Persistent decreases in blood plasmacytoid dendritic cell number and function despite effective highly active antiretroviral therapy and increased blood myeloid dendritic cells in HIV-infected individuals

Journal of Immunology

Volumn 168, Issue 9, 2002, Pages 4796-4801

  Chehimi, Jihed ^a   Campbell, Donald E ^a   Azzoni, Livio ^a   Bacheller, Darlene ^a   Papasavvas, Emmanouil ^a   Jerandi, Ghassen ^a   Mounzer, Karam ^a   Kostman, Jay ^a   Trinchieri, Giorgio ^a   Montaner, Luis J ^a  

^a WISTAR INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ANTIRETROVIRUS AGENT; HLA DR ANTIGEN; INTERLEUKIN 12;

ARTICLE; CELL COUNT; CONTROLLED STUDY; DENDRITIC CELL; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HOST RESISTANCE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOREACTIVITY; INTERFERON PRODUCTION; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; VIRUS LOAD;

EID: 0036569399     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.9.4796     Document Type: Article

References (32)

1. Pathogenesis of human immunodeficiency virus infection
2. Immunopathogenesis of HIV infection
3. Identification of a novel cell type in peripheral lymphoid organs of mice. V. Purification of spleen dendritic cells, new surface markers, and maintenance in vitro
4. Dendritic cells and the control of immunity
5. Myeloid dendritic cells
6. Will the making of plasmacytoid dendritic cells in vitro help unravel their mysteries?
7. Immunobiology of dendritic cells
8. Dendritic cell lineage, plasticity and cross-regulation
9. + cell subsets in human peripheral blood
10. + IFN-α producing cells
11. Understanding dendritic cell and T-lymphocyte traffic through the analysis of chemokine receptor expression
12. A leukocyte subset bearing HLA-DR antigens is responsible for in vitro α interferon production in response to viruses
13. The nature of the principal type 1 interferon-producing cells in human blood
14. Severe acquired immune deficiency syndrome in male homosexuals: Diminished capacity to make interferon-α in vitro associated with severe opportunistic infections
15. Deficiency of interferon-α generating capacity is associated with susceptibility to opportunistic infections in patients with AIDS
16. Opportunistic infections in acquired immune deficiency syndrome result from synergistic defects of both the natural and adaptive components of cellular immunity
17. Selective decrease in human immunodeficiency virus type 1 (HIV-1)-induced α interferon production by peripheral blood mononuclear cells during HIV-1 infection
18. Depletion in blood CD11c-positive dendritic cells from HIV-infected patients
19. + (myeloid) dendritic cell numbers in primary HIV-1 infection
20. Depletion of circulating natural type 1 interferon-producing cells in HIV-infected AIDS patients
21. - plasmacytoid dendritic cells in patients with HIV-1 infection correlates with HIV-1 RNA virus load
22. Increase in dendritic cell numbers, their function and the proportion uninfected during AZT therapy
23. BDCA-2, BDCA-3, and BDCA-4: Three markers for distinct subsets of dendritic cells in human peripheral blood
24. Accessory cell requirements for the mixed-leukocyte reaction and polyclonal mitogens, as studied with a new technique for enriching blood dendritic cells
25. + T cells clonal expansion
26. Dendritic cells and the replication of HIV-1
27. HIV infection of human peripheral blood, cord blood and tonsillar dendritic cells
28. Interferon-α generation and immune reconstitution during antiretroviral therapy for human immunodeficiency virus infection
29. Decreased interferon-α production in HIV-infected patients correlates with numerical and functional deficiencies in circulating type 2 dendritic cell precursors
30. Plasmacytoid dendritic cells are highly susceptible to human immunodeficiency virus type 1 infection and release infectious virus
31. Measles virus suppresses cell-mediated immunity by interfering with the survival and functions of dendritic and T cells
32. Consequences of Fas-mediated human dendritic cell apoptosis induced by measles virus