Identification of mucin-depleted foci in the unsectioned colon of azoxymethane-treated rats: Correlation with carcinogenesis

Cancer Research

Volumn 63, Issue 10, 2003, Pages 2388-2392

  Caderni, Giovanna ^a   Femia, Angelo Pietro ^a   Giannini, Augusto ^b   Favuzza, Alessandro ^a   Luceri, Cristina ^a   Salvadori, Maddalena ^a   Dolara, Piero ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b SANTA MARIA ANNUNZIATA HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AZOXYMETHANE; MUCIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GRADING; CHEMICAL CARCINOGENESIS; COLON CANCER; COLON CARCINOGENESIS; CONTROLLED STUDY; DYSPLASIA; HISTOLOGY; INTESTINE CRYPT; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; AZOXYMETHANE; CARCINOGENS; COLON; COLONIC NEOPLASMS; MALE; MUCINS; PRECANCEROUS CONDITIONS; PROBIOTICS; RATS; RATS, INBRED F344;

EID: 0038181338     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Chang, W. W. L. Histogenesis of colon cancer in experimental animals. Scand. J. Gastroenterol., 19: 27-43, 1984.
2. Bird, R. P. Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings. Cancer Lett., 37: 147-151, 1987.
3. Mc Lellan, E. A., and Bird, R. P. Aberrant crypts: potential preneoplastic lesions in the murine colon. Cancer Res., 48: 6187-6192, 1988.
4. Pretlow, T. P., Barrow, B. J., Ashton, W. S., O'Riordan, M. A., Pretlow, T. G., Jurcisek, J. A., and Stellato, T. A. Aberrant crypts: putative preneoplastic foci. In human colonic mucosa. Cancer Res., 51: 1564-1567, 1991.
5. Roncucci, L., Stamp, D., Medline, A., Cullen, J. B., and Bruce, W. R. Identification and quantification of aberrant crypt foci and microadenomas in the human colon. Hum. Pathol., 22: 287-294, 1991.
6. Pretlow, T. P., and Bird, R. P., Correspondence re: Yamada et al., Frequent β-catenin gene mutations and accumulation of the protein in the putative preneoplastic lesions lacking macroscopic aberrant crypt foci appearance, in rat colon carcinogenesis. Cancer Res., 60: 3323-3327, 2000; and Sequential analysis of morphological and biological properties of β-catenin-accumulated crypts, provable premalignant lesions independent of aberrant crypt foci in rat colon carcinogenesis. Cancer Res., 61: 1874-1878, 2001. Cancer Res., 61: 7699-7700, 2001.
7. Pretlow, T. P., and Bird, R. P., Correspondence re: Yamada et al., Frequent β-catenin gene mutations and accumulation of the protein in the putative preneoplastic lesions lacking macroscopic aberrant crypt foci appearance, in rat colon carcinogenesis. Cancer Res., 60: 3323-3327, 2000; and Sequential analysis of morphological and biological properties of β-catenin-accumulated crypts, provable premalignant lesions independent of aberrant crypt foci in rat colon carcinogenesis. Cancer Res., 61: 1874-1878, 2001. Cancer Res., 61: 7699-7700, 2001.
8. Pretlow, T. P., and Bird, R. P., Correspondence re: Yamada et al., Frequent β-catenin gene mutations and accumulation of the protein in the putative preneoplastic lesions lacking macroscopic aberrant crypt foci appearance, in rat colon carcinogenesis. Cancer Res., 60: 3323-3327, 2000; and Sequential analysis of morphological and biological properties of β-catenin-accumulated crypts, provable premalignant lesions independent of aberrant crypt foci in rat colon carcinogenesis. Cancer Res., 61: 1874-1878, 2001. Cancer Res., 61: 7699-7700, 2001.
9. Jen, J., Powell, S. M., Papadopoulos, N., Smith, K. J., Hamilton, S. R., Vogelstein, B., and Kinzler, K. W. Molecular determinants of dysplasia in colorectal lesions. Cancer Res., 54: 5523-5526, 1994.
10. Roncucci, L., Medline, A., and Bruce, W. R. Classification of aberrant crypt foci and microadenomas in human colon. Cancer Epidemiol. Biomark. Prev., 1: 57-60, 1991.
11. Siu, I. M., Pretlow, T. G., Amini, S. B., and Pretlow, T. P. Identification of dysplasia in human colonic aberrant crypt foci. Am. J. Pathol., 150: 1805-1813, 1997.
12. Di Gregorio, C., Losi, L., Fante, R., Modica, S., Guidoni, M., Pedroni, M., Tamassia, M. G., Gafa, L., Ponz De Leon, M., and Roncucci, L. Histology of aberrant crypt foci in the human colon. Histopathology, 30: 328-334, 1997.
13. Corpet, D. E., and Taché, S. Most effective colon cancer chemopreventive agents in rats: a review of aberrant crypt foci and tumour data, ranked by potency. Nutr. Cancer, 43: 1-21, 2002.
14. Magnusson, B. A., Carr, I., and Bird, R. P. Ability of aberrant crypt foci characteristics to predict colonic tumor incidence in rats fed cholic acid. Cancer Res., 53: 4499-4504, 1993.
15. Zheng, Y., Kramer, P. M., Lubet, R. A., Steele, V. E., Keloff, G. J., and Pereira, M. A. Effect of retinoids on AOM-induced colon cancer in rats: modulation of cell proliferation, apoptosis and aberrant crypt foci. Carcinogenesis (Lond.), 20: 255-260, 1999.
16. Papanikolaou, A., Wang, Q. S., Papanikolaou, D., Whiteley, H. E., and Rosenberg, D. W. Sequential and morphological analyses of aberrant crypt foci formation in mice of different susceptibility to azoxymethane-induced colon carcinogenesis. Carcinogenesis (Lond.), 21: 1567-1572, 2000.
17. Yamada, Y., Yoshimi, N., Hiroshe, Y., Kawabata, K., Matsunaga, K., Shimizu, M., Hara, A., and Mori, H. Frequent β-catenin gene mutations and accumulation of the protein in the putative preneoplastic lesions lacking macroscopic aberrant crypt foci appearance, in rat colon carcinogenesis. Cancer Res., 60: 3323-3327, 2000.
18. Femia, A. P., Luceri, C., Dolara, P., Giannini, A., Biggeri, A., Salvadori, M., Clune, Y., Collins, K. J., Paglierani, M., and Caderni, G. Antitumorigenic activity of the prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis on azoxymethane-induced colon carcinogenesis in rats. Carcinogenesis (Lond.), 23: 1953-1960, 2002.
19. nd ed. Berlin: Springer-Verlag, pp. 29-40, 1989.
20. Caderni, G., Giannini, A., Lancioni, L., Luceri, C., Biggeri, A., and Dolara, P. Characterisation of aberrant crypt foci in carcinogen-treated rats: association with intestinal carcinogenesis. Br. J. Cancer, 71: 763-769, 1995.
21. Nucci, M. R., Robinson, C. R., Longo, P., Campbell, P., and Hamilton, S. R. Phenotypic and genotypic characteristics of aberrant crypt foci in human colorectal mucosa. Hum. Pathol., 12: 1396-1407, 1997.
22. Paulsen, J. E., Steffensen, I. L., Loberg, E. M., Husoy, T., Namork, E., and Alexander, J. Qualitative and quantitative relationship between dysplastic aberrant crypt foci and tumorigenesis in the Min/+ mouse colon. Cancer Res., 61: 5010-5015, 2001.