Effects of dimethyl sulfoxide on the gene induction of cytochrome P450 isoforms, UGT-dependent glucuronosyl transferase isoforms, and ABCB1 in primary culture of human hepatocytes

Biological and Pharmaceutical Bulletin

Volumn 26, Issue 7, 2003, Pages 1052-1056

  Nishimura, Masuhiro ^a   Ueda, Nobuhiko ^a   Naito, Shinsaku ^a  

^a OTSUKA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Cytochrome P450 isoform; Dimethyl sulfoxide (DMSO); Gene induction; Human hepatocyte

Indexed keywords

ABC TRANSPORTER; BETA NAPHTHOFLAVONE; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; CYTOCHROME P450 2A6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; CYTOCHROME P450 3A7; CYTOCHROME P450 ISOENZYME; DIMETHYL SULFOXIDE; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A6; GLUCURONOSYLTRANSFERASE 1A9; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; RIFAMPICIN; UNCLASSIFIED DRUG; CYTOCHROME P450; ISOENZYME; UGT1A6 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; CONCENTRATION PROCESS; DRUG EFFECT; DRUG EXPOSURE; DRUG MECHANISM; DRUG METABOLISM; ENZYME INDUCTION; ENZYME REPRESSION; FEMALE; GENE EXPRESSION; GENE INDUCTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LIVER CELL CULTURE; MALE; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; REDUCTION; RNA ANALYSIS; BIOSYNTHESIS; CELL SURVIVAL; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; LIVER CELL; PHYSIOLOGY;

ADULT; AGED; ATP-BINDING CASSETTE TRANSPORTERS; CELL SURVIVAL; CYTOCHROME P-450 ENZYME SYSTEM; DIMETHYL SULFOXIDE; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCURONOSYLTRANSFERASE; HEPATOCYTES; HUMANS; ISOENZYMES; MALE; RNA, MESSENGER;

EID: 1542497666     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.26.1052     Document Type: Article

References (16)

1. Bowen W. P., Carey J. E., Miah A., McMurray H. F., Munday P. W., James R. S., Coleman R. A., Brown A. M., Drug Metab. Dispos., 28, 781-788 (2000).
2. Kostrubsky V. E., Lewis L. D., Strom S. C., Wood S. G., Schuetz E. G., Schuetz J. D., Sinclair P. R., Wrighton S. A., Sinclair J. F., Arch. Biochem. Biophys., 355, 131-136 (1998).
3. Pichard-Garcia L., Hyland R., Baulieu J., Fabre J., Milton A., Maurel P., Drug Metab. Dispos., 28, 51-57 (2000).
4. Luo G., Cunningham M., Kim S., Burn T., Lin J., Sinz M., Hamilton G., Rizzo C., Jolley S., Gilbert D., Downey A., Mudra D., Graham R., Carroll K., Xie J., Madra A., Parkinson A., Christ D., Selling B., Lecluyse E., Gan L. S., Drug Metab. Dispos., 30, 795-804 (2002).
5. Meunier V., Bourrie M., Julian B., Marti E., Guillou F., Berger Y., Fabre G., Xenobiotica, 30, 589-607 (2000).
6. Gerbal-Haloin S., Pascussi J., Pichard-Garcia L., Daujat M., Waechter F., Fabre J., Carrere N., Maurel P., Drug Metab. Dispos., 29, 242-251 (2001).
7. Silva J. M., Morin P. E., Day S. H., Kennedy B. P., Payette P., Rushmore T., Yergey J. A., Nicoll-Griffith D. A., Drug Metab. Dispos., 26, 490-496 (1998).
8. Nishimura M., Yoshitsugu H., Naito S., Hiraoka I., Yakugaku Zasshi, 122, 339-361 (2002).
9. Münzel P. A., Schmohl S., Heel H., Kälberer K., Bock-Hennig B. S., Bock K. W., Drug Metab. Dispos., 27, 569-573 (1999).
10. Chin K. V., Pastan I., Gottesman M. M., Adv. Cancer Res., 60, 157-180 (1993).
11. Lambertina E., Penolazzi L., Aguiari G., del Senno L., Pezzetti F., Sollazzo V., Piva R., Biochem. Biophys. Res. Commun., 292, 761-770 (2002).
12. Limbourg F. P., Huang Z., Plumier J., Simoncini T., Fujioka M., Tuckermann J., Schutz G., Moskowitz M. A., Liao J. K., J. Clin., Invest., 110, 1729-1738 (2002).
13. Zangar R. C., Novak R. F., Arch. Biochem. Biophys., 353, 1-9 (1998).
14. Lindley C., Hamilton G., McCune J. S., Faucette S., Shord S. S., Hawke R. L., Wang H., Gilbert D., Jolley S., Yan B., Lecluyse E. L., Drug Metab. Dispos., 30, 814-821 (2002).
15. Ramachandran V., Kostrubsky V. E., Komoroski B. J., Zhang S., Dorko K., Esplen J. E., Strom S. C., Venkataramanan R., Drug Metab. Dispos., 27, 1194-1199 (1999).
16. Kostrubsky V. E., Ramachandran V., Venkataramanan R., Dorko K., Esplen J. E., Zhang S., Sinclair J. F., Wrighton S. A., Strom S. C., Drug Metab. Dispos., 27, 887-894 (1999).