메뉴 건너뛰기




Volumn 18, Issue 5, 2004, Pages 709-718

Is antiretroviral treatment of primary HIV infection clinically justified on the basis of current evidence?

Author keywords

Acute; Antiretroviral therapy; HIV; Primary

Indexed keywords

3 [(4,7 DICHLORO 2 BENZOXAZOLYLMETHYL)AMINO] 5 ETHYL 6 METHYL 2(1H) PYRIDONE; ABACAVIR; ALPHA INTERFERON; AMPRENAVIR; ANTIRETROVIRUS AGENT; CD4 ANTIGEN; CYCLOSPORIN; CYCLOSPORIN A; DIDANOSINE; HYDROXYUREA; IMMUNOMODULATING AGENT; INDINAVIR; INTERLEUKIN 2; LAMIVUDINE; MARKER; NELFINAVIR; NEVIRAPINE; PLACEBO; PROTEINASE INHIBITOR; RITONAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; SAQUINAVIR; STAVUDINE; ZIDOVUDINE;

EID: 2042515582     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-200403260-00001     Document Type: Review
Times cited : (99)

References (67)
  • 1
    • 0023268502 scopus 로고
    • The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial
    • Fischl MA, Richman DD, Grieco MH, Gottlieb MS, Volberding PA, Laskin OL, et al. The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial. N Engl J Med 1987, 317:185-191.
    • (1987) N Engl J Med , vol.317 , pp. 185-191
    • Fischl, M.A.1    Richman, D.D.2    Grieco, M.H.3    Gottlieb, M.S.4    Volberding, P.A.5    Laskin, O.L.6
  • 2
    • 0029095483 scopus 로고
    • Time to hit HIV, early and hard
    • Ho DD. Time to hit HIV, early and hard. N Engl J Med 1995, 333:450-451.
    • (1995) N Engl J Med , vol.333 , pp. 450-451
    • Ho, D.D.1
  • 3
    • 0030869269 scopus 로고    scopus 로고
    • Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy
    • Gulick RM, Mellors JW, Havlir D, Eron JJ, Gonzalez C, McMahon D, et al. Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy. N Engl J Med 1997, 337:734-739.
    • (1997) N Engl J Med , vol.337 , pp. 734-739
    • Gulick, R.M.1    Mellors, J.W.2    Havlir, D.3    Eron, J.J.4    Gonzalez, C.5    McMahon, D.6
  • 4
    • 0345064728 scopus 로고    scopus 로고
    • Acute human immunodeficiency virus type 1 infection
    • Kahn JO, Walker BD. Acute human immunodeficiency virus type 1 infection. N Engl J Med 1998, 339:33-39.
    • (1998) N Engl J Med , vol.339 , pp. 33-39
    • Kahn, J.O.1    Walker, B.D.2
  • 5
    • 0001507107 scopus 로고    scopus 로고
    • Time from HIV-1 seroconversion to AIDS and death before widespread use of highly-active antiretroviral therapy: A collaborative re-analysis. Collaborative Group on AIDS Incubation and HIV Survival including the CASCADE EU Concerted Action. Concerted Action on SeroConversion to AIDS and Death in Europe
    • Cascade. Time from HIV-1 seroconversion to AIDS and death before widespread use of highly-active antiretroviral therapy: a collaborative re-analysis. Collaborative Group on AIDS Incubation and HIV Survival including the CASCADE EU Concerted Action. Concerted Action on SeroConversion to AIDS and Death in Europe. Lancet 2000, 355:1131-1137.
    • (2000) Lancet , vol.355 , pp. 1131-1137
  • 9
    • 0031905322 scopus 로고    scopus 로고
    • Severity and prognosis of acute human immunodeficiency virus type 1 illness: A dose-response relationship
    • Vanhems P, Lambert J, Cooper DA, Perrin L, Carr A, Hirschel B, et al. Severity and prognosis of acute human immunodeficiency virus type 1 illness: a dose-response relationship. Clin Infect Dis 1998, 26:323-329.
    • (1998) Clin Infect Dis , vol.26 , pp. 323-329
    • Vanhems, P.1    Lambert, J.2    Cooper, D.A.3    Perrin, L.4    Carr, A.5    Hirschel, B.6
  • 11
    • 0034030697 scopus 로고    scopus 로고
    • Natural history of human immunodeficiency virus type 1 viremia after seroconversion and proximal to AIDS in a large cohort of homosexual men. Multicenter AIDS Cohort Study
    • Lyles RH, Munoz A, Yamashita TE, Bazmi H, Detels R, Rinaldo CR, et al. Natural history of human immunodeficiency virus type 1 viremia after seroconversion and proximal to AIDS in a large cohort of homosexual men. Multicenter AIDS Cohort Study. J Infect Dis 2000, 181:872-880.
    • (2000) J Infect Dis , vol.181 , pp. 872-880
    • Lyles, R.H.1    Munoz, A.2    Yamashita, T.E.3    Bazmi, H.4    Detels, R.5    Rinaldo, C.R.6
  • 12
    • 0037124139 scopus 로고    scopus 로고
    • Guidelines for using antiretroviral agents among HIV-infected adults and adolescents. Recommendations of the Panel on Clinical Practices for Treatment of HIV
    • Dybul M, Fauci AS, Bartlett JG, Kaplan JE, Pau AK. Guidelines for using antiretroviral agents among HIV-infected adults and adolescents. Recommendations of the Panel on Clinical Practices for Treatment of HIV. MMWR Recomm Rep 2002, 51:1-55.
    • (2002) MMWR Recomm Rep , vol.51 , pp. 1-55
    • Dybul, M.1    Fauci, A.S.2    Bartlett, J.G.3    Kaplan, J.E.4    Pau, A.K.5
  • 13
    • 15644375194 scopus 로고    scopus 로고
    • Report of the NIH panel to define principles of therapy of HIV infection
    • National Institutes of Health. Report of the NIH panel to define principles of therapy of HIV infection. Ann Intern Med 1998, 128:1057-1078.
    • (1998) Ann Intern Med , vol.128 , pp. 1057-1078
  • 14
    • 0033823552 scopus 로고    scopus 로고
    • Virological and immunological effects of combination antiretroviral therapy with zidovudine, lamivudine, and indinavir during primary human immunodeficiency virus type 1 infection
    • Smith D, Berrey MM, Robertson M, Mehrotra D, Markowitz M, Perrin L, et al. Virological and immunological effects of combination antiretroviral therapy with zidovudine, lamivudine, and indinavir during primary human immunodeficiency virus type 1 infection. J Infect Dis 2000, 182:950-954.
    • (2000) J Infect Dis , vol.182 , pp. 950-954
    • Smith, D.1    Berrey, M.M.2    Robertson, M.3    Mehrotra, D.4    Markowitz, M.5    Perrin, L.6
  • 16
    • 0033402781 scopus 로고    scopus 로고
    • The effect of commencing combination antiretroviral therapy soon after human immunodeficiency virus type 1 infection on viral replication and antiviral immune responses
    • Markowitz M, Vesanen M, Tenner-Racz K, Cao Y, Binley JM, Talal A, et al. The effect of commencing combination antiretroviral therapy soon after human immunodeficiency virus type 1 infection on viral replication and antiviral immune responses. J Infect Dis 1999, 179:527-537.
    • (1999) J Infect Dis , vol.179 , pp. 527-537
    • Markowitz, M.1    Vesanen, M.2    Tenner-Racz, K.3    Cao, Y.4    Binley, J.M.5    Talal, A.6
  • 17
    • 0032814791 scopus 로고    scopus 로고
    • T cell changes after combined nucleoside analogue therapy in HIV primary infection
    • Carcelain G, Blanc C, Leibowitch J, Mariot P, Mathez D, Schneider V, et al. T cell changes after combined nucleoside analogue therapy in HIV primary infection. AIDS 1999, 13:1077-1081.
    • (1999) AIDS , vol.13 , pp. 1077-1081
    • Carcelain, G.1    Blanc, C.2    Leibowitch, J.3    Mariot, P.4    Mathez, D.5    Schneider, V.6
  • 18
    • 0001090794 scopus 로고    scopus 로고
    • Viral load and burden modification following early antiretroviral therapy of primary HIV-1 infection
    • Lillo FB, Ciuffreda D, Veglia F, Capiluppi B, Mastrorilli E, Vergani B, et al. Viral load and burden modification following early antiretroviral therapy of primary HIV-1 infection. AIDS 1999, 13:791-796.
    • (1999) AIDS , vol.13 , pp. 791-796
    • Lillo, F.B.1    Ciuffreda, D.2    Veglia, F.3    Capiluppi, B.4    Mastrorilli, E.5    Vergani, B.6
  • 19
    • 0034092561 scopus 로고    scopus 로고
    • Time of initiation of antiretroviral therapy: Impact on HIV-1 viraemia. The Swiss HIV Cohort Study
    • Yerly S, Kaiser L, Perneger TV, Cone RW, Opravil M, Chave JP, et al. Time of initiation of antiretroviral therapy: impact on HIV-1 viraemia. The Swiss HIV Cohort Study. AIDS 2000, 14: 243-249.
    • (2000) AIDS , vol.14 , pp. 243-249
    • Yerly, S.1    Kaiser, L.2    Perneger, T.V.3    Cone, R.W.4    Opravil, M.5    Chave, J.P.6
  • 20
    • 0034014018 scopus 로고    scopus 로고
    • Prevalence of drug resistant mutants and virological response to combination therapy in patients with primary HIV-1 infection
    • Tamalet C, Pasquier C, Yahi N, Colson P, Poizot-Martin I, Lepeu G, et al. Prevalence of drug resistant mutants and virological response to combination therapy in patients with primary HIV-1 infection. J Med Virol 2000, 61:181-186.
    • (2000) J Med Virol , vol.61 , pp. 181-186
    • Tamalet, C.1    Pasquier, C.2    Yahi, N.3    Colson, P.4    Poizot-Martin, I.5    Lepeu, G.6
  • 21
    • 0035958765 scopus 로고    scopus 로고
    • Early control of HIV replication in primary HIV-1 infection treated with antiretroviral drugs and pegylated IFN alpha: Results from the Primoferon A (ANRS 086) Study
    • Emilie D, Burgard M, Lascoux-Combe C, Laughlin M, Krzysiek R, Pignon C, et al. Early control of HIV replication in primary HIV-1 infection treated with antiretroviral drugs and pegylated IFN alpha: results from the Primoferon A (ANRS 086) Study. AIDS 2001, 15:1435-1437.
    • (2001) AIDS , vol.15 , pp. 1435-1437
    • Emilie, D.1    Burgard, M.2    Lascoux-Combe, C.3    Laughlin, M.4    Krzysiek, R.5    Pignon, C.6
  • 22
    • 6844240219 scopus 로고    scopus 로고
    • Randomised placebo-controlled trial of ritonavir in advanced HIV-1 disease
    • The Advanced HIV Disease Ritonavir Study Group
    • Cameron DW, Heath-Chiozzi M, Danner S, Danner S, Cohen C, Kravcik S, Maurath C, et al. Randomised placebo-controlled trial of ritonavir in advanced HIV-1 disease. The Advanced HIV Disease Ritonavir Study Group. Lancet 1997, 351:543-549.
    • (1997) Lancet , vol.351 , pp. 543-549
    • Cameron, D.W.1    Heath-Chiozzi, M.2    Danner, S.3    Danner, S.4    Cohen, C.5    Kravcik, S.6    Maurath, C.7
  • 24
    • 0034724371 scopus 로고    scopus 로고
    • Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes
    • Oxenius A, Price DA, Easterbrook PJ, O'Callaghan CA, Kelleher AD, Whelan JA, et al. Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes. Proc Natl Acad Sci USA 2000, 97:3382-3387.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 3382-3387
    • Oxenius, A.1    Price, D.A.2    Easterbrook, P.J.3    O'Callaghan, C.A.4    Kelleher, A.D.5    Whelan, J.A.6
  • 25
    • 0035862330 scopus 로고    scopus 로고
    • Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection
    • Altfeld M, Rosenberg ES, Shankarappa R, Mukherjee JS, Hecht FM, Eldridge RL, et al. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J Exp Med 2001, 193:169-180.
    • (2001) J Exp Med , vol.193 , pp. 169-180
    • Altfeld, M.1    Rosenberg, E.S.2    Shankarappa, R.3    Mukherjee, J.S.4    Hecht, F.M.5    Eldridge, R.L.6
  • 26
    • 0033503076 scopus 로고    scopus 로고
    • Potent antiretroviral therapy of primary human immunodeficiency virus type 1 (HIV-1) infection: Partial normalization of T lymphocyte subsets and limited reduction of HIV-1 DNA despite clearance of plasma viremia
    • Zaunders JJ, Cunningham PH, Kelleher AD, Kaufmann GR, Jaramillo AB, Wright R, et al. Potent antiretroviral therapy of primary human immunodeficiency virus type 1 (HIV-1) infection: partial normalization of T lymphocyte subsets and limited reduction of HIV-1 DNA despite clearance of plasma viremia. J Infect Dis 1999, 180:320-329.
    • (1999) J Infect Dis , vol.180 , pp. 320-329
    • Zaunders, J.J.1    Cunningham, P.H.2    Kelleher, A.D.3    Kaufmann, G.R.4    Jaramillo, A.B.5    Wright, R.6
  • 28
    • 0030729665 scopus 로고    scopus 로고
    • Early postinfection antiviral treatment reduces viral load and prevents CD4+ cell decline in HIV type 2-infected macaques
    • Watson A, McClure J, Ranchalis J, Scheibel M, Schmidt A, Kennedy B, et al. Early postinfection antiviral treatment reduces viral load and prevents CD4+ cell decline in HIV type 2-infected macaques. AIDS Res Hum Retroviruses 1997, 13:1375-1381.
    • (1997) AIDS Res Hum Retroviruses , vol.13 , pp. 1375-1381
    • Watson, A.1    McClure, J.2    Ranchalis, J.3    Scheibel, M.4    Schmidt, A.5    Kennedy, B.6
  • 29
    • 0033797658 scopus 로고    scopus 로고
    • Induction of HIV-1-specific T-helper responses and type 1 cytokine secretion following therapeutic vaccination of macaques with a recombinant fowlpoxvirus co-expressing interferon-gamma
    • Dale CJ, Zhao A, Jones SL, Boyle DB, Ramshaw IA, Kent SJ. Induction of HIV-1-specific T-helper responses and type 1 cytokine secretion following therapeutic vaccination of macaques with a recombinant fowlpoxvirus co-expressing interferon-gamma. J Med Primatol 2000, 29:240-247.
    • (2000) J Med Primatol , vol.29 , pp. 240-247
    • Dale, C.J.1    Zhao, A.2    Jones, S.L.3    Boyle, D.B.4    Ramshaw, I.A.5    Kent, S.J.6
  • 31
    • 0035951458 scopus 로고    scopus 로고
    • Treatment interruption after one year of triple nucleoside analogue therapy for primary HIV infection
    • Girard PM, Schneider V, Dehee A, Mariot P, Jacomet C, Delphin N, et al. Treatment interruption after one year of triple nucleoside analogue therapy for primary HIV infection. AIDS 2001, 15:275-277.
    • (2001) AIDS , vol.15 , pp. 275-277
    • Girard, P.M.1    Schneider, V.2    Dehee, A.3    Mariot, P.4    Jacomet, C.5    Delphin, N.6
  • 32
    • 0027122957 scopus 로고
    • 1993 Revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults
    • Centers for Disease Control and Prevention. 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. MMWR Recomm Rep 1992, 41:1-19.
    • (1992) MMWR Recomm Rep , vol.41 , pp. 1-19
  • 34
    • 0031845233 scopus 로고    scopus 로고
    • Zidovudine treatment in patients with primary (acute) human immunodeficiency virus type 1 infection: A randomized, double-blind, placebo-controlled trial
    • DATRI 002 Study Group. Division of AIDS Treatment Research Initiative
    • Niu MT, Bethel J, Holodniy M, Standiford HC, Schnittman SM. Zidovudine treatment in patients with primary (acute) human immunodeficiency virus type 1 infection: a randomized, double-blind, placebo-controlled trial. DATRI 002 Study Group. Division of AIDS Treatment Research Initiative. J Infect Dis 1998, 178:80-91.
    • (1998) J Infect Dis , vol.178 , pp. 80-91
    • Niu, M.T.1    Bethel, J.2    Holodniy, M.3    Standiford, H.C.4    Schnittman, S.M.5
  • 35
    • 0032556928 scopus 로고    scopus 로고
    • Effect of combined zidovudine and didanosine therapy in early asymptomatic primary HIV-1 infection
    • Khajotia RR, Feigley CE, Lee E, Gu J. Effect of combined zidovudine and didanosine therapy in early asymptomatic primary HIV-1 infection. AIDS 1998, 12:222-224.
    • (1998) AIDS , vol.12 , pp. 222-224
    • Khajotia, R.R.1    Feigley, C.E.2    Lee, E.3    Gu, J.4
  • 37
    • 0032811568 scopus 로고    scopus 로고
    • Long-term evaluation of triple nucleoside therapy administered from primary HIV-1 infection
    • Poggi C, Profizi N, Djediouane A, Chollet L, Hittinger G, Lafeuillade A. Long-term evaluation of triple nucleoside therapy administered from primary HIV-1 infection. AIDS 1999, 13:1213-1220.
    • (1999) AIDS , vol.13 , pp. 1213-1220
    • Poggi, C.1    Profizi, N.2    Djediouane, A.3    Chollet, L.4    Hittinger, G.5    Lafeuillade, A.6
  • 38
    • 0035695104 scopus 로고    scopus 로고
    • Decay of HIV type 1 DNA and development of drug-resistant mutants in patients with primary HIV type 1 infection receiving highly active antiretroviral therapy
    • Riva E, Pistello M, Narciso P, D'Offizi G, Isola P, Galati V, et al. Decay of HIV type 1 DNA and development of drug-resistant mutants in patients with primary HIV type 1 infection receiving highly active antiretroviral therapy. AIDS Res Hum Retroviruses 2001, 17:1599-1604.
    • (2001) AIDS Res Hum Retroviruses , vol.17 , pp. 1599-1604
    • Riva, E.1    Pistello, M.2    Narciso, P.3    D'Offizi, G.4    Isola, P.5    Galati, V.6
  • 39
    • 0030944193 scopus 로고    scopus 로고
    • Effects of a combination of zidovudine, didanosine, and lamivudine on primary human immunodeficiency virus type 1 infection
    • Lafeuillade A, Poggi C, Tamalet C, Profizi N, Tourres C, Costes O. Effects of a combination of zidovudine, didanosine, and lamivudine on primary human immunodeficiency virus type 1 infection. J Infect Dis 1997, 175:1051-1055.
    • (1997) J Infect Dis , vol.175 , pp. 1051-1055
    • Lafeuillade, A.1    Poggi, C.2    Tamalet, C.3    Profizi, N.4    Tourres, C.5    Costes, O.6
  • 40
    • 0037040375 scopus 로고    scopus 로고
    • Parallel decline of CD8+/CD38++ T cells and viraemia in response to quadruple highly active antiretroviral therapy in primary HIV infection
    • Tilling R, Kinloch S, Goh LE, Cooper D, Perrin L, Lampe F, et al. Parallel decline of CD8+/CD38++ T cells and viraemia in response to quadruple highly active antiretroviral therapy in primary HIV infection. AIDS 2002, 16:589-596.
    • (2002) AIDS , vol.16 , pp. 589-596
    • Tilling, R.1    Kinloch, S.2    Goh, L.E.3    Cooper, D.4    Perrin, L.5    Lampe, F.6
  • 41
    • 0036192919 scopus 로고    scopus 로고
    • Treatment of primary HIV-1 infection with cyclosporin A coupled with highly active antiretroviral therapy
    • Rizzardi GP, Harari A, Capiluppi B, Tambussi G, Ellefsen K, Ciuffreda D, et al. Treatment of primary HIV-1 infection with cyclosporin A coupled with highly active antiretroviral therapy. J Clin Invest 2002, 109:681-688.
    • (2002) J Clin Invest , vol.109 , pp. 681-688
    • Rizzardi, G.P.1    Harari, A.2    Capiluppi, B.3    Tambussi, G.4    Ellefsen, K.5    Ciuffreda, D.6
  • 42
    • 0033402781 scopus 로고    scopus 로고
    • The effect of commencing combination antiretroviral therapy soon after human immunodeficiency virus type 1 infection on viral replication and antiviral immune responses
    • Markowitz M, Vesanen M, Tenner-Racz K, Cao Y, Binley JM, Talal A, et al. The effect of commencing combination antiretroviral therapy soon after human immunodeficiency virus type 1 infection on viral replication and antiviral immune responses. J Infect Dis 1999, 179:527-537.
    • (1999) J Infect Dis , vol.179 , pp. 527-537
    • Markowitz, M.1    Vesanen, M.2    Tenner-Racz, K.3    Cao, Y.4    Binley, J.M.5    Talal, A.6
  • 43
    • 0034491401 scopus 로고    scopus 로고
    • Rapid restoration of CD4 T cell subsets in subjects receiving antiretroviral therapy during primary HIV-1 infection
    • Kaufmann GR, Zaunders JJ, Cunningham P, Kelleher AD, Grey P, Smith D, et al. Rapid restoration of CD4 T cell subsets in subjects receiving antiretroviral therapy during primary HIV-1 infection. AIDS 2000, 14:2643-2651.
    • (2000) AIDS , vol.14 , pp. 2643-2651
    • Kaufmann, G.R.1    Zaunders, J.J.2    Cunningham, P.3    Kelleher, A.D.4    Grey, P.5    Smith, D.6
  • 44
    • 0033966634 scopus 로고    scopus 로고
    • Effect of combination antiretroviral therapy on T-cell immunity in acute human immunodeficiency virus type 1 infection
    • Malhotra U, Berrey MM, Huang Y, Markee J, Brown DJ, Ap S, et al. Effect of combination antiretroviral therapy on T-cell immunity in acute human immunodeficiency virus type 1 infection. J Infect Dis 2000, 181:121-131.
    • (2000) J Infect Dis , vol.181 , pp. 121-131
    • Malhotra, U.1    Berrey, M.M.2    Huang, Y.3    Markee, J.4    Brown, D.J.5    Ap, S.6
  • 45
    • 0033758427 scopus 로고    scopus 로고
    • Viral dynamics in primary HIV-1 infection
    • Karolinska Institutet Primary HIV Infection Study Group
    • Lindback S, Karlsson AC, Mittler J, Blaxhult A, Carlsson M, Briheim G, et al. Viral dynamics in primary HIV-1 infection. Karolinska Institutet Primary HIV Infection Study Group. AIDS 2000, 14:2283-2291.
    • (2000) AIDS , vol.14 , pp. 2283-2291
    • Lindback, S.1    Karlsson, A.C.2    Mittler, J.3    Blaxhult, A.4    Carlsson, M.5    Briheim, G.6
  • 46
    • 0036139572 scopus 로고    scopus 로고
    • Pilot study of the effects of intermittent interleukin-2 on human immunodeficiency virus (HIV)-specific immune responses in patients treated during recently acquired HIV infection
    • Dybul M, Hidalgo B, Chun TW, Belson M, Migueles SA, Justement JS, et al. Pilot study of the effects of intermittent interleukin-2 on human immunodeficiency virus (HIV)-specific immune responses in patients treated during recently acquired HIV infection. J Infect Dis 2002, 185:61-68.
    • (2002) J Infect Dis , vol.185 , pp. 61-68
    • Dybul, M.1    Hidalgo, B.2    Chun, T.W.3    Belson, M.4    Migueles, S.A.5    Justement, J.S.6
  • 47
    • 0035853422 scopus 로고    scopus 로고
    • Proviral HIV-1 DNA in subjects followed since primary HIV-1 infection who suppress plasma viral load after one year of highly active antiretroviral therapy
    • Ngo-Giang-Huong N, Deveau C, Da Silva I, Pellegrin I, Venet A, Harzic M, et al. Proviral HIV-1 DNA in subjects followed since primary HIV-1 infection who suppress plasma viral load after one year of highly active antiretroviral therapy. AIDS 2001, 15:665-673.
    • (2001) AIDS , vol.15 , pp. 665-673
    • Ngo-Giang-Huong, N.1    Deveau, C.2    Da Silva, I.3    Pellegrin, I.4    Venet, A.5    Harzic, M.6
  • 48
    • 0032995701 scopus 로고    scopus 로고
    • Long-term prognosis following zidovudine monotherapy in primary human immunodeficiency virus type 1 infection
    • Lindback S, Vizzard J, Cooper DA, Gaines H. Long-term prognosis following zidovudine monotherapy in primary human immunodeficiency virus type 1 infection. J Infect Dis 1999, 179:1549-1552.
    • (1999) J Infect Dis , vol.179 , pp. 1549-1552
    • Lindback, S.1    Vizzard, J.2    Cooper, D.A.3    Gaines, H.4
  • 49
    • 0035873685 scopus 로고    scopus 로고
    • Treatment of primary human immunodeficiency virus type 1 infection with potent antiretroviral therapy reduces frequency of rapid progression to aids
    • Berrey MM, Schacker T, Collier AC, Shea T, Brodie SJ, Mayers D, et al. Treatment of primary human immunodeficiency virus type 1 infection with potent antiretroviral therapy reduces frequency of rapid progression to aids. J Infect Dis 2001, 183: 1466-1475.
    • (2001) J Infect Dis , vol.183 , pp. 1466-1475
    • Berrey, M.M.1    Schacker, T.2    Collier, A.C.3    Shea, T.4    Brodie, S.J.5    Mayers, D.6
  • 50
    • 0033393313 scopus 로고    scopus 로고
    • Highly active antiretroviral treatment initiated early in the course of symptomatic primary HIV-1 infection: Results of the ANRS 053 trial
    • Hoen B, Dumon B, Harzic M, Venet A, Dubeaux B, Lascoux C, et al. Highly active antiretroviral treatment initiated early in the course of symptomatic primary HIV-1 infection: results of the ANRS 053 trial. J Infect Dis 1999, 180:1342-1346.
    • (1999) J Infect Dis , vol.180 , pp. 1342-1346
    • Hoen, B.1    Dumon, B.2    Harzic, M.3    Venet, A.4    Dubeaux, B.5    Lascoux, C.6
  • 51
    • 0036535260 scopus 로고    scopus 로고
    • Higher rate of toxicity with no increased efficacy when hydroxyurea is added to a regimen of stavudine plus didanosine and nevirapine in primary HIV infection
    • Zala C, Salomon H, Ochoa C, Kijak G, Federico A, Perez H, et al. Higher rate of toxicity with no increased efficacy when hydroxyurea is added to a regimen of stavudine plus didanosine and nevirapine in primary HIV infection. J Acquir Immune Defic Syndr 2002, 29:368-373.
    • (2002) J Acquir Immune Defic Syndr , vol.29 , pp. 368-373
    • Zala, C.1    Salomon, H.2    Ochoa, C.3    Kijak, G.4    Federico, A.5    Perez, H.6
  • 53
    • 0036720475 scopus 로고    scopus 로고
    • Discontinuation of antiretroviral therapy commenced early during the course of human immunodeficiency virus type 1 infection, with or without adjunctive vaccination
    • Markowitz M, Jin X, Hurley A, Simon V, Ramratnam B, Louie M, et al. Discontinuation of antiretroviral therapy commenced early during the course of human immunodeficiency virus type 1 infection, with or without adjunctive vaccination. J Infect Dis 2002, 186:634-643.
    • (2002) J Infect Dis , vol.186 , pp. 634-643
    • Markowitz, M.1    Jin, X.2    Hurley, A.3    Simon, V.4    Ramratnam, B.5    Louie, M.6
  • 54
    • 0037131341 scopus 로고    scopus 로고
    • Virological and immunological effects of short-course antiretroviral therapy in primary HIV infection
    • Fidler S, Oxenius A, Brady M, Clarke J, Cropley I, Babiker A, et al. Virological and immunological effects of short-course antiretroviral therapy in primary HIV infection. AIDS 2002, 16:2049-2054.
    • (2002) AIDS , vol.16 , pp. 2049-2054
    • Fidler, S.1    Oxenius, A.2    Brady, M.3    Clarke, J.4    Cropley, I.5    Babiker, A.6
  • 56
    • 0031736294 scopus 로고    scopus 로고
    • Patterns of viral dynamics during primary human immunodeficiency virus type 1 infection
    • The Sydney Primary HIV Infection Study Group
    • Kaufmann GR, Cunningham P, Kelleher AD, Zaunders J, Carr A, Vizzard J, et al. Patterns of viral dynamics during primary human immunodeficiency virus type 1 infection. The Sydney Primary HIV Infection Study Group. J Infect Dis 1998, 178:1812-1815.
    • (1998) J Infect Dis , vol.178 , pp. 1812-1815
    • Kaufmann, G.R.1    Cunningham, P.2    Kelleher, A.D.3    Zaunders, J.4    Carr, A.5    Vizzard, J.6
  • 57
    • 0037169213 scopus 로고    scopus 로고
    • Homogeneous quasispecies in 16 out of 17 individuals during very early HIV-1 primary infection
    • Delwart E, Magierowska M, Royz M, Foley B, Peddada L, Smith R, et al. Homogeneous quasispecies in 16 out of 17 individuals during very early HIV-1 primary infection. AIDS 2002, 16: 189-195.
    • (2002) AIDS , vol.16 , pp. 189-195
    • Delwart, E.1    Magierowska, M.2    Royz, M.3    Foley, B.4    Peddada, L.5    Smith, R.6
  • 58
    • 0033943843 scopus 로고    scopus 로고
    • Incubation time of acute human immunodeficiency virus (HIV) infection and duration of acute HIV infection are independent prognostic factors of progression to AIDS
    • Vanhems P, Hirschel B, Phillips AN, Cooper DA, Vizzard J, Brassard J, et al. Incubation time of acute human immunodeficiency virus (HIV) infection and duration of acute HIV infection are independent prognostic factors of progression to AIDS. J Infect Dis 2000, 182:334-337.
    • (2000) J Infect Dis , vol.182 , pp. 334-337
    • Vanhems, P.1    Hirschel, B.2    Phillips, A.N.3    Cooper, D.A.4    Vizzard, J.5    Brassard, J.6
  • 59
    • 0032524124 scopus 로고    scopus 로고
    • Acute HIV syndrome after discontinuation of antiretroviral therapy in a patient treated before seroconversion
    • Daar ES, Bai J, Hausner MA, Majchrowicz M, Tamaddon M, Giorgi JV. Acute HIV syndrome after discontinuation of antiretroviral therapy in a patient treated before seroconversion. Ann Intern Med 1998, 128:827-829.
    • (1998) Ann Intern Med , vol.128 , pp. 827-829
    • Daar, E.S.1    Bai, J.2    Hausner, M.A.3    Majchrowicz, M.4    Tamaddon, M.5    Giorgi, J.V.6
  • 60
    • 0035862330 scopus 로고    scopus 로고
    • Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection
    • Altfeld M, Rosenberg ES, Shankarappa R, Mukherjee JS, Hecht FM, Eldridge RL, et al. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J Exp Med 2001, 193:169-180.
    • (2001) J Exp Med , vol.193 , pp. 169-180
    • Altfeld, M.1    Rosenberg, E.S.2    Shankarappa, R.3    Mukherjee, J.S.4    Hecht, F.M.5    Eldridge, R.L.6
  • 61
    • 0035875860 scopus 로고    scopus 로고
    • HIV dynamics and T-cell immunity after three structured treatment interruptions in chronic HIV-1 infection
    • Ruiz L, Carcelain G, Martinez-Picado J, Frost S, Marfil S, Paredes R, et al. HIV dynamics and T-cell immunity after three structured treatment interruptions in chronic HIV-1 infection. AIDS 2001, 15:F19-F27.
    • (2001) AIDS , vol.15
    • Ruiz, L.1    Carcelain, G.2    Martinez-Picado, J.3    Frost, S.4    Marfil, S.5    Paredes, R.6
  • 62
    • 0034749278 scopus 로고    scopus 로고
    • Transient mobilization of human immunodeficiency virus (HIV)-specific CD4 T-helper cells fails to control virus rebounds during intermittent antiretroviral therapy in chronic HIV type 1 infection
    • Carcelain G, Tubiana R, Samri A, Calvez V, Delaugerre C, Agut H, et al. Transient mobilization of human immunodeficiency virus (HIV)-specific CD4 T-helper cells fails to control virus rebounds during intermittent antiretroviral therapy in chronic HIV type 1 infection. J Virol 2001, 75:234-241.
    • (2001) J Virol , vol.75 , pp. 234-241
    • Carcelain, G.1    Tubiana, R.2    Samri, A.3    Calvez, V.4    Delaugerre, C.5    Agut, H.6
  • 63
    • 0037122796 scopus 로고    scopus 로고
    • Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes
    • Barouch DH, Kunstman J, Kuroda MJ, Schmitz JE, Santra S, Peyerl FW, et al. Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes. Nature 2002, 415:335-339.
    • (2002) Nature , vol.415 , pp. 335-339
    • Barouch, D.H.1    Kunstman, J.2    Kuroda, M.J.3    Schmitz, J.E.4    Santra, S.5    Peyerl, F.W.6
  • 64
    • 0034110009 scopus 로고    scopus 로고
    • Maximum suppression of HIV replication leads to the restoration of HIV-specific responses in early HIV disease
    • Al-Harthi L, Siegel J, Spritzler J, Pottage J, Agnoli M, Landay A. Maximum suppression of HIV replication leads to the restoration of HIV-specific responses in early HIV disease. AIDS 2000, 14:761-770.
    • (2000) AIDS , vol.14 , pp. 761-770
    • Al-Harthi, L.1    Siegel, J.2    Spritzler, J.3    Pottage, J.4    Agnoli, M.5    Landay, A.6
  • 65
    • 0242629783 scopus 로고    scopus 로고
    • Evolution of envelope sequences of human immunodeficiency virus type 1 in cellular reservoirs in the setting of potent antiviral therapy
    • Gunthard HF, Frost SD, Leigh-Brown AJ, Ignacio CC, Kee K, Perelson AS, et al. Evolution of envelope sequences of human immunodeficiency virus type 1 in cellular reservoirs in the setting of potent antiviral therapy. J Virol 1999, 73:9404-9412.
    • (1999) J Virol , vol.73 , pp. 9404-9412
    • Gunthard, H.F.1    Frost, S.D.2    Leigh-Brown, A.J.3    Ignacio, C.C.4    Kee, K.5    Perelson, A.S.6
  • 67
    • 0037348225 scopus 로고    scopus 로고
    • Greater reversal of CD4(+) cell abnormalities and viral load reduction after initiation of antiretroviral therapy with zidovudine, lamivudine, and nelfinavir before complete HIV type 1 seroconversion
    • Smith DE, Kaufmann GR, Kahn JO, Hecht FM, Grey PA, Zaunders JJ, et al. Greater reversal of CD4(+) cell abnormalities and viral load reduction after initiation of antiretroviral therapy with zidovudine, lamivudine, and nelfinavir before complete HIV type 1 seroconversion. AIDS Res Hum Retroviruses 2003, 19: 189-199.
    • (2003) AIDS Res Hum Retroviruses , vol.19 , pp. 189-199
    • Smith, D.E.1    Kaufmann, G.R.2    Kahn, J.O.3    Hecht, F.M.4    Grey, P.A.5    Zaunders, J.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.