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Volumn 78, Issue 4, 2003, Pages 447-456

Contributions of insulin-resistance and insulin-secretory defects to the pathogenesis of type 2 diabetes mellitus

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN;

EID: 0037382455     PISSN: 00256196     EISSN: None     Source Type: Journal    
DOI: 10.4065/78.4.447     Document Type: Review
Times cited : (169)

References (121)
  • 1
    • 0031897103 scopus 로고    scopus 로고
    • Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in US adults: The Third National Health and Nutrition Examination Survey, 1988-1994
    • Harris MI, Flegal KM, Cowie CC, et al. Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in US adults: The Third National Health and Nutrition Examination Survey, 1988-1994. Diabetes Care. 1998;21:518-524.
    • (1998) Diabetes Care , vol.21 , pp. 518-524
    • Harris, M.I.1    Flegal, K.M.2    Cowie, C.C.3
  • 2
    • 0348079729 scopus 로고    scopus 로고
    • American Diabetes Association: Clinical practice recommendations 2002
    • Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. American Diabetes Association: clinical practice recommendations 2002. Diabetes Care. 2002;25(suppl 1):S1-S147.
    • (2002) Diabetes Care , vol.25 , Issue.SUPPL. 1
  • 3
    • 0032489358 scopus 로고    scopus 로고
    • Type 2 diabetes: When insulin secretion fails to compensate for insulin resistance
    • Kahn BB. Type 2 diabetes: when insulin secretion fails to compensate for insulin resistance. Cell. 1998;92:593-596.
    • (1998) Cell , vol.92 , pp. 593-596
    • Kahn, B.B.1
  • 5
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
    • Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993;329:977-986.
    • (1993) N Engl J Med , vol.329 , pp. 977-986
  • 6
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
    • [published correction appears in Lancet. 1999;354:602]
    • UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33) [published correction appears in Lancet. 1999;354:602]. Lancet. 1998;352:837-853.
    • (1998) Lancet , vol.352 , pp. 837-853
  • 7
    • 0032511566 scopus 로고    scopus 로고
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
    • published correction appears in Lancet. 1998;352:1557
    • UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34) [published correction appears in Lancet. 1998;352:1557]. Lancet. 1998;352:854-865.
    • (1998) Lancet , vol.352 , pp. 854-865
  • 8
    • 0034641568 scopus 로고    scopus 로고
    • Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): Prospective observational study
    • Stratton IM, Adler AI, Neil HA, et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ. 2000;321:405-412.
    • (2000) BMJ , vol.321 , pp. 405-412
    • Stratton, I.M.1    Adler, A.I.2    Neil, H.A.3
  • 9
    • 0033765856 scopus 로고    scopus 로고
    • The American Association of Clinical Endocrinologists Medical Guidelines for the Management of Diabetes Mellitus: The AACE system of intensive diabetes self-management-2000 update
    • American Association of Clinical Endocrinologists. The American Association of Clinical Endocrinologists Medical Guidelines for the Management of Diabetes Mellitus: the AACE system of intensive diabetes self-management-2000 update. Endocr Pract. 2000;6:43-84.
    • (2000) Endocr Pract , vol.6 , pp. 43-84
  • 10
    • 0034066993 scopus 로고    scopus 로고
    • Glycemic control of older adults with type 2 diabetes: Findings from the Third National Health and Nutrition Examination Survey, 1988-1994
    • Shorr RI, Franse LV, Resnick HE, Di Bari M, Johnson KC, Pahor M. Glycemic control of older adults with type 2 diabetes: findings from the Third National Health and Nutrition Examination Survey, 1988-1994. J Am Geriatr Soc. 2000;48:264-267.
    • (2000) J Am Geriatr Soc , vol.48 , pp. 264-267
    • Shorr, R.I.1    Franse, L.V.2    Resnick, H.E.3    Di Bari, M.4    Johnson, K.C.5    Pahor, M.6
  • 11
    • 0033188211 scopus 로고    scopus 로고
    • Is insulin resistance the principal cause of type 2 diabetes?
    • Gerich JE. Is insulin resistance the principal cause of type 2 diabetes? Diabetes Obes Metab. 1999;1:257-263.
    • (1999) Diabetes Obes Metab , vol.1 , pp. 257-263
    • Gerich, J.E.1
  • 12
    • 0024235277 scopus 로고
    • Role of insulin resistance in the pathogenesis of type 2 (non-insulin-dependent) diabetes mellitus
    • Gerich JE. Role of insulin resistance in the pathogenesis of type 2 (non-insulin-dependent) diabetes mellitus. Baillieres Clin Endocrinol Metab. 1988;2:307-326.
    • (1988) Baillieres Clin Endocrinol Metab , vol.2 , pp. 307-326
    • Gerich, J.E.1
  • 13
    • 0028031070 scopus 로고
    • Insulin resistance as the major cause of impaired glucose tolerance: A self-fulfilling prophesy?
    • O'Rahilly S, Hattersley A, Vaag A, Gray H. Insulin resistance as the major cause of impaired glucose tolerance: a self-fulfilling prophesy? Lancet. 1994;344:585-589.
    • (1994) Lancet , vol.344 , pp. 585-589
    • O'Rahilly, S.1    Hattersley, A.2    Vaag, A.3    Gray, H.4
  • 14
    • 0029056128 scopus 로고
    • Insulin deficiency and insulin resistance in the pathogenesis of NIDDM: Is a divorce possible?
    • Cerasi E. Insulin deficiency and insulin resistance in the pathogenesis of NIDDM: is a divorce possible? Diabetologia. 1995;38: 992-997.
    • (1995) Diabetologia , vol.38 , pp. 992-997
    • Cerasi, E.1
  • 15
    • 0032456709 scopus 로고    scopus 로고
    • Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: Problems and prospects
    • Ferrannini E. Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: problems and prospects. Endocr Rev. 1998;19:477-490.
    • (1998) Endocr Rev , vol.19 , pp. 477-490
    • Ferrannini, E.1
  • 17
    • 0032577376 scopus 로고    scopus 로고
    • Signals that regulate food intake and energy homeostasis
    • Woods SC, Seeley RJ, Porte D Jr, Schwartz MW, Signals that regulate food intake and energy homeostasis. Science, 1998;280:1378-1383.
    • (1998) Science , vol.280 , pp. 1378-1383
    • Woods, S.C.1    Seeley, R.J.2    Porte D., Jr.3    Schwartz, M.W.4
  • 18
    • 0031888121 scopus 로고    scopus 로고
    • Consensus Development Conference on Insulin Resistance: 5-6 November 1997
    • American Diabetes Association. Consensus Development Conference on Insulin Resistance: 5-6 November 1997. Diabetes Care. 1998;21:310-314.
    • (1998) Diabetes Care , vol.21 , pp. 310-314
  • 19
    • 0014188893 scopus 로고
    • Plasma insulin responses to oral and intravenous glucose: Studies in normal and diabetic subjects
    • Perley MJ, Kipnis DM. Plasma insulin responses to oral and intravenous glucose: studies in normal and diabetic subjects. J Clin Invest. 1967;46:1954-1962.
    • (1967) J Clin Invest , vol.46 , pp. 1954-1962
    • Perley, M.J.1    Kipnis, D.M.2
  • 20
    • 0025800354 scopus 로고
    • Different aetiologies of type 2 (non-insulin-dependent) diabetes mellitus in obese and non-obese subjects
    • Arner P, Pollare T, Lithell H. Different aetiologies of type 2 (non-insulin-dependent) diabetes mellitus in obese and non-obese subjects. Diabetologia. 1991;34:483-487.
    • (1991) Diabetologia , vol.34 , pp. 483-487
    • Arner, P.1    Pollare, T.2    Lithell, H.3
  • 21
    • 0032710788 scopus 로고    scopus 로고
    • Disruption of circadian insulin secretion is associated with reduced glucose uptake in first-degree relatives of patients with type 2 diabetes
    • Boden G, Chen X, Polansky M. Disruption of circadian insulin secretion is associated with reduced glucose uptake in first-degree relatives of patients with type 2 diabetes. Diabetes. 1999;48:2182-2188.
    • (1999) Diabetes , vol.48 , pp. 2182-2188
    • Boden, G.1    Chen, X.2    Polansky, M.3
  • 22
    • 0023267332 scopus 로고
    • Insulin deficiency and insulin resistance in type 2 (non-insulin-dependent) diabetes: Quantitative contributions of pancreatic and peripheral responses to glucose homeostasis
    • Nesher R, Della Casa L, Litvin Y, et al. Insulin deficiency and insulin resistance in type 2 (non-insulin-dependent) diabetes: quantitative contributions of pancreatic and peripheral responses to glucose homeostasis. Eur J Clin Invest. 1987;17:266-274.
    • (1987) Eur J Clin Invest , vol.17 , pp. 266-274
    • Nesher, R.1    Della Casa, L.2    Litvin, Y.3
  • 24
    • 0032834250 scopus 로고    scopus 로고
    • Evolution of β-cell dysfunction in impaired glucose tolerance and diabetes
    • Polonsky KS, Evolution of β-cell dysfunction in impaired glucose tolerance and diabetes. Exp Clin Endocrinol Diabetes. 1999;107(suppl 4):S124-S127.
    • (1999) Exp Clin Endocrinol Diabetes , vol.107 , Issue.SUPPL. 4
    • Polonsky, K.S.1
  • 25
    • 0028837903 scopus 로고
    • Insulin secretion, insulin action, and hepatic glucose production in identical twins discordant for non-insulin-dependent diabetes mellitus
    • Vaag A, Henriksen JE, Madsbad S, Holm N, Beck-Nielsen H. Insulin secretion, insulin action, and hepatic glucose production in identical twins discordant for non-insulin-dependent diabetes mellitus. J Clin Invest. 1995;95:690-698.
    • (1995) J Clin Invest , vol.95 , pp. 690-698
    • Vaag, A.1    Henriksen, J.E.2    Madsbad, S.3    Holm, N.4    Beck-Nielsen, H.5
  • 26
    • 0029927782 scopus 로고    scopus 로고
    • Elevated plasma glucose 2 h postchallenge predicts defects in β-cell function
    • Byme MM, Sturis J, Sobel RJ, Polonsky KS. Elevated plasma glucose 2 h postchallenge predicts defects in β-cell function. Am J Physiol. 1996;270(4, pt 1):E572-E579.
    • (1996) Am J Physiol , vol.270 , Issue.4 PART 1
    • Byme, M.M.1    Sturis, J.2    Sobel, R.J.3    Polonsky, K.S.4
  • 27
    • 0033312608 scopus 로고    scopus 로고
    • Heritability of pancreatic β-cell function among nondiabetic members of caucasian familial type 2 diabetic kindreds
    • Elbein SC, Hasstedt SJ, Wegner K, Kahn SE. Heritability of pancreatic β-cell function among nondiabetic members of caucasian familial type 2 diabetic kindreds. J Clin Endocrinol Metab. 1999;84:1398-1403,
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 1398-1403
    • Elbein, S.C.1    Hasstedt, S.J.2    Wegner, K.3    Kahn, S.E.4
  • 28
    • 0033960006 scopus 로고    scopus 로고
    • Reduced β-cell compensation to the insulin resistance associated with obesity in members of Caucasian familial type 2 diabetic kindreds
    • Elbein SC, Wegner K, Kahn SE. Reduced β-cell compensation to the insulin resistance associated with obesity in members of Caucasian familial type 2 diabetic kindreds. Diabetes Care. 2000;23:221-227.
    • (2000) Diabetes Care , vol.23 , pp. 221-227
    • Elbein, S.C.1    Wegner, K.2    Kahn, S.E.3
  • 29
    • 0024348996 scopus 로고
    • Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus
    • Eriksson J, Franssila-Kallunki A, Ekstrand A, et al. Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus. N Engl J Med. 1989;321:337-343.
    • (1989) N Engl J Med , vol.321 , pp. 337-343
    • Eriksson, J.1    Franssila-Kallunki, A.2    Ekstrand, A.3
  • 30
    • 0028848244 scopus 로고
    • Decreased insulin secretion and increased insulin resistance are independently related to the 7-year risk of NIDDM in Mexican-Americans
    • Haffner SM, Miettinen H, Gaskill SP, Stem MP. Decreased insulin secretion and increased insulin resistance are independently related to the 7-year risk of NIDDM in Mexican-Americans. Diabetes. 1995;44:1386-1391.
    • (1995) Diabetes , vol.44 , pp. 1386-1391
    • Haffner, S.M.1    Miettinen, H.2    Gaskill, S.P.3    Stem, M.P.4
  • 31
    • 0031437952 scopus 로고    scopus 로고
    • Risk and mechanism of dexamethasone-induced deterioration of glucose tolerance in non-diabetic first-degree relatives of NIDDM patients
    • Henriksen JE, Alford F, Ward GM, Beck-Nielsen H. Risk and mechanism of dexamethasone-induced deterioration of glucose tolerance in non-diabetic first-degree relatives of NIDDM patients. Diabetologia. 1997;40:1439-1448.
    • (1997) Diabetologia , vol.40 , pp. 1439-1448
    • Henriksen, J.E.1    Alford, F.2    Ward, G.M.3    Beck-Nielsen, H.4
  • 32
    • 0029022819 scopus 로고
    • Pancreatic betacell dysfunction as the primary genetic lesion in NIDDM: Evidence from studies in normal glucose-tolerant individuals with a first-degree NIDDM relative
    • Pimenta W, Korytkowski M, Mitrakou A, et al. Pancreatic betacell dysfunction as the primary genetic lesion in NIDDM: evidence from studies in normal glucose-tolerant individuals with a first-degree NIDDM relative. JAMA. 1995;273:1855-1861.
    • (1995) JAMA , vol.273 , pp. 1855-1861
    • Pimenta, W.1    Korytkowski, M.2    Mitrakou, A.3
  • 33
    • 0031890769 scopus 로고    scopus 로고
    • Insulin secretion in normal glucose-tolerant relatives of type 2 diabetic subjects: Assessments using hyperglycemic glucose clamps and oral glucose tolerance tests
    • van Haeften TW, Dubbeldam S, Zonderland ML, Erkelens DW. Insulin secretion in normal glucose-tolerant relatives of type 2 diabetic subjects: assessments using hyperglycemic glucose clamps and oral glucose tolerance tests. Diabetes Care. 1998;21:278-282.
    • (1998) Diabetes Care , vol.21 , pp. 278-282
    • Van Haeften, T.W.1    Dubbeldam, S.2    Zonderland, M.L.3    Erkelens, D.W.4
  • 34
    • 0035132672 scopus 로고    scopus 로고
    • Insulin resistance and insulin secretory dysfunction are independent predictors of worsening of glucose tolerance during each stage of type 2 diabetes development
    • Weyer C, Tataranni PA, Bogardus C, Pratley RE. Insulin resistance and insulin secretory dysfunction are independent predictors of worsening of glucose tolerance during each stage of type 2 diabetes development. Diabetes Care. 2001;24:89-94.
    • (2001) Diabetes Care , vol.24 , pp. 89-94
    • Weyer, C.1    Tataranni, P.A.2    Bogardus, C.3    Pratley, R.E.4
  • 35
    • 0033849777 scopus 로고    scopus 로고
    • Obesity and insulin resistance
    • Kahn BB, Flier JS. Obesity and insulin resistance. J Clin Invest. 2000;106:473-481.
    • (2000) J Clin Invest , vol.106 , pp. 473-481
    • Kahn, B.B.1    Flier, J.S.2
  • 36
    • 0031799224 scopus 로고    scopus 로고
    • Insulin resistance: Current concepts
    • Bloomgarden ZT. Insulin resistance: current concepts. Clin Ther. 1998;20:216-231.
    • (1998) Clin Ther , vol.20 , pp. 216-231
    • Bloomgarden, Z.T.1
  • 37
    • 0000454838 scopus 로고    scopus 로고
    • Insulin resistance: The fundamental trigger of type 2 diabetes
    • Groop LC. Insulin resistance: the fundamental trigger of type 2 diabetes. Diabetes Obes Metab. 1999;1(suppl 1):S1-S7.
    • (1999) Diabetes Obes Metab , vol.1 , Issue.SUPPL. 1
    • Groop, L.C.1
  • 38
    • 0035786908 scopus 로고    scopus 로고
    • Insulin resistance and its treatment by thiazolidinediones
    • Lebovitz HE, Banerji MA. Insulin resistance and its treatment by thiazolidinediones. Recent Prog Horm Res. 2001;56:265-294.
    • (2001) Recent Prog Horm Res , vol.56 , pp. 265-294
    • Lebovitz, H.E.1    Banerji, M.A.2
  • 39
    • 0032786924 scopus 로고    scopus 로고
    • Insulin resistance: A chicken that has come to roost
    • Reaven GM. Insulin resistance: a chicken that has come to roost. Ann N Y Acad Sci. 1999;892:45-57.
    • (1999) Ann N Y Acad Sci , vol.892 , pp. 45-57
    • Reaven, G.M.1
  • 41
    • 0035897696 scopus 로고    scopus 로고
    • Executive summary of the Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel HI)
    • Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel HI). JAMA. 2001;285:2486-2497.
    • (2001) JAMA , vol.285 , pp. 2486-2497
  • 42
    • 0037116641 scopus 로고    scopus 로고
    • Prevalence of the metabolic syndrome among US adults: Findings from the third National Health and Nutrition Examination Survey
    • Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA. 2002;287:356-359.
    • (2002) JAMA , vol.287 , pp. 356-359
    • Ford, E.S.1    Giles, W.H.2    Dietz, W.H.3
  • 43
    • 0032018107 scopus 로고    scopus 로고
    • Focus on insulin resistance in type 2 diabetes: Therapeutic implications
    • Reusch JE. Focus on insulin resistance in type 2 diabetes: therapeutic implications. Diabetes Educ. 1998;24:188-193.
    • (1998) Diabetes Educ , vol.24 , pp. 188-193
    • Reusch, J.E.1
  • 44
    • 0035936763 scopus 로고    scopus 로고
    • New perspectives into the molecular pathogenesis and treatment of type 2 diabetes
    • Saltiel AR. New perspectives into the molecular pathogenesis and treatment of type 2 diabetes. Cell. 2001;104:517-529.
    • (2001) Cell , vol.104 , pp. 517-529
    • Saltiel, A.R.1
  • 45
    • 17344388503 scopus 로고    scopus 로고
    • Insulin sensitivity and acute insulin response in African-Americans, non-Hispanic whites, and Hispanics with NIDDM: The Insulin Resistance Atherosclerosis Study
    • Haffner SM, Howard G, Mayer E, et al. Insulin sensitivity and acute insulin response in African-Americans, non-Hispanic whites, and Hispanics with NIDDM: the Insulin Resistance Atherosclerosis Study. Diabetes. 1997;46:63-69.
    • (1997) Diabetes , vol.46 , pp. 63-69
    • Haffner, S.M.1    Howard, G.2    Mayer, E.3
  • 46
    • 0027762766 scopus 로고
    • Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus: Prospective studies of Pima Indians
    • Lillioja S, Mott DM, Spraul M, et al. Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus: prospective studies of Pima Indians. N Engl J Med. 1993;329:1988-1992.
    • (1993) N Engl J Med , vol.329 , pp. 1988-1992
    • Lillioja, S.1    Mott, D.M.2    Spraul, M.3
  • 47
    • 0026793446 scopus 로고
    • Role of glucose and insulin resistance in development of type 2 diabetes mellitus: Results of a 25-year follow-up study
    • Martin BC, Warram JH, Krolewski AS, Bergman RN, Soeldner JS, Kahn CR. Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study. Lancet. 1992;340:925-929.
    • (1992) Lancet , vol.340 , pp. 925-929
    • Martin, B.C.1    Warram, J.H.2    Krolewski, A.S.3    Bergman, R.N.4    Soeldner, J.S.5    Kahn, C.R.6
  • 48
    • 0026539663 scopus 로고
    • The metabolic profile of NIDDM is fully established in glucose-tolerant offspring of two Mexican-American NIDDM parents
    • Gulli G, Ferrannini E, Stem M, Haffner S, DeFronzo RA. The metabolic profile of NIDDM is fully established in glucose-tolerant offspring of two Mexican-American NIDDM parents. Diabetes. 1992;41:1575-1586.
    • (1992) Diabetes , vol.41 , pp. 1575-1586
    • Gulli, G.1    Ferrannini, E.2    Stem, M.3    Haffner, S.4    DeFronzo, R.A.5
  • 49
    • 0025663581 scopus 로고
    • Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents
    • Warram JH, Martin BC, Krolewski AS, Soeldner JS, Kahn CR. Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents. Ann Intern Med. 1990;113:909-915.
    • (1990) Ann Intern Med , vol.113 , pp. 909-915
    • Warram, J.H.1    Martin, B.C.2    Krolewski, A.S.3    Soeldner, J.S.4    Kahn, C.R.5
  • 50
    • 0023924773 scopus 로고
    • Impaired glucose tolerance as a disorder of insulin action: Longitudinal and cross-sectional studies in Pima Indians
    • Lillioja S, Mott DM, Howard BV, et al. Impaired glucose tolerance as a disorder of insulin action: longitudinal and cross-sectional studies in Pima Indians. N Engl J Med. 1988;318:1217-1225.
    • (1988) N Engl J Med , vol.318 , pp. 1217-1225
    • Lillioja, S.1    Mott, D.M.2    Howard, B.V.3
  • 51
    • 0032449219 scopus 로고    scopus 로고
    • The genetic basis of type 2 diabetes mellitus: Impaired insulin secretion versus impaired insulin sensitivity
    • Gerich J. The genetic basis of type 2 diabetes mellitus: impaired insulin secretion versus impaired insulin sensitivity. Endocr Rev. 1998;19:491-503.
    • (1998) Endocr Rev , vol.19 , pp. 491-503
    • Gerich, J.1
  • 52
    • 0034853485 scopus 로고    scopus 로고
    • Clinical review 135: The importance of β-cell failure in the development and progression of type 2 diabetes
    • Kahn SE. Clinical review 135: the importance of β-cell failure in the development and progression of type 2 diabetes. J Clin Endocrinol Metab. 2001;86:4047-4058.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 4047-4058
    • Kahn, S.E.1
  • 53
    • 0033846404 scopus 로고    scopus 로고
    • Strategies and prospects for finding insulin resistance genes
    • Stern MP. Strategies and prospects for finding insulin resistance genes. J Clin Invest. 2000;106:323-327.
    • (2000) J Clin Invest , vol.106 , pp. 323-327
    • Stern, M.P.1
  • 54
    • 0033063033 scopus 로고    scopus 로고
    • On the pathophysiology of late onset non-insulin dependent diabetes mellitus: Current controversies and new insights
    • Vaag A. On the pathophysiology of late onset non-insulin dependent diabetes mellitus: current controversies and new insights. Dan Med Bull. 1999;46:197-234.
    • (1999) Dan Med Bull , vol.46 , pp. 197-234
    • Vaag, A.1
  • 55
    • 0034616931 scopus 로고    scopus 로고
    • Biomedicine: New insights into type 2 diabetes
    • Alper J. Biomedicine: new insights into type 2 diabetes. Science. 2000;289:37-39.
    • (2000) Science , vol.289 , pp. 37-39
    • Alper, J.1
  • 56
    • 0034525135 scopus 로고    scopus 로고
    • Knockout mice challenge our concepts of glucose homeostasis and the pathogenesis of diabetes mellitus
    • Kahn CR, Brüning JC, Michael MD, Kulkarni RN. Knockout mice challenge our concepts of glucose homeostasis and the pathogenesis of diabetes mellitus, J Pediatr Endocrinot Metab. 2000;13(suppl 6):1377-1384.
    • (2000) J Pediatr Endocrinot Metab , vol.13 , Issue.SUPPL. 6 , pp. 1377-1384
    • Kahn, C.R.1    Brüning, J.C.2    Michael, M.D.3    Kulkarni, R.N.4
  • 57
    • 0036042628 scopus 로고    scopus 로고
    • Genetics of type 2 diabetes and insulin resistance: Knowledge from human studies
    • McIntyre EA, Walker M. Genetics of type 2 diabetes and insulin resistance: knowledge from human studies. Clin Endocrinot (Oxf). 2002;57:303-311.
    • (2002) Clin Endocrinot (Oxf) , vol.57 , pp. 303-311
    • McIntyre, E.A.1    Walker, M.2
  • 58
    • 0033772073 scopus 로고    scopus 로고
    • Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus
    • published correction appears in Nat Genet. 2000;26:502
    • Horikawa Y, Oda N, Cox NJ, et al. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus [published correction appears in Nat Genet. 2000;26:502]. Nat Genet. 2000;26:163-175.
    • (2000) Nat Genet , vol.26 , pp. 163-175
    • Horikawa, Y.1    Oda, N.2    Cox, N.J.3
  • 59
    • 0033624575 scopus 로고    scopus 로고
    • The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
    • Altshuler D, Hirschhorn JN, Klannemark M, et al. The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet. 2000;26:76-80.
    • (2000) Nat Genet , vol.26 , pp. 76-80
    • Altshuler, D.1    Hirschhorn, J.N.2    Klannemark, M.3
  • 60
    • 0036320603 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-γ2 Pro12Ala polymorphism
    • Stumvoll M, Häring H. The peroxisome proliferator-activated receptor-γ2 Pro12Ala polymorphism. Diabetes. 2002;51:2341-2347.
    • (2002) Diabetes , vol.51 , pp. 2341-2347
    • Stumvoll, M.1    Häring, H.2
  • 61
    • 0035475967 scopus 로고    scopus 로고
    • Challenges in identifying genetic variation affecting susceptibility to type 2 diabetes: Examples from studies of the calpain-10 gene
    • Cox NJ. Challenges in identifying genetic variation affecting susceptibility to type 2 diabetes: examples from studies of the calpain-10 gene. Hum Mol Genet. 2001;10:2301-2305.
    • (2001) Hum Mol Genet , vol.10 , pp. 2301-2305
    • Cox, N.J.1
  • 62
    • 0033779714 scopus 로고    scopus 로고
    • Free fatty acids and pathogenesis of type 2 diabetes mellitus
    • Bergman RN, Ader M. Free fatty acids and pathogenesis of type 2 diabetes mellitus. Trends Endocrinol Metab. 2000;11:351-356.
    • (2000) Trends Endocrinol Metab , vol.11 , pp. 351-356
    • Bergman, R.N.1    Ader, M.2
  • 63
    • 0034079725 scopus 로고    scopus 로고
    • Visceral adiposity and risk of type 2 diabetes: A prospective study among Japanese Americans
    • Boyko EJ, Fujimoto WY, Leonetti DL, Newell-Morris L. Visceral adiposity and risk of type 2 diabetes: a prospective study among Japanese Americans. Diabetes Care. 2000;23:465-471.
    • (2000) Diabetes Care , vol.23 , pp. 465-471
    • Boyko, E.J.1    Fujimoto, W.Y.2    Leonetti, D.L.3    Newell-Morris, L.4
  • 64
    • 0034678614 scopus 로고    scopus 로고
    • The importance of insulin resistance in the pathogenesis of type 2 diabetes mellitus
    • Fujimoto WY. The importance of insulin resistance in the pathogenesis of type 2 diabetes mellitus. Am J Med. 2000;108(suppl 6a):9S-14S.
    • (2000) Am J Med , vol.108 , Issue.SUPPL. 6A
    • Fujimoto, W.Y.1
  • 65
    • 0028919252 scopus 로고
    • Does intra-abdominal adipose tissue in black men determine whether NIDDM is insulin-resistant or insulin-sensitive?
    • Banerji MA, Chaiken RL, Gordon D, Kral JG, Lebovitz HE. Does intra-abdominal adipose tissue in black men determine whether NIDDM is insulin-resistant or insulin-sensitive? Diabetes. 1995;44:141-146.
    • (1995) Diabetes , vol.44 , pp. 141-146
    • Banerji, M.A.1    Chaiken, R.L.2    Gordon, D.3    Kral, J.G.4    Lebovitz, H.E.5
  • 66
    • 0029874313 scopus 로고    scopus 로고
    • Abdominal fat and insulin resistance in normal and overweight women: Direct measurements reveal a strong relationship in subjects at both low and high risk of NIDDM
    • Carey DG, Jenkins AB, Campbell LV, Freund J, Chisholm DJ. Abdominal fat and insulin resistance in normal and overweight women: direct measurements reveal a strong relationship in subjects at both low and high risk of NIDDM. Diabetes. 1996;45:633-638.
    • (1996) Diabetes , vol.45 , pp. 633-638
    • Carey, D.G.1    Jenkins, A.B.2    Campbell, L.V.3    Freund, J.4    Chisholm, D.J.5
  • 67
    • 0026651566 scopus 로고
    • In vivo insulin action and muscle glycogen synthase activity in type 2 (non-insulin-dependent) diabetes mellitus: Effects of diet treatment
    • Bak JF, Möller N, Schmitz O, Saaek A, Pedersen O. In vivo insulin action and muscle glycogen synthase activity in type 2 (non-insulin-dependent) diabetes mellitus: effects of diet treatment. Diabetologia. 1992;35:777-784.
    • (1992) Diabetologia , vol.35 , pp. 777-784
    • Bak, J.F.1    Möller, N.2    Schmitz, O.3    Saaek, A.4    Pedersen, O.5
  • 68
    • 0018373044 scopus 로고
    • Normalization of the insulin sensitivity and the cellular insulin binding during treatment of obese diabetics for one year
    • Beck-Nielsen H, Pedersen O, Lindskov HO. Normalization of the insulin sensitivity and the cellular insulin binding during treatment of obese diabetics for one year. Acta Endocrinol (Copenh). 1979;90:103-112.
    • (1979) Acta Endocrinol (Copenh) , vol.90 , pp. 103-112
    • Beck-Nielsen, H.1    Pedersen, O.2    Lindskov, H.O.3
  • 69
    • 0023798487 scopus 로고
    • Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus: Effect of weight loss
    • Freidenberg GR, Reichart D, Olefsky JM, Henry RR. Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus: effect of weight loss. J Clin Invest. 1988;82:1398-1406.
    • (1988) J Clin Invest , vol.82 , pp. 1398-1406
    • Freidenberg, G.R.1    Reichart, D.2    Olefsky, J.M.3    Henry, R.R.4
  • 70
    • 0028258309 scopus 로고
    • Weight loss in severely obese subjects prevents the progression of impaired glucose tolerance to type II diabetes: A longitudinal interventional study
    • Long SD, O'Brien K, MacDonald KG Jr, et al. Weight loss in severely obese subjects prevents the progression of impaired glucose tolerance to type II diabetes: a longitudinal interventional study. Diabetes Care. 1994;17:372-375.
    • (1994) Diabetes Care , vol.17 , pp. 372-375
    • Long, S.D.1    O'Brien, K.2    MacDonald K.G., Jr.3
  • 71
    • 0030935652 scopus 로고    scopus 로고
    • Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance: The Da Qing IGT and Diabetes Study
    • Pan XR, Li GW, Hu YH, et al. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance: the Da Qing IGT and Diabetes Study. Diabetes Care. 1997;20:537-544.
    • (1997) Diabetes Care , vol.20 , pp. 537-544
    • Pan, X.R.1    Li, G.W.2    Hu, Y.H.3
  • 72
    • 0037034257 scopus 로고    scopus 로고
    • Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    • Knowler W, Barrett-Connor E, Fowler SE, et al, Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002;346:393-403.
    • (2002) N Engl J Med , vol.346 , pp. 393-403
    • Knowler, W.1    Barrett-Connor, E.2    Fowler, S.E.3
  • 73
    • 0035799806 scopus 로고    scopus 로고
    • Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
    • Tuomilehto J, Lindström J, Eriksson J, et al, Finnish Diabetes Prevention Study Group. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med. 2001;344:1343-1350.
    • (2001) N Engl J Med , vol.344 , pp. 1343-1350
    • Tuomilehto, J.1    Lindström, J.2    Eriksson, J.3
  • 74
    • 0033009862 scopus 로고    scopus 로고
    • Free fatty acids, insulin resistance, and type 2 diabetes mellitus
    • Boden G. Free fatty acids, insulin resistance, and type 2 diabetes mellitus. Proc Assoc Am Physicians. 1999;111:241-248.
    • (1999) Proc Assoc Am Physicians , vol.111 , pp. 241-248
    • Boden, G.1
  • 75
    • 0035905758 scopus 로고    scopus 로고
    • The hormone resistin links obesity to diabetes
    • Steppan CM, Bailey ST, Bhat S, et al. The hormone resistin links obesity to diabetes. Nature. 2001;409:307-312.
    • (2001) Nature , vol.409 , pp. 307-312
    • Steppan, C.M.1    Bailey, S.T.2    Bhat, S.3
  • 76
    • 0037066603 scopus 로고    scopus 로고
    • ACRP30, a new hormone controlling fat and glucosemetabolism
    • Tsao TS, Lodish HF, Fruebis J. ACRP30, a new hormone controlling fat and glucosemetabolism. Eur J Pharmacol. 2002;440:213-221.
    • (2002) Eur J Pharmacol , vol.440 , pp. 213-221
    • Tsao, T.S.1    Lodish, H.F.2    Fruebis, J.3
  • 77
    • 0034096988 scopus 로고    scopus 로고
    • Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients
    • Hotta K, Funahashi T, Arita Y, et al. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol. 2000;20:1595-1599.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 1595-1599
    • Hotta, K.1    Funahashi, T.2    Arita, Y.3
  • 78
    • 0034999667 scopus 로고    scopus 로고
    • Hypoadiponectinemia in obesity and type 2 diabetes: Close association with insulin resistance and hyperinsulinemia
    • Weyer C, Funahashi T, Tanaka S, et al. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab. 2001;86:1930-1935.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 1930-1935
    • Weyer, C.1    Funahashi, T.2    Tanaka, S.3
  • 79
    • 0034881391 scopus 로고    scopus 로고
    • The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
    • Berg AH, Combs TP, Du X, Brownlee M, Scherer PE. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med. 2001;7:947-953.
    • (2001) Nat Med , vol.7 , pp. 947-953
    • Berg, A.H.1    Combs, T.P.2    Du, X.3    Brownlee, M.4    Scherer, P.E.5
  • 80
    • 0035462629 scopus 로고    scopus 로고
    • PPARγ ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein
    • Maeda N, Takahashi M, Funahashi T, et al. PPARγ ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes. 2001;50:2094-2099.
    • (2001) Diabetes , vol.50 , pp. 2094-2099
    • Maeda, N.1    Takahashi, M.2    Funahashi, T.3
  • 81
    • 17944365228 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
    • Yamauchi T, Kamon J, Waki H, et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med. 2001;7:941-946.
    • (2001) Nat Med , vol.7 , pp. 941-946
    • Yamauchi, T.1    Kamon, J.2    Waki, H.3
  • 82
    • 0035852760 scopus 로고    scopus 로고
    • Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice
    • Fruebis J, Tsao TS, Javorschi S, et al. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc Natl Acad Sci U S A. 2001;98:2005-2010.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 2005-2010
    • Fruebis, J.1    Tsao, T.S.2    Javorschi, S.3
  • 83
    • 0037062657 scopus 로고    scopus 로고
    • Obesity, metabolic syndrome, and coronary atherosclerosis
    • Grundy SM. Obesity, metabolic syndrome, and coronary atherosclerosis [editorial]. Circulation. 2002;105:2696-2698.
    • (2002) Circulation , vol.105 , pp. 2696-2698
    • Grundy, S.M.1
  • 84
    • 0002549514 scopus 로고
    • The insulin resistance of relatives of type 2 diabetic subjects is significantly related to a reduced VO2 max
    • Abstract 104
    • Nyholm B, Mengel A, Nielson S, Møller N, Schmitz O. The insulin resistance of relatives of type 2 diabetic subjects is significantly related to a reduced VO2 max [abstract]. Diabetologia. 1994;37(suppl 1):A28. Abstract 104.
    • (1994) Diabetologia , vol.37 , Issue.SUPPL. 1
    • Nyholm, B.1    Mengel, A.2    Nielson, S.3    Møller, N.4    Schmitz, O.5
  • 85
    • 0027323051 scopus 로고
    • Effect of dietary lipid on insulin action: Clinical studies
    • Swinburn BA. Effect of dietary lipid on insulin action: clinical studies. Ann N Y Acad Sci. 1993;683:102-109.
    • (1993) Ann N Y Acad Sci , vol.683 , pp. 102-109
    • Swinburn, B.A.1
  • 87
    • 0026731869 scopus 로고
    • Glucose toxicity
    • Yki-Jarvinen H. Glucose toxicity. Endocr Rev. 1992;13:415-431.
    • (1992) Endocr Rev , vol.13 , pp. 415-431
    • Yki-Jarvinen, H.1
  • 88
    • 0027314215 scopus 로고
    • In vivo glucose metabolism in obese and type II diabetic subjects with or without hypertension
    • Bonora E, Bonadonna RC, Del Prato S, et al. In vivo glucose metabolism in obese and type II diabetic subjects with or without hypertension. Diabetes. 1993;42:764-772.
    • (1993) Diabetes , vol.42 , pp. 764-772
    • Bonora, E.1    Bonadonna, R.C.2    Del Prato, S.3
  • 89
    • 0023832956 scopus 로고
    • Quantification of the relative impairment in actions of insulin on hepatic glucose production and peripheral glucose uptake in non-insulin-dependent diabetes mellitus
    • Campbell PJ, Mandarino LJ, Gerich JE. Quantification of the relative impairment in actions of insulin on hepatic glucose production and peripheral glucose uptake in non-insulin-dependent diabetes mellitus. Metabolism. 1988;37:15-21.
    • (1988) Metabolism , vol.37 , pp. 15-21
    • Campbell, P.J.1    Mandarino, L.J.2    Gerich, J.E.3
  • 90
    • 0027458051 scopus 로고
    • Insulin resistance and insulin deficiency in the pathogenesis of type 2 (non-insulin-dependent) diabetes mellitus: Errors of metabolism or of methods?
    • Groop LC, Widén E, Ferrannini E. Insulin resistance and insulin deficiency in the pathogenesis of type 2 (non-insulin-dependent) diabetes mellitus: errors of metabolism or of methods? Diabetologia. 1993;36:1326-1331.
    • (1993) Diabetologia , vol.36 , pp. 1326-1331
    • Groop, L.C.1    Widén, E.2    Ferrannini, E.3
  • 91
    • 0020030828 scopus 로고
    • Insulin responsiveness of superficial forearm tissues in type 2 (non-insulin dependent) diabetes
    • Kalant N, Leibovici D, Fukushima N, Kuyumjian J, Ozaki S. Insulin responsiveness of superficial forearm tissues in type 2 (non-insulin dependent) diabetes. Diabetologia. 1982;22:239-244.
    • (1982) Diabetologia , vol.22 , pp. 239-244
    • Kalant, N.1    Leibovici, D.2    Fukushima, N.3    Kuyumjian, J.4    Ozaki, S.5
  • 92
    • 0027979955 scopus 로고
    • Impaired insulin-induced glucose uptake by extrahepatic tissue is hallmark of NIDDM patients who have or will develop hypertension and microalbuminuria
    • Nosadini R, Solini A, Velussi M, et al. Impaired insulin-induced glucose uptake by extrahepatic tissue is hallmark of NIDDM patients who have or will develop hypertension and microalbuminuria. Diabetes. 1994;43:491-499.
    • (1994) Diabetes , vol.43 , pp. 491-499
    • Nosadini, R.1    Solini, A.2    Velussi, M.3
  • 93
    • 0035125526 scopus 로고    scopus 로고
    • IRS proteins and β-cell function
    • Burks DJ, White MF. IRS proteins and β-cell function. Diabetes. 2001;50(suppl 1):S140-S145.
    • (2001) Diabetes , vol.50 , Issue.SUPPL. 1
    • Burks, D.J.1    White, M.F.2
  • 94
    • 0033842027 scopus 로고    scopus 로고
    • Interactions between insulin resistance and insulin secretion in the development of glucose intolerance
    • Cavaghan MK, Ehrmann DA, Polonsky KS. Interactions between insulin resistance and insulin secretion in the development of glucose intolerance. J Clin Invest. 2000;106:329-333.
    • (2000) J Clin Invest , vol.106 , pp. 329-333
    • Cavaghan, M.K.1    Ehrmann, D.A.2    Polonsky, K.S.3
  • 95
    • 0034678739 scopus 로고    scopus 로고
    • The importance of the β-cell in the pathogenesis of type 2 diabetes mellitus
    • Kahn SE. The importance of the β-cell in the pathogenesis of type 2 diabetes mellitus. Am J Med. 2000;108(suppl 6a):2S-8S.
    • (2000) Am J Med , vol.108 , Issue.SUPPL. 6A
    • Kahn, S.E.1
  • 96
    • 0026110135 scopus 로고
    • β-Cells in type II diabetes mellitus
    • Porte D Jr. β-Cells in type II diabetes mellitus. Diabetes. 1991;40:166-180.
    • (1991) Diabetes , vol.40 , pp. 166-180
    • Porte D., Jr.1
  • 97
    • 0002653490 scopus 로고
    • Pancreatic hormones and diabetes mellitus
    • Greenspan FS, Baxter JD, eds. Norwalk, Conn: Appleton & Lange
    • Karam JH, Forsham PH. Pancreatic hormones and diabetes mellitus. In: Greenspan FS, Baxter JD, eds. Basic and Clinical Endocrinology. 4th ed. Norwalk, Conn: Appleton & Lange; 1994:571-634.
    • (1994) Basic and Clinical Endocrinology. 4th Ed. , pp. 571-634
    • Karam, J.H.1    Forsham, P.H.2
  • 98
    • 0033807337 scopus 로고    scopus 로고
    • Post-prandial hyperglycemia and diabetes
    • Gin H, Rigalleau V. Post-prandial hyperglycemia and diabetes. Diabetes Metab. 2000;26:265-272.
    • (2000) Diabetes Metab , vol.26 , pp. 265-272
    • Gin, H.1    Rigalleau, V.2
  • 99
    • 0027375768 scopus 로고
    • Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects: Evidence for a hyperbolic function
    • Kahn SE, Prigeon RL, McCulloch DK, et al. Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects: evidence for a hyperbolic function. Diabetes. 1993;42:1663-1672.
    • (1993) Diabetes , vol.42 , pp. 1663-1672
    • Kahn, S.E.1    Prigeon, R.L.2    McCulloch, D.K.3
  • 100
    • 0034884627 scopus 로고    scopus 로고
    • The role of impaired early insulin secretion in the pathogenesis of type II diabetes mellitus
    • Pratley RE, Weyer C. The role of impaired early insulin secretion in the pathogenesis of type II diabetes mellitus. Diabetologia. 2001;44:929-945.
    • (2001) Diabetologia , vol.44 , pp. 929-945
    • Pratley, R.E.1    Weyer, C.2
  • 101
    • 0034293371 scopus 로고    scopus 로고
    • Relative contributions of β-cell function and tissue insulin sensitivity to fasting and postglucose-load glycemia
    • van Haeften TW, Pimenta W, Mitrakou A, et al. Relative contributions of β-cell function and tissue insulin sensitivity to fasting and postglucose-load glycemia. Metabolism. 2000;49:1318-1325.
    • (2000) Metabolism , vol.49 , pp. 1318-1325
    • Van Haeften, T.W.1    Pimenta, W.2    Mitrakou, A.3
  • 102
    • 0019810028 scopus 로고
    • Physiologic evaluation of factors controlling glucose tolerance in man: Measurement of insulin sensitivity and β-cell glucose sensitivity from the response to intravenous glucose
    • Bergman RN, Phillips LS, Cobelli C. Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and β-cell glucose sensitivity from the response to intravenous glucose. J Clin Invest. 1981;68:1456-1467.
    • (1981) J Clin Invest , vol.68 , pp. 1456-1467
    • Bergman, R.N.1    Phillips, L.S.2    Cobelli, C.3
  • 103
    • 0029010141 scopus 로고
    • Genetics and the metabolic syndrome
    • Bouchard C. Genetics and the metabolic syndrome. Int J Obes Relat Metab Disord. 1995;19(suppl 1):S52-S59.
    • (1995) Int J Obes Relat Metab Disord , vol.19 , Issue.SUPPL. 1
    • Bouchard, C.1
  • 104
    • 0031972156 scopus 로고    scopus 로고
    • UKPDS 26: Sulphonylurea failure in non-insulin-dependent diabetic patients over six years
    • Matthews DR, Cull CA, Stratton IM, Holman RR, Turner RC, UK Prospective Diabetes Study (UKPDS) Group. UKPDS 26: sulphonylurea failure in non-insulin-dependent diabetic patients over six years. Diabet Med. 1998;15:297-303.
    • (1998) Diabet Med , vol.15 , pp. 297-303
    • Matthews, D.R.1    Cull, C.A.2    Stratton, I.M.3    Holman, R.R.4    Turner, R.C.5
  • 105
    • 0031961242 scopus 로고    scopus 로고
    • Beta-cell deterioration determines the onset and rate of progression of secondary dietary failure in type 2 diabetes mellitus: The 10-year follow-up of the Belfast Diet Study
    • Levy J, Atkinson AB, Bell PM, McCance DR, Hadden DR. Beta-cell deterioration determines the onset and rate of progression of secondary dietary failure in type 2 diabetes mellitus: the 10-year follow-up of the Belfast Diet Study. Diabet Med. 1998;15:290-296.
    • (1998) Diabet Med , vol.15 , pp. 290-296
    • Levy, J.1    Atkinson, A.B.2    Bell, P.M.3    McCance, D.R.4    Hadden, D.R.5
  • 106
    • 0029147687 scopus 로고
    • Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: A randomized prospective 6-year study
    • Ohkubo Y, Kishikawa H, Araki E, et al. Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study. Diabetes Res Clin Pract. 1995;28:103-117.
    • (1995) Diabetes Res Clin Pract , vol.28 , pp. 103-117
    • Ohkubo, Y.1    Kishikawa, H.2    Araki, E.3
  • 107
    • 0034690657 scopus 로고    scopus 로고
    • Cost effectiveness of an intensive blood glucose control policy in patients with type 2 diabetes: Economic analysis alongside randomised controlled trial (UKPDS 41)
    • Gray A, Raikou M, McGuire A, et al, United Kingdom Prospective Diabetes Study Group. Cost effectiveness of an intensive blood glucose control policy in patients with type 2 diabetes: economic analysis alongside randomised controlled trial (UKPDS 41). BMJ. 2000;320:1373-1378.
    • (2000) BMJ , vol.320 , pp. 1373-1378
    • Gray, A.1    Raikou, M.2    McGuire, A.3
  • 108
    • 0035675342 scopus 로고    scopus 로고
    • Postprandial blood glucose as a risk factor for cardiovascular disease in type II diabetes: The epidemiological evidence
    • Bonora E, Muggeo M. Postprandial blood glucose as a risk factor for cardiovascular disease in type II diabetes: the epidemiological evidence. Diabetologia. 2001;44:2107-2114.
    • (2001) Diabetologia , vol.44 , pp. 2107-2114
    • Bonora, E.1    Muggeo, M.2
  • 109
    • 0032902850 scopus 로고    scopus 로고
    • The relationship between glucose and incident cardiovascular events: A metaregression analysis of published data from 20 studies of 95,783 individuals followed for 12.4 years
    • Coutinho M, Gerstein HC, Wang Y, Yusuf S. The relationship between glucose and incident cardiovascular events: a metaregression analysis of published data from 20 studies of 95,783 individuals followed for 12.4 years. Diabetes Care. 1999;22:233-240.
    • (1999) Diabetes Care , vol.22 , pp. 233-240
    • Coutinho, M.1    Gerstein, H.C.2    Wang, Y.3    Yusuf, S.4
  • 110
    • 0031665831 scopus 로고    scopus 로고
    • The importance of hyperglycemia in the nonfasting state to the development of cardiovascular disease
    • Haffner SM. The importance of hyperglycemia in the nonfasting state to the development of cardiovascular disease. Endocr Rev. 1998;19:583-592.
    • (1998) Endocr Rev , vol.19 , pp. 583-592
    • Haffner, S.M.1
  • 111
    • 0035089534 scopus 로고    scopus 로고
    • Subclinical states of glucose intolerance and risk of death in the U.S
    • Saydah SH, Loria CM, Eberhardt MS, Brancati FL. Subclinical states of glucose intolerance and risk of death in the U.S. Diabetes Care. 2001;24:447-453.
    • (2001) Diabetes Care , vol.24 , pp. 447-453
    • Saydah, S.H.1    Loria, C.M.2    Eberhardt, M.S.3    Brancati, F.L.4
  • 112
    • 0035512782 scopus 로고    scopus 로고
    • Fasting versus postload glucose levels: Why the controversy?
    • Gerstein HC. Fasting versus postload glucose levels: why the controversy? [editorial]. Diabetes Care. 2001;24:1855-1857.
    • (2001) Diabetes Care , vol.24 , pp. 1855-1857
    • Gerstein, H.C.1
  • 113
    • 0027210706 scopus 로고
    • Hyperglycaemic progression in subjects with impaired glucose tolerance: Association with decline in beta cell function
    • Cook JT, Page RC, Levy JC, Hammersley MS, Walravens EK, Turner RC. Hyperglycaemic progression in subjects with impaired glucose tolerance: association with decline in beta cell function. Diabet Med. 1993;10:321-326.
    • (1993) Diabet Med , vol.10 , pp. 321-326
    • Cook, J.T.1    Page, R.C.2    Levy, J.C.3    Hammersley, M.S.4    Walravens, E.K.5    Turner, R.C.6
  • 114
    • 0026602267 scopus 로고
    • Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance
    • Mitrakou A, Kelley D, Mokan M, et al. Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance. N Engl J Med. 1992;326:22-29.
    • (1992) N Engl J Med , vol.326 , pp. 22-29
    • Mitrakou, A.1    Kelley, D.2    Mokan, M.3
  • 115
    • 0029075672 scopus 로고
    • In vivo β-cell function at the transition to early non-insulin-dependent diabetes mellitus
    • Swinburn BA, Gianchandani R, Saad MF, Lillioja S. In vivo β-cell function at the transition to early non-insulin-dependent diabetes mellitus. Metabolism. 1995;44:757-764.
    • (1995) Metabolism , vol.44 , pp. 757-764
    • Swinburn, B.A.1    Gianchandani, R.2    Saad, M.F.3    Lillioja, S.4
  • 116
    • 0036314216 scopus 로고    scopus 로고
    • Phasic insulin release and metabolic regulation in type 2 diabetes
    • Del Prato S, Marchetti P, Bonadonna RC. Phasic insulin release and metabolic regulation in type 2 diabetes. Diabetes. 2002; 51(suppl 1):S109-S116.
    • (2002) Diabetes , vol.51 , Issue.SUPPL. 1
    • Del Prato, S.1    Marchetti, P.2    Bonadonna, R.C.3
  • 117
    • 0024216182 scopus 로고
    • Physiological importance of deficiency in early prandial insulin secretion in non-insulin-dependent diabetes
    • Bruce DG, Chisholm DJ, Storlien LH, Kraegen EW. Physiological importance of deficiency in early prandial insulin secretion in non-insulin-dependent diabetes. Diabetes. 1988;37:736-744.
    • (1988) Diabetes , vol.37 , pp. 736-744
    • Bruce, D.G.1    Chisholm, D.J.2    Storlien, L.H.3    Kraegen, E.W.4
  • 118
    • 0028817815 scopus 로고
    • Prospective Diabetes Study 16: Overview of 6 years' therapy of type II diabetes: A progressive disease
    • published correction appears in Diabetes. 1996;45:1655
    • U.K. Prospective Diabetes Study Group. U.K. Prospective Diabetes Study 16: Overview of 6 years' therapy of type II diabetes: a progressive disease [published correction appears in Diabetes. 1996;45:1655]. Diabetes. 1995;44:1249-1258.
    • (1995) Diabetes , vol.44 , pp. 1249-1258
  • 119
    • 0032983666 scopus 로고    scopus 로고
    • Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: Progressive requirement for multiple therapies (UKPDS 49)
    • Turner RC, Cull CA, Frighi V, Holman RR, UK Prospective Diabetes Study (UKPDS) Group. Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). JAMA. 1999;281:2005-2012.
    • (1999) JAMA , vol.281 , pp. 2005-2012
    • Turner, R.C.1    Cull, C.A.2    Frighi, V.3    Holman, R.R.4
  • 120
    • 0037380061 scopus 로고    scopus 로고
    • Pharmacological management of type 2 diabetes mellitus: Rationale for rational use of insulin
    • Chan JL, Abrahamson MJ. Pharmacological management of type 2 diabetes mellitus: rationale for rational use of insulin. Mayo Clin Proc. 2003;78:459-467.
    • (2003) Mayo Clin Proc , vol.78 , pp. 459-467
    • Chan, J.L.1    Abrahamson, M.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.