Spatial working memory deficits and their relationship to negative symptoms in unmedicated schizophrenia patients

Biological Psychiatry

Volumn 40, Issue 9, 1996, Pages 930-932

  Carter, Cameron ^a,c   Robertson, Lynn ^b   Nordahl, Thomas ^b   Chaderjian, Marc ^d   Kraft, Louis ^b   O'Shora Celaya, Linda ^b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

^d NONE

Author keywords

Attention; Dopamine; Frontal cortex; Negative symptoms; Schizophrenia; Spatial working memory

Indexed keywords

ADULT; ARTICLE; CLINICAL ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; FEMALE; HUMAN; MALE; MEMORY; NEGATIVE SYNDROME; PRIORITY JOURNAL; SCHIZOPHRENIA; SPATIAL MEMORY;

EID: 0030298506     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(96)00350-2     Document Type: Article

References (15)

1. Andreasen NC (1982): Negative symptoms in schizophrenia: Definition and reliability. Arch Gen Psychiatry 39:784-788.
2. Alphs LD, Sommerfelt A, Lann H, Mulle R (1989): The Negative Symptom Assessment: A new instrument to assess negative symptoms of schizophrenia. Psychopharmacol Bull 25:159-163.
3. Baddeley AD (1976): The Psychology of Memory. New York: Basic Books.
4. Brozoski TJ, Brown RM, Rosvold PS, Goldman PS (1979): Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey. Science 205:929-931.
5. Clow A, Theodurou A, Jenner P, Marsden CD (1980): Cerebral dopamine function in rats following withdrawal from one year of continuous neuroleptic administration. Eur J Pharmacol 63:145-157.
6. Goldman-Rakic PS (1987): Circuitry of primate prefrontal cortex and regulation of behavior by representational memory. In F Plum (ed) Handbook of Physiology: The Nervous System. Bethesda, MD: American Physiological Society, vol 5, pp 373-417.
7. Holzman P (1994): Parsing cognition. The power of cognitive paradigms. Arch Gen Psychiatry 51:952-954.
8. Jonides J, Smith EE, Koeppe RA, Awh E, Minoshima S, Mintun M (1993): Spatial working memory in humans as revealed by PET. Nature 362:342-345.
9. Kane J, Honigfield G, Singer J, Meltzer H (1988): Clozapine for the treatment resistant schizophrenic. Arch Gen Psychiatry 45:789-796.
10. Liddle PF, Morris DL (1991): Schizophrenic syndromes and frontal lobe performance. Br J Psychiatry 158:340-345.
11. Overall J, Gorham D (1962): The brief psychiatric rating scale. Psychol Rep 10:799-812.
12. Park S, Holtzman PS (1992): Schizophrenics show spatial working memory deficits. Arch Gen Psychiatry 49:975-982.
13. Park S, Holtzman PS (1993): Association of working memory deficit and eye tracking dysfunction in schizophrenia. Schizophr Res 11:55-61.
14. Park S, Holzman PS, Goldman-Rakic P (1995): Spatial working memory deficits in the relatives of schizophrenic patients. Arch Gen Psychiatry 52:821-828.
15. Sawaguchi T, Goldman-Rakic PS (1991): D1 receptors in prefrontal cortex: Involvement in working memory. Science 251:947-949.