Deficits in multiple systems of working memory in schizophrenia

Schizophrenia Research

Volumn 27, Issue 1, 1997, Pages 1-10

  Spindler, Karen A ^a,b   Sullivan, Edith V ^a   Menon, Vinod ^a   Lim, Kelvin O ^a,d   Pfefferbaum, Adolf ^a,c  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY   (United States)

^c SRI INTERNATIONAL   (United States)

^d VA PALO ALTO HEALTH CARE SYSTEM   (United States)

Author keywords

Central executive model; Multiple frontal pathways model; Schizophrenia; Working memory

Indexed keywords

BENZATROPINE; CHLORPROMAZINE; CLOZAPINE; FLUPHENAZINE; LITHIUM; LORAZEPAM; PERPHENAZINE; RISPERIDONE; TIOTIXENE; TRIHEXYPHENIDYL; VALPROIC ACID;

ADULT; ANTICHOLINERGIC EFFECT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; MALE; MENTAL DISEASE; MODEL; NEUROPSYCHOLOGY; PRIORITY JOURNAL; PSYCHOSIS; SCHIZOPHRENIA; SPATIAL MEMORY; SUBSTANCE ABUSE; TASK PERFORMANCE; WORKING MEMORY;

ADULT; ATTENTION; COLOR PERCEPTION; DISCRIMINATION LEARNING; HUMANS; MALE; MENTAL RECALL; MIDDLE AGED; ORIENTATION; PATTERN RECOGNITION, VISUAL; RETENTION (PSYCHOLOGY); SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY;

EID: 0030669536     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-9964(97)00074-1     Document Type: Article

References (37)

1. Alexander, G.E., DeLong, M.R., Strick, P.L., 1986. Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu. Rev. Neurosci. 9, 377-381.
2. American Psychiatric Association, 1980. Diagnostic and Statistical Manual of Mental Disorders, 3rd ed. American Psychiatric Association, Washington, DC.
3. American Psychiatric Association, 1995. Diagnostic and Statistical Manual of Mental Disorders, 4th ed. American Psychiatric Association, Washington, DC.
4. Baddeley, A., 1992. Working memory. Science 255, 556-559.
5. Baddeley, A.D., Bressi, S., Della Sala, S., Logie, R., Spinnler, H., 1991. The decline of working memory in Alzheimer's disease. Brain 114, 2521-2542.
6. Berman, K., Illowsky, B., Weinberger, D., 1988. Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia. Arch. Gen. Psychiatry 45, 616-622.
7. Braff, D.L., 1993. Information processing and attention dysfunctions in schizophrenia. Schizophr. Bull. 19, 233-259.
8. Crovitz, H.F., Zener, K.A., 1962. Group test for assessing hand and eye dominance. Am. J. Psychol. 75, 271-276.
9. Fleming, K., Goldberg, T.E., Gold, J.M., Weinberger, D.R., 1995. Verbal working memory dysfunction in schizophrenia: use of a Brown-Peterson paradigm. Psychiatry Res. 56, 155-161.
10. Fournet, N., Moreaud, O., Roulin, J.L., Naegele, B., Pellat, J., 1996. Working memory in medicated patients with Parkinson's disease: the central executive seems to work. J. Neurol. Neurosurg. Psychiatry 60, 313-317.
11. Fuster, J.M., 1995. Memory in the Cerebral Cortex. MIT Press, Cambridge, MA.
12. Gabrieli, J.D.E., 1995. A systematic view of human memory processes. J. Int. Neuropsychol. Soc. 1, 115-118.
13. Gold, J.M., Carpenter, C., Randolph, C., Goldberg, T.E., Weinberger, D.R., 1997. Auditory working memory and Wisconsin Card Sorting Test performance in schizophrenia. Arch. Gen. Psychiatry 54, 159-165.
14. Goldman-Rakic, P.S., 1991. Prefrontal cortical dysfunction in schizophrenia: the relevance of working memory. In: Carroll, B.J., Barret, J.E. (Eds.), Psychopathology and the Brain. Raven Press, New York, pp. 1-23.
15. Goldman-Rakic, P.S., Funahashi, S., Bruce, C.J., 1990. Neocortical memory circuits. Cold Spring Harbor Symposia on Quantitative Biology I.V.
16. Greene, M.F., 1996. What are the functional consequences of neurocognitive deficits in schizophrenia? Am. J. Psychiatry 153 (3), 321-330.
17. Heaton, R., Paulsen, J.S., McAdams, L.A., Kuck, J., Zisook, S., Braff, D., Harris, M.J., Jeste, D.V., 1994. Neuropsychological deficits in schizophrenics: relationship to age, chronicity, and dementia. Arch. Gen. Psychiatry 51, 469-476.
18. Hollingshead, A.B., 1975. Four-factor Index of Social Status. Yale University, New Haven, CT.
19. Kolb, B., Whishaw, I.Q., 1983. Performance of schizophrenic patients on tests sensitive to left or right frontal, temporal. or parietal function in neurological patients. J. Nerv. Ment. Dis. 171, 435-443.
20. McCarthy, G., Blamire, A.M., Puce, A., Nobre, A.C., Bloch, G., Hyder, F., Goldman-Rakic, P., Shulman, R.G., 1994. Functional magnetic resonance imaging of human prefrontal cortex activation during a spatial working memory task. Proc. Natl. Acad. Sci. USA 91, 8690-8694.
21. McCarthy, G., Puce, A., Constable, R.T., Krystal, J.H., Gore, J.C., Goldman-Rakic, P., 1996. Activation of human prefrontal cortex during spatial and nonspatial working memory tasks measured by functional MRI. Cereb. Cortex. 6 (4), 600-611.
22. Nelson, H.E., 1982. The National Adult Reading Scale (NART). Nelson, Windsor.
23. Overall, J.E., Gorham, D.R., 1962. The brief psychiatric rating scale (BPRS). Psychol. Rep. 10, 799-812.
24. Park, S., Holzman, P.S., 1992. Schizophrenics show spatial working memory deficits. Arch. Gen. Psychiatry 49, 975-982.
25. Paulesu, E., Frith, C.D., Frackowiak, R.S.J., 1993. The neural correlates of the verbal component of working memory. Nature 362, 342-345.
26. Saykin, A.J., Gur, R.C., Gur, R.E., Mozley, P.D., Mozley, L.H., Resnick, S.M., Kester, D.B., Stafiniak, P., 1991. Neuropsychological function in schizophrenia-selective impairment in memory and learning. Arch. Gen. Psychiatry 48 (7), 618-624.
27. Schlaepfer, T.E., Harris, G.J., Tien, A.Y., Peng, L.W., Lee, S., Federman, E.B., Chase, G.A., Barta, P.E., Pearlson, G.D., 1994. Decreased regional cortical gray matter volume in schizophrenia. Am. J. Psychiatry 151, 842-848.
28. Seidman, L.J., Oscar-Berman, M., Kalinowski, A.C., Ajilore, O., Kremen, W.S., Faraone, S.V., Tsuang, M.T., 1995. Experimental and clinical neuropsychological measures of prefrontal dysfunction in schizophrenia. Neuropsychology 9 (4), 481-490.
29. Selemon, L.D., Rajkowska, G., Goldman-Rakic, P.S., 1995. Abnormally high neuronal density in the schizophrenic cortex. Arch. Gen. Psychiatry 52, 805-818.
30. Spitzer, R.L., Endicott, J., Robins, E., 1975. Research diagnostic criteria (RDC). Biometrics Research, New York State Psychiatric Institute, New York.
31. Spitzer, R.L., Williams, J.B.W., Gibbon, M., First, M.B., 1992. The structured clinical interview for DSM-III-R (SCID). 1. History, rationale, and description. Arch. Gen. Psychiatry 49 (8), 624-629.
32. Stone, M., Gabrieli, J.D., Stebbins, G., Sullivan, E.V., in press. Working and strategic memory deficits in schizophrenia. Neuropsychology.
33. Sullivan, E.V., Lim, K.O., Mathalon, D.H., Marsh, L., Pfefferbaum, A., in press. Patterns of regional brain dysmorphology distinguishing schizophrenia and chronic alcoholism. Biol. Psychiatry.
34. Sullivan, E.V., Shear, P.K., Zipursky, R.B., Sagar, H.J., Pfefferbaum, A., 1994. A deficit profile of executive, memory, and motor functions in schizophrenia. Biol. Psychiatry 36 (10), 641-653.
35. Vanderplas, J.M., Garvin, E.A., 1959. The association value of random shapes. J. Exp. Psychiatry 57, 147-154.
36. Weinberger, D.R., Berman, K., Suddath, R., Torrey, E.F., 1992. Evidence of dysfunction of a prefrontal-limbic network in schizophrenia: a magnetic resonance imaging and regional cerebral blood flow study of discordant monozygotic twins. Am. J. Psychiatry 149 (7), 890-897.
37. Wilson, F.A.W., Shalaidhe, P.O., Goldman-Rakic, P.S., 1993. Dissociation of object and spatial processing domains in primate prefrontal cortex. Science 260, 1955-1958.