High frequency of K-ras mutations in human colorectal hyperplastic polyps

Gut

Volumn 40, Issue 5, 1997, Pages 660-663

  Otori, K ^a   Oda, Y ^b   Sugiyama, K ^a   Hasebe, T ^a   Mukai, K ^a   Fujii, T ^b   Tajiri, H ^b   Yoshida, S ^b   Fukushima, S ^c   Esumi, H ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b NATIONAL CANCER CENTER HOSPITAL EAST   (Japan)

^c OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Adenoma; Colon; Colorectal carcinogenesis; Hyperplastic polyps; K ras

Indexed keywords

ADULT; AGED; ARTICLE; CANCER GENETICS; CLINICAL ARTICLE; COLON POLYP; CONTROLLED STUDY; FEMALE; GENE MUTATION; HUMAN; HUMAN TISSUE; HYPERPLASIA; MALE; ONCOGENE K RAS; POLYMERASE CHAIN REACTION; PRECANCER; PRIORITY JOURNAL; RECTUM POLYP; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

EID: 8544270183     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.40.5.660     Document Type: Article

References (22)

1. Arthur JF. Structure and significance of metaplastic nodules in the rectal mucosa. J Clin Pathol 1968; 21: 735-43.
2. Fenoglio CH, Lane NT. The anatomical precursor of colorectal carcinoma. Cancer 1974; 34: 819-23.
3. Bengoecha O, Martinez-Penuela JM, Larrinaga B, Valerdi J, Borda F. Hyperplastic polyposis of the colorectum and adenocarcinoma in a 24-year-old man. Am J Surg Pathol 1987; 11: 323-7.
4. Urbanski SJ, Kossakowska AE, Marcon N, Bruce WR. Mixed hyperplastic adenomatous polyps - an underdiagnosed entity. Am J Surg Pathol 1984; 8: 551-6.
5. Cooper HS, Patschefsky AS, Marks G. Adenomatous and carcinomatous changes within hyperplastic colonic epithelium. Dis Coton Rectum 1979; 22: 152-6.
6. Estrada RE, Spuji HJ. Hyperplastic polyps of the large bowel. Am J Surg Pathol 1980; 4: 127-33.
7. Franzin G, Dina R, Zamboni G, Iannucci A, Scarpa A, Novelli P. Hyperplastic (metaplastic) polyps of the colon. Am J Surg Pathol 1984; 8: 687-98.
8. Sumner HW, Wasserman NF, McClain CJ. Giant hyperplastic polyposis of the colon. Dig Dis Sci 1981; 26: 85-9.
9. Williams GT, Arthur JF, Bussey HJR, Morson BC. Metaplastic polyps and polyposis of the colorectum. Histopathology 1980; 4: 155-70.
10. Longacre TA, Fenoglio-Preiser CM. Mixed hyperplastic adenomatous polyps/serrated adenomas. Am J Surg Pathol 1990; 14: 524-37.
11. Fearon RE, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990; 61: 759-67.
12. Kudo S, Hirota S, Nakajima T, Hosobe S, Kusaka H, Kobayashi T, et al. Colorectal tumours and pit pattern. J Clin Pathol 1994; 47: 880-5.
13. Jass JR, Sobin LH. Histological typing of intestinal tumors. Geneva: World Health Organisation, 1989.
14. Mimamoto T, Sawaguchi K, Mai M, Yamashita N, Sugimura T, Esumi H. Infrequent K-ras activation in superficial-type (flat) colorectal adenomas and adenocarcinomas. Cancer Res 1994; 54: 2841-4.
15. Otori K, Sugiyama K, Hasebe H, Fukushima S, Esumi H. Emergence of adenomatous aberrant crypt foci (ACF) from hyperplastic ACF with concomitant increase in cell proliferation. Cancer Res 1995; 55: 4743-6.
16. Yanagisawa A, Ohtake K, Ohnishi K, Hori M, Kitagawa T, Sugano H, et al. Frequent c-Ki-ras oncogene activation in mucous cell hyperplasia of pancreas suffering from chronic inflammation. Cancer Res 1993; 53: 953-6.
17. Caldas C, Hahn SA, Hruban RH, Redston MS, Yeo CJ, Kern SE. Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia. Cancer 1994; 54: 3568-73.
18. DiGiuseppe JA, Hruban RH, Offerhaus GJ, Clement MJ, van den Berg FM, Cameron JL, et al. Detection of K-ras mutations in mucinous pancreatic duct hyperplasia from a patient with a family history of pancreatic carcinoma. Am J Pathol 1994; 144: 889-95.
19. Tada M, Ohashi M, Shiratori Y, Okudaira T, Komatsu Y, Kawabe T, et al. Analysis of K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease. Gastroenterology 1996; 110: 227-31.
20. Skinner JM, Whitehead JR. Tumor-associated antigen in polyps and carcinoma of the human large bowel. Cancer 1981; 47: 1241-5.
21. Jass JR, Filipe MI, Abbas S, Falcon CAJ, Wilson Y, Lovell D. A morphological and histochemical study of metaplastic polyps of the colorectum. Cancer 1984; 53: 510-5.
22. Bronner MP, Culin C, Reed JC, Furth EE. The bcl-2 proto-oncogene and the gastrointestinal epithelial tumor progression model. Am J Pathol 1995; 146: 20-6.