A truly simultaneous combination of functional transcranial Doppler sonography and H215O PET adds fundamental new information on differences in cognitive activation between schizophrenics and healthy control subjects

Journal of Nuclear Medicine

Volumn 44, Issue 5, 2003, Pages 671-681

  Sabri, Osama ^a,b   Owega, Ammar ^a   Schreckenberger, Mathias ^a   Sturz, Laszlo ^a   Fimm, Bruno ^a   Kunert, Philipp ^a   Meyer, Philipp T ^a,b   Sander, Dirk ^c   Klingelhöfer, Jürgen ^c,d  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d KLINIKUM CHEMNITZ   (Germany)

Author keywords

Functional MRI; Functional transcranial Doppler sonography; PET; Schizophrenia; Working memory

Indexed keywords

ARTICLE; BLOOD FLOW VELOCITY; BRAIN BLOOD FLOW; BRAIN SIZE; CLINICAL ARTICLE; COGNITION; CONTROLLED STUDY; CORRELATION ANALYSIS; DOPPLER ECHOGRAPHY; EDUCATION; HUMAN; INTELLIGENCE QUOTIENT; MENTAL TASK; NEUROIMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SCHIZOPHRENIA; TASK PERFORMANCE; WORKING MEMORY; ADULT; BRAIN CIRCULATION; COMPUTER ASSISTED EMISSION TOMOGRAPHY; ECHOGRAPHY; FEMALE; MALE; PATHOPHYSIOLOGY; SCINTISCANNING;

ADULT; CEREBROVASCULAR CIRCULATION; COGNITION; FEMALE; HUMANS; MALE; SCHIZOPHRENIA; TOMOGRAPHY, EMISSION-COMPUTED; ULTRASONOGRAPHY, DOPPLER, TRANSCRANIAL;

EID: 0038282729     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Weinberger DR, Berman KF. Prefrontal function in schizophrenia, confounds and controversies. Philos Trans R Soc Lond B Biol Sci 1996;351:1495-1503
2. Sabri O, Erkwoh R, Schreckenberger M, et al. Regional cerebral blood flow and negative/positive symptoms in 24 drug-naive schizophrenics J Nucl Med. 1997;38:181-188.
3. Sabri O, Erkwoh R, Schreckenberger M, Owega A, Sass H, Buell U. Correlation of positive symptoms exclusively to hyperperfusion or hypoperfusion of cerebral cortex in never-treated schizophrenics. Lancet. 1997;349;1735-1739.
4. Owega A, Klingelhofer J, Sabri O, Kunert HJ, Albers M, Sass H Cerebral blood flow velocity in acute schizophrenic patients a transcranial Doppler ultrasonography study Stroke. 1998;29:1149-1154.
5. Bertolino A, Esposito G, Callicott JH, et al. Specific relationship between prefrontal neuronal N-acetylaspartate and activation of the working memory cortical network in schizophrenia. Am J Psychiatry. 2000;157:26-33.
6. Liddle PF. Cognitive impairment in schizophrenia: its impact on social functioning. Acta Psychiatr Scand Suppl 2000;400:11-16.
7. Baddeley A Working memory. Science 1992;255:556-559.
8. Gevins A, Smith ME, Le J, et al. High resolution evoked potential imaging of the cortical dynamics of human working memory. Electroencephalogr Clin Neurophysiol. 1996;98:327-348
9. Conrad B, Klingelhofer J. Dynamics of regional cerebral blood flow for various visual stimuli. Exp Biain Res. 1989;77:437-441
10. Cupini LM, Matteis M, Troisi E, et al. Bilateral simultaneous transcranial Doppler monitoring of flow velocity changes during visuospatial and verbal working memory tasks. Brain. 1996;119:1249-1253
11. Artiges E, Salame P, Recasens C, et al Working memory control in patients with schizophrenia: a PET study during a random number generation task. Am J Psychiatry. 2000;157:1517-1519.
12. American Psychiatric Association. Diagnose and Statistical Manual of Mental Disorders 4th ed., text revision. Washington, DC: American Psychiatric Association; 2000
13. Carter CS, Perlstein W, Ganguli R, Brar J, Mintun M, Cohen JD Functional hypofrontality and working memory dysfunction in schizophrenia. Am J Psychiatry. 1998;155:1285-1287.
14. Callicou JH, Ramsey NF, Tallent K, et al Functional magnetic resonance imaging brain mapping in psychiatry: methodological issues illustrated in a study of working memory in schizophrenia Neuropsychopharmacology. 1998;18:186-196
15. Callicott JH, Mattay VS, Bertolino A, et al Physiological characteristics of capacity constraints in working memory as revealed by functional MRI. Cereb Cortex. 1999;9:20-26.
16. Sabri O, Hellwig D, Schreckenberger M, et al Correlation of neuropsychological, morphological and functional (regional cerebral blood flow and glucose utilization) findings in cerebral microangiopathy J Nucl Med 1998;39:147-154.
17. Sabri O, Ringelstein EB, Hellwig D, et al. Neuropsychological impairment correlates with hypoperfusion and hypometabolism but not with severity of white matter lesions on MRI in patients with cerebral microangiopathy. Stroke. 1999;30:556-566.
18. Klingelhofer J, Matzander G, Sander D, Schwarze J, Boecker H, Bischoff C. Assessment of functional hemispheric asymmetry by bilateral simultaneous cerebral blood flow velocity monitoring. J Cereb Blood Flow Metab. 1997;17:577-585.
19. Newell DW, Aaslid R, Lam A, Mayberg TS, Winn HR Comparison of flow and velocity during dynamic autoregulation testing in humans. Stroke 1994;25:793-797
20. Aaslid R, Newell DW, Stooss R, Sorteberg W, Lindegaard KF. Assessment of cerebral autoregulation dynamics from simultaneous arterial and venous transcranial Doppler recordings in humans. Stroke. 1991;22:1148-1154.
21. Knecht S, Deppe M, Ringelstein EB, et al Reproducibility of functional transcranial Doppler sonography in determining hemispheric language lateralization, Stroke. 1998;29:1155-1159.
22. Isoardi RA, Townsend DW, Carter CS, Herbster A, Dachille MA, Meltzer CC. A study of injected dose for brain mapping on the ECAT HR +: activation maps for a parametric verbal working memory task. Neuroimage. 1999;9:145-153.
23. Talairach J, Toumoux P. Co-Planar Stereotaxic Atlas of the Human Brain. New York, NY: Thieme Medical, 1988.
24. Schmidt P, Krings T, Willmes K, Roessler F, Reul J, Thron A Determination of cognitive hemispheric lateralization by "functional" transcranial Doppler cross-validated by functional MRI. Stroke. 1999;30:939-945.
25. Bishop CC, Powell S, Rutt D, Browse NL. Transcranial Doppler measurement of middle cerebral artery blood flow velocity: a validation study. Stroke. 1986;17: 913-915.
26. Deppe M, Knecht S, Papke K, et al. Assessment of hemispheric language lateralization a comparison between fMRI and fTCD. J Cereb Blood Flow Metab. 2000;20:263-268.
27. Ringelstein EB, Kahlscheuer B, Niggemeyer E, Otis SM. Transcranial Doppler sonography: anatomical landmarks and normal velocity values. Ultrasound Med Biol. 1990;16:745-761.
28. Owen AM, Herrod NJ, Menon DK, et al. Redefining the functional organization of working memory processes within human lateral prefrontal cortex Eur J Neurosci. 1999;11:567-574.
29. Cabeza R, Nyberg L Imaging cognition II: an empirical review of 275 PET and fMRI studies. J Cogn Neurosci. 2000;12:1-47.
30. Jonides J, Schumacher EH, Smith EE, et al. The role of parietal cortex in verbal working memory. J Neurosci 1998;18:5026-5034
31. Rypma B, D'Esposito M. Isolating the neural mechanisms of age-related changes in human working memory. Nat Neurosci. 2000;3:509-515.
32. Cowell SF, Egan GF, Code C, Harasty J, Watson JD. The functional neuroanatomy of simple calculation and number repetition: a parametric PET activation study. Neuroimage 2000;12:565-573.
33. Petrides M, Alivisatos B, Meyer E, Evans AC. Functional activation of the human frontal cortex during the performance of verbal working memory tasks. Proc Natl Acad Sci USA. 1993;90:878-882.
34. Petrides M, Alivisatos B, Evans AC, Meyer E Dissociation of human middorsolateral from posterior dorsolateral frontal cortex in memory processing. Proc Natl Acad Sci USA. 1993;90:873-877.
35. Schumacher EH, Lauber E, Awh E, Jonides J, Smith EE, Koeppe RA. PET evidence for an amodal verbal working memory system. Neuroimage 1996;3: 79-88.
36. Smith EE, Jonides J. Storage and executive processes in the frontal lobes. Science. 1999;283:1657-1661.
37. Van der Linden M, Collette F, Salmon E, et al. The neural correlates of updating information in verbal working memory. Memory. 1999;7:549-560.
38. Esposito G, Kirkby BS, Van Horn JD, Ellmore TM, Berman KF. Context-dependent, neural system-specific neurophysiological concomitants of ageing: mapping PET correlates during cognitive activation Brain. 1999;122:963-979
39. Jonides J, Marshuetz C, Smith EE, Reuter-Lorenz PA, Koeppe RA, Hartley A. Age differences in behavior and PET activation reveal differences in interference resolution in verbal working memory. J Cogn Neurosci 2000;12:188-196
40. Reuter-Lorenz PA, Jonides J, Smith EE, et al Age differences in the frontal lateralization of verbal and spatial working memory revealed by PET. J Cogn Neurosci. 2000;12:174-187.
41. 15O]water for positron emission tomography activation studies. J Cereb Blood flow Metab. 1999;19:843-852.
42. Andreasen NC. Linking mind and brain in the study of mental illnesses: a project for a scientific psychopathology. Science. 1997;275:1586-1593.