Akt-dependent and -independent survival signaling pathways utilized by insulin-like growth factor I

Molecular and Cellular Biology

Volumn 18, Issue 11, 1998, Pages 6711-6718

  Kulik, George ^a   Weber, Michael J ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE C; SOMATOMEDIN C;

APOPTOSIS; ARTICLE; CELL SURVIVAL; ENZYME ACTIVATION; ENZYME ACTIVITY; FIBROBLAST; GENE EXPRESSION; PRIORITY JOURNAL; RNA SYNTHESIS; RNA TRANSCRIPTION; SIGNAL TRANSDUCTION;

EID: 0031770827     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.18.11.6711     Document Type: Article

References (49)

1. Berra, E., M. T. Diaz-Meco, I. Dominguez, M. M. Municio, L. Sanz, J. Lozano, R. S. Chapkin, and J. Moscat. 1998. Protein kinase C zeta isoform is critical for mitogenic signal transduction. Cell 74:555-563.
2. Berra, E., M. M. Municio, L. Sanz, S. Frutos, M. T. Diaz-Meco, and J. Moscat. 1997. Positioning atypical protein kinase C isoforms in the UV-induced apoptotic signaling cascade. Mol. Cell. Biol. 17:4346-4544.
3. Bertollini, L., M. T. Ciotti, E. Cherubini, and A. Cattaneo. 1997. Neurotrophin-3 promotes the survival of oligodendrocyte precursors in embryonic hippocampal cultures under chemically defined conditions. Brain Res. 746: 19-24.
4. Blakesley, V. A., B. S. Stannard, T. Kalebic, L. J. Helman, and D. LeRoith. 1997. Role of the IGF-I receptor in mutagenesis and tumor promotion. J. Endocrinol. 152:339-344.
5. Cardone, M. H., G. S. Salvesen, C. Widmann, G. Johnson, and S. M. Frisch. 1997. The regulation of anoikis: MEKK-1 activation requires cleavage by caspases. Cell 90:315-323.
6. Chen, Y. R., X. Wang, D. Templeton, R. J. Davis, and T. H. Tan. 1996. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation. J. Biol. Chem. 271:31929-31936.
7. Darnay, B. G., and B. B. Aggarwal. 1997. Early events in TNF signaling: a story of associations and dissociations. J. Leukoc. Biol. 61:559-566.
8. Datta, S. R., H. Dudek, X. Tao, S. Masters, H. Fu, Y. Gotoh, and M. E. Greenberg. 1997. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91:231-241.
9. Delpeso L., M. Gonzalez-Garcia, C. Page, R. Herrera, and G. Nunez. 1997. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 278:687-689.
10. Diaz-Meco, M. T., M. M. Municio, S. Frutos, P. Sanchez, J. Lozano, L. Sanz, and J. Moscat. 1996. The product of par-4, a gene induced during apoptosis. interacts selectively with the atypical isoforms of protein kinase C. Cell 86:777-786.
11. Dudek, H., S. R. Datta, T. F. Franke, M. J. Birnbaum, R. Yao, G. M. Cooper, R. A. Segal, D. R. Kaplan, and M. E. Greenberg. 1997. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275: 661-665.
12. Franke, T. F., D. R. Kaplan, and L. C. Cantley. 1997. PI3K: downstream AKTion blocks apoptosis. Cell 88:435-437.
13. Hack, N., H. Hidaka, M. J. Wakefield, and R. Balazs. 1993. Promotion of granule cell survival by high K+ or excitatory amino acid treatment and Ca2+/calmodulin-dependent protein kinase activity. Neuroscience 57:9-20.
14. Heidenreich, K. A., and J. L. Kummer. 1996. Inhibition of p38 mitogen-activated protein kinase by insulin in cultured fetal neurons. J. Biol. Chem. 271:9891-9894.
15. Ichijo, H., E. Nishida, K. Irie, P. ten Dijke, M. Saitoh, T. Moriguchi, M. Takagi, K. Matsumoto, K. Miyazono, and Y. Gotoh. 1997. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science 275:90-94.
16. Ikizawa, K., K. Kajiwara, Y. Basaki, T. Koshio, and Y. Yanagihara. 1996. Evidence for a role of phosphatidylinositol 3-kinase in IL-4-induced germline C epsilon transcription. Cell. Immunol. 170:134-140.
17. Kauffmann-Zeh, A., P. Rodriguez-Viciana, E. Ulrich, C. Gilbert, P. Coffer, J. Downward, and G. Evan. 1997. Suppression of c-Myc-induced apoptosis by Ras signaling through PI(3)K and PKB. Nature 385:544-548.
18. Kennedy, S. G., A. J. Wagner, S. D. Conzen, J. Jordan, A. Bellacosa, P. N. Tsichlis, and N. Hay. 1997. The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. Genes Dev. 11:701-713.
19. Khwaja A., P. Rodriguez-Viciana, S. Wennstrom, P. H. Warne, and J. Downward. 1997. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J. 16:2783-2793.
20. Klippel, A., C. Reinhard, W. M. Kavanaugh, G. Apell, M. A. Escobedo, and L. T. Williams. 1996. Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways. Mol. Cell. Biol. 16:4117-4127.
21. Konishi, H., H. Matsuzaki, M. Tanaka, Y. Ono, C. Tokunaga, S. Kuroda, and U. Kikkawa. 1996. Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of phosphatidylinositol 3-kinase. Proc. Natl. Acad. Sci. USA 93:7639-7643.
22. Konishi, H., H. Matsuzaki, M. Tanaka, Y. Takemura, S. Kuroda, Y. Ono, and U. Kikkawa. 1997. Activation of protein kinase B (Akt/RAC-protein kinase) by cellular stress and its association with heat shock protein Hsp27. FEBS Lett. 410:493-498.
23. Koumenis, C., and A. Giaccia. 1997. Transformed cells require continuous activity of RNA polymerase II to resist oncogene-induced apoptosis. Mol. Cell. Biol. 17:7306-7316.
24. Kulik, G., A. Klippel, and M. J. Weber. 1997. Antiapoptotic signaling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Mol. Cell. Biol. 17:1595-1606.
25. Kulik, G., and Weber, M. J. Unpublished data. 1997.
26. LeRoith, D., H. Werner, S. Neuenschwander, T. Kalebic, and L. J. Helman. 1995. The role of the insulin-like growth factor-I receptor in cancer. Ann. N Y. Acad. Sci. 766:402-408.
27. Lozano J., E. Berra, M. M. Municio, M. T. Diaz-Meco, I. Dominguez, L. Sanz, and J. Moscat. 1994. Protein kinase C zeta isoform is critical for kappa B-dependem promoter activation by sphingomyelinase. J. Biol. Chem. 269: 19200-19202.
28. Marte, B. M., and J. Downward. 1997. PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond. Trends Biochem. Sci. 22:355-358.
29. Mayo, M. W., C. Y. Wang, P. C. Cogswell, K. S. Rogersgraham, S. W. Lowe, C. J. Der, and A. S. Baldwin. 1997. Requirement of NF-kappa-B activation to suppress p53-independent apoptosis induced by oncogenic ras. Science 278:1812-1815.
30. Minshall, C., S. Arkins, G. G. Freund, and K. W. Kelley. 1996. Requirement for phosphatidylinositol 3′-kinase to protect hemopoietic progenitors against apoptosis depends upon the extracellular survival factor. J. Immunol. 156: 939-947.
31. Mizukami, Y., T. Hirata, and K. Yoshida. 1997. Nuclear translocation of PKC zeta during ischemia and its inhibition by wortmannin, an inhibitor of phosphatidylinositol 3-kinase. FEBS Lett. 401:247-251.
32. Nakanishi, H., K. A. Brewer, and J. H. Exton. 1993. Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem. 268:13-16.
33. Nishina, H., K. D. Fischer, L. Radvanyi, A. Shahinian, R. Hakem, E. A. Rubie, A. Bernstein, T. W. Mak, J. R. Woodgett, and J. M. Penninger. 1997. Stress-signaling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3. Nature 385:350-353.
34. 33a. Parizzas, M., A. R. Saltiel, and D. LeRoth. 1997. Insulin-like growth factor inhibits apoptosis using the phosphatidylinositol 3′-kinase and mitogen-activated protein kinase pathways. J. Biol. Chem. 272:154-161.
35. Peterson, J. E., G. Kulik, T. Jelinek, C. W. Reuter, J. A. Shannon, and M. J. Weber. 1996. Src phbsphorylates the insulin-like growth factor type I receptor on the autophosphorylation sites. J. Biol. Chem. 271:31562-31571.
36. Philpott, K. L., M. J. McCarthy, A. Klippel, and L. L. Rubin. 1997. Activated phosphatidylinositol 3-kinase and Akt kinase promote survival of superior cervical neurons. J. Cell Biol. 139:809-815.
37. Railo, M. J., S. K. von Smitten, and F. Pekonen. 1994. The prognostic value of insulin-like growth factor-I in breast cancer patients. Results of a follow-up study on 126 patients. Eur. J. Cancer 30A:307-311.
38. Resnik, J. L., D. B. Reichart, K. Huey, N. J. Webster, and B. L. Seely. 1998. Elevated insulin-like growth factor I receptor autophosphorylation and kinase activity in human breast cancer. Cancer Res. 58:1159-1164.
39. Sable, C. L., N. Filippa, B. Hemmings, and O. E. VanObbergen. 1997. cAMP stimulates protein kinase B in a wortmannin-insensitive manner. FEBS Lett. 409:253-257.
40. Schultz, R. M., R. L. Merriman, S. L. Andis, R. Bonjouklian, G. B. Grindey, P. G. Rutherford, A. Gallegos, K. Massey, and G. Powis. 1995. In vitro and in vivo antitumor activity of the phosphatidylinositol-3-kinase inhibitor, wortmannin. Anticancer Res. 15:1135-1139.
41. Toker, A., M. Meyer, K. K. Reddy, J. R. Falck, R. Aneja, S. Aneja, A. Parra, D. J. Burns, L. M. Ballas, and L. C. Cantley. 1994. Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3. J. Biol. Chem. 269:32358-32367.
42. Tombes, R. M., S. Grant, E. H. Westin, and G. Krystal. 1995. G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase). Cell Growth Differ. 6:1063-1070.
43. Wang, H. G., U. R. Rapp, and J. C. Reed. 1996. Bcl-2 targets the protein kinase Raf-1 to mitochondria. Cell 87:629-638.
44. Weber, M. J. 1994. Unpublished data.
45. Xia Z., M. Dickens, J. Raingeaud, R. J. Davis, and M. E. Greenberg. 1995. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270:1326-1331.
46. Yao, R., and G. M. Cooper. 1995. Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 267: 2003-2006.
47. Yao, R., and G. M. Cooper. 1996. Growth factor-dependent survival of rodent fibroblasts requires phosphatidylinositol 3-kinase but is independent of pp70S6K activity. Oncogene 13:343-351.
48. 46a. Zamorano, J., H. Y. Wang, L.-M. Wang, J. H. Pierce, and A. D Keegan. 1996. IL-4 protects cells from apoptosis via the insulin receptor substrate pathway and a second independent signaling pathway. J. Immunol. 157:4926-4933.
49. Zha, J., H. Harada, E. Yang, J. Jockel, and S. J. Korsmeyer. 1996. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L). Cell 87:619-628.