The H89 cAMP-dependent protein kinase inhibitor blocks Plasmodium falciparum development in infected erythrocytes

European Journal of Biochemistry

Volumn 268, Issue 18, 2001, Pages 4842-4849

  Syin, Chiang ^a   Parzy, Daniel ^b   Traincard, Francois ^c   Boccaccio, Irène ^d   Joshi, Manju B ^a   Lin, David T ^a,f   Yang, Xiao Ming ^a   Assemat, Karine ^c   Doerig, Christian ^e   Langsley, Gordon ^c  

^a CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^b SERVICE DE SANTÉ DES ARMÉES   (France)

^c INSTITUT PASTEUR   (France)

^d 4INSERM U399 ^*  (France)

^e PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^f CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

H89; Inhibition; Parasite; PKA

Indexed keywords

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; ERYTHROCYTE ENZYME; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE;

ANIMAL CELL; ARTICLE; CATALYSIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ERYTHROCYTE; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMAN; MALARIA; MOSQUITO; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITE DEVELOPMENT; PARASITE TRANSMISSION; PARASITE VECTOR; PARASITOSIS; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SCHIZONT;

AMINO ACID SEQUENCE; ANIMALS; ANTIMALARIALS; BLOTTING, WESTERN; CATALYTIC DOMAIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DRUG DESIGN; ENZYME INHIBITORS; ERYTHROCYTES; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; INHIBITORY CONCENTRATION 50; ISOQUINOLINES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PLASMODIUM FALCIPARUM; PROTEIN CONFORMATION; PROTEIN SUBUNITS; RNA, MESSENGER; SEQUENCE ALIGNMENT; SULFONAMIDES;

ANIMALIA; PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 0034785963     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2001.02403.x     Document Type: Article

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