Evaluation of mRNA expression of human drug-metabolizing enzymes and transporters in chimeric mouse with humanized liver

Xenobiotica

Volumn 35, Issue 9, 2005, Pages 877-890

  Nishimura, M ^a   Yoshitsugu, H ^a   Yokoi, T ^b   Tateno, C ^c   Kataoka, M ^c   Horie, T ^d   Yoshizato, K ^c,e   Naito, S ^a  

^a OTSUKA PHARMACEUTICAL CO LTD   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

^c Hiroshima Prefectural Univ   (Japan)

^d PhoenixBio USA Corporation   (Japan)

^e HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Chimeric mouse; Humanized liver; Transporters

Indexed keywords

ALBUMIN; CARRIER PROTEIN; CYTOCHROME P450; DRUG METABOLIZING ENZYME; MESSENGER RNA;

ANIMAL EXPERIMENT; ARTICLE; CHIMERA; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME LOCALIZATION; ENZYME METABOLISM; ENZYMOLOGY; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL; LIVER FUNCTION; LIVER MICROSOME; MALE; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; TISSUE LEVEL;

ANIMALS; ENZYMES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEPATOCYTES; HUMANS; LIVER; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, SCID; TRANSPLANTATION CHIMERA;

ANIMALIA;

EID: 28744442170     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.1080/00498250500307251     Document Type: Article

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