Development of diabetes mellitus in aging transgenic mice following suppression of pancreatic homeoprotein IDX-1

Journal of Clinical Investigation

Volumn 108, Issue 2, 2001, Pages 319-329

  Thomas, Melissa K ^a   Devon, Octavia N ^a   Lee, Jee H ^a   Peter, Andreas ^a   Schlosser, David A ^a   Tenser, Matthew S ^a   Habener, Joel F ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY RNA; DOXYCYCLINE; HOMEODOMAIN PROTEIN; PROTEIN IDX 1; RIBOZYME; UNCLASSIFIED DRUG;

AGING; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE PREDISPOSITION; GENE CONSTRUCT; GENE MUTATION; GENETIC CODE; GENETIC TRANSCRIPTION; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTECTION; TRANSGENIC MOUSE;

AGING; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PANCREAS; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; TRANS-ACTIVATORS;

EID: 0034959266     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200112029     Document Type: Article

References (62)

1. IPF1, a homeodomain-containing transactivator of the insulin gene
2. Characterization of somatostatin transactivating Factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells
3. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
4. Purification of the beta-cell glucose-sensitive Factor that transactivates the insulin gene differentially in normal and transformed islet cells
5. Homeodomain protein IDX-1: A master regulator of pancreas development and insulin gene expression
6. Transcribing pancreas
7. Early-onset type-II diabetes mellitus (MODY4) linked to IPF-1
8. Defective mutations in the insulin promoter factor- 1 (IPF-1) gene in late-onser type 2 diabetes mellitus
9. Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes
10. Regulatory factor linked to late-onset diabetes?
11. β-cell-specific inactivation of the mouse 1pf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetes
12. Insulin-promoter-factor 1 is required for pancreas development in mice
13. Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 coding region
14. The insulin and islet amyloid polypeptide genes contain similar cell-specific promoter elements that bind identical beta-cell nuclear complexes
15. Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1
16. Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor
17. PDX-1 induces insulin and glucokinase gene expressions in αTC1 clone 6 cells in the presence of betacellulin
18. Reduction of insulin gene transcription in HIT-T15 β cells chronically exposed to a suptaphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression
19. The reduction of insulin gene transcription in HIT-T15 β cells chronically exposed to high glucose concentration is associated with the loss of RIPE3b1 and STF-1 transcription Factor expression
20. Reduced insulin, GLUT2, and IDX-1 in β-cells after partial pancreatectomy
21. Differential expression of the insulin gene transcriptional repressor CCAAT/enhancer-binding protein beta and transactivator islet duodenum homeobox-1 in rat pancreatic beta cells during the development of diabetes mellitus
22. Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels
23. Hormonal regulation of an islet-specific enhancer in the pancreatic homeobox gene STF-1
24. Insulin promoter factor-1 gene mutation linked to early-onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein
25. Bridge-1, a novel PDZ-domain coacrivator of E2A-mediated regulation of insulin gene transcription
26. Hedgehog signaling regulation of homeodomain protein IDX-1 expression in pancreatic β cells
27. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
28. Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice
29. Transcriptional regulation by tetracyclines in mammalian cells
30. Gene transfer into mouse embryos: Production of transgenic mice by pronuclear injection
31. Simplified mammalian DNA isolation procedure
32. Hedgehog signaling regulates insulin production by pancreatic β-cells
33. Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: Special reference to expression of glucose transporter isoforms
34. Glucose induces insulin gene transcription in a murine pancreatic β-cell line
35. Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas
36. Simple RNA enzymes with new and highly specific endoribonuclease activities
37. Oligonucleotide-mediated modulation of mammalian gene expression
38. Heritable formation of pancreatic β-cell rumors in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes
39. Synergistic activation of the insulin gene by a LIM-homeodomain protein and a basic helix-loop-helix protein: Building a functional insulin minienhancer complex
40. The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter
41. Developmental expression of the homeodomain protein IDX-1 in mice transgenic for an IDX-1 promoter/lacZ transcriptional reporter
42. Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles
43. Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2
44. Maintenance of functional equivalence during paralogous Hox gene evolution
45. Regulation of B lymphocyte and macrophage development by graded expression of PU.1
46. Functional conservation of regulatory elements in the pdx-1 gene: PDX-1 and hepatocyte nuclear factor 3β transcription factors mediate β-cell-specific expression
47. The PIT-1 gene is regulated by distinct early and late pituitary-specific enhancers
48. Impaired insulin secretion and increased insulin sensitivity in familial maturity-onset diabetes of the young 4 (insulin promoter factor 1 gene)
49. Stabilization of plasma glucose during fasting
50. Gender differences in counterregulation to hypoglycemia
51. Effects of insulin on the counterregulatory response to equivalent hypoglycemia in normal females
52. Relative roles of insulin and hypoglycaemia on induction of neuroendocrine responses to, symptoms of, and deterioration of cognitive function in hypoglycaemia in male and female humans
53. Effects of gender on neuroendocrine and metabolic counterregulatory responses to exercise in normal man
54. Age-dependent reduction in insulin secretion and insulin mRNA in isolated islets from rats
55. Gene expression profile of aging and its retardation by caloric restriction
56. Sir2 links chromatin silencing, metabolism, and aging
57. Mitotic misregulation and human aging
58. Genome-wide study of aging and oxidative stress response in Drosophila melanogaster
59. Dynamics of β-cell mass in the growing rat pancreas: Estimation with a simple mathematical model
60. Glucagon-like peptide-1 regulates the beta cell transcription factor, PDX-1, in insulinoma cells