Effects of rolipram, a phosphodiesterase 4 inhibitor, in combination with imipramine on depressive behavior, CRE-binding activity and BDNF level in learned helplessness rats

European Journal of Pharmacology

Volumn 498, Issue 1-3, 2004, Pages 135-142

  Itoh, Tetsuji ^a   Tokumura, Miwa ^a   Abe, Kohji ^a  

^a SHIONOGI AND CO LTD   (Japan)

Author keywords

Antidepressant; Brain derived neurotrophic factor; cAMP response element; Learned helplessness; Phosphodiesterase 4; Rolipram

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; IMIPRAMINE; PHOSPHODIESTERASE IV INHIBITOR; ROLIPRAM; TRICYCLIC ANTIDEPRESSANT AGENT;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DEPRESSION; DOSE RESPONSE; DRUG EFFECT; FRONTAL CORTEX; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ANIMALS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; BRAIN-DERIVED NEUROTROPHIC FACTOR; CORPUS STRIATUM; CORTICOSTERONE; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DEPRESSIVE DISORDER; DRUG SYNERGISM; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ELECTROSHOCK; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESCAPE REACTION; FRONTAL LOBE; HELPLESSNESS, LEARNED; HIPPOCAMPUS; IMIPRAMINE; MALE; PHOSPHODIESTERASE INHIBITORS; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; ROLIPRAM;

EID: 4444318007     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2004.07.084     Document Type: Article

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