ADAM 12-S cleaves IGFBP-3 and IGFBP-5 and is inhibited by TIMP-3

Biochemical and Biophysical Research Communications

Volumn 278, Issue 3, 2000, Pages 511-515

  Loechel, Frosty ^a   Fox, Jay W ^b   Murphy, Gillian ^c   Albrechtsen, Reidar ^a   Wewer, Ulla M ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^c UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

Disintegrin metalloprotease; Insulin like growth factor binding protein 3; Insulin like growth factor binding protein 5; Tissue inhibitor of metalloproteinase 3

Indexed keywords

DISINTEGRIN; PROTEIN ADAM 12 S; PROTEINASE; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN BINDING PROTEIN 5; TISSUE INHIBITOR OF METALLOPROTEINASE 3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL LINE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PURIFICATION;

ANIMALIA;

EID: 0034736115     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.3835     Document Type: Article

References (28)

1. Structure-function analysis of the ADAM family of disintegrin-like and metalloproteinase-containing proteins
2. The ADAM gene family: Surface proteins with adhesion and protease activity
3. ADAMs: Focus on the protease domain
4. Metalloprotease-disintegrins: Modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding
5. Human ADAM 12 (meltrin α) is an active metalloprotease
6. The new kids on the block: ADAMTSs, potentially multifunctional metalloproteinases of the ADAM family
7. A novel, secreted form of human ADAM 12 (meltrin α) provokes myogenesis in vivo
8. A metalloprotease-disintegrin participating in myoblast fusion
9. Expression of meltrin-alpha mRNA is not restricted to fusagenic cells
10. Cloning and initial characterization of mouse meltrin beta and analysis of the expression of four metalloprotease-disintegrins in bone cells
11. ADAM 12, a disintegrin metalloprotease, interacts with insulin-like growth factor-binding protein-3
12. Cysteine-rich domain of human ADAM 12 (meltrin α) supports tumor cell adhesion
13. The cysteine-rich domain of human ADAM 12 supports cell adhesion through syndecans and triggers signaling events that lead to beta1 integrin-dependent cell spreading
14. Insulin-like growth factor binding proteins: New proteins, new functions
15. Proteolysis of insulin-like growth factor binding proteins by a novel 50-kilodalton metalloproteinase in human pregnancy serum
16. Human pregnancy serum contains at least two distinct proteolytic activities with the ability to degrade insulin-like growth factor binding protein-3
17. The activity of the tissue inhibitors of metalloproteinases is regulated by C-terminal domain interactions: A kinetic analysis of the inhibition of gelatinase A
18. Intracellular maturation of the mouse metalloprotease disintegrin MDC15
19. The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A
20. TNF-alpha converting enzyme (TACE) is inhibited by TIMP-3
21. The in vitro activity of ADAM-10 is inhibited by TIMP-1 and TIMP-3
22. Human placental trophoblasts secrete a disintegrin metalloproteinase very similar to the insulin-like growth factor binding protein-3 protease in human pregnancy serum
23. Characterization of insulin-like growth factor-binding protein 5-degrading proteases produced throughout murine osteoblast differentiation
24. Characterization and hormonal regulation of a rat ovarian insulin-like growth factor binding protein-5 endopeptidase: An FSH-inducible granulosa cell-derived metalloprotease
25. Characterization of an insulin-like growth factor binding protein-5 protease produced by rat articular chondrocytes and a neuroblastoma cell line
26. Regulation of human ADAM 12 protease by the prodomain. Evidence for a functional cysteine switch
27. Tissue inhibitors of metalloproteinases: Structure, regulation and biological functions
28. Tissue inhibitors of metalloproteinases: Evolution, structure and function