Doxycycline-regulated lentiviral vector system with a novel reverse transactivator rtTA2S-M2 shows a tight control of gene expression in vitro and in vivo

Gene Therapy

Volumn 10, Issue 6, 2003, Pages 459-466

  Koponen, J K ^a   Kankkonen, H ^a   Kannasto, J ^a   Wirth, T ^a   Hillen, W ^b   Bujard, H ^c   Yla Herttuala S ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Brain; Doxycycline; Lentivirus; Rat; Regulation

Indexed keywords

BETA GALACTOSIDASE; DOXYCYCLINE; LENTIVIRUS VECTOR; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; BRAIN; CELL CULTURE; CHO CELL; CONTROLLED STUDY; DOSE RESPONSE; GENE EXPRESSION REGULATION; GENE THERAPY; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HYBRIDOMA; IN VITRO STUDY; IN VIVO STUDY; LONG TERM CARE; MOLECULAR STABILITY; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RAT; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; VIRUS INACTIVATION;

ANIMALS; ANTI-BACTERIAL AGENTS; BRAIN; CHO CELLS; CRICETINAE; DOXYCYCLINE; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION; GENE THERAPY; GENETIC VECTORS; HIV-1; HUMANS; HYBRIDOMAS; LAC OPERON; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANS-ACTIVATORS; TRANSDUCTION, GENETIC;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; LENTIVIRUS; RNA VIRUSES;

EID: 0037351165     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301889     Document Type: Review

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