-
1
-
-
0037219411
-
β-Cell deficit and increased β-cell apoptosis in humans with type 2 diabetes
-
Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC 2003 β-Cell deficit and increased β-cell apoptosis in humans with type 2 diabetes. Diabetes 52:102-110
-
(2003)
Diabetes
, vol.52
, pp. 102-110
-
-
Butler, A.E.1
Janson, J.2
Bonner-Weir, S.3
Ritzel, R.4
Rizza, R.A.5
Butler, P.C.6
-
2
-
-
0037382455
-
Contributions of insulin-resistance and insulin-secretory defects to the pathogenesis of type 2 diabetes mellitus
-
Gerich JE 2003 Contributions of insulin-resistance and insulin-secretory defects to the pathogenesis of type 2 diabetes mellitus. Mayo Clin Proc 78:447-456
-
(2003)
Mayo Clin Proc
, vol.78
, pp. 447-456
-
-
Gerich, J.E.1
-
3
-
-
0038707331
-
Selective β-cell loss and α-cell expansion in patients with type 2 diabetes mellitus in Korea
-
Yoon KH, Ko SH, Cho JH, Lee JM, Ahn YB, Song KH, Yoo SJ, Kang MI, Cha BY, Lee KW, Son HY, Kang SK, Kim HS, Lee IK, Bonner-Weir S 2003 Selective β-cell loss and α-cell expansion in patients with type 2 diabetes mellitus in Korea. J Clin Endocrinol Metab 88:2300-2308
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 2300-2308
-
-
Yoon, K.H.1
Ko, S.H.2
Cho, J.H.3
Lee, J.M.4
Ahn, Y.B.5
Song, K.H.6
Yoo, S.J.7
Kang, M.I.8
Cha, B.Y.9
Lee, K.W.10
Son, H.Y.11
Kang, S.K.12
Kim, H.S.13
Lee, I.K.14
Bonner-Weir, S.15
-
4
-
-
0035960122
-
Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young
-
Fajans SS, Bell GI, Polonsky KS 2001 Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young. N Engl J Med 345:971-980
-
(2001)
N Engl J Med
, vol.345
, pp. 971-980
-
-
Fajans, S.S.1
Bell, G.I.2
Polonsky, K.S.3
-
6
-
-
0026471057
-
Synergistic activation of the insulin gene by a LIM-homeodomain protein and a basic helix-loop-helix protein: Building a functional insulin mini-enhancer complex
-
German MS, Wang J, Chadwick RB, Rutter WJ 1992 Synergistic activation of the insulin gene by a LIM-homeodomain protein and a basic helix-loop-helix protein: building a functional insulin mini-enhancer complex. Genes Dev 6:2165-2176
-
(1992)
Genes Dev
, vol.6
, pp. 2165-2176
-
-
German, M.S.1
Wang, J.2
Chadwick, R.B.3
Rutter, W.J.4
-
7
-
-
0033962883
-
The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter
-
Ohneda K, Mirmira RG, Wang J, Johnson JD, German MS 2000 The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter. Mol Cell Biol 20:900-911
-
(2000)
Mol Cell Biol
, vol.20
, pp. 900-911
-
-
Ohneda, K.1
Mirmira, R.G.2
Wang, J.3
Johnson, J.D.4
German, M.S.5
-
8
-
-
0033506651
-
Pbx-Hox heterodimers recruit coactivator-corepressor complexes in an isoform-specific manner
-
Asahara H, Dutta S, Kao HY, Evans RM, Montminy M 1999 Pbx-Hox heterodimers recruit coactivator-corepressor complexes in an isoform-specific manner. Mol Cell Biol 19:8219-8225
-
(1999)
Mol Cell Biol
, vol.19
, pp. 8219-8225
-
-
Asahara, H.1
Dutta, S.2
Kao, H.Y.3
Evans, R.M.4
Montminy, M.5
-
9
-
-
0036134978
-
Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47
-
Qiu Y, Guo M, Huang S, Stein R 2002 Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47. Mol Cell Biol 22:412-420
-
(2002)
Mol Cell Biol
, vol.22
, pp. 412-420
-
-
Qiu, Y.1
Guo, M.2
Huang, S.3
Stein, R.4
-
10
-
-
2542430265
-
Pancreas duodenum homeobox-1 transcriptional activation requires interactions with p300
-
Stanojevic V, Habener JF, Thomas MK 2004 Pancreas duodenum homeobox-1 transcriptional activation requires interactions with p300. Endocrinology 145:2918-2928
-
(2004)
Endocrinology
, vol.145
, pp. 2918-2928
-
-
Stanojevic, V.1
Habener, J.F.2
Thomas, M.K.3
-
11
-
-
0033499802
-
Bridge-1, a novel PDZ-domain coactivator of E2A-mediated regulation of insulin gene transcription
-
Thomas MK, Yao KM, Tenser MS, Wong GG, Habener JF 1999 Bridge-1, a novel PDZ-domain coactivator of E2A-mediated regulation of insulin gene transcription. Mol Cell Biol 19:8492-8404
-
(1999)
Mol Cell Biol
, vol.19
, pp. 8492-8404
-
-
Thomas, M.K.1
Yao, K.M.2
Tenser, M.S.3
Wong, G.G.4
Habener, J.F.5
-
12
-
-
19544394114
-
The coactivator Bridge-1 increases transcriptional activation by pancreas duodenum homeobox-1 (PDX-1)
-
Stanojevic V, Yao KM, Thomas MK 2005 The coactivator Bridge-1 increases transcriptional activation by pancreas duodenum homeobox-1 (PDX-1). Mol Cell Endocrinol 237:67-74
-
(2005)
Mol Cell Endocrinol
, vol.237
, pp. 67-74
-
-
Stanojevic, V.1
Yao, K.M.2
Thomas, M.K.3
-
13
-
-
0033303666
-
Developmental expression of the homeodomain protein IDX-1 in mice transgenic for an IDX-1 promoter/lacZ transcriptional reporter
-
Stoffers DA, Heller RS, Miller CP, Habener JF 1999 Developmental expression of the homeodomain protein IDX-1 in mice transgenic for an IDX-1 promoter/lacZ transcriptional reporter. Endocrinology 140:5374-5381
-
(1999)
Endocrinology
, vol.140
, pp. 5374-5381
-
-
Stoffers, D.A.1
Heller, R.S.2
Miller, C.P.3
Habener, J.F.4
-
14
-
-
0035476437
-
Regulatory regions driving developmental and tissue-specific expression of the essential pancreatic gene pdx1
-
Gannon M, Gamer LW, Wright CV 2001 Regulatory regions driving developmental and tissue-specific expression of the essential pancreatic gene pdx1. Dev Biol 238:185-201
-
(2001)
Dev Biol
, vol.238
, pp. 185-201
-
-
Gannon, M.1
Gamer, L.W.2
Wright, C.V.3
-
15
-
-
0034524101
-
Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of β-cell formation in the pancreas
-
Sander M, Sussel L, Conners J, Scheel D, Kalamaras J, Dela Cruz F, Schwitzgebel V, Hayes-Jordan A, German M 2000 Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of β-cell formation in the pancreas. Development 127:5533-5540
-
(2000)
Development
, vol.127
, pp. 5533-5540
-
-
Sander, M.1
Sussel, L.2
Conners, J.3
Scheel, D.4
Kalamaras, J.5
Dela Cruz, F.6
Schwitzgebel, V.7
Hayes-Jordan, A.8
German, M.9
-
16
-
-
2542478686
-
IDX-1: Pancreatic agenesis and type 2 diabetes
-
Erikson P, Epstein CJ, Wynshaw-Boris A, eds. Oxford, UK: Oxford University Press
-
Thomas MK, Habener JF 2004 IDX-1: pancreatic agenesis and type 2 diabetes. In: Erikson P, Epstein CJ, Wynshaw-Boris A, eds. Molecular basis of inborn errors of development. Oxford, UK: Oxford University Press; 552-556
-
(2004)
Molecular Basis of Inborn Errors of Development
, pp. 552-556
-
-
Thomas, M.K.1
Habener, J.F.2
-
17
-
-
0030907390
-
Hormonal regulation of an islet-specific enhancer in the pancreatic homeobox gene STF-1
-
Sharma S, Jhala US, Johnson T, Ferreri K, Leonard J, Montminy M 1997 Hormonal regulation of an islet-specific enhancer in the pancreatic homeobox gene STF-1. Mol Cell Biol 17:2598-2604
-
(1997)
Mol Cell Biol
, vol.17
, pp. 2598-2604
-
-
Sharma, S.1
Jhala, U.S.2
Johnson, T.3
Ferreri, K.4
Leonard, J.5
Montminy, M.6
-
18
-
-
0030873949
-
Hepatocyte nuclear factor 3β is involved in pancreatic β-cell-specific transcription of the pdx-1 gene
-
Wu KL, Gannon M, Peshavaria M, Offield MF, Henderson E, Ray M, Marks A, Gamer LW, Wright CV, Stein R 1997 Hepatocyte nuclear factor 3β is involved in pancreatic β-cell-specific transcription of the pdx-1 gene. Mol Cell Biol 17:6002-6013
-
(1997)
Mol Cell Biol
, vol.17
, pp. 6002-6013
-
-
Wu, K.L.1
Gannon, M.2
Peshavaria, M.3
Offield, M.F.4
Henderson, E.5
Ray, M.6
Marks, A.7
Gamer, L.W.8
Wright, C.V.9
Stein, R.10
-
19
-
-
0036323652
-
Foxa2 controls Pdx1 gene expression in pancreatic β-cells in vivo
-
Lee CS, Sund NJ, Vatamaniuk MZ, Matschinsky FM, Stoffers DA, Kaestner KH 2002 Foxa2 controls Pdx1 gene expression in pancreatic β-cells in vivo. Diabetes 51:2546-2551
-
(2002)
Diabetes
, vol.51
, pp. 2546-2551
-
-
Lee, C.S.1
Sund, N.J.2
Vatamaniuk, M.Z.3
Matschinsky, F.M.4
Stoffers, D.A.5
Kaestner, K.H.6
-
20
-
-
0036950665
-
The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic β cell growth
-
Kitamura T, Nakae J, Kitamura Y, Kido Y, Biggs 3rd WH, Wright CV, White MF, Arden KC, Accili D 2002 The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic β cell growth. J Clin Invest 110:1839-847
-
(2002)
J Clin Invest
, vol.110
, pp. 1839-1847
-
-
Kitamura, T.1
Nakae, J.2
Kitamura, Y.3
Kido, Y.4
Biggs III, W.H.5
Wright, C.V.6
White, M.F.7
Arden, K.C.8
Accili, D.9
-
21
-
-
0037076351
-
Identification of β-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA
-
USA
-
Olbrot M, Rud J, Moss LG, Sharma A 2002 Identification of β-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA. Proc Natl Acad Sci USA 99:6737-6742
-
(2002)
Proc Natl Acad Sci
, vol.99
, pp. 6737-6742
-
-
Olbrot, M.1
Rud, J.2
Moss, L.G.3
Sharma, A.4
-
22
-
-
0041970072
-
Members of the large Maf transcription family regulate insulin gene transcription in islet β cells
-
Matsuoka TA, Zhao L, Artner I, Jarrett HW, Friedman D, Means A, Stein R 2003 Members of the large Maf transcription family regulate insulin gene transcription in islet β cells. Mol Cell Biol 23:6049-6062
-
(2003)
Mol Cell Biol
, vol.23
, pp. 6049-6062
-
-
Matsuoka, T.A.1
Zhao, L.2
Artner, I.3
Jarrett, H.W.4
Friedman, D.5
Means, A.6
Stein, R.7
-
23
-
-
0030712878
-
POU domain transcription factor brain 4 confers pancreatic α-cell-specific expression of the proglucagon gene through interaction with a novel proximal promoter G1 element
-
Hussain MA, Lee J, Miller CP, Habener JF 1997 POU domain transcription factor brain 4 confers pancreatic α-cell-specific expression of the proglucagon gene through interaction with a novel proximal promoter G1 element. Mol Cell Biol 17:7186-7194
-
(1997)
Mol Cell Biol
, vol.17
, pp. 7186-7194
-
-
Hussain, M.A.1
Lee, J.2
Miller, C.P.3
Habener, J.F.4
-
24
-
-
0142091542
-
Opposing actions of Arx and Pax4 in endocrine pancreas development
-
Collombat P, Mansouri A, Hecksher-Sorensen J, Serup P, Krull J, Gradwohl G, Gruss P 2003 Opposing actions of Arx and Pax4 in endocrine pancreas development. Genes Dev 17:2591-2603
-
(2003)
Genes Dev
, vol.17
, pp. 2591-2603
-
-
Collombat, P.1
Mansouri, A.2
Hecksher-Sorensen, J.3
Serup, P.4
Krull, J.5
Gradwohl, G.6
Gruss, P.7
-
25
-
-
0033606972
-
Notch signalling controls pancreatic cell differentiation
-
Apelqvist A, Li H, Sommer L, Beatus P, Anderson DJ, Honjo T, Hrabe de Angelis M, Lendahl U, Edlund H 1999 Notch signalling controls pancreatic cell differentiation. Nature 400:877-881
-
(1999)
Nature
, vol.400
, pp. 877-881
-
-
Apelqvist, A.1
Li, H.2
Sommer, L.3
Beatus, P.4
Anderson, D.J.5
Honjo, T.6
Hrabe De Angelis, M.7
Lendahl, U.8
Edlund, H.9
-
26
-
-
0034652287
-
Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
-
USA
-
Gradwohl G, Dierich A, LeMeur M, Guillemot F 2000 Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci USA 97:1607-1611
-
(2000)
Proc Natl Acad Sci
, vol.97
, pp. 1607-1611
-
-
Gradwohl, G.1
Dierich, A.2
LeMeur, M.3
Guillemot, F.4
-
27
-
-
0033996527
-
Regulation of the pancreatic islet-specific gene BETA2 (neuroD) by neurogenin 3
-
Huang HP, Liu M, El-Hodiri HM, Chu K, Jamrich M, Tsai MJ 2000 Regulation of the pancreatic islet-specific gene BETA2 (neuroD) by neurogenin 3. Mol Cell Biol 20:3292-3307
-
(2000)
Mol Cell Biol
, vol.20
, pp. 3292-3307
-
-
Huang, H.P.1
Liu, M.2
El-Hodiri, H.M.3
Chu, K.4
Jamrich, M.5
Tsai, M.J.6
-
28
-
-
0028358092
-
The insulin gene contains multiple transcriptional elements that respond to glucose
-
German MS, Wang J 1994 The insulin gene contains multiple transcriptional elements that respond to glucose. Mol Cell Biol 14:4067-4075
-
(1994)
Mol Cell Biol
, vol.14
, pp. 4067-4075
-
-
German, M.S.1
Wang, J.2
-
29
-
-
0030447883
-
Purification of the β-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells
-
USA
-
Marshak S, Totary H, Cerasi E, Melloul D 1996 Purification of the β-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells. Proc Natl Acad Sci USA 93:15057-15062
-
(1996)
Proc Natl Acad Sci
, vol.93
, pp. 15057-15062
-
-
Marshak, S.1
Totary, H.2
Cerasi, E.3
Melloul, D.4
-
30
-
-
0033305205
-
Increase in PDX-1 levels suppresses insulin gene expression in RIN 1046-38 cells
-
Seijffers R, Ben-David O, Cohen Y, Karasik A, Berezin M, Newgard CB, Ferber S 1999 Increase in PDX-1 levels suppresses insulin gene expression in RIN 1046-38 cells. Endocrinology 140:3311-3317
-
(1999)
Endocrinology
, vol.140
, pp. 3311-3317
-
-
Seijffers, R.1
Ben-David, O.2
Cohen, Y.3
Karasik, A.4
Berezin, M.5
Newgard, C.B.6
Ferber, S.7
-
31
-
-
0037191099
-
Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3
-
Heremans Y, Van De Casteele M, in't Veld P, Gradwohl G, Serup P, Madsen O, Pipeleers D, Heimberg H 2002 Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3. J Cell Biol 159:303-312
-
(2002)
J Cell Biol
, vol.159
, pp. 303-312
-
-
Heremans, Y.1
Van De Casteele, M.2
In't Veld, P.3
Gradwohl, G.4
Serup, P.5
Madsen, O.6
Pipeleers, D.7
Heimberg, H.8
-
32
-
-
0032525981
-
β-Cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetes
-
Ahlgren U, Jonsson J, Jonsson L, Simu K, Edlund H 1998 β-Cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetes. Genes Dev 12:1763-1768
-
(1998)
Genes Dev
, vol.12
, pp. 1763-1768
-
-
Ahlgren, U.1
Jonsson, J.2
Jonsson, L.3
Simu, K.4
Edlund, H.5
-
33
-
-
0038686576
-
Suppression of β cell energy metabolism and insulin release by PGC-1α
-
Yoon JC, Xu G, Deeney JT, Yang SN, Rhee J, Puigserver P, Levens AR, Yang R, Zhang CY, Lowell BB, Berggren PO, Newgard CB, Bonner-Weir S, Weir G, Spiegelman BM 2003 Suppression of β cell energy metabolism and insulin release by PGC-1α. Dev Cell 5:73-83
-
(2003)
Dev Cell
, vol.5
, pp. 73-83
-
-
Yoon, J.C.1
Xu, G.2
Deeney, J.T.3
Yang, S.N.4
Rhee, J.5
Puigserver, P.6
Levens, A.R.7
Yang, R.8
Zhang, C.Y.9
Lowell, B.B.10
Berggren, P.O.11
Newgard, C.B.12
Bonner-Weir, S.13
Weir, G.14
Spiegelman, B.M.15
-
34
-
-
0034959266
-
Development of diabetes mellitus in aging transgenic mice following suppression of pancreatic homeoprotein IDX-1
-
Thomas MK, Devon ON, Lee JH, Peter A, Schlosser DA, Tenser MS, Habener JF 2001 Development of diabetes mellitus in aging transgenic mice following suppression of pancreatic homeoprotein IDX-1. J Clin Invest 108:319-329
-
(2001)
J Clin Invest
, vol.108
, pp. 319-329
-
-
Thomas, M.K.1
Devon, O.N.2
Lee, J.H.3
Peter, A.4
Schlosser, D.A.5
Tenser, M.S.6
Habener, J.F.7
-
35
-
-
0032966813
-
Mutagenesis and selection of PDZ domains that bind new protein targets
-
Schneider S, Buchert M, Georgiev O, Catimel B, Halford M, Stacker SA, Baechi T, Moelling K, Hovens CM 1999 Mutagenesis and selection of PDZ domains that bind new protein targets. Nat Biotechnol 17:170-175
-
(1999)
Nat Biotechnol
, vol.17
, pp. 170-175
-
-
Schneider, S.1
Buchert, M.2
Georgiev, O.3
Catimel, B.4
Halford, M.5
Stacker, S.A.6
Baechi, T.7
Moelling, K.8
Hovens, C.M.9
-
36
-
-
15644379801
-
Recognition of unique carboxyl-terminal motifs by distinct PDZ domains
-
Songyang Z, Fanning AS, Fu C, Xu J, Marfatia SM, Chishti AH, Crompton A, Chan AC, Anderson JM, Cantley LC 1997 Recognition of unique carboxyl-terminal motifs by distinct PDZ domains. Science 275:73-77
-
(1997)
Science
, vol.275
, pp. 73-77
-
-
Songyang, Z.1
Fanning, A.S.2
Fu, C.3
Xu, J.4
Marfatia, S.M.5
Chishti, A.H.6
Crompton, A.7
Chan, A.C.8
Anderson, J.M.9
Cantley, L.C.10
-
37
-
-
0034740693
-
Mechanism and role of PDZ domains in signaling complex assembly
-
Harris BZ, Lim WA 2001 Mechanism and role of PDZ domains in signaling complex assembly. J Cell Sci 114:3219-3231
-
(2001)
J Cell Sci
, vol.114
, pp. 3219-3231
-
-
Harris, B.Z.1
Lim, W.A.2
-
38
-
-
0029066512
-
FAP-1: A protein tyrosine phosphatase that associates with Fas
-
Sato T, Irie S, Kitada S, Reed JC 1995 FAP-1: a protein tyrosine phosphatase that associates with Fas. Science 268:411-415
-
(1995)
Science
, vol.268
, pp. 411-415
-
-
Sato, T.1
Irie, S.2
Kitada, S.3
Reed, J.C.4
-
39
-
-
3342928043
-
Re-expression of TSLC1 in a non-small-cell lung cancer cell line induces apoptosis and inhibits tumor growth
-
Mao X, Seidlitz E, Truant R, Hitt M, Ghosh HP 2004 Re-expression of TSLC1 in a non-small-cell lung cancer cell line induces apoptosis and inhibits tumor growth. Oncogene 23:5632-5642
-
(2004)
Oncogene
, vol.23
, pp. 5632-5642
-
-
Mao, X.1
Seidlitz, E.2
Truant, R.3
Hitt, M.4
Ghosh, H.P.5
-
40
-
-
0038155702
-
Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles
-
Bruning JC, Winnay J, Bonner-Weir S, Taylor SI, Accili D, Kahn CR 1997 Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Cell 88:561-572
-
(1997)
Cell
, vol.88
, pp. 561-572
-
-
Bruning, J.C.1
Winnay, J.2
Bonner-Weir, S.3
Taylor, S.I.4
Accili, D.5
Kahn, C.R.6
-
41
-
-
18144391553
-
Estrogen, insulin, and dietary signals cooperatively regulate longevity signals to enhance resistance to oxidative stress in mice
-
Baba T, Shimizu T, Suzuki Y, Ogawara M, Isono K, Koseki H, Kurosawa H, Shirasawa T 2005 Estrogen, insulin, and dietary signals cooperatively regulate longevity signals to enhance resistance to oxidative stress in mice. J Biol Chem 280:16417-16426
-
(2005)
J Biol Chem
, vol.280
, pp. 16417-16426
-
-
Baba, T.1
Shimizu, T.2
Suzuki, Y.3
Ogawara, M.4
Isono, K.5
Koseki, H.6
Kurosawa, H.7
Shirasawa, T.8
-
42
-
-
0016346501
-
Stabilization of plasma glucose during fasting; Normal variations in two separate studies
-
Merimee TJ, Tyson JE 1974 Stabilization of plasma glucose during fasting; Normal variations in two separate studies. N Engl J Med 291:1275-1278
-
(1974)
N Engl J Med
, vol.291
, pp. 1275-1278
-
-
Merimee, T.J.1
Tyson, J.E.2
-
43
-
-
0027229299
-
Gender differences in counterregulation to hypoglycaemia
-
Amiel SA, Maran A, Powrie JK, Umpleby AM, Macdonald IA 1993 Gender differences in counterregulation to hypoglycaemia. Diabetologia 36:460-464
-
(1993)
Diabetologia
, vol.36
, pp. 460-464
-
-
Amiel, S.A.1
Maran, A.2
Powrie, J.K.3
Umpleby, A.M.4
Macdonald, I.A.5
-
44
-
-
0034457408
-
Effects of gender on neuroendocrine and metabolic counterregulatory responses to exercise in normal man
-
Davis SN, Galassetti P, Wasserman DH, Tate D 2000 Effects of gender on neuroendocrine and metabolic counterregulatory responses to exercise in normal man. J Clin Endocrinol Metab 85:224-230
-
(2000)
J Clin Endocrinol Metab
, vol.85
, pp. 224-230
-
-
Davis, S.N.1
Galassetti, P.2
Wasserman, D.H.3
Tate, D.4
-
45
-
-
1542347695
-
Convergence of Wnt, β-catenin, and cadherin pathways
-
Nelson WJ, Nusse R 2004 Convergence of Wnt, β-catenin, and cadherin pathways. Science 303:1483-1487
-
(2004)
Science
, vol.303
, pp. 1483-1487
-
-
Nelson, W.J.1
Nusse, R.2
-
46
-
-
0032104261
-
cDNA cloning and characterization of a human proteasomal modulator subunit, p27
-
Watanabe TK, Saito A, Suzuki M, Fujiwara T, Takahashi E, Slaughter CA, DeMartino GN, Hendil KB, Chung CH, Tanahashi N, Tanaka K 1998 cDNA cloning and characterization of a human proteasomal modulator subunit, p27. Genomics 50:241-250
-
(1998)
Genomics
, vol.50
, pp. 241-250
-
-
Watanabe, T.K.1
Saito, A.2
Suzuki, M.3
Fujiwara, T.4
Takahashi, E.5
Slaughter, C.A.6
DeMartino, G.N.7
Hendil, K.B.8
Chung, C.H.9
Tanahashi, N.10
Tanaka, K.11
-
47
-
-
0030042442
-
Identification, purification, and characterization of a PA700-dependent activator of the proteasome
-
DeMartino GN, Proske RJ, Moomaw CR, Strong AA, Song X, Hisamatsu H, Tanaka K, Slaughter CA 1996 Identification, purification, and characterization of a PA700-dependent activator of the proteasome. J Biol Chem 271:3112-3118
-
(1996)
J Biol Chem
, vol.271
, pp. 3112-3118
-
-
DeMartino, G.N.1
Proske, R.J.2
Moomaw, C.R.3
Strong, A.A.4
Song, X.5
Hisamatsu, H.6
Tanaka, K.7
Slaughter, C.A.8
-
48
-
-
0027465924
-
The type 1 human immunodeficiency virus Tat binding protein is a transcriptional activator belonging to an additional family of evolutionarily conserved genes
-
USA
-
Ohana B, Moore PA, Ruben SM, Southgate CD, Green MR, Rosen CA 1993 The type 1 human immunodeficiency virus Tat binding protein is a transcriptional activator belonging to an additional family of evolutionarily conserved genes. Proc Natl Acad Sci USA 90:138-142
-
(1993)
Proc Natl Acad Sci
, vol.90
, pp. 138-142
-
-
Ohana, B.1
Moore, P.A.2
Ruben, S.M.3
Southgate, C.D.4
Green, M.R.5
Rosen, C.A.6
-
49
-
-
0037134015
-
Recruitment of a 19S proteasome subcomplex to an activated promoter
-
Gonzalez F, Delahodde A, Kodadek T, Johnston SA 2002 Recruitment of a 19S proteasome subcomplex to an activated promoter. Science 296:548-550
-
(2002)
Science
, vol.296
, pp. 548-550
-
-
Gonzalez, F.1
Delahodde, A.2
Kodadek, T.3
Johnston, S.A.4
-
50
-
-
0035979738
-
Regulation of transcriptional activation domain function by ubiquitin
-
Salghetti SE, Caudy AA, Chenoweth JG, Tansey WP 2001 Regulation of transcriptional activation domain function by ubiquitin. Science 293:1651-1653
-
(2001)
Science
, vol.293
, pp. 1651-1653
-
-
Salghetti, S.E.1
Caudy, A.A.2
Chenoweth, J.G.3
Tansey, W.P.4
-
52
-
-
0037123605
-
Emerging roles of ubiquitin in transcription regulation
-
Conaway RC, Brower CS, Conaway JW 2002 Emerging roles of ubiquitin in transcription regulation. Science 296:1254-1258
-
(2002)
Science
, vol.296
, pp. 1254-1258
-
-
Conaway, R.C.1
Brower, C.S.2
Conaway, J.W.3
-
53
-
-
0037432773
-
Polyubiquitination of p53 by a ubiquitin ligase activity of p300
-
Grossman SR, Deato ME, Brignone C, Chan HM, King AL, Tagami H, Nakatani Y, Livingston DM 2003 Polyubiquitination of p53 by a ubiquitin ligase activity of p300. Science 300:342-344
-
(2003)
Science
, vol.300
, pp. 342-344
-
-
Grossman, S.R.1
Deato, M.E.2
Brignone, C.3
Chan, H.M.4
King, A.L.5
Tagami, H.6
Nakatani, Y.7
Livingston, D.M.8
-
55
-
-
0036478904
-
Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice
-
Yamauchi T, Oike Y, Kamon J, Waki H, Komeda K, Tsuchida A, Date Y, Li MX, Miki H, Akanuma Y, Nagai R, Kimura S, Saheki T, Nakazato M, Naitoh T, Yamamura K, Kadowaki T 2002 Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice. Nat Genet 30:221-226
-
(2002)
Nat Genet
, vol.30
, pp. 221-226
-
-
Yamauchi, T.1
Oike, Y.2
Kamon, J.3
Waki, H.4
Komeda, K.5
Tsuchida, A.6
Date, Y.7
Li, M.X.8
Miki, H.9
Akanuma, Y.10
Nagai, R.11
Kimura, S.12
Saheki, T.13
Nakazato, M.14
Naitoh, T.15
Yamamura, K.16
Kadowaki, T.17
-
56
-
-
0037184960
-
SRC-1 and TIF2 control energy balance between white and brown adipose tissues
-
Picard F, Gehin M, Annicotte JS, Rocchi S, Champy MF, O'Malley BW, Chambon P, Auwerx J 2002 SRC-1 and TIF2 control energy balance between white and brown adipose tissues. Cell 111:931-941
-
(2002)
Cell
, vol.111
, pp. 931-941
-
-
Picard, F.1
Gehin, M.2
Annicotte, J.S.3
Rocchi, S.4
Champy, M.F.5
O'Malley, B.W.6
Chambon, P.7
Auwerx, J.8
-
57
-
-
0037326196
-
Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α): Transcriptional coactivator and metabolic regulator
-
Puigserver P, Spiegelman BM 2003 Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α): transcriptional coactivator and metabolic regulator. Endocr Rev 24:78-90
-
(2003)
Endocr Rev
, vol.24
, pp. 78-90
-
-
Puigserver, P.1
Spiegelman, B.M.2
-
58
-
-
0035985096
-
A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to type II diabetes
-
Hara K, Tobe K, Okada T, Kadowaki H, Akanuma Y, Ito C, Kimura S, Kadowaki T 2002 A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to type II diabetes. Diabetologia 45:740-743
-
(2002)
Diabetologia
, vol.45
, pp. 740-743
-
-
Hara, K.1
Tobe, K.2
Okada, T.3
Kadowaki, H.4
Akanuma, Y.5
Ito, C.6
Kimura, S.7
Kadowaki, T.8
-
59
-
-
0032700272
-
Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus
-
Malecki MT, Jhala US, Antonellis A, Fields L, Doria A, Orban T, Saad M, Warram JH, Montminy M, Krolewski AS 1999 Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus. Nat Genet 23:323-328
-
(1999)
Nat Genet
, vol.23
, pp. 323-328
-
-
Malecki, M.T.1
Jhala, U.S.2
Antonellis, A.3
Fields, L.4
Doria, A.5
Orban, T.6
Saad, M.7
Warram, J.H.8
Montminy, M.9
Krolewski, A.S.10
-
60
-
-
0034964730
-
Maturity-onset diabetes of the young type 1 (MODY1)-associated mutations R154X and E2767Q in hepatocyte nuclear factor 4α (HNF4α) gene impair recruitment of p300, a key transcriptional coactivator
-
Eeckhoute J, Formstecher P, Laine B 2001 Maturityonset diabetes of the young type 1 (MODY1)-associated mutations R154X and E2767Q in hepatocyte nuclear factor 4α (HNF4α) gene impair recruitment of p300, a key transcriptional coactivator. Mol Endocrinol 15:1200-1210
-
(2001)
Mol Endocrinol
, vol.15
, pp. 1200-1210
-
-
Eeckhoute, J.1
Formstecher, P.2
Laine, B.3
-
61
-
-
16044374799
-
Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families
-
Mahtani MM, Widen E, Lehto M, Thomas J, McCarthy M, Brayer J, Bryant B, Chan G, Daly M, Forsblom C, Kanninen T, Kirby A, Kruglyak L, Munnelly K, Parkkonen M, Reeve-Daly MP, Weaver A, Brettin T, Duyk G, Lander ES, Groop LC 1996 Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families. Nat Genet 14:90-94
-
(1996)
Nat Genet
, vol.14
, pp. 90-94
-
-
Mahtani, M.M.1
Widen, E.2
Lehto, M.3
Thomas, J.4
McCarthy, M.5
Brayer, J.6
Bryant, B.7
Chan, G.8
Daly, M.9
Forsblom, C.10
Kanninen, T.11
Kirby, A.12
Kruglyak, L.13
Munnelly, K.14
Parkkonen, M.15
Reeve-Daly, M.P.16
Weaver, A.17
Brettin, T.18
Duyk, G.19
Lander, E.S.20
Groop, L.C.21
more..
-
62
-
-
0031713870
-
Novel susceptibility gene for late-onset NIDDM is localized to human chromosome 12q
-
Shaw JT, Lovelock PK, Kesting JB, Cardinal J, Duffy D, Wainwright B, Cameron DP 1998 Novel susceptibility gene for late-onset NIDDM is localized to human chromosome 12q. Diabetes 47:173-1796
-
(1998)
Diabetes
, vol.47
, pp. 173-1796
-
-
Shaw, J.T.1
Lovelock, P.K.2
Kesting, J.B.3
Cardinal, J.4
Duffy, D.5
Wainwright, B.6
Cameron, D.P.7
-
63
-
-
0033942075
-
Genomewide search for type 2 diabetes susceptibility genes in four American populations
-
Ehm MG, Karnoub MC, Sakul H, Gottschalk K, Holt DC, Weber JL, Vaske D, Briley D, Briley L, Kopf J, McMillen P, Nguyen Q, Reisman M, Lai EH, Joslyn G, Shepherd NS, Bell C, Wagner MJ, Burns DK 2000 Genomewide search for type 2 diabetes susceptibility genes in four American populations. Am J Hum Genet 66:1871-1881
-
(2000)
Am J Hum Genet
, vol.66
, pp. 1871-1881
-
-
Ehm, M.G.1
Karnoub, M.C.2
Sakul, H.3
Gottschalk, K.4
Holt, D.C.5
Weber, J.L.6
Vaske, D.7
Briley, D.8
Briley, L.9
Kopf, J.10
McMillen, P.11
Nguyen, Q.12
Reisman, M.13
Lai, E.H.14
Joslyn, G.15
Shepherd, N.S.16
Bell, C.17
Wagner, M.J.18
Burns, D.K.19
-
64
-
-
18244399128
-
Genomewide search for type 2 diabetes mellitus susceptibility loci in Finnish families: The Botnia study
-
Lindgren CM, Mahtani MM, Widen E, McCarthy MI, Daly MJ, Kirby A, Reeve MP, Kruglyak L, Parker A, Meyer J, Almgren P, Lehto M, Kanninen T, Tuomi T, Groop LC, Lander ES 2002 Genomewide search for type 2 diabetes mellitus susceptibility loci in Finnish families: the Botnia study. Am J Hum Genet 70:509-516
-
(2002)
Am J Hum Genet
, vol.70
, pp. 509-516
-
-
Lindgren, C.M.1
Mahtani, M.M.2
Widen, E.3
McCarthy, M.I.4
Daly, M.J.5
Kirby, A.6
Reeve, M.P.7
Kruglyak, L.8
Parker, A.9
Meyer, J.10
Almgren, P.11
Lehto, M.12
Kanninen, T.13
Tuomi, T.14
Groop, L.C.15
Lander, E.S.16
-
65
-
-
0344837809
-
A genome-wide scan in families with maturity-onset diabetes of the young
-
Frayling TM, Lindgren CM, Chevre JC, Menzel S, Wishart M, Benmezroua Y, Brown A, Evans JC, Rao PS, Dina C, Lecoeur C, Kanninen T, Almgren P, Bulman MP, Wang Y, Mills J, Wright-Pascoe R, Mahtani MM, Prisco F, Costa A, Cognet I, Hansen T, Pedersen O, Ellard S, Tuomi T, Groop LC, Froguel P, Hattersley AT, Vaxillaire M 2003 A genome-wide scan in families with maturity-onset diabetes of the young. Diabetes 52:872-881
-
(2003)
Diabetes
, vol.52
, pp. 872-881
-
-
Frayling, T.M.1
Lindgren, C.M.2
Chevre, J.C.3
Menzel, S.4
Wishart, M.5
Benmezroua, Y.6
Brown, A.7
Evans, J.C.8
Rao, P.S.9
Dina, C.10
Lecoeur, C.11
Kanninen, T.12
Almgren, P.13
Bulman, M.P.14
Wang, Y.15
Mills, J.16
Wright-Pascoe, R.17
Mahtani, M.M.18
Prisco, F.19
Costa, A.20
Cognet, I.21
Hansen, T.22
Pedersen, O.23
Ellard, S.24
Tuomi, T.25
Groop, L.C.26
Froguel, P.27
Hattersley, A.T.28
Vaxillaire, M.29
more..
-
66
-
-
10744224697
-
Evidence from a large U.K. family collection that genes influencing age of onset of Type 2 diabetes map to chromosome 12p and to the MODY3/NIDDM2 locus on 12q24
-
Wiltshire S, Frayling TM, Groves CJ, Levy JC, Hitman GA, Sampson M, Walker M, Menzel S, Hattersley AT, Cardon LR, McCarthy MI 2004 Evidence from a large U.K. family collection that genes influencing age of onset of Type 2 diabetes map to chromosome 12p and to the MODY3/NIDDM2 locus on 12q24. Diabetes 53:855-860
-
(2004)
Diabetes
, vol.53
, pp. 855-860
-
-
Wiltshire, S.1
Frayling, T.M.2
Groves, C.J.3
Levy, J.C.4
Hitman, G.A.5
Sampson, M.6
Walker, M.7
Menzel, S.8
Hattersley, A.T.9
Cardon, L.R.10
McCarthy, M.I.11
-
67
-
-
0037192501
-
Molecular determinants for the tissue specificity of SERMs
-
Shang Y, Brown M 2002 Molecular determinants for the tissue specificity of SERMs. Science 295:2465-2468
-
(2002)
Science
, vol.295
, pp. 2465-2468
-
-
Shang, Y.1
Brown, M.2
-
69
-
-
0004270170
-
-
New York: John Wiley and Sons
-
Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K 1994 Current protocols in molecular biology. New York: John Wiley and Sons
-
(1994)
Current Protocols in Molecular Biology
-
-
Ausubel, F.M.1
Brent, R.2
Kingston, R.E.3
Moore, D.D.4
Seidman, J.G.5
Smith, J.A.6
Struhl, K.7
-
70
-
-
0037002444
-
Huntington's disease of the endocrine pancreas: Insulin deficiency and diabetes mellitus due to impaired insulin gene expression
-
Andreassen OA, Dedeoglu A, Stanojevic V, Hughes DB, Browne SE, Leech CA, Ferrante RJ, Habener JF, Beal MF, Thomas MK 2002 Huntington's disease of the endocrine pancreas: insulin deficiency and diabetes mellitus due to impaired insulin gene expression. Neurobiol Dis 11:410-424
-
(2002)
Neurobiol Dis
, vol.11
, pp. 410-424
-
-
Andreassen, O.A.1
Dedeoglu, A.2
Stanojevic, V.3
Hughes, D.B.4
Browne, S.E.5
Leech, C.A.6
Ferrante, R.J.7
Habener, J.F.8
Beal, M.F.9
Thomas, M.K.10
-
71
-
-
0033668338
-
Hedgehog signaling regulation of insulin production by pancreatic β-cells
-
Thomas MK, Rastalsky N, Lee JH, Habener JF 2000 Hedgehog signaling regulation of insulin production by pancreatic β-cells. Diabetes 49:2039-2047
-
(2000)
Diabetes
, vol.49
, pp. 2039-2047
-
-
Thomas, M.K.1
Rastalsky, N.2
Lee, J.H.3
Habener, J.F.4
-
73
-
-
0141483035
-
Hypoglycemia, defective islet glucagon secretion, but normal islet mass in mice with a disruption of the gastrin gene
-
Boushey RP, Abadir A, Flamez D, Baggio LL, Li Y, Berger V, Marshall BA, Finegood D, Wang TC, Schuit F, Drucker DJ 2003 Hypoglycemia, defective islet glucagon secretion, but normal islet mass in mice with a disruption of the gastrin gene. Gastroenterology 125:1164-1174
-
(2003)
Gastroenterology
, vol.125
, pp. 1164-1174
-
-
Boushey, R.P.1
Abadir, A.2
Flamez, D.3
Baggio, L.L.4
Li, Y.5
Berger, V.6
Marshall, B.A.7
Finegood, D.8
Wang, T.C.9
Schuit, F.10
Drucker, D.J.11
-
74
-
-
0029022369
-
Transcriptional activation by tetracyclines in mammalian cells
-
Gossen M, Freundlieb S, Bender G, Muller G, Hillen W, Bujard H 1995 Transcriptional activation by tetracyclines in mammalian cells. Science 268:1766-1769
-
(1995)
Science
, vol.268
, pp. 1766-1769
-
-
Gossen, M.1
Freundlieb, S.2
Bender, G.3
Muller, G.4
Hillen, W.5
Bujard, H.6
-
75
-
-
0029763587
-
Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice
-
USA
-
Kistner A, Gossen M, Zimmermann F, Jerecic J, Ullmer C, Lubbert H, Bujard H 1996 Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice. Proc Natl Acad Sci USA 93:10933-10938
-
(1996)
Proc Natl Acad Sci
, vol.93
, pp. 10933-10938
-
-
Kistner, A.1
Gossen, M.2
Zimmermann, F.3
Jerecic, J.4
Ullmer, C.5
Lubbert, H.6
Bujard, H.7
|