Prefrontal cortex dysfunction mediates deficits in working memory and prepotent responding in schizophrenia

Biological Psychiatry

Volumn 53, Issue 1, 2003, Pages 25-38

  Perlstein, William M ^a   Dixit, Neha K ^a   Carter, Cameron S ^b   Noll, Douglas C ^c   Cohen, Jonathan D ^d  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d PRINCETON UNIVERSITY   (United States)

Author keywords

Cognitive control; Functional magnetic resonance imaging; Prefrontal cortex; Response inhibition; Schizophrenia; Working memory

Indexed keywords

ADULT; ARTICLE; CLINICAL ARTICLE; COGNITION; CONTROLLED STUDY; FEMALE; HUMAN; MALE; NEUROSCIENCE; NUCLEAR MAGNETIC RESONANCE IMAGING; PARIETAL LOBE; PREFRONTAL CORTEX; PRIORITY JOURNAL; SCHIZOPHRENIA; WORKING MEMORY;

ADULT; ANTIPSYCHOTIC AGENTS; CHLORPROMAZINE; COGNITION DISORDERS; DELAYED-ACTION PREPARATIONS; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MEMORY DISORDERS; NEURAL INHIBITION; PREFRONTAL CORTEX; REACTION TIME; SCHIZOPHRENIA;

EID: 0037219327     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(02)01675-X     Document Type: Article

References (73)

1. Akil M., Pierri J.N., Whitehead R.E., Edgar C.L., Mohila C., Sampson A.R., Lewis D.A. Lamina-specific alterations in the dopamine innervation of the prefrontal cortex in schizophrenic subjects. Am J Psychiatry. 156:1999;1580-1589.
2. (1994) Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: Author.
3. Baddeley A.D. Working Memory. 1986;Oxford University Press, Oxford.
4. Baldesserini R.J. Chemotherapy in Psychiatry. 1985;Harvard University Press, Cambridge, MA.
5. Barch D.M., Braver T.S., Cohen J.D., Servan-Screiber D. Context processing deficits in schizophrenia. Arch Gen Psychiatry. 55:1998;187-188.
6. Barch D.M., Carter C.S., Braver T.S., Sabb F.W., MacDonald A., Noll D.C., Cohen J.D. Selective deficits in prefrontal cortex function in medication-naïve patients with schizophrenia. Arch Gen Psychiatry. 58:2001;280-288.
7. Benes F.M., McSparren J., Bird E.D., SanGiovanni J.P., Vincent S.L. Deficits in small interneurons in prefrontal and cingulate cortices of schizophrenic and schizoaffective patients. Arch Gen Psychiatry. 48:1991;996-1001.
8. Blanchard J.J., Neale J.M. The neuropsychological signature of schizophrenia Generalized or differential deficit . Am J Psychiatry. 151:1994;40-48.
9. Bleuler E. Dementia Praecox or the Group of Schizophrenias. 1950;International Universities Press, New York. (J. Zinkin, trans; original work published 1911).
10. Braver T.S., Barch D.M., Cohen J.D. Cognition and control in schizophrenia A computational model of dopamine and prefrontal function . Biol Psychiatry. 46:1999;312-328.
11. Braver T.S., Cohen J.D., Nystrom L.E., Jonides J., Smith E.E., Noll D.C. A parametric study of prefrontal cortex involvement in human working memory. Neuroimage. 5:1997;49-62.
12. Callicott J.H., Bertolino A., Mattay V.S., Langheim F.J.P., Duyn J., Coppola R., et al. Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited. Cereb Cortex. 10:2000;1078-1092.
13. Callicott J.H., Mattay V.S., Bertolino A., Finn K., Coppola R., Frank J.A., et al. Physiological characteristics of capacity constraints in working memory as revealed by functional MRI. Cereb Cortex. 9:1999;20-26.
14. Carter C.S., Perlstein W.M., Ganguli R., Brar J., Mintun M., Cohen J.D. Functional hypofrontality and working memory dysfunction in schizophrenia. Am J Psychiatry. 155:1998;1285-1287.
15. Carter C.S., Robertson L.C., Nordahl T.E., Kraft L., Chaderjian M., Oshora-Celaya L. Spatial working memory deficits and their relationship to negative symptoms in unmedicated schizophrenic patients. Biol Psychiatry. 40:1996;930-932.
16. Casey B.J., Cohen J.D., Jezzard P., Turner R., Noll D.C., Trainor R.J., et al. A developmental functional MRI study of prefrontal activation during performance on a go-nogo task. J Cogn Neurosci. 9:1997;835-847.
17. Casey B.J., Forman S.D., Franzen P., Berkowitz A., Braver T.S., Nystrom L.E., et al. Sensitivity of prefrontal cortex to changes in target probability A functional MRI study . Hum Brain Map. 13:2001;26-33.
18. Chapman L.J., Chapman J.P. The measurement of differential deficit. J Psychiatric Res. 14:1973;303-311.
19. Chapman L.J., Chapman J.P. Commentary on two articles concerning generalized and specific cognitive deficits. J Abnorm Psychol. 110:2001;31-39.
20. Cohen J.D., Barch D.M., Carter C.S., Servan-Schreiber D. Schizophrenic deficits in the processing of context Converging evidence from three theoretically motivated cognitive tasks . J Abnorm Psychol. 108:1999;120-133.
21. Cohen J.D., Braver T.S., O'Reilly R.C. A computational approach to prefrontal cortex, cognitive control and schizophrenia Recent developments and current challenges . Phil Trans Royal Soc Lond B. 351:1996;1515-1527.
22. Cohen J.D., Forman S.D., Braver T.S., Casey B.J., Servan-Schreiber D., Noll D.C. Activation of prefrontal cortex in a non-spatial working memory task with functional MRI. Hum Brain Map. 1:1994;293-304.
23. Cohen J.D., MacWhinney B., Flatt M.R., Provost J. PsyScope A new graphic interactive environment for designing psychology experiments . Behav Res Methods Instr Comput. 25:1993;257-271.
24. Cohen J.D., Perlstein W.M., Braver T.S., Nystrom L.E., Noll D.C., Jonides J., Smith E.E. Temporal dynamics of brain activation during a working memory task. Nature. 386:1997;604-608.
25. Cohen J.D., Servan-Schreiber D. Context, cortex, and dopamine A connectionist approach to behavior and biology in schizophrenia . Psychol Rev. 99:1992;45-77.
26. Cox R.W. AFNI Software for analysis and visualization of functional magnetic resonance neuroimages . Comput Biomed Res. 29:1996;162-173.
27. Davis J, Nanicak P, Linden R, Moloney J, Pavkovic I. (1983). Neuroleptics and psychotic disorders. In: Cle JT, Enn SJ, editors. Neuroleptics: Neurochemical, Behavioral, and Clinical Perspectives. New York: Raven Press.
28. de Zubicaray G.I., Andrew C., Zelaya F.O., Williams S.C.R., Dumonoir C. Motor response suppression and the prepotent tendency to respond A parametric fMRI study . Neuropsychologica. 38:2000;1280-1291.
29. Diamond A., Goldman-Rakic P.S. Comparison of human infants and rhesus monkeys on Piaget's A B task Evidence for dependence on dorsolateral prefrontal cortex . Exp Brain Res. 74:1989;24-40.
30. Duncan J., Owen A.M. Common regions of the human prefrontal lobe recruited by diverse cognitive demands. Trends Cogn Sci. 23:2000;475-483.
31. First M.B., Spitzer R.L., Gibbon M., Williams J.B. The Structured Clinic Interview for DSM-IV Axis I Disorders. 1995;New York State Psychiatric Institute, New York.
32. Fletcher P.C., McKenna P.J., Frith C.D., Grasby P.M., Friston K.J., Dolan R.J. Brain activations in schizophrenia during a graded memory task studied with functional neuroimaging. Arch Gen Psychiatry. 55:1998;1001-1008.
33. Forman S.D., Cohen J.D., Fitzgerald M., Eddy W.F., Mintun M.A., Noll D.C. Improved assessment of significant activation in functional magnetic resonance imaging (fMRI) Use of a cluster-size threshold . Magn Reson Med. 33:1995;636-647.
34. Fuster J.M. (1997): The Prefrontal Cortex: Anatomy, Physiology and Neuropsychology of the Frontal Lobe. 3rd ed. New York: Raven Press.
35. Garavan H., Ross T.J., Stein E.A. Right hemispheric dominance of inhibitory control An event-related functional MRI study . Proc Natl Acad Sci U S A. 96:1999;8301-8306.
36. Goldman-Rakic P.S. Circuitry of primate prefrontal cortex and regulation of behavior by representational memory. Plum F., Mountcastle V. Handbook of Physiology - The Nervous System V. 1987;373-417 American Physiological Society, Bethesda, MD.
37. Gooding D.C., Tallent K.A. The association between antisaccade task and working memory task performance in schizophrenic and bipolar disorder. J Nerv Ment Dis. 189:2001;8-16.
38. Honey G.D., Bullmore E.T., Sharma T. De-coupling of cognitive performance and cerebral functional response during working memory in schizophrenia. Schizophr Res. 53:2002;45-56.
39. Jansma J.M., Ramsey N.F., Coppola R., Kahn R.S. Specific versus nonspecific brain activity in a parametric n-back task. Neuroimage. 12:2000;688-697.
40. Kawashima R., Satoh K., Itoh H., Ono S., Furumoto S., Grotoh R., et al. Functional anatomy of GO/NO-GO discrimination and response selection - A PET study in man. Brain Res. 728:1996;79-89.
41. Kay S.R., Fiszbein A., Olper L.A. The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophr Bull. 13:1987;261-276.
42. Kimberg D.Y., D'Esposito M., Farah M.J. Cognitive functions in the prefrontal cortex - Working memory and executive control. Curr Dir Psychol Sci. 6:1998;185-192.
43. Kraepelin E., Barclay R.M. Dementia Praecox and Paraphrenia. 1971;Robert E Krieger, New York.
44. Liddle P.F. Syndromes of chronic schizophrenia A re-examination of the positive-negative dichotomy . Br J Psychiatry. 151:1987;145-151.
45. MacDonald A.W., Cohen J.D., Stenger V.A., Carter C.S. Dissociating the role of the dorsolateral prefrontal and anterior cingulate cortex in cognitive control. Science. 288:2000;1835-1838.
46. MacDonald A.W., Ross L.L., Becker J., Carter C.S. Attentional control processes in DLPFC Domain specific or domain general? Soc Neurosci Abstr. 26:2000;550.
47. Manoach D.S., Gollub R.L., Benson E.S., Searl M.M., Goff D.C., Halpern E., et al. Schizophrenic subjects show aberrant fMRI activation of dorsolateral prefrontal cortex and basal ganglia during working memory performance. Biol Psychiatry. 48:2000;99-109.
48. Manoach D.S., Press D.Z., Thangaraj V., Searl M.M., Goff D.C., Halpern E., et al. Schizophrenia subjects activate dorsolateral prefrontal cortex during a working memory task, as measured by fMRI. Biol Psychiatry. 45:1999;1128-1137.
49. McDowell J.E., Brown G.G., Paulus M., Martinez A., Stewart S.E., Dubowitz D.J., Braff D.L. Neural correlates of refixation saccades and antisaccades in normal and schizophrenia subjects. Biol Psychiatry. 51:2002;216-233.
50. Miller E.K. The prefrontal cortex and cognitive control. Nat Rev Neurosci. 1:2000;59-65.
51. Miller E.K., Cohen J.D. An integrative theory of prefrontal cortex function. Ann Rev Neurosci. 24:2001;176-202.
52. Mitchell J.P., Macrae C.N., Gilchrist I.D. Working memory and the suppression of reflexive saccades. J Cogn Neurosci. 14:2002;95-103.
53. Nauta W.J.H. The problem of the frontal lobe A reinterpretation . J Psychiatry Res. 8:1971;167-187.
54. Noll D.C., Cohen J.D., Meyer C.H., Schneider W. Spiral K-space MR imaging of cortical activity. J Magn Reson Imaging. 5:1995;49-56.
55. Park S., Holzman P.S. Schizophrenics show spatial working memory deficits. Arch Gen Psychiatry. 49:1992;975-982.
56. Perlstein W.M., Carter C.S., Barch D.M., Baird J.W. The Stroop task and attention deficits in schizophrenia A critical evaluation of card and single-trial Stroop methodologies . Neuropsychology. 12:1998;414-425.
57. Perlstein W.M., Carter C.S., Noll D.C., Cohen J.D. Relation of prefrontal cortex dysfunction to working memory and symptoms in schizophrenia. Am J Psychiatry. 158:2001;1105-1113.
58. Pochon J.-B., Levy R., Poline J.-B., Crozier S., Lehèricy S., Pillon B., et al. The role of the dorsolateral prefrontal cortex in the preparation of forthcoming actions An fMRI study . Cereb Cortex. 11:2001;260-266.
59. Roberts R.J., Hager L.D., Heron C. Prefrontal cognitive processes Working memory and inhibition in the antisaccade task . J Exp Psychol Gen. 123:1994;374-393.
60. Roberts R.J., Pennington B.F. An interactive framework for examining prefrontal cognitive processing. Dev Neuropsychol. 12:1996;105-126.
61. Selemon L.D., Goldman-Rakic P.S. The reduced neuropil hypothesis A circuit based model of schizophrenia . Biol Psychiatry. 45:1999;17-25.
62. Selemon L.D., Mrzljak J., Kleinman J.E., Herman M.M., Goldman-Rakic P.S. Selective neuropil deficit in prefrontal area 9, not Broca's area 44, in a new cohort of schizophrenic brains. Soc Neurosci Abstr. 25:1999;574.
63. Servan-Schreiber D., Cohen J.D., Steingard S. Schizophrenic deficits in the processing of context A test of a theoretical model . Arch Gen Psychiatry. 53:1996;1105-1113.
64. Shrout P.E., Fleiss J.L. Intraclass correlations Uses in assessing rater reliability . Psychol Bull. 86:1979;420-428.
65. Smith E.E., Jonides J. Neuroimaging analysis of human working memory. Proc Natl Acac Sci U S A. 95:1999;1657-1661.
66. Stevens A.A., Goldman-Rakic P.S., Gore J.C., Fullbright R.K., Wexler B.E. Cortical dysfunction in schizophrenia during auditory word and tone working memory demonstrated by functional magnetic resonance imaging. Arch Gen Psychiatry. 55:1998;1097-1103.
67. Stratta P., Daneluzzo E., Massimiliano B., Prosperini P., Rossi A. Processing of context information in schizophrenia Relation to clinical symptoms and WCST performance . Schiz Res. 44:2000;57-67.
68. Stuss DT, Eskes GA, Foster JK (1994): Experimental neuropsychological studies of frontal lobe function. In: Boller F, Grafman, J, editors. Handbook of Neuropsychology, vol 9. Amsterdam: Elsevier.
69. Talairach J., Tournoux P. Co-Planar Stereotaxic Atlas of the Human Brain. 1988;George Thieme Verlag, Stuttgart.
70. Ullsperger M., von Cramon D.Y. Subprocesses of performance monitoring A dissociation of error processing and response competition revealed by event-related fMRI and ERPs . NeuroImage. 14:2001;1387-1401.
71. van Veen V., Cohen J.D., Botvinick M.M., Stenger V.A., Carter C.S. Anterior cingulate cortex, conflict monitoring, and levels of processing. Neuroimage. 14:2001;1302-1308.
72. Weinberger D.R., Berman K., Zec R. Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia I. Regional cerebral blood flow evidence . Arch Gen Psychiatry. 43:1986;114-124.
73. Woods R.P., Cherry S.R., Maziotta J.C. Rapid automation algorithm for aligning and reslicing PET images. J Comp Assist Tomog. 16:1992;620-633.