregnane X receptor-mediated transcription Toxicol. Appl. Pharmacol. 199 2004 266 274
-
(2004)
Toxicol. Appl. Pharmacol.
, vol.199
, pp. 266-274
-
-
Hurst, C.H.1
Waxman, D.J.2
-
20
-
-
30144435776
-
Interactions of endocrine-active environmental chemicals with the nuclear receptor PXR
-
Hurst C.H., and Waxman D.J. Interactions of endocrine-active environmental chemicals with the nuclear receptor PXR Toxicol. Environ. Chem. 2005 In press.
-
(2005)
Toxicol. Environ. Chem.
-
-
Hurst, C.H.1
Waxman, D.J.2
-
21
-
-
0034777488
-
Natural protein variants of pregnane X receptor with altered transactivation activity toward CYP3A4
-
Hustert E., Zibat A., Presecan-Siedel E., Eiselt R., Mueller R., Fub C., Brehm I., Brinkmann U., Eichelbaum M., Wojnowski L., and Burk O. Natural protein variants of pregnane X receptor with altered transactivation activity toward CYP3A4 Drug Metab. Dispos. 29 2001 1454 1459
-
(2001)
Drug Metab. Dispos.
, vol.29
, pp. 1454-1459
-
-
Hustert, E.1
Zibat, A.2
Presecan-siedel, E.3
Eiselt, R.4
Mueller, R.5
Fub, C.6
Brehm, I.7
Brinkmann, U.8
Eichelbaum, M.9
Wojnowski, L.10
Burk, O.11
-
22
-
-
17744375160
-
The pregnane X receptor: A promiscuous xenobiotic receptor that has diverged during evolution
-
Jones S.A., Moore L.B., Shenk J.L., Wisely G.B., Hamilton G.A., McKee D.D., Tomkinson N.C.O., LeCluyse E.L., Lambert M.H., Willson T.M., Kliewer S.A., and Moore J.T. The pregnane X receptor: A promiscuous xenobiotic receptor that has diverged during evolution Mol. Endocrinol. 14 2000 27 39
-
(2000)
Mol. Endocrinol.
, vol.14
, pp. 27-39
-
-
Jones, S.A.1
Moore, L.B.2
Shenk, J.L.3
Wisely, G.B.4
Hamilton, G.A.5
McKee, D.D.6
Tomkinson, N.C.O.7
Lecluyse, E.L.8
Lambert, M.H.9
Willson, T.M.10
Kliewer, S.A.11
Moore, J.T.12
-
23
-
-
0036030926
-
Use of in vitro pregnane X receptor assays to assess CYP3A4 induction potential of drug candidates
-
Jones S.A., Moore L.B., Wisely G.B., and Kliewer S.A. Use of in vitro pregnane X receptor assays to assess CYP3A4 induction potential of drug candidates Methods Enzymol. 357 2002 161 170
-
(2002)
Methods Enzymol.
, vol.357
, pp. 161-170
-
-
Jones, S.A.1
Moore, L.B.2
Wisely, G.B.3
Kliewer, S.A.4
-
24
-
-
3242735503
-
Loss of detoxification in inflammatory bowel disease: Dysregulation of pregnane X receptor target genes
-
Langmann T., Moehle C., Mauerer R., Scharl M., Liebisch G., Zahn A., Stremmel W., and Schmitz G. Loss of detoxification in inflammatory bowel disease: Dysregulation of pregnane X receptor target genes Gastroenterology 127 2004 26 40
-
(2004)
Gastroenterology
, vol.127
, pp. 26-40
-
-
Langmann, T.1
Moehle, C.2
Mauerer, R.3
Scharl, M.4
Liebisch, G.5
Zahn, A.6
Stremmel, W.7
Schmitz, G.8
-
25
-
-
0032169485
-
The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
-
Lehmann J.M., McKee D.D., Watson M.A., Willson T.M., Moore J.T., and Kliewer S.A. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions J. Clin. Invest. 102 1998 1016 1023
-
(1998)
J. Clin. Invest.
, vol.102
, pp. 1016-1023
-
-
Lehmann, J.M.1
McKee, D.D.2
Watson, M.A.3
Willson, T.M.4
Moore, J.T.5
Kliewer, S.A.6
-
26
-
-
8844228096
-
A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides
-
Lemaire G., de Sousa G., and Rahmani R. A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides Biochem. Pharmacol. 68 2004 2347 2358
-
(2004)
Biochem. Pharmacol.
, vol.68
, pp. 2347-2358
-
-
Lemaire, G.1
De Sousa, G.2
Rahmani, R.3
-
27
-
-
0036765785
-
Nuclear pregnane X receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification
-
Maglich J.M., Stoltz C.M., Goodwin B., Hawkins-Brown D., Moore J.T., and Kliewer S.A. Nuclear pregnane X receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification Mol. Pharmacol. 62 2002 638 646
-
(2002)
Mol. Pharmacol.
, vol.62
, pp. 638-646
-
-
Maglich, J.M.1
Stoltz, C.M.2
Goodwin, B.3
Hawkins-brown, D.4
Moore, J.T.5
Kliewer, S.A.6
-
28
-
-
0034691064
-
St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor
-
Moore L.B., Goodwin B., Jones S.A., Wisely G.B., Serabjit-Singh C.J., Willson T.M., Collins J.L., and Kliewer S.A. St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor Proc. Natl. Acad. Sci. USA 97 2000 7500 7502
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 7500-7502
-
-
Moore, L.B.1
Goodwin, B.2
Jones, S.A.3
Wisely, G.B.4
Serabjit-singh, C.J.5
Willson, T.M.6
Collins, J.L.7
Kliewer, S.A.8
-
29
-
-
0034685779
-
Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands
-
Moore L.B., Parks D.J., Jones S.A., Bledsoe R.K., Consler T.G., Stimmel J.B., Goodwin B., Liddle C., Blanchard S.G., Willson T.M., Collins J.L., and Kliewer S.A. Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands J. Biol. Chem. 275 2000 15122 15127
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 15122-15127
-
-
Moore, L.B.1
Parks, D.J.2
Jones, S.A.3
Bledsoe, R.K.4
Consler, T.G.5
Stimmel, J.B.6
Goodwin, B.7
Liddle, C.8
Blanchard, S.G.9
Willson, T.M.10
Collins, J.L.11
Kliewer, S.A.12
-
30
-
-
0033931266
-
Dexamethasone induces pregnane X receptor and retinoid X receptor-α expression in human hepatocytes: Synergistic increase of CYP3A4 induction by pregnane X receptor activators
-
Pascussi J.M., Drocourt L., Fabre J.M., Maurel P., and Vilarem M.J. Dexamethasone induces pregnane X receptor and retinoid X receptor-α expression in human hepatocytes: Synergistic increase of CYP3A4 induction by pregnane X receptor activators Mol. Pharmacol. 58 2000 361 372
-
(2000)
Mol. Pharmacol.
, vol.58
, pp. 361-372
-
-
Pascussi, J.M.1
Drocourt, L.2
Fabre, J.M.3
Maurel, P.4
Vilarem, M.J.5
-
31
-
-
0036784511
-
A cell-based reporter gene assay for determining induction of CYP3A4 in a high-volume system
-
Raucy J., Warfe L., Yueh M.F., and Allen S.W. A cell-based reporter gene assay for determining induction of CYP3A4 in a high-volume system J. Pharmacol. Exp. Ther. 303 2002 412 423
-
(2002)
J. Pharmacol. Exp. Ther.
, vol.303
, pp. 412-423
-
-
Raucy, J.1
Warfe, L.2
Yueh, M.F.3
Allen, S.W.4
-
32
-
-
0037972688
-
Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor
-
Rosenfeld J.M., Vargas R. Jr., Xie W., and Evans R.M. Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor Mol. Endocrinol. 17 2003 1268 1282
-
(2003)
Mol. Endocrinol.
, vol.17
, pp. 1268-1282
-
-
Rosenfeld, J.M.1
Vargas Jr., R.2
Xie, W.3
Evans, R.M.4
-
33
-
-
0036765746
-
Development of a real-time in vivo transcription assay: Application reveals pregnane X receptor-mediated induction of CYP3A4 by cancer chemotherapeutic agents
-
Schuetz E., Lan L., Yasuda K., Kim R., Kocarek T.A., Schuetz J., and Strom S. Development of a real-time in vivo transcription assay: Application reveals pregnane X receptor-mediated induction of CYP3A4 by cancer chemotherapeutic agents Mol. Pharmacol. 62 2002 439 445
-
(2002)
Mol. Pharmacol.
, vol.62
, pp. 439-445
-
-
Schuetz, E.1
Lan, L.2
Yasuda, K.3
Kim, R.4
Kocarek, T.A.5
Schuetz, J.6
Strom, S.7
-
34
-
-
13244298263
-
Simultaneous substitution of phenylanlanine-305 and aspartate-318 of rat pregnane X receptor with the corresponding human residue abolishes the ability to transactivate the CYP3A23 promoter
-
Song X., Li Y., Liu J., Mukundan M., and Yan B. Simultaneous substitution of phenylanlanine-305 and aspartate-318 of rat pregnane X receptor with the corresponding human residue abolishes the ability to transactivate the CYP3A23 promoter J. Pharmacol. Exp. Ther. 312 2005 571 582
-
(2005)
J. Pharmacol. Exp. Ther.
, vol.312
, pp. 571-582
-
-
Song, X.1
Li, Y.2
Liu, J.3
Mukundan, M.4
Yan, B.5
-
35
-
-
0035853165
-
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
-
Staudinger J.L., Goodwin B., Jones S.A., Hawkins-Brown D., MacKenzie K.I., LaTour A., Liu Y., Klassen C.D., Brown K.K., Reinhard J., Willson T.M., Koller B.H., and Kliewer S.A. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity Proc. Natl. Acad. Sci. USA 98 2001 3369 3374
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 3369-3374
-
-
Staudinger, J.L.1
Goodwin, B.2
Jones, S.A.3
Hawkins-brown, D.4
MacKenzie, K.I.5
Latour, A.6
Liu, Y.7
Klassen, C.D.8
Brown, K.K.9
Reinhard, J.10
Willson, T.M.11
Koller, B.H.12
Kliewer, S.A.13
-
36
-
-
1042280916
-
Highly chlorinated PCBs inhibits the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR)
-
Tabb M.M., Kholodovych V., Grun F., Zhou C., Welsh W.J., and Blumberg B. Highly chlorinated PCBs inhibits the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR) Environ. Health Perspect. 112 2004 163 169
-
(2004)
Environ. Health Perspect.
, vol.112
, pp. 163-169
-
-
Tabb, M.M.1
Kholodovych, V.2
Grun, F.3
Zhou, C.4
Welsh, W.J.5
Blumberg, B.6
-
37
-
-
1642454581
-
Identification of amino acids in rat pregnane X receptor that determine species-specific activation
-
Tirona R.G., Leake B.F., Podust L.M., and Kim R.B. Identification of amino acids in rat pregnane X receptor that determine species-specific activation Mol. Pharmacol. 65 2004 36 44
-
(2004)
Mol. Pharmacol.
, vol.65
, pp. 36-44
-
-
Tirona, R.G.1
Leake, B.F.2
Podust, L.M.3
Kim, R.B.4
-
38
-
-
1042290478
-
Vitamin E, nuclear receptors and xenobiotic metabolism
-
Traber M.G. Vitamin E, nuclear receptors and xenobiotic metabolism Arch. Biochem. Biophys. 423 2004 6 11
-
(2004)
Arch. Biochem. Biophys.
, vol.423
, pp. 6-11
-
-
Traber, M.G.1
-
39
-
-
0043168030
-
Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor
-
Watkins R.E., Davis-Searles P.R., Lambert M.H., and Redinbo M.R. Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor J. Mol. Biol. 331 2003 815 828
-
(2003)
J. Mol. Biol.
, vol.331
, pp. 815-828
-
-
Watkins, R.E.1
Davis-searles, P.R.2
Lambert, M.H.3
Redinbo, M.R.4
-
40
-
-
0033199499
-
P450 gene induction by structurally diverse xenochemicals: Central role of nuclear receptors CAR, PXR, and PPAR
-
Waxman D.J. P450 gene induction by structurally diverse xenochemicals: Central role of nuclear receptors CAR, PXR, and PPAR Arch. Biochem. Biophys. 369 1999 11 23
-
(1999)
Arch. Biochem. Biophys.
, vol.369
, pp. 11-23
-
-
Waxman, D.J.1
-
41
-
-
0034721159
-
Humanized xenobiotic response in mice expressing nuclear receptor SXR
-
Xie W., Barwick J.L., Downes M., Blumberg B., Simon C.M., Nelson M.C., Neuschwander-Tetri B.A., Brunt E.M., Guzelian P.S., and Evans R.M. Humanized xenobiotic response in mice expressing nuclear receptor SXR Nature 406 2000 435 439
-
(2000)
Nature
, vol.406
, pp. 435-439
-
-
Xie, W.1
Barwick, J.L.2
Downes, M.3
Blumberg, B.4
Simon, C.M.5
Nelson, M.C.6
Neuschwander-tetri, B.A.7
Brunt, E.M.8
Guzelian, P.S.9
Evans, R.M.10
-
42
-
-
0035853057
-
An essential role for nuclear receptor SXR/PXR in detoxification of cholestatic bild acids
-
Xie W., Radominska-Pandya A., Shi Y., Simon C.M., Nelson M.C., Ong E.S., Waxman D.J., and Evans R.M. An essential role for nuclear receptor SXR/PXR in detoxification of cholestatic bild acids Proc. Natl. Acad. Sci. USA 98 2001 3375 3380
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 3375-3380
-
-
Xie, W.1
Radominska-pandya, A.2
Shi, Y.3
Simon, C.M.4
Nelson, M.C.5
Ong, E.S.6
Waxman, D.J.7
Evans, R.M.8
-
43
-
-
0037386735
-
Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor
-
Xie W., Yeuh M.F., Radominska-Pandya A., Saini S.P.S., Negishi Y., Bottroff B.S., Cabrera G.Y., Tukey R.H., and Evans R.M. Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor Proc. Natl. Acad. Sci. USA 100 2003 4150 4155
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 4150-4155
-
-
Xie, W.1
Yeuh, M.F.2
Radominska-pandya, A.3
Saini, S.P.S.4
Negishi, Y.5
Bottroff, B.S.6
Cabrera, G.Y.7
Tukey, R.H.8
Evans, R.M.9
-
44
-
-
0033178677
-
Rat pregnane X receptor: Molecular cloning, tissue distribution, and xenobiotic regulation
-
Zhang H., LeCluyse E.L., Liu L., Hu M., Matoney L., Zhu W., and Yan B. Rat pregnane X receptor: Molecular cloning, tissue distribution, and xenobiotic regulation Arch. Biochem. Biophys. 368 1999 14 22
-
(1999)
Arch. Biochem. Biophys.
, vol.368
, pp. 14-22
-
-
Zhang, H.1
Lecluyse, E.L.2
Liu, L.3
Hu, M.4
Matoney, L.5
Zhu, W.6
Yan, B.7
-
45
-
-
16644388319
-
Correlation of high-throughput pregnane X receptor (PXR) transactivation and binding assays
-
Zhu Z., Kim S., Chen T., Lin J.H., Bell A., Bryson J., Dubaquie Y., Yan N., Yanchunas J., Xie D., Stoffel R., Sinz M., and Dickinson K. Correlation of high-throughput pregnane X receptor (PXR) transactivation and binding assays J. Biomol. Screen. 9 2004 533 540
-
(2004)
J. Biomol. Screen.
, vol.9
, pp. 533-540
-
-
Zhu, Z.1
Kim, S.2
Chen, T.3
Lin, J.H.4
Bell, A.5
Bryson, J.6
Dubaquie, Y.7
Yan, N.8
Yanchunas, J.9
Xie, D.10
Stoffel, R.11
Sinz, M.12
Dickinson, K.13
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