QT interval prolongation: And the beat goes on

Mini-Reviews in Medicinal Chemistry

Volumn 5, Issue 12, 2005, Pages 1083-1091

  Jalaie, Mehran ^a   Holsworth, Daniel D ^a,b  

^a PFIZER INC   (United States)

^b Department of Cardiovascular Chemistry ^*

Author keywords

Docking; HERG; High throughput screen; Homology; Ion channels; QSAR; QT; Torsade de Pointes

Indexed keywords

1' (6 CYANO 1,2,3,4 TETRAHYDRO 2 NAPHTHYL) 3,4 DIHYDRO 6 METHANESULFONAMIDOSPIRO[2H 1 BENZOPYRAN 2,4' PIPERIDIN] 4 OL; ASTEMIZOLE; CISAPRIDE; DOCKING PROTEIN; FLUVOXAMINE; ION CHANNEL; POTASSIUM CHANNEL HERG; TERFENADINE;

AMINO ACID SEQUENCE; BINDING AFFINITY; BINDING ASSAY; BINDING SITE; CELL ASSAY; COMPUTER MODEL; COMPUTER PROGRAM; DRUG DETERMINATION; DRUG RESEARCH; ELECTROCARDIOGRAM; HEART ARRHYTHMIA; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; HIGH THROUGHPUT SCREENING; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LINEAR REGRESSION ANALYSIS; NONHUMAN; PATCH CLAMP; PATHOPHYSIOLOGY; PHARMACOPHORE; PREDICTION; PROTEIN STRUCTURE; PURKINJE FIBER; QT PROLONGATION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RELIABILITY; REVIEW; RISK ASSESSMENT; RISK FACTOR; SEQUENCE HOMOLOGY; TORSADE DES POINTES;

EID: 28444431652     PISSN: 13895575     EISSN: None     Source Type: Journal    
DOI: 10.2174/138955705774933338     Document Type: Review

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