Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy

Nature Medicine

Volumn 8, Issue 1, 2002, Pages 35-40

  Asakura, Masanori ^a   Kitakaze, Masafumi ^a   Takashima, Seiji ^a   Liao, Yulin ^a   Ishikura, Fuminobu ^b   Yoshinaka, Tsuyoshi ^d   Ohmoto, Hiroshi ^d   Node, Koichi ^a   Yoshino, Kohichiro ^d   Ishiguro, Hiroshi ^c   Asanuma, Hiroshi ^a   Sanada, Shoji ^a   Matsumura, Yasushi ^b   Takeda, Hiroshi ^b   Beppu, Shintaro ^b   Tada, Michihiko ^b   Hori, Masatsugu ^a   Higashiyama, Shigeki ^b  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^c FUJITA HEALTH UNIVERSITY   (Japan)

^d Nippon Organon KK   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 (N HYDROXYAMINO)ISOBUTYLMETHYLSUCCINYLPHENYLGLYCINE N METHYLAMIDE; DISINTEGRIN; G PROTEIN COUPLED RECEPTOR; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; KB R 7785; METALLOPROTEINASE; METALLOPROTEINASE 12; METALLOPROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME INHIBITION; HEART HYPERTROPHY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; RAT; SIGNAL TRANSDUCTION; TRANSACTIVATION;

ADAM PROTEINS; ANGIOTENSIN II; ANIMALS; AORTA, THORACIC; CARDIOMEGALY; DISEASE MODELS, ANIMAL; DISINTEGRINS; EPIDERMAL GROWTH FACTOR; GLYCINE; GTP-BINDING PROTEINS; HEART VENTRICLES; HYDROXAMIC ACIDS; HYPERTENSION; MALE; MEMBRANE PROTEINS; METALLOENDOPEPTIDASES; PHENYLEPHRINE; PROTEASE INHIBITORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; SYSTOLE; TRANS-ACTIVATION (GENETICS);

ANIMALIA;

EID: 0036152858     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0102-35     Document Type: Article

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