Transfer of human CD4+ T lymphocytes producing beta interferon in Hu- PBL-SCID mice controls human immunodeficiency virus infection

Journal of Virology

Volumn 73, Issue 12, 1999, Pages 10281-10288

  Vieillard, Vincent ^a,c   Jouveshomme, Stephane ^b   Leflour, Nicole ^b   Jean Pierre, Eric ^b   Debre, Patrice ^b   De Maeyer, Edward ^a   Autran, Brigitte ^b  

^a INSTITUT CURIE   (France)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^c HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CYTOKINE; PHYTOHEMAGGLUTININ;

ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CELL TRANSFER; CONTROLLED STUDY; HELPER CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; LYMPHOBLAST; MOUSE; NONHUMAN; PRIORITY JOURNAL; VIRUS REPLICATION;

EID: 0032735124     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.12.10281-10288.1999     Document Type: Article

References (48)

1. Albert, S. E., C. McKerlie, A. Pester, B. J. Edgell, J. Carlyle, M. Petric, and J. W. Chamberlain. 1997. Time-dependent induction of protective anti-influenza immune responses in human peripheral blood lymphocyte SCID mice. J. Immunol. 159:1393-1403.
2. + T cell homeostasis and function in advanced HIV disease. Science 277:112-116.
3. Baca-Regen, I., N. Heinzinger, M. Stevenson, and H. E. Gendelman. 1994. Alpha interferon-induced antiretroviral activities: restriction of viral nucleic acid synthesis and progeny virion production in human immunodeficiency virus type 1-infected monocytes. J. Virol. 68:7559-7565.
4. Borvak, J., C. S. Chou, K. Bell, G. Van Dyke, H. Zola, O. Ramilo, and E. S. Vitetta. 1995. Expression of CD25 defines peripheral blood mononuclear cells with productive versus latent HIV infection. J. Immunol. 155:3196-3204.
5. Bregni, M., M. Magni, S. Siena, M. Di Nicola, G. Bonadonna, and A. M. Gianni. 1992. Human peripheral blood hematopoietic progenitors are optimal targets of retroviral-mediated gene transfer. Blood 80:1418-1422.
6. Bridges, S. H., and N. Sarver. 1995. Gene therapy and immune restoration for HIV disease. Lancet 345:427-432.
7. Clerici, M., and G. M. Shearer. 1994. The Th1-Th2 hypothesis of HIV infection: new insights. Immunol. Today 15:575-581.
8. Coccia, E. M., B. Krust, and A. G. Hovanessian. 1994. Specific response to interferon treatment. J. Biol. Chem. 269:23087-23094.
9. Delhem N., F. Hadida, G. Gorochov, F. Carpentier, J. P. De Cavel, J. F. Andreani, B. Autran, and J. Y. Cesbron. 1998. Primary Th1-cell immunisation against HIV gp160 in SCID-hu mice co-engrafted with peripheral blood lymphocytes and skin. J. Immunol. 161:2060-2069.
10. De Maeyer, E., and J. De Maeyer-Guignard. 1988. Interferons and other regulatory cytokines. John Wiley & Sons, Chichester, England.
11. Finzi, D., and R. F. Siliciano. 1998. Viral dynamics in HIV-1 infection. Cell 93:665-671.
12. + T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nat. Med. 5:512-517.
13. Francis, M. L., M. S. Meltzer, and H. E. Gendelman. 1992. Interferons in the persistence, pathogenesis and treatment of HIV infection. AIDS Res. Hum. Retroviruses 8:199-207.
14. Hammer, S. M., K. E. Squires, M. D. Hughes, J. M. Grimes, L. M. Demeter, J. S. Currier, J. J. Eron, Jr., J. E. Feinberg, H. H. Balfour, Jr., L. R. Deyton, J. A. Chodakewitz, and M. A. Fischl. 1997. A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. N. Engl. J. Med. 337:725-733.
15. Hansen, B. D., P. L. Nara, R. K. Maheshwari, G. S. Sidhu, J. Bernbaum, D. Hoekzema, M. S. Meltzer, and H. E. Gendelman. 1992. Loss of infectivity by progeny virus from alpha interferon-treated human immunodeficiency virus type 1-infected T cells is associated with defective assembly of envelope gp120. J. Virol. 64:7543-7548.
16. Ho, D. D. 1998. Toward HIV eradication or remission: the tasks ahead. Science 280:1866-1867.
17. Kollmann, T. R., M. Pettoello-Mantovani, N. F. Katopodis, M. Hachamovitch, A. Rubinstein, A., Kim, and H. Goldstein. 1996. Inhibition of acute in vivo human immunodeficiency virus infection by interleukin 10 treatment of SCID mice implanted with human fetal thymus and liver. Proc. Natl. Acad. Sci. USA 93:3126-3131.
18. Kornbluth, R. S., P. S. Oh, J. R. Munis, P. H. Cleveland, and D. D. Richman. 1990. The role of interferons in the control of HIV replication in macrophages. Clin. Immunol. Immunopathol. 54:200-219.
19. Lauret, E., I. Rivière, V. Rousseau, V. Vieillard, J. De Maeyer-Guignard, and E. De Maeyer. 1993. Development of methods for somatic cell gene therapy directed against viral diseases, using retroviral vectors carrying the murine or human interferon-beta coding sequence: establishment of the antiviral state in human cells. Hum. Gene Ther. 4:567-577.
20. Mace, K., I. Seif, C. Anjard, J. De Maeyer-Guignard, M. D. Dodon, L. Gazzolo, and E. De Maeyer. 1991. Enhanced resistance to HIV-1 replication in U937 cells stably transfected with the human IFN-beta gene behind an MHC promoter fragment. J. Immunol. 147:3553-3559.
21. Marrack, P., J. Kappler, and T. Mitchell. 1999. Type I interferons keep activated T cells alive. J. Exp. Med. 189:521-530.
22. Matheux, F., R. Legrand, V. Rousseau, E. De Maeyer, D. Dormont, and E. Lauret. 1999. Macaque lymphocytes transduced by a constitutively expressed interferon beta gene display an enhanced resistance to SIVmac251 infection. Hum. Gene Ther. 10:429-440.
23. McCune, J. M., R. Namikawa, C. C. Shih, L. Rabin, and H. Kaneshima. 1990. Suppression of HIV infection in AZT-treated SCID-Hu mice. Science 247:564-566.
24. McCune, J. M. 1997. Animal models of HIV-1 disease. Science 278:2141-2142.
25. + T cells in human-PBL-SCID mice by noncytopathic HIV isolates. Science 260:689-692.
26. Mosier, D. E., R. J. Gulizia, S. M. Baird, and D. B. Wilson. 1988. Transfer of a functional human immune system to mice with severe combined immunodeficiency. Nature 335:256-259.
27. Mosier, D. E., R. J. Gulizia,. S. M. Baird, D. B. Wilson, D. H. Spector, and S. A. Spector. 1991. Human immunodeficiency virus infection of human PBL-SCID mice. Science 251:791-794.
28. Neumann, A. U., R. Tubiana, V. Calvez, C. Robert, T. S. Li, H. Agut, B. Autran, C. Katlama, and the Comet Study Group. 1999. HIV-1 rebound during interruption of HAART has no deleterious effect on reinitiated treatment. AIDS 13:677-683.
29. Ogg, G., X. Jin, S. Bonhoeffer, P. R. Dunbar, M. A. Nowak, S. Monard, J. P. Segal, Y. Cao, S. L. Rowland-Jones, V. Cerundolo, A. Hurley, M. Markowitz, D. D. Ho, D. F. Nixon and A. J. McMichael. 1998. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA. Science 279:2103-2106.
30. Pantaleo, G. 1997. How immune-based interventions can change HIV therapy. Nat. Med. 3:483-486.
31. Parronchi, P., M. De Carli, R. Manetti, C. Simonelli, S. Sampognaro, M. P. Piccinni. D. Macchia, E. Maggi, G. Del Prete, and S. Romagnani. 1992. IL-4 and IFN (α and γ) exert opposite regulatory effects on the development of cytolytic potential by Th1 or Th2 human T cell clones. J. Immunol. 149: 2977-2983.
32. Parronchi, P., S. Mohapatra, S. Sampognaro, L. Giannarini, U. Wahn, P. Chong, S. Mohapatra, E. Maggi, H. Renz, and S. Romagnani. 1996. Effects of interferon-α on cytokine profile, T cell receptor repertoire and peptide reactivity of human allergen-specific T cells. Eur. J. Immunol. 26:697-703.
33. Poli, G., J. M, Orenstein, A. Kinter, T. M. Folks, and A. S. Fauci. 1989. Interferon alpha but not AZT suppresses HIV expression in chronically infected cell lines. Science 244:575-577.
34. Shirazi, Y., and P. M. Pitha. 1993. Interferon-alpha-mediated inhibition of HIV type 1 provirus synthesis in T cells. Virology 193:303-312.
35. Stevenson, M., T. L. Stanwick, M. P. Dempsey, and C. A. Lamonica. 1990. HIV-1 replication is controlled at the level of T cell activation and proviral integration. EMBO J. 9:1551-1560.
36. Tary-Lehmann, M., and A. Saxon. 1992. Human mature T cells that are anergic in vivo prevail in SCID mice reconstituted with human peripheral blood. J. Exp. Med. 175:503-516.
37. Tary-Lehmann, M., and A. Saxon. 1995. The human immune model in hu-PBL-SCID mice. Immunol. Today 16:529-533.
38. Torbett, B. E., G. Picchio, and D. E. Mosier. 1991. Hu-PBL-SCID mice: a model for human immune function, AIDS, and lymphomagenesis. Immunol. Rev. 124:139-164.
39. Vieillard, V., E. Lauret, V. Maguer, C. Jacomet, W. Rozenbaum, L. Gazzolo, and E. De Maeyer. 1995. Autocrine interferon-β synthesis for gene therapy of HIV infection: increased resistance to HIV-1 in lymphocytes from healthy and HIV-infected individuals. AIDS 9:1221-1228.
40. Vieillard, V., E. Lauret, V. Rousseau, and E. De Maeyer. 1994. Blocking of retroviral infection at a step prior to reverse transcription in cells transformed to constitutively express interferon beta. Proc. Natl. Acad. Sci. USA 91:2689-2693.
41. Vieillard, V., I. Cremer, E. Lauret, W. Rozenbaum, P. Debré, B. Autran, and E. De Maeyer. 1997. Interferon-beta transductior of PBL from HIV-infected donors increases Th1-type cytokine production and improves the proliferative response to recall antigens. Proc. Natl. Acad. Sci. USA 94:11595-11600.
42. Walker, W., C. W. Roberts, J. M. Brewer, and J. Alexander. 1995. Antibody response to Toxoplasma gondii antigen in peripheral blood lymphocyte-reconstituted severe-combined immunodeficient mice reproduces the immunological status of the lymphocyte donor. Eur. J. Immunol. 25:1426-1430.
43. Wenner, C. A., M. L. Guler, S. E. Macatonia, A. O'Garra, and K. M. Murphy. 1996. Roles of IFN-γ and IFN-α in IL-12-induced T helper cell-1 development. J. Immunol. 156:1442-1447.
44. Withers-Ward, E. S., R. G. Amado, P. S. Koka, B. D. Jamieson, A. H. Kaplan, I. S. Chen, and J. A. Zack. 1997. Transient renewal of thymopoiesis in HIV-infected human thymic implants following antiviral therapy. Nat. Med. 3:1102-1109.
45. Wong, J. K., M. Hezareh, H. F. Gunthard, D. V. Havlir, C. C. Ignacio, C. A. Spina, and D. D. Richman. 1997. Recovery of replication-competent HIV despite prolonged suppression of plasmia viremia. Science 278:1291-1295.
46. Yu, M., E. Poeschla, and F. Wong-Staal. 1994. Progress towards gene therapy for HIV infection. Gene Ther. 1:13-26.
47. Zhang, C., Y. Cui, S. Houston, and L. J. Chang. 1996. Protective immunity to HIV-1 in SCID/beige mice reconstituted with peripheral blood lymphocytes of exposed but uninfected individuals. Proc. Natl. Acad. Sci. USA 93:14720-14725.
48. + blood dendritic cells. Blood 86:3295-3301.