Evaluation of gene induction of drug-metabolizing enzymes and transporters in primary culture of human hepatocytes using high-sensitivity real-time reverse transcription PCR

Yakugaku Zasshi

Volumn 122, Issue 5, 2002, Pages 339-361

  Nishimura, Masuhiro ^a   Yoshitsugu, Hiroki ^a   Naito, Shinsaku ^a   Hiraoka, Isao ^a  

^a OTSUKA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Gene induction; Human hepatocytes; Quantitative real time RT PCR

Indexed keywords

CARRIER PROTEIN; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; CYTOCHROME P450 2B6; CYTOCHROME P450 2C8; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; DIMETHYL SULFOXIDE; DRUG METABOLIZING ENZYME; MESSENGER RNA; OMEPRAZOLE; PROTEIN; PROTEIN ABCB4; PROTEIN ABCG1; PROTEIN ADH3; PROTEIN ALDH3; PROTEIN ALDH6; RIFAMPICIN; UNCLASSIFIED DRUG; ABC TRANSPORTER; ABCG1 PROTEIN, HUMAN; ADH1C PROTEIN, HUMAN; ALCOHOL DEHYDROGENASE; CYTOCHROME P450;

AGED; ANALYTIC METHOD; ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE INDUCTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; INSTRUMENTATION; LIVER CELL; NUCLEOTIDE SEQUENCE; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIVITY ANALYSIS; UNINDEXED SEQUENCE; CELL CULTURE; ENZYME INDUCTION; ENZYMOLOGY; GENETICS; METABOLISM; SENSITIVITY AND SPECIFICITY;

AGED; ALCOHOL DEHYDROGENASE; ATP-BINDING CASSETTE TRANSPORTERS; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; FEMALE; HEPATOCYTES; HUMANS; OMEPRAZOLE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIFAMPIN; RNA, MESSENGER; SENSITIVITY AND SPECIFICITY;

EID: 0036561247     PISSN: 00316903     EISSN: None     Source Type: Journal    
DOI: 10.1248/yakushi.122.339     Document Type: Article

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