Commentary: Aβ N- terminal isoforms: Critical contributors in the course of AD pathophysiology

Journal of Alzheimer's Disease

Volumn 3, Issue 2, 2001, Pages 241-248

  Tekirian, T L ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ASPARTIC ACID; BETA SECRETASE; CATHEPSIN D; GAMMA SECRETASE; ISOPROTEIN; PRESENILIN 1;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; CARBOXY TERMINAL SEQUENCE; DOWN SYNDROME; ENZYME ACTIVITY; ENZYME INHIBITION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; SENILE PLAQUE;

EID: 0034989501     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2001-3209     Document Type: Review

References (59)

1. Occurence of Amyloid β-protein (Aβ) containing glial cells in Alzheimer's disease brain
2. Cleavage of a β-amyloid pre-cursor sequence by Cathepsin D. Biomed Peptides
3. Racemization of amino acids in nature
4. In vivo racemization in mammalian proteins
5. Preferential adsorption, internalization and resistance to degradation of the major isoform of the Alzheimer's amyloid peptide, Aβ1-42, in differentiated PC12 cells
6. Beta-Amyloid peptide free radical fragments initiate synaptosomal lipoperoxidation in a sequence-specific fashion: Implications to Alzheimer's disease
7. Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha secretase cleavage of the Alzheimer amyloid protein precursor
8. Increased generation of alternatively cleaved β-amyloid peptides in cells expressing mutants of the amyloid precursor protein defective in endocytosis
9. Carboxyl-terminal fragments of Alzheimer β-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1 deficient cells
10. Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of Aβ by zinc
11. The presence of isoaspartic acid in beta-amyloid plaques indicates plaque age
12. Differential effects of the swedish mutant amyloid pre-cursor protein on beta-amyloid accumulation and secretion in neurons and nonneuronal cells
13. Generation and regulation of β-amyloid peptide variants by neurons
14. Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer β-Amyloid peptides
15. Cortical cathepsin D activity and Immunolocalization in Alzheimer disease, critical coronary artery disease and aging
16. The Aβ-pyroglutamyl and 1 l-pyroglutamyl peptides found in senile plaque have greater beta-sheet forming and aggregation propensities in vitro than full-length A beta
17. A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: Relevance to Alzheimer disease
18. Quantification of modified amyloid β peptides in Alzheimer's disease and Down syndrome brains
19. The Aβ peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction
20. Identification of the major Aβ1-42 degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition
21. Full-length amyloid β1-42(43) and amino terminally modified and truncated amyloid β42(43) deposit in diffuse plaques
22. The carboxy terminus of the β-amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease
23. The C-terminus of the β protein is critical in amyloidogenesis
24. Conservation of the sequence of the Alzheimer's disease amyloid peptide in dog, polar bear, and five other mammals by cross-species polymerase chain reaction analysis
25. Biogenesis of peroxisomes in mammals
26. Processing of Amyloid Precursor Protein in Human Primary Neuron and Astrocyte Cultures
27. Temporal sequence of deposition of Aβ peptides bearing heterogeneous N- termini and Apo J in PD-APP transgenic mice
28. DMSO reduces CSF-I receptor levels and causes apoptosis in v-myc immortalized mouse macrophages
29. Neuronal expression of beta-amyloid precursor protein Alzheimer mutations causes intracellular accumulation of a C-terminal fragment containing both the amyloid beta and cytoplasmic domains
30. Racemization: Its biological significance on neuropathogenesis of Alzheimer's disease
31. Peroxisomal membrane ascorbate peroxidase is sorted to a membranous network that resembles a subdomain of the endoplasmic reticulum
32. Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging
33. Phie and R. Etcheberrigaray, enhanced BK-induced calcium responsiveness in PC 12 cells expressing the C100 fragment of the amyloid precursor protein
34. Peroxisome biogenesis: Involvement of ARF and coatomer
35. Amino-terminal deletions enhance aggregation of beta-amyloid peptides in vitro
36. Homology of the amyloid beta protein precursor in monkey and human supports a primate model for beta amyloidosis in Alzheimer's disease
37. Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease
38. Heterogeneity of water-soluble amyloid betapeptide in Alzheimer's disease and Down's syndrome brains
39. Presenilin-1 utations in Alzheimer's disease
40. N3(pE), in senile plaques
41. Amino- and carboxyl-terminal heterogeneity of β-amyloid peptides deposited in human brain
42. Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids
43. Neuritic plaque amyloid in Alzheimer's disease is highly racemized
44. Protein kinase C dependent alpha-secretase competes with beta-secretase cleavage of amyloid-beta precursor protein in the trans-Golgi network
45. The alpha-helical to β-strand transition in the amino- terminal fragment of the amyloid β-peptide modulates amyloid formation
46. Carboxy terminal of β-amyloid deposits in aged human, canine, and polar bear brains
47. N-terminal heterogeneity of parenchymal and cerebrovascular Abeta deposits
48. Toxicity of pyroglutaminated amyloid beta-peptides 3(pE)-40 and -42 is similar to that of A beta 1-40 and -42
49. Presence of soluble amyloid beta-peptide precedes amyloid plaque n formation in Down's syndrome
50. Fleecy amyloid deposits in the internal layers of the human entorhinal cortex are comprised of N- terminal truneated fragments of Aβ
51. 23 residue affects the aggregation properties of Alzheimer amyloid β protein analogues
52. Plasmin cleavage of the amyloid beta-protein: Alteration of secondary structure and stimulation of tissue plasminogen activator activity
53. β-Secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
54. Aspartate residue 7 in amyloid beta-protein is critical for classical complement pathway activation: Implications for Alzheimer's disease pathogenesis
55. N-terminal heterogeneity of Aβ caused by HCHWA-D mutation
56. Intracellular generation and accumulation of amyloid β-peptide terminating at amino acid 42
57. Evidence that Aβ42 is the real culprit in Alzheimer's disease