-
1
-
-
0029868156
-
PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
-
Offield MF, Jetton TL, Labosky PA, Ray M, Stein RW, Magnuson MA, Hogan BLM, Wright CVE 1996 PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development 122:983-995
-
(1996)
Development
, vol.122
, pp. 983-995
-
-
Offield, M.F.1
Jetton, T.L.2
Labosky, P.A.3
Ray, M.4
Stein, R.W.5
Magnuson, M.A.6
Hogan, B.L.M.7
Wright, C.V.E.8
-
2
-
-
0028314969
-
IDX-1: A new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene
-
Miller CP, McGehee RE, Habener JF 1994 IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene. EMBO J 13:1145-1156
-
(1994)
EMBO J
, vol.13
, pp. 1145-1156
-
-
Miller, C.P.1
McGehee, R.E.2
Habener, J.F.3
-
3
-
-
0027384997
-
IPF1, a homeodomain-containing transactivator of the insulin gene
-
Ohlsson H, Karlsson K, Edlund T 1993 IPF1, a homeodomain-containing transactivator of the insulin gene. EMBO J 12:4251-4259
-
(1993)
EMBO J
, vol.12
, pp. 4251-4259
-
-
Ohlsson, H.1
Karlsson, K.2
Edlund, T.3
-
4
-
-
0027373441
-
Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells
-
Leonard J, Peers B, Johnson T, Ferreri K, Lee S, Montminy MR 1993 Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells. Mol Endocrinol 7:1275-1283
-
(1993)
Mol Endocrinol
, vol.7
, pp. 1275-1283
-
-
Leonard, J.1
Peers, B.2
Johnson, T.3
Ferreri, K.4
Lee, S.5
Montminy, M.R.6
-
5
-
-
0028149890
-
Insulin-promoter-factor 1 is required for pancreas development in mice
-
Jonsson J, Carlsson L, Edlund T, Edlund H 1994 Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 371:606-609
-
(1994)
Nature
, vol.371
, pp. 606-609
-
-
Jonsson, J.1
Carlsson, L.2
Edlund, T.3
Edlund, H.4
-
6
-
-
0031031571
-
Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 coding region
-
Stoffers DA, Zinkin NT, Stanojevic V, Clarke WL, Habener JF 1997 Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 coding region. Nat Genet 15:106-110
-
(1997)
Nat Genet
, vol.15
, pp. 106-110
-
-
Stoffers, D.A.1
Zinkin, N.T.2
Stanojevic, V.3
Clarke, W.L.4
Habener, J.F.5
-
7
-
-
0026471057
-
Synergistic activation of the insulin gene by a LIM-homeodomain protein and a basic helix-loop-helix protein: Building a functional insulin minienhancer complex
-
German MS, Wang J, Chadwick RB, Rutter WJ 1992 Synergistic activation of the insulin gene by a LIM-homeodomain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex. Genes Dev 6:2165-2176
-
(1992)
Genes Dev
, vol.6
, pp. 2165-2176
-
-
German, M.S.1
Wang, J.2
Chadwick, R.B.3
Rutter, W.J.4
-
8
-
-
0027944249
-
Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through CT boxes
-
Petersen HV, Serup P, Leonard J, Michelsen BK, Madsen OD 1994 Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through CT boxes. Proc Natl Acad Sci USA 91:10465-10469
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 10465-10469
-
-
Petersen, H.V.1
Serup, P.2
Leonard, J.3
Michelsen, B.K.4
Madsen, O.D.5
-
9
-
-
0027154077
-
Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and the human insulin promoters
-
Melloul D, Ben-Neriah Y, Cerasi E 1993 Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and the human insulin promoters. Proc Natl Acad Sci USA 90:3865-3869
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 3865-3869
-
-
Melloul, D.1
Ben-Neriah, Y.2
Cerasi, E.3
-
10
-
-
0030447883
-
Purification of the β-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells
-
Marshak S, Totary H, Cerasi E, Melloul D 1996 Purification of the β-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells. Proc Natl Acad Sci USA 93:15057-15062
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 15057-15062
-
-
Marshak, S.1
Totary, H.2
Cerasi, E.3
Melloul, D.4
-
11
-
-
0031011850
-
Transcriptional synergy between LIM-homeodomain proteins and basic helix-loop-helix proteins: The L1M2 domain determines specificity
-
Johnson JD, Zhang W, Rudnick A, Rutter WJ, German MS 1997 Transcriptional synergy between LIM-homeodomain proteins and basic helix-loop-helix proteins: the L1M2 domain determines specificity. Mol Cell Biol 17:3488-3496
-
(1997)
Mol Cell Biol
, vol.17
, pp. 3488-3496
-
-
Johnson, J.D.1
Zhang, W.2
Rudnick, A.3
Rutter, W.J.4
German, M.S.5
-
12
-
-
0033962883
-
The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter
-
Ohneda K, Mirmira RG, Wang J, Johnson JD, German MS 2000 The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter. Mol Cell Biol 20:900-911
-
(2000)
Mol Cell Biol
, vol.20
, pp. 900-911
-
-
Ohneda, K.1
Mirmira, R.G.2
Wang, J.3
Johnson, J.D.4
German, M.S.5
-
13
-
-
0033506651
-
Pbx-Hox heterodimers recruit coactivator-corepressor complexes in a isoform-specific manner
-
Asahara H, Dutta S, Kao HY, Evans RM, Montminy M 1999 Pbx-Hox heterodimers recruit coactivator-corepressor complexes in a isoform-specific manner. Mol Cell Biol 19:8219-8225
-
(1999)
Mol Cell Biol
, vol.19
, pp. 8219-8225
-
-
Asahara, H.1
Dutta, S.2
Kao, H.Y.3
Evans, R.M.4
Montminy, M.5
-
14
-
-
0031943003
-
p300 Mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin gene
-
Qiu Y, Sharma A, Stein R 1998 p300 Mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin gene. Mol Cell Biol 18:2957-2964
-
(1998)
Mol Cell Biol
, vol.18
, pp. 2957-2964
-
-
Qiu, Y.1
Sharma, A.2
Stein, R.3
-
15
-
-
0033499802
-
Bridge-1, a novel PDZ-domain coactivator of E2A-mediated regulation of insulin gene transcription
-
Thomas MK, Yao KM, Tenser MS, Wong GG, Habener JF 1999 Bridge-1, a novel PDZ-domain coactivator of E2A-mediated regulation of insulin gene transcription. Mol Cell Biol 19:8492-8504
-
(1999)
Mol Cell Biol
, vol.19
, pp. 8492-8504
-
-
Thomas, M.K.1
Yao, K.M.2
Tenser, M.S.3
Wong, G.G.4
Habener, J.F.5
-
16
-
-
0036134978
-
Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47
-
Qiu Y, Guo M, Huang S, Stein R 2002 Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47. Mol Cell Biol 22:412-420
-
(2002)
Mol Cell Biol
, vol.22
, pp. 412-420
-
-
Qiu, Y.1
Guo, M.2
Huang, S.3
Stein, R.4
-
18
-
-
0032718689
-
Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus
-
Hani EH, Stoffers DA, Chevre JC, Durand E, Stanojevic V, Dina C, Habener JF, Froguel P 1999 Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus. J Clin Invest 104:R41-R48
-
(1999)
J Clin Invest
, vol.104
-
-
Hani, E.H.1
Stoffers, D.A.2
Chevre, J.C.3
Durand, E.4
Stanojevic, V.5
Dina, C.6
Habener, J.F.7
Froguel, P.8
-
19
-
-
0032742985
-
Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes
-
Macfarlane WM, Frayling TM, Ellard S, Evans JC, Alien LI, Bulman MP, Ayres S, Shepherd M, Clark P, Millward A, Demaine A, Wilkin T, Docherty K, Hattersley AT 1999 Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes. J Clin Invest 104:R33-R39
-
(1999)
J Clin Invest
, vol.104
-
-
Macfarlane, W.M.1
Frayling, T.M.2
Ellard, S.3
Evans, J.C.4
Alien, L.I.5
Bulman, M.P.6
Ayres, S.7
Shepherd, M.8
Clark, P.9
Millward, A.10
Demaine, A.11
Wilkin, T.12
Docherty, K.13
Hattersley, A.T.14
-
20
-
-
0035137251
-
Functional consequences of mutations in the MODY4 gene (IPF1) and coexistence with MODY3 mutations
-
Weng J, Macfarlane WM, Lehto M, Gu HF, Shepherd LM, Ivarsson SA, Wibell L, Smith T, Groop LC 2001 Functional consequences of mutations in the MODY4 gene (IPF1) and coexistence with MODY3 mutations. Diabetologia 44:249-258
-
(2001)
Diabetologia
, vol.44
, pp. 249-258
-
-
Weng, J.1
Macfarlane, W.M.2
Lehto, M.3
Gu, H.F.4
Shepherd, L.M.5
Ivarsson, S.A.6
Wibell, L.7
Smith, T.8
Groop, L.C.9
-
21
-
-
0036364915
-
Screening for MODY mutations, GAD antibodies, and type 1 diabetes-associated HLA genotypes in women with gestational diabetes mellitus
-
Weng J, Ekelund M, Lehto M, Li H, Ekberg G, Frid A, Aberg A, Groop LC, Berntorp K 2002 Screening for MODY mutations, GAD antibodies, and type 1 diabetes-associated HLA genotypes in women with gestational diabetes mellitus. Diabetes Care 25:68-71
-
(2002)
Diabetes Care
, vol.25
, pp. 68-71
-
-
Weng, J.1
Ekelund, M.2
Lehto, M.3
Li, H.4
Ekberg, G.5
Frid, A.6
Aberg, A.7
Groop, L.C.8
Berntorp, K.9
-
22
-
-
0032525981
-
β-Cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetes
-
Ahlgren U, Jonsson J, Jonsson L, Simu K, Edlund H 1998 β-Cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetes. Genes Dev 12:1763-1768
-
(1998)
Genes Dev
, vol.12
, pp. 1763-1768
-
-
Ahlgren, U.1
Jonsson, J.2
Jonsson, L.3
Simu, K.4
Edlund, H.5
-
24
-
-
0037192799
-
Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion
-
Brissova M, Shiota M, Nicholson WE, Cannon M, Knobel SM, Piston DW, Wright CV, Powers AC 2002 Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion. J Biol Chem 277:11225-11232
-
(2002)
J Biol Chem
, vol.277
, pp. 11225-11232
-
-
Brissova, M.1
Shiota, M.2
Nicholson, W.E.3
Cannon, M.4
Knobel, S.M.5
Piston, D.W.6
Wright, C.V.7
Powers, A.C.8
-
25
-
-
0034959266
-
Development of diabetes mellitus in aging transgenic mice following suppression of pancreatic homeoprotein IDX-1
-
Thomas MK, Devon ON, Lee JH, Peter A, Schlosser DA, Tenser MS, Habener JF 2001 Development of diabetes mellitus in aging transgenic mice following suppression of pancreatic homeoprotein IDX-1. J Clin Invest 108:319-329
-
(2001)
J Clin Invest
, vol.108
, pp. 319-329
-
-
Thomas, M.K.1
Devon, O.N.2
Lee, J.H.3
Peter, A.4
Schlosser, D.A.5
Tenser, M.S.6
Habener, J.F.7
-
26
-
-
0037125977
-
Experimental control of pancreatic development and maintenance
-
Holland AM, Hale MA, Kagami H, Hammer RE, MacDonald RJ 2002 Experimental control of pancreatic development and maintenance. Proc Natl Acad Sci USA 99:12236-12241
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 12236-12241
-
-
Holland, A.M.1
Hale, M.A.2
Kagami, H.3
Hammer, R.E.4
MacDonald, R.J.5
-
27
-
-
0034454416
-
Missense mutations in the human insulin promoter factor-1 gene and their relation to maturity-onset diabetes of the young and late-onset type 2 diabetes mellitus in Caucasians
-
Hansen L, Urioste S, Petersen HV, Jensen JN, Eiberg H, Barbetti F, Setup P, Hansen T, Pedersen O 2000 Missense mutations in the human insulin promoter factor-1 gene and their relation to maturity-onset diabetes of the young and late-onset type 2 diabetes mellitus in Caucasians. J Clin Endocrinol Metab 85:1323-1326
-
(2000)
J Clin Endocrinol Metab
, vol.85
, pp. 1323-1326
-
-
Hansen, L.1
Urioste, S.2
Petersen, H.V.3
Jensen, J.N.4
Eiberg, H.5
Barbetti, F.6
Setup, P.7
Hansen, T.8
Pedersen, O.9
-
28
-
-
0032128288
-
Insulin promoter factor-1 gene mutation linked to early-onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein
-
Stoffers DA, Stanojevic V, Habener JF 1998 Insulin promoter factor-1 gene mutation linked to early-onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein. J Clin Invest 102:232-241
-
(1998)
J Clin Invest
, vol.102
, pp. 232-241
-
-
Stoffers, D.A.1
Stanojevic, V.2
Habener, J.F.3
-
29
-
-
0033668338
-
Hedgehog signaling regulates insulin production by pancreatic β-cells
-
Thomas MK, Rastalsky N, Lee JH, Habener JF 2000 Hedgehog signaling regulates insulin production by pancreatic β-cells. Diabetes 49:2039-2047
-
(2000)
Diabetes
, vol.49
, pp. 2039-2047
-
-
Thomas, M.K.1
Rastalsky, N.2
Lee, J.H.3
Habener, J.F.4
-
30
-
-
0035094925
-
Hedgehog signaling regulation of homeodomain protein IDX-1 expression in pancreatic β cells
-
Thomas MK, Lee JH, Rastalsky N, Habener JF 2001 Hedgehog signaling regulation of homeodomain protein IDX-1 expression in pancreatic β cells. Endocrinol 142:1033-1040
-
(2001)
Endocrinol
, vol.142
, pp. 1033-1040
-
-
Thomas, M.K.1
Lee, J.H.2
Rastalsky, N.3
Habener, J.F.4
-
31
-
-
0028567837
-
Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1
-
Peers B, Leonard J, Sharma S, Teitelman G, Montminy MR 1994 Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1. Mol Endocrinol 8:1798-1806
-
(1994)
Mol Endocrinol
, vol.8
, pp. 1798-1806
-
-
Peers, B.1
Leonard, J.2
Sharma, S.3
Teitelman, G.4
Montminy, M.R.5
-
32
-
-
0024459639
-
Insulin gene enhancer activity is inhibited by adenovirus 5 E1a gene products
-
Stein RW, Whelan J 1989 Insulin gene enhancer activity is inhibited by adenovirus 5 E1a gene products. Mol Cell Biol 9:4531-4534
-
(1989)
Mol Cell Biol
, vol.9
, pp. 4531-4534
-
-
Stein, R.W.1
Whelan, J.2
-
33
-
-
0025004460
-
Analysis of E1A-mediated growth regulation functions: Binding of the 300-kildalton cellular product correlates with E1A enhancer repression function and DNA synthesis-inducing activity
-
Stein RW, Corrigan M, Yaciuk P, Whelan J, Moran E 1990 Analysis of E1A-mediated growth regulation functions: binding of the 300-kildalton cellular product correlates with E1A enhancer repression function and DNA synthesis-inducing activity. J Virol 64:4421-4427
-
(1990)
J Virol
, vol.64
, pp. 4421-4427
-
-
Stein, R.W.1
Corrigan, M.2
Yaciuk, P.3
Whelan, J.4
Moran, E.5
-
34
-
-
0029817669
-
Role of CBP/p300 in nuclear receptor signaling
-
Chakravarti D, LaMorte VJ, Nelson MC, Nakajima T, Schulman IG, Juguilon H, Montminy M, Evans RM 1996 Role of CBP/p300 in nuclear receptor signaling. Nature 383:99-103
-
(1996)
Nature
, vol.383
, pp. 99-103
-
-
Chakravarti, D.1
LaMorte, V.J.2
Nelson, M.C.3
Nakajima, T.4
Schulman, I.G.5
Juguilon, H.6
Montminy, M.7
Evans, R.M.8
-
35
-
-
2542478686
-
IDX1 and pancreatic agenesis and type 2 diabetes
-
Epstein CJ, Erickson RP, Wynshaw-Boris A, eds. Oxford, UK: Oxford University Press
-
Thomas MK, Habener JF 2004 IDX1 and pancreatic agenesis and type 2 diabetes. In: Epstein CJ, Erickson RP, Wynshaw-Boris A, eds. Inborn errors of development: the molecular basis of clinical disorders of morphogenesis. Oxford, UK: Oxford University Press; 552-556
-
(2004)
Inborn Errors of Development: the Molecular Basis of Clinical Disorders of Morphogenesis
, pp. 552-556
-
-
Thomas, M.K.1
Habener, J.F.2
-
36
-
-
0242587820
-
A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors
-
Kamei Y, Xu L, Heinzel T, Torchia J, Kurokawa R, Gloss B, Lin SC, Heyman RA, Rose DW, Glass CK, Rosenfeld MG 1996 A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85:403-414
-
(1996)
Cell
, vol.85
, pp. 403-414
-
-
Kamei, Y.1
Xu, L.2
Heinzel, T.3
Torchia, J.4
Kurokawa, R.5
Gloss, B.6
Lin, S.C.7
Heyman, R.A.8
Rose, D.W.9
Glass, C.K.10
Rosenfeld, M.G.11
-
37
-
-
0037002444
-
Huntington's disease of the endocrine pancreas: Insulin deficiency and diabetes mellitus due to impaired insulin gene expression
-
Andreassen OA, Dedeoglu A, Stanojevic V, Hughes DB, Browne SE, Leech CA, Ferrante RJ, Habener JF, Beal MF, Thomas MK 2002 Huntington's disease of the endocrine pancreas: insulin deficiency and diabetes mellitus due to impaired insulin gene expression. Neurobiol Dis 11:410-424
-
(2002)
Neurobiol Dis
, vol.11
, pp. 410-424
-
-
Andreassen, O.A.1
Dedeoglu, A.2
Stanojevic, V.3
Hughes, D.B.4
Browne, S.E.5
Leech, C.A.6
Ferrante, R.J.7
Habener, J.F.8
Beal, M.F.9
Thomas, M.K.10
-
38
-
-
0032700272
-
Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus
-
Malecki MT, Jhala US, Antonellis A, Fields L, Doria A, Orban T, Saad M, Warram JH, Montminy M, Krolewski AS 1999 Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus. Nat Genet 23:323-328
-
(1999)
Nat Genet
, vol.23
, pp. 323-328
-
-
Malecki, M.T.1
Jhala, U.S.2
Antonellis, A.3
Fields, L.4
Doria, A.5
Orban, T.6
Saad, M.7
Warram, J.H.8
Montminy, M.9
Krolewski, A.S.10
-
39
-
-
0034964730
-
Maturity-onset diabetes of the young type 1 (MODY1)-associated mutations R154X and E276Q in hepatocyte nuclear factor 4alpha (HNF4α) gene impair recruitment of p300, a key transcriptional coactivator
-
Eeckhoute J, Formstecher P, Laine B 2001 Maturity-onset diabetes of the young type 1 (MODY1)-associated mutations R154X and E276Q in hepatocyte nuclear factor 4alpha (HNF4α) gene impair recruitment of p300, a key transcriptional coactivator. Mol Endocrinol 15:1200-1210
-
(2001)
Mol Endocrinol
, vol.15
, pp. 1200-1210
-
-
Eeckhoute, J.1
Formstecher, P.2
Laine, B.3
|