Low CD83, but normal MHC class II and costimulatory molecule expression, on spleen dendritic cells from HIV+ patients

AIDS Research and Human Retroviruses

Volumn 14, Issue 6, 1998, Pages 505-513

  McIlroy, Dorian ^a   Autran, Brigitte ^a   Clauvel, Jean Pierre ^b   Oksenhendler, Eric ^b   Debré, Patrice ^a   Hosmalin, Anne ^a,c  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b SAINT LOUIS HOSPITAL   (France)

^c INSTITUT COCHIN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; LYMPHOCYTE ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

EID: 0032502698     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/aid.1998.14.505     Document Type: Article

References (46)

1. Steinman RM: The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 1991;9:271-296.
2. Patterson S, Gross J, Bedford P, and Knight SC: Morphology and phenotype of dendritic cells from peripheral blood and their productive and nonproductive infection with human immunodeficiency virus type 1. Immunology 1991;72:361-367.
3. Langhoff E, Terwilliger EF, Bos HJ, Kalland KH, Poznansky MC, Bacon OML, and Haseltine WA: Replication of human immunodeficiency virus type 1 in primary dendritic cell cultures. Proc Natl Acad Sci USA 1991;88:7998-8002.
4. Pope M, Gezelter S, Gallo N, Hoffman L, and Steinman RM: Low levels of HIV-1 in cutaneous dendritic cells promote extensive viral replication on binding to memory CD4+ T-cells. J Exp Med 1995;182:2045-2056.
5. + T lymphocyte infection frequency in spleens of HIV-positive patients. J Virol 1995;69:4737-4745.
6. Zambruno G, Mori L, Marconi A, Mongiardo N, Rienzo BD, Bertazzoni U, and Gianetti A: Detection of HIV-1 in epidermal Langerhans cells of HIV-infected patients using polymerase chain reaction. J Invest Dermatol 1991;96:979-982.
7. Cameron PU, Freudenthal PS, Barker JM, Gezelter S, Inaba K, and Steinman RM: Dendritic cells exposed to human immunodeficiency virus type 1 transmit a vigorous cytopathic infection to CD4+ T cells. Science 1992;257:383-387.
8. Weissman D, Barker TD, and Fauci AS: The efficiency of acute infection of CD4+ T cells is markedly enhanced in the setting of antigen-specific immune activation. J Exp Med 1996;183:687-692.
9. Macatonia SE, Lau R, Patterson S, Pinching AJ, and Knight SC: Dendritic cell infection, depletion and dysfunction in HIV-infected individuals. Immunology 1990;71:38-45.
10. Zinkernagel R and Hengartner H: T-cell mediated immunopathology versus direct cytolysis by virus: Implications for HIV and AIDS. Immunol Today 1994;15:262-268.
11. Knight SC: A problem of antigen presentation? Curr Biol 1994;4: 1131-1134.
12. Meyaard L, Schuitemaker H, and Miedema F: T-cell dysfunction in HIV infection: Anergy due to defective antigen-presenting cell function? Immunol Today 1993;14:161-164.
13. Cameron PU, Forsum U, Teppler H, Granelli-Piperno A, and Steinman RM: During HIV-1 infection most blood dendritic cells are not productively infected and can induce allogeneic CD4+ T cells clonal expansion. Clin Exp Immunol 1992;88:226-236.
14. Macatonia SE, Gompels M, Pinching AJ, Patterson S, and Knight SC: Antigen presentation by macrophages but not by dendritic cells in human immunodeficiency virus (HIV) infection. Immunology 1992;75:576-581.
15. Karhumäki E, Viljanen ME, Cottler-Fox M, Ranki A, Fox CH, and Krohn KJE: An improved enrichment method for functionally competent, highly purified peripheral blood dendritic cells and its application to HIV-infected blood samples. Clin Exp Immunol 1993;91:482-488.
16. Belsito DV, Sanchez MR, Baer RL, Valentine F, and Thorbecke GJ: Reduced Langerhans cell Ia antigen and ATPase activity in patients with the acquired immunodeficiency syndrome. N Engl J Med 1984;310:1279-1282.
17. Tschachler E, Groh V, Popovic M, Mann DL, Konrad K, Safai B, Eron L, Veronese F, Wolff K, and Stingl G: Langerhans cells - a target for HTLVIII/LAV infection. J Invest Dermatol 1987; 88:233-237.
18. Kanikatis J, Marchand C, Su H, Thivolet J, Zambruno G, Schmitt D, and Gazzolo L: Immunohistochemical study of normal skin of HIV-1 infected patients shows no evidence of infection of epidermal Langerhans cells by HIV. AIDS Res Hum Retroviruses 1989;5:293-302.
19. Kalter DC, Greenhouse JJ, Orenstein JM, Schnittman SM, Gendelman HE, and Meltzer MS: Epidermal Langerhans cells are not principal reservoirs of virus in HIV disease. J Immunol 1991; 146:3396-3404.
20. Blauvelt A, Clerici M, Lucey DR, Steinberg SM, Yarchoan R, Walker R, Shearer GM, and Katz SI: Functional studies of epidermal Langerhans cells and blood monocytes in HIV-infected persons. J Immunol 1995;154:3506-3515.
21. McLellan AD, Starling GC, Williams LA, Hock BD, and Hart DNJ: Activation of human peripheral blood dendritic cells induces the CD86 co-stimulatory molecule. Eur J Immunol 1995;25: 2064-2068.
22. Inaba K, Witmer-Pack M, Inaba M, Hathcock KS, Sakuta H, Azuma M, Yagita H, Okumura K, Linsley PS, Ikehara S, Muramatsu S, Hodes RJ, and Steinman RM: The tissue distribution of the B7-2 costimulator in mice: Abundant expression on dendritic cells in situ and during maturation in culture. J Exp Med 1994;180:1849-1860.
23. Rattis F-M, Péguet-Navarro J, Staquet M-J, Dezutter-Dambuyant C, Redziniak G, and Schmitt D: Expression and function of B7-1 (CD80) and B7-2 (CD86) on human epidermal Langerhans cells. Eur J Immunol 1996;26:449-453.
24. Caux C, Vanbervliet B, Massacrier C, Azuma M, Okumura K, and Lanier LL: B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells. J Exp Med 1994;180:1841-1847.
25. McLellan AD, Sorg RV, Williams LA, and Hart DNJ: Human dendritic cells activate T lymphocytes via a CD40:CD40 ligand-dependent pathway. Eur J Immunol 1996;26:1204-1210.
26. O'Doherty U, Peng M, Gezelter S, Swiggard WJ, Betjes M, Bharwaj N, and Steinman RM: Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature. Immunology 1994;82:487-493.
27. Hart DNJ, Starling GC, Calder VL, and Fernando NS: B7/BB-1 is a leucocyte differentiation antigen on human dendritic cells induced by activation. Immunology 1993;79:616-620.
28. O'Doherty U, Steinman RM, Peng M, Cameron PU, Gezelter S, Kopeloff I, Swiggard WJ, Pope M, and Bhardwaj N: Dendritic cells freshly isolated from human blood express CD4 and mature into typical immunostimulatory dendritic cells after culture in monocyte conditioned medium. J Exp Med 1993;178:1067-1078.
29. Giorgi JV and Detels R: T-cell subset alterations in homosexual men: NIAID multicenter AIDS cohort study. Clin Immunol Immunopathol 1989;52:10.
30. Zhou L-J and Tedder TF: Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily. J Immunol 1995;154:3821-3835.
31. Triozzi P and Aldrich W: Phenotypic and functional differences between human dendritic cells derived in vitro from hematopoietic progenitors and from monocytes/macrophages. J Leukocyte Biol 1997;61:600-608.
32. Winkel K, Sotzik F, Vremec D, Cameron PU, and Shortman K: CD4 and CD8 expression by human and mouse thymic dendritic cells. Immunol Lett. 1994;40:93-99.
33. Williams LA, Egner W, and Hart DNJ: Isolation and function of human dendritic cells. Int Rev Cytol 1994;153:41-101.
34. Zhou LJ, Schwarting R, Smith HM, and Tedder TF: A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of the Ig superfamily. J Immunol 1992;149:735-742.
35. Clerici M, Stocks NI, Zajac RA, Boswell RN, Lucey DR, Via CS, and Shearer GM: Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, human immunodeficiency virus-seropositive patients: Independence of CD4 cell numbers and clinical staging. J Clin Invest 1989;84:1892-1899.
36. Levy JA: Pathogenesis of human immunodeficiency virus infection. Microbiol Rev 1993;57:183-289.
37. Biberfeld P, Chayt KJ, Marselle LM, Biberfeld G, Gallo RC, and Harper ME: HTLV-III expression in infected lymph nodes and relevance to pathogenesis of lymphadenopathy. Am J Pathol 1986; 125:436-442.
38. Pantaleo G, Graziosi C, Butini L, Pizzo PA, Schnittman SM, Kotler DP, and Fauci AS: Lympoid organs function as major reservoirs for human immunodeficiency virus. Proc Natl Acad Sci USA 1991;88:9838-9842.
39. Cheynier R, Henrichwark S, Hadida F, Pelletier E, Oksenhendler E, Autran B, and Wain-Hobson S: HIV and T-cell expansion in splenic white pulps is accompanied by infiltration of HIV-specific cytotoxic T-lymphocytes. Cell 1994;78:373-387.
40. Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM, and Markowitz M: Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature (London) 1995;373:123-126.
41. Wei X, Ghosh SK, Taylor ME, Johnson VA, Emini EA, Deutsch P, Lifson JD, Bonhoeffer S, Nowak MA, Hahn BH, Saag MS, and Shaw GM: Viral dynamics in human immunodeficiency virus type 1 infection. Nature (London) 1995;373:117-122.
42. Dudhane A, Wang ZQ, Orlikowsky T, Gupta A, Wormser GP, Horowitz H, Kufer P, and Hoffmann MK: AIDS patient monocytes target CD4 T cells for cellular conjugate formation and deletion thorugh the membrane expression of HIV-1 envelope molecules. AIDS Res Hum Retroviruses 1996;12:893-899.
43. Fidler SJ, Dorrell L, Ball S, Lombardi G, Weber J, Hawrylowicz C, and Rees ADM: An early antigen-presenting cell defect in HIV-1 infected patients correlates with CD4 dependency in human T-cell clones. Immunology 1996;89:46-53.
44. Armitage RJ, Macduff BM, Ulrich DT, Zappone J, Otten C, and Fanslow WC: Evidence for a functional role of CD83 in T- and B-cell responses. Tissue Antigens 1996;48:453.
45. Dudhane A, Conti B, Orlikowsky T, Wang ZQ, Mangla N, Gupta A, Wormser GP, and Hoffmann MK: Monocytes in HIV-type 1-infected individuals lose expression of costimulatory B7 molecules and acquire cytotoxic activity. AIDS Res Hum Retroviruses 1996;12:885-892.
46. Ferbas J, Navratil J, Logar A, and Rinaldo C: Selective decrease in HIV-1-induced alpha interferon production by peripheral blood mononuclear cells during HIV-1 infection. Clin Diag Lab Immunol 1995;2:138-142.