Protein kinases as targets for antimalarial intervention: Kinomics, structure-based design, transmission-blockade, and targeting host cell enzymes

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1754, Issue 1-2, 2005, Pages 132-150

  Doerig, Christian ^a   Billker, Oliver ^b   Pratt, David ^c,d   Endicott, Jane ^c  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

Development; Drug discovery; Entamoeba; Inhibitor; Malaria; Parasite; Plasmodium; Protein kinase; Theileria; Toxoplasma; Trypanosoma

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 6 CYCLOHEXYLMETHOXY 2 (4 SULFAMOYLANILINO)PURINE; AMINO ACID; ANTIMALARIAL AGENT; CASEIN KINASE I; CHLOROQUINE; CYCLACEL; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR; FANSIDAR; HYMENIALDISINE; INDIRUBIN 5 SULFONATE; MITOGEN ACTIVATED PROTEIN KINASE; O 6 CYCLOHEXYLMETHYL 2 (4' SULFAMOYLANILINO)PURINE; OXINDOLE; OXINDOLE 3; OXINDOLE 4; PROTEIN KINASE; PROTEIN KINASE 5; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; PURINE DERIVATIVE; PURVALANOL; PURVALANOL B; QUINAZOLINE; ROSCOVITINE; STAUROSPORINE; UNCLASSIFIED DRUG;

BREAST CANCER; CELL CYCLE; CLINICAL TRIAL; CONFERENCE PAPER; DATA BASE; DEVELOPMENTAL STAGE; DISEASE CONTROL; DRUG TARGETING; ENZYME ACTIVITY; GAMETE; GENE SEQUENCE; GENETIC ANALYSIS; HOST CELL; HUMAN; LUNG NON SMALL CELL CANCER; NONHUMAN; PARASITE TRANSMISSION; PARASITE VECTOR; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN TARGETING; PROTOZOON; STRUCTURE ANALYSIS; VALIDATION PROCESS; ZYGOTE;

ANIMALS; ANTIMALARIALS; ANTIPROTOZOAL AGENTS; CYCLINS; DRUG DESIGN; HUMANS; LIFE CYCLE STAGES; MALARIA, FALCIPARUM; MODELS, BIOLOGICAL; MODELS, GENETIC; MOLECULAR STRUCTURE; PLASMODIUM FALCIPARUM; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTOZOAN PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

ARTHROPODA; ENTAMOEBA; PLASMODIUM FALCIPARUM; PROTOZOA; THEILERIA; TOXOPLASMA; TRYPANOSOMA;

EID: 29144446249     PISSN: 15709639     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbapap.2005.08.027     Document Type: Conference Paper

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