BRAF mutations in aberrant crypt foci and hyperplastic polyposis

American Journal of Pathology

Volumn 166, Issue 4, 2005, Pages 1069-1075

  Beach, Robyn ^a   Chan, Annie On On ^b   Wu, Tsung Teh ^a   White, Jill A ^a   Morris, Jeffrey S ^a   Lunagomez, Simon ^a   Broaddus, Russell R ^a   Issa, Jean Pierre J ^a   Hamilton, Stanley R ^a   Rashid, Asif ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ABERRANT CRYPT FOCUS; ADENOMA; ADENOMATOUS POLYP; ADULT; AGED; ARTICLE; BRAF GENE; CANCER RISK; CHROMOSOME 1P; CLINICAL ARTICLE; COLORECTAL CARCINOMA; CONTROLLED STUDY; CORRELATION ANALYSIS; CRYPT CELL; DISEASE ASSOCIATION; DNA METHYLATION; DNA SEQUENCE; FEMALE; GASTROINTESTINAL POLYPOSIS; GENE; GENE LOCUS; GENE MUTATION; GENETIC HETEROGENEITY; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERPLASTIC ADENOMATOUS POLYP; HYPERPLASTIC POLYPOSIS; LOGISTIC REGRESSION ANALYSIS; MALE; MINT31 GENE; MIXED TUMOR; MUTATIONAL ANALYSIS; ONCOGENE K RAS; PATHOGENESIS; PHENOTYPE; PRECANCER; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SERRATED ADENOMA; TUMOR SUPPRESSOR GENE;

EID: 20244383984     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)62327-9     Document Type: Article

References (46)

1. Otori K, Oda Y, Sugiyama K, Hasebe T, Kinzler KW, Vogelstein B: Lessons from hereditary colorectal cancer. Cell 1996, 87:159-170
2. Fearon ER, Dang CV: Cancer genetics: tumor suppressor meets oncogene. Curr Biol 1999, 9:R62-R65
3. Chung DC: The genetic basis of colorectal cancer: insights into critical pathways of tumorigenesis. Gastroenterology 2000, 119:854-865
4. Nucci MR, Robinson CR, Longo P, Campbell P, Hamilton SR: Phenotypic and genotypic characteristics of aberrant crypt foci in human colorectal mucosa. Hum Pathol 1997, 28:1396-1407
5. Pretlow TP, Brasitus TA, Fulton NC, Cheyer C, Kaplan EL: K-ras mutations in putative preneoplastic lesions in human colon. J Natl Cancer Inst 1993, 85:2004-2007
6. Heinen CD, Shivapurkar N, Tang Z, Groden J, Alabaster O: Microsatellite instability in aberrant crypt foci from human colons. Cancer Res 1996, 56:5339-5341
7. Yamashita N, Minamoto T, Ochiai A, Onda M, Esumi H: Frequent and characteristic K-ras activation and absence of p53 protein accumulation in aberrant crypt foci of the colon. Gastroenterology 1995, 108:434-440
8. Otori K, Konishi M, Sugiyama K, Hasebe T, Shimoda T, Kikuchi-Yanoshita R, Mukai K, Fukushima S, Miyaki M. Esumi H: Infrequent somatic mutation of the adenomatous polyposis coli gene in aberrant crypt foci of human colon tissue. Cancer 1998, 83:896-900
9. Takayama T, Ohi M, Hayashi T, Miyanishi K, Nobuoka A, Nakajima T, Satoh T, Takimoto R, Kato J, Sakamaki S, Niitsu Y: Analysis of K-ras, APC, and β-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis. Gastroenterology 2001, 121:599-611
10. Chan AO, Broaddus RB, Houlihan PS, Issa J-PJ, Morris JS, Hamilton SR, Rashid A: CpG island methylation in aberrant crypt foci of the colorectum. Am J Pathol 2002, 160:1823-1830
11. Longacre TA, Fenoglio-Preiser CM: Mixed hyperplastic adenomatous polyps/serrated adenoma. A distinct form of colorectal neoplasia. Am J Surg Pathol 1990, 14:524-537
12. Hawkins NJ, Ward RL: Sporadic colorectal cancers with microsatellite instability and their possible origin in hyperplastic polyps and serrated adenomas. J Natl Cancer Inst 2001, 93:1307-1313
13. Jass JR, Cottier DS, Pokos V, Parry S, Winship IM: Mixed epithelial polyps in association with hereditary non-polyposis colorectal cancer providing an alternative pathway of cancer histogenesis. Pathology 1997, 29:28-33
14. Iino H, Jass JR, Simms LA, Young J, Leggett B, Ajioka Y, Watanabe H: DNA microsatellite instability in hyperplastic polyps, serrated adenomas, and mixed polyps: a mild mutator pathway for colorectal cancer? J Clin Pathol 1999, 52:5-9
15. Jass JR, Iino H, Ruszkiewicz A, Painter D, Solomon MJ, Koorey DJ, Cohn D, Furlong KL, Walsh MD, Palazzo J, Edmonston TB, Fishel R, Young J, Leggett BA: Neoplastic progression occurs through mutator pathways in hyperplastic polyposis of the colorectum. Gut 2000, 47:43-49
16. Rashid A, Houlihan PS, Booker S, Peterson GM, Giardiello FM, Hamilton SR: Phenotypic and molecular characteristics of hyperplastic polyposis. Gastroenterology 2000, 119:323-332
17. Williams GT: Metaplastic (hyperplastic) polyps of the large bowel: benign neoplasms after all? Gut 1997, 40:691-692
18. Jass JR: Serrated route to colorectal cancer: back street or super highway? J Pathol 2001, 193:283-285
19. Jass JR, Whitehall VL, Young J, Leggett BA: Emerging concepts in colorectal neoplasia. Gastroenterology 2002, 123:862-876
20. Cohen SM, Brown L, Janower ML, McCready FJ: Multiple metaplastic (hyperplastic) polyposis of the colon. Gastrointest Radiol 1981, 6:333-335
21. Urbanski SJ, Kossakowska AE, Marcon N, Bruce WR: Mixed hyperplastic adenomatous polyps - an underdiagnosed entity. Am J Surg Pathol 1984, 8:551-556
22. Bengoechea O, Martinez-Penuela JM, Larrinaga B, Valerdi J, Borda F: Hyperplastic polyposis of the colorectum and adenocarcinoma in a 24-year-old man. Am J Surg Pathol 1987, 11:323-327
23. McCann BG: A case of metaplastic polyposis of the colon associated with focal adenomatous change and metachronous adenocarcinomas. Histopathology 1988, 13:700-702
24. Teoh HH, Delahunt B, Isbister WH: Dysplastic and malignant areas in hyperplastic polyps of the large intestine. Pathology 1989, 21:138-142
25. Lieverse RJ, Kibbelaar RE, Griffioen G, Lamers CBHW: Colonic adenocarcinoma in a patient with multiple hyperplastic polyps. Neth J Med 1995, 46:185-188
26. Torlakovic E, Snover DC: Serrated adenomatous polyposis in humans. Gastroenterology 1996, 110:748-55
27. Cooke SAR: Polyposis coli: the clinical spectrum in adults. S Afr Med J 1978, 53:454-457
28. Torlakovic E, Skovlund E, Snover DC, Torlakovic G, Nesland JM: Morphologic reappraisal of serrated colorectal polyps. Am J Surg Pathol 2003, 27:65-81
29. Jen J, Powell SM, Papadopoulos N, Smith KJ, Hamilton SR, Vogelstein B, Kinzler KW: Molecular determinants of dysplasia in colorectal lesions. Cancer Res 1994, 54:5523-5526
30. Mukai K, Fujii T, Tajiri H, Yoshida S, Fukushima S, Esumi H: High frequency of K-ras mutations in human colorectal hyperplastic polyps. Gut 1997, 40:660-663
31. Chan AO, Issa J-PJ, Morris JS, Hamilton SR, Rashid A: Concordant CpG island methylation in hyperplastic polyposis. Am J Pathol 2002, 160:529-536
32. Bardi G, Johansson B, Pandis N, Bak-Jensen E, Orndal C, Heim S, Mandahl N, Andren-Sandberg A, Mitelman F: Cytogenetic aberrations in colorectal adenocarcinomas and their correlation with clinicopathologic features. Cancer 1993, 71:306-314
33. Lothe RA, Peltomaki P, Meling GI, Aaltonen LA, Nystrom-Lahti M, Pylkkanen L, Heimdal K, Andersen TI, Moller P, Rognum TO: Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history. Cancer Res 1993, 53:5849-5852
34. Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, Teague J, Woffendin H, Garnett MJ, Bottomley W, Davis N, Dicks E, Ewing R, Floyd Y, Gray K, Hall S, Hawes R, Hughes J, Kosmidou V, Menzies A, Mould C, Parkar A, Stevens C, Watt S, Hooper S, Wilson R, Jayatilake H, Gusterson BA, Cooper C, Shipley J, Hargrave D, Pritchard-Jones K, Maitland N, Chenevix-Trench G, Riggins GJ, Bigner DD, Palmieri G, Cossu A, Flanagan A, Nicholson A, Ho JWC, Leung SY, Yuen ST, Yuen ST, Weber BL, Seigier HF, Darrow TL, Paterson H, Marais R, Marshall CJ, Wooster R, Stratton MR and Futreal PA: Mutations of the BRAF gene in human cancer. Nature 2000, 417:949-954
35. Yuen ST, Davies H, Chan TL, Ho JW, Bignell GR, Cox C, Stephens P, Edkins S, Tsui WW, Chan AS, Futreal PA, Stratton MR, Wooster R, Leung SY: Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia. Cancer Res 2002, 62:6451-6455
36. Domingo E, Espin E, Armengol M, Oliveira C, Pinto M, Duval A, Brennetot C, Seruca R, Hamelin R, Yamamoto H, Schwartz Jr S: Activated BRAF targets proximal colon tumors with mismatch repair deficiency and MLH1 inactivation. Genes Chromosom Cancer 2004, 39:138-142
37. Fransen K, Klintenas M, Osterstrom A, Dimberg J, Monstein HJ, Soderkvist P: Mutation analysis of the BRAF, ARAF and RAF-1 genes in human colorectal adenocarcinomas Carcinogenesis 2004, 25:527-533
38. Oliveira C, Pinto M, Duval A, Brennetot C, Domingo E, Espin E, Armengol M, Yamamoto H, Hamelin R, Seruca R, Schwartz Jr S: BRAF mutations characterize colon but not gastric cancer with mismatch repair deficiency. Oncogene 2003, 22:9192-9196
39. Wang L, Cunningham JM, Winters JL, Guenther JC, French AJ, Boardman LA, Burgart LJ, McDonnell SK, Schaid DJ, Thibodeau SN: BRAF mutations in colon cancer are not likely attributable to defective DNA mismatch repair. Cancer Res 2003, 63:5209-5212
40. Wan PT, Garnett MJ, Roe SM, Lee S, Niculescu-Duvaz D, Good VM, Jones CM, Marshall CJ, Springer CJ, Barford D, Marais R: Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell 2004, 116:855-867
41. Chan TL, Zhao W, Leung SY, Yuen ST: BRAF and KRAS mutations in colorectal hyperplastic polyps and serrated adenomas. Cancer Res 2003, 63:4878-4881
42. Kambara T, Simms LA, Whitehall VL, Spring KJ, Wynter CV, Walsh MD, Barker MA, Arnold S, McGivern A, Matsubara N, Tanaka N, Higuchi T, Young J, Jass JR, Leggett BA: BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum. Gut 2004, 53:1137-1144
43. Yang S, Farraye FA, Mack C, Posnik O, O'Brien MJ: BRAF and KRAS mutations in hyperplastic polyps and serrated adenomas of the colorectum. Am J Surg Pathol 2004, 28:1452-1459
44. Carey V, Zeger SL, Diggle P: Modelling multivariate binary data with alternating logistic regression. Biometrika 1993, 80:517-526
45. Wynter CVA, Walsh MD, Higuchi T, Leggett BA, Young J, Jass JR: Methylation patterns define two types of hyperplastic polyp associated with colorectal cancer. Gut 2003, 53:573-580
46. Lothe RA, Andersen SN, Hofstad B, Meling GI, Peltomaki P, Heim S, Brogger A, Vatn M, Rognum TO, Borresen AL: Deletion of 1p loci and microsatellite instability in colorectal polyps. Genes Chromosom Cancer 1995, 14:182-188