Genetic dissection of the Drosophila Cubitus interruptus signaling complex

Developmental Biology

Volumn 236, Issue 2, 2001, Pages 411-420

  Lefers, Mark A ^a   Wang, Q Tian ^a   Holmgren, Robert A ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Ci; Fu; Hedgehog; Nuclear import; Pattern formation; Signal transduction; Su(fu)

Indexed keywords

HYBRID PROTEIN; KINESIN; PROTEIN SERINE THREONINE KINASE; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR;

ARTICLE; DROSOPHILA; GENE ACTIVATION; GENE EXPRESSION; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN STABILITY; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

CUBITUS; CUBITUS INTERRUPTUS; DROSOPHILA; ERINACEIDAE;

EID: 0035881953     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.2001.0345     Document Type: Article

References (37)

1. Modulation of Hedgehog target gene expression by the Fused serine-threonine kinase in wing imaginal discs
2. Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor
3. Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein
4. Engrailed expression in the anterior lineage compartment of the developing wing blade of Drosophila
5. Expression of the Drosophila gooseberry locus defines a subset of lineages in the central nervous system
6. Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression
7. Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus
8. In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex
9. Compartments and polyclones in insect development
10. Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Glil
11. Sending and receiving the hedgehog signal: Control by the Drosophila Gli protein Cubitus interruptus
12. Developmental compartmentalisation of the wing disk of Drosophila
13. Cubitus interruptus is necessary but not sufficient for direct activation of a wing-specific decapentaplegic enhancer
14. Drosophila cubitus interruptus forms a negative feedback loop with patched and regulates expression of Hedgehog target genes
15. Role of the Drosophila patched gene in positional signaling
16. Regulation of the Hedgehog and Wingless signaling pathways by the F-box/WD40-repeat protein Slimb
17. Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1
18. Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1
19. Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus
20. Suppressor of Fused opposes Hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus
21. Suppressor of fused links fused and Cubitus interruptus on the hedgehog signalling pathway
22. The Drosophila cubitus interruptus protein and its roles in the wingless and hedgehog signal transduction pathways
23. Gli regulation by the opposing activities of Fused and Suppressor of Fused
24. Hedgehog stimulates maturation of Cubitus interruptus into a labile transcription activator
25. Characterization of Suppressor of fused, a complete suppressor of the fused segment polarity gene of Drosophila melanogaster
26. Segmental polarity in Drosophila melanogaster: Genetic dissection of fused in a Suppressor of fused background reveals interactions with costal-2
27. Proteolysis of cubitus interruptus in Drosophila requires phosphorylation by protein kinase A
28. Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2
29. Gli proteins and Hedgehog signaling: Development and cancer
30. Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway
31. Identification of a tetrameric Hedgehog signaling complex
32. Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli
33. Functional domains of Fused, a serine-theronine kinase required for signaling in Drosophila
34. The COE transcription factor Collier is a mediator of short-range Hedgehog-induced patterning of the Drosophila wing
35. Interactions with Costal2 and Suppressor of fused regulate nuclear translocation and activation of Cubitus interruptus
36. The subcellular localization and activity of Drosophila Cubitus interruptus are regulated at multiple levels
37. Nuclear import of Cubitus interruptus is regulated by Hedgehog via a mechanism distinct from Ci stabilization and Ci activation