TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells

EMBO Journal

Volumn 22, Issue 10, 2003, Pages 2411-2421

  Gschwind, Andreas ^b   Hart, Stefan ^a   Fischer, Oliver M ^a   Ullrich, Axel ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b GENENTECH INC   (United States)

Author keywords

Amphiregulin; EGFR; HNSCC; TACE; Transactivation

Indexed keywords

AMPHIREGULIN; CARBACHOL; EPIDERMAL GROWTH FACTOR RECEPTOR; G PROTEIN COUPLED RECEPTOR; HEPARIN; LYSOPHOSPHATIDIC ACID; NEUTRALIZING ANTIBODY; PROAMPHIREGULIN; PROTEIN KINASE B; RNA; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CELL MIGRATION; CELL MOTILITY; CELL PROLIFERATION; CELL STIMULATION; GENE SILENCING; HUMAN; HUMAN CELL; MITOGENESIS; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA;

ADAM PROTEINS; ANTIBODIES; CARBACHOL; CARCINOMA, SQUAMOUS CELL; CELL DIVISION; CELL MOVEMENT; ENZYME ACTIVATION; GLYCOPROTEINS; GTP-BINDING PROTEINS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; LYSOPHOSPHOLIPIDS; MEMBRANE PROTEINS; METALLOENDOPEPTIDASES; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN PRECURSORS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, CELL SURFACE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

STAPHYLOCOCCUS PHAGE 3A;

EID: 0038581051     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdg231     Document Type: Article

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