Role of the alternating reading frame (P19)-p53 pathway in an in vivo murine colon tumor model

Cancer Research

Volumn 62, Issue 13, 2002, Pages 3667-3674

  Nambiar, Prashant R ^a   Giardina, Charles ^b   Guda, Kishore ^a   Aizu, Wataru ^b   Raja, Rajiv ^c   Rosenberg, Daniel W ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b UNIVERSITY OF CONNECTICUT   (United States)

^c Arcturus Bioscience Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYCLIN DEPENDENT KINASE INHIBITOR; MESSENGER RNA; PROTEIN P53;

ALTERNATING READING FRAME; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLON CARCINOGENESIS; COLON TUMOR; CONTROLLED STUDY; DNA BINDING; DNA MICROARRAY; DNA SEQUENCE; GENE MUTATION; HISTOPATHOLOGY; IMMUNOBLOTTING; MALE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TUMOR MODEL; TUMOR SUPPRESSOR GENE;

ADENOCARCINOMA; ANIMALS; AZOXYMETHANE; CARCINOGENS; COLONIC NEOPLASMS; DNA, NEOPLASM; GENE EXPRESSION REGULATION; GENES, P53; MALE; MICE; MICE, INBRED A; MICE, INBRED AKR; READING FRAMES; RNA, MESSENGER; TRANS-ACTIVATION (GENETICS); TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 0036644837     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (56)

1. Cancer statistics
2. Organ-specific carcinogenesis in the digestive tract
3. Colon epithelium. II. In vivo studies of colon carcinogenesis. Light microscopic, histochemical, and ultrastructural studies of histogenesis of azoxymethane-induced colon carcinomas in Fischer 344 rats
4. Quantitative assessment of azoxymethane-induced aberrant crypt foci in inbred mice
5. Azoxymethane-induced colon tumors and aberrant crypt foci in mice of different genetic susceptibility
6. A genetic model for colorectal tumorigenesis
7. Altered expression of cyclin D1 and cyclin-dependent kinase 4 in azoxymethane-induced mouse colon tumorigenesis
8. Modulation of azoxymethane-induced mutational activation of ras protooncogenes by chemopreventive agents in colon carcinogenesis
9. AOM-induced mouse colon tumors do not express full-length APC protein
10. Differential expression of p16(INK4a) in azoxymethane-induced mouse colon tumorigenesis
11. K-ras mutations in aberrant crypt foci, adenomas and adenocarcinomas during azoxymethane-induced colon carcinogenesis
12. Azoxymethane induces Ki-ras activation in the tumor resistant AKR/J mouse colon
13. Aberrant crypt foci: A review
14. The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53
15. Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2
16. Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
17. E1A signaling to p53 involves the pl9(ARF) tumor suppressor
18. p14ARF links the tumour suppressors RB and p53
19. p19ARF links the tumour suppressor p53 to Ras
20. Tumor surveillance via the ARF-p53 pathway
21. Role of the INK4a locus in tumor suppression and cell mortality
22. The tumor suppressor protein p16INK4a
23. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF
24. Loss of the ARF tumor suppressor reverses premature replicative arrest but not radiation hypersensitivity arising from disabled arm function
25. Aberrant regulation and function of wild-type p53 in radioresistant melanoma cells
26. Distinct pattern of p53 phosphorylation in human tumors
27. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
28. Mutational analysis of tumor suppressor gene p53 in feline vaccine site-associated sarcomas
29. Alternative reading frames of the 1NK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
30. TNF activates NF-B by phosphatidyl choline-specific phospholipase C-induced "acidic" sphingomyelin breakdown
31. Establishment of conditionally immortalized epithelial cell lines from both colon and small intestine of adult H-2Kb-tsA58 transgenic mice
32. Transcription factor NF-κB participates in regulation of epithelial cell turnover in the colon
33. The luminal short-chain fatty acid butyrate modulates NF-κB activity in a human colonic epithelial cell line
34. p53 mutations in colorectal cancer
35. Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines
36. Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis
37. WAF1, a potential mediator of p53 tumor suppression
38. The p21 Cdk-interacting protein Cipl is a potent inhibitor of G1 cyclin-dependent kinases
39. Cell cycle control and cancer
40. The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAFI/Cipl promoter
41. p53: Puzzle and paradigm
42. PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family
43. p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage
44. Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a
45. Regulation of the specific DNA binding function of p53
46. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
47. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
48. Control of p53 Ubiquitination and nuclear export by MDM2 and ARF
49. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
50. Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers
51. Twist is a potential oncogene that inhibits apoptosis
52. Alterations of the p16INK4A gene in human ovarian cancers
53. The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2
54. The p16INK4a/CDKN2A tumor suppressor and its relatives
55. Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53
56. The INK4a/ARF locus in murine tumorigenesis