Sulfur-containing amino acid metabolism in parasitic protozoa

Advances in Parasitology

Volumn 60, Issue , 2005, Pages 1-99

  Nozaki, Tomoyoshi ^a,b,c   Ali, Vahab ^a,b   Tokoro, Masaharu ^d  

^a GUNMA UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d KANAZAWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CYSTEINE; GLUTATHIONE; METHIONINE; METHIONINE DERIVATIVE; METHIONINE GAMMA LYASE; POLYAMINE; PROPARGYLGLYCINE; SERINE; SULFUR; TRIFLUOROMETHIONINE; UNCLASSIFIED DRUG;

AMINO ACID METABOLISM; BIOLOGICAL ACTIVITY; BIOLOGY; BIOSYNTHESIS; CATABOLISM; CHEMICAL REACTION; CHEMOTHERAPY; DEGRADATION; DEVELOPMENTAL STAGE; DRUG HALF LIFE; ENTAMOEBA; ENTAMOEBA HISTOLYTICA; EUKARYOTE; GENOMICS; GIARDIA DUODENALIS; LEISHMANIA; MAMMAL; METABOLISM; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITISM; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROPHYLAXIS; PROTOZOON; REVIEW; SPECTROSCOPY; TOXICITY; TRICHOMONAS VAGINALIS; TRYPANOSOMA; TRYPANOSOMA CRUZI; VIRULENCE;

AMINO ACIDS, SULFUR; ANIMALS; CYSTEINE; DRUG DESIGN; ENTAMOEBA HISTOLYTICA; EUKARYOTIC CELLS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; LYASES; MAMMALS; METHIONINE; PROTOZOA; PROTOZOAN INFECTIONS; SERINE; SULFUR; TRICHOMONAS VAGINALIS; TRYPANOSOMA CRUZI;

ENTAMOEBA; ENTAMOEBA HISTOLYTICA; EUKARYOTA; GIARDIA INTESTINALIS; MAMMALIA; PROTOZOA; TRICHOMONAS VAGINALIS; TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 26844478710     PISSN: 0065308X     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-308X(05)60001-2     Document Type: Review

References (362)

1. M.S. Abrahamsen, T.J. Templeton, S. Enomoto, J.E. Abrahante, G. Zhu, C.A. Lancto, M. Deng, C. Liu, G. Widmer, S. Tzipori, G.A. Buck, P. Xu, A.T. Bankier, P.H. Dear, B.A. Konfortov, H.F. Spriggs, L. Iyer, V. Anantharaman, L. Aravind, and V. Kapur Complete genome sequence of the apicomplexan, Cryptosporidium parvum Science 304 2004 441 445
2. Y. Achouri, M.H. Rider, E.V. Schaftingen, and M. Robbi Cloning, sequencing and expression of rat liver 3-phosphoglycerate dehydrogenase Biochemical Journal 323 1997 365 370
3. Y. Achouri, M. Robbi, and E. Van Schaftingen Role of cysteine in the dietary control of the expression of 3-phosphoglycerate dehydrogenase in rat liver Biochemical Journal 344 1999 15 21
4. R.D. Adam The biology of Giardia spp Microbiology Reviews 55 1991 706 732
5. S. Alfadhli, and P.K. Rathod Gene organization of a Plasmodium falciparum serine hydroxymethyltransferase and its functional expression in Escherichia coli Molecular and Biochemical Parasitology 110 2000 283 291
6. V. Ali, Y. Shigeta, and T. Nozaki Molecular and structural characterization of NADPH-dependent d-glycerate dehydrogenase from the enteric parasitic protist Entamoeba histolytica Biochemical Journal 375 2003 729 736
7. V. Ali, Y. Shigeta, U. Tokumoto, Y. Takahashi, and T. Nozaki An intestinal parasitic protist, Entamoeba histolytica, possesses a non-redundant nitrogen fixation-like system for iron-sulfur cluster assembly under anaerobic conditions Journal of Biological Chemistry 279 2004 16863 16874
8. V. Ali, T. Hashimoto, Y. Shigeta, and T. Nozaki Molecular and biochemical characterization of d-phosphoglycerate dehydrogenase from Entamoeba histolytica. A unique enteric protozoan parasite that possesses both phosphorylated and nonphosphorylated serine metabolic pathways European Journal of Biochemistry 271 2004 2670 2681
9. L. Alvarez, F. Corrales, A. Martin-Duce, and J.M. Mato Characterization of a full-length cDNA encoding human liver S-adenosylmethionine synthetase: tissue-specific gene expression and mRNA levels in hepatopathies Biochemical Journal 293 1993 481 486
10. J.W. Anderson Sulfur in Biology 1978 University Park Press Baltimore, MD
11. D.R. Appling Compartmentation of folate-mediated one-carbon metabolism in eukaryotes FASEB Journal 5 1991 2645 2651
12. M.R. Ariyanayagam, and A.H. Fairlamb Entamoeba histolytica lacks trypanothione metabolism Molecular and Biochemical Parasitology 103 1999 61 69
13. M.R. Ariyanayagam, and A.H. Fairlamb Ovothiol and trypanothione as antioxidants in trypanosomatids Molecular and Biochemical Parasitology 115 2001 189 198
14. M.R. Ariyanayagam, S.L. Oza, A. Mehlert, and A.H. Fairlamb Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi Journal of Biological Chemistry 278 2003 27612 27619
15. W. Asawamahasakda, and Y. Yuthavong The methionine synthesis cycle and salvage of methyltetrahydrofolate from host red cells in the malaria parasite (Plasmodium falciparum) Parasitology 107 1993 1 10
16. Y.G. Assaraf, J. Golenser, D.T. Spira, and U. Bachrach Polyamine levels and the activity of their biosynthetic enzymes in human erythrocytes infected with the malarial parasite, Plasmodium falciparum Biochemical Journal 222 1984 815 819
17. J.L. Avila, and M.A. Polegre Uptake and metabolism of S-adenosyl-l-methionine by Leishmania mexicana and Leishmania braziliensis promastigotes Molecular and Biochemical Parasitology 58 1993 123 134
18. C.J. Bacchi, J. Garofalo, M. Ciminelli, D. Rattendi, B. Goldberg, P.P. McCann, and N. Yarlett Resistance to dl-α-difluoromethylornithine by clinical isolates of Trypanosoma brucei rhodesiense. Role of S-adenosylmethionine Biochemical Pharmacology 46 1993 471 481
19. C.J. Bacchi, and N. Yarlett Effects of antagonists of polyamine metabolism on African trypanosomes Acta Tropica 54 1993 225 236
20. C.J. Bacchi, and N. Yarlett Polyamine metabolism as chemotherapeutic target in protozoan parasites Mini Review Medicinal Chemistry 2 2002 553 563
21. C.J. Bacchi, J. Garofalo, D. Mockenhaupt, P.P. McCann, K.A. Diekema, A.E. Pegg, H.C. Nathan, E.A. Mullaney, L. Chunosoff, A. Sjoerdsma, and S.H. Hutner In vivo effects of α-dl-difluoromethylornithine on the metabolism and morphology of Trypanosoma brucei brucei Molecular and Biochemical Parasitology 7 1983 209 225
22. C.J. Bacchi, H.C. Nathan, A.B. Clarkson jr, E.J. Bienen, A.J. Bitonti, P.P. McCann, and A. Sjoerdsma Effects of the ornithine decarboxylase inhibitors dl-α-difluoromethylornithine and α-monofluoromethyldehydroornithine methyl ester alone and in combination with suramin against Trypanosoma brucei brucei central nervous system models American Journal of Tropical Medicine and Hygiene 36 1987 46 52
23. C.J. Bacchi, J.R. Sufrin, H.C. Nathan, A.J. Spiess, T. Hannan, J. Garofalo, K. Alecia, L. Katz, and N. Yarlett 5′-Alkyl-substituted analogs of 5′-methylthioadenosine as trypanocides Antimicrobial Agents and Chemotherapy 35 1991 1315 1320
24. C.J. Bacchi, H.C. Nathan, N. Yarlett, B. Goldberg, P.P. McCann, A.J. Bitonti, and A. Sjoerdsma Cure of murine Trypanosoma brucei rhodesiense infections with an S-adenosylmethionine decarboxylase inhibitor Antimicrobial Agents and Chemotherapy 36 1992 2736 2740
25. C.J. Bacchi, B. Goldberg, J. Garofalo-Hannan, D. Rattendi, P. Lyte, and N. Yarlett Fate of soluble methionine in African trypanosomes: effects of metabolic inhibitors Biochemical Journal 309 1995 737 743
26. U. Bachrach, Y.C. Wang, and A. Tabib Polyamines: new cues in cellular signal transduction News on Physiological Sciences 16 2001 106 109
27. J.Y. Baek, Y. Jun do, D. Taub, and Y.H. Kim Characterization of human phosphoserine aminotransferase involved in the phosphorylated pathway of l-serine biosynthesis Biochemical Journal 373 2003 191 200
28. A.S. Bagnara, V.E. Tucker, L. Minotto, E.R. Howes, G.A. Ko, M.R. Edwards, and I.W. Dawes Molecular characterisation of adenosylhomocysteinase from Trichomonas vaginalis Molecular and Biochemical Parasitology 81 1996 1 11
29. 13C-NMR spectroscopy Journal of Eukaryotic Microbiology 42 1995 346 349
30. M.J. Basurko, M. Marche, M. Darriet, and A. Cassaigne Phosphoserine aminotransferase, the second step-catalyzing enzyme for serine biosynthesis IUBMB Life 48 1999 525 529
31. H. Beinert Iron-sulfur proteins: ancient structures, still full of surprises Journal of Biological Inorganic Chemistry 5 2000 2 15
32. H. Beinert, R.H. Holm, and E. Munck Iron-sulfur clusters: nature's modular, multipurpose structures Science 277 1997 653 659
33. B.J. Berger, W.W. Dai, H. Wang, R.E. Stark, and A. Cerami Aromatic amino acid transamination and methionine recycling in trypanosomatids Proceedings of the National Academy of Sciences of the USA 93 1996 4126 4130
34. B.J. Berger, W.W. Dai, and J. Wilson Methionine formation from α-ketomethiobutyrate in the trypanosomatid Crithidia fasciculata FEMS Microbiology Letters 165 1998 305 312
35. L.C. Berger, J. Wilson, P. Wood, and B.J. Berger Methionine regeneration and aspartate aminotransferase in parasitic protozoa Journal of Bacteriology 183 2001 4421 4434
36. L. Birkholtz, F. Joubert, A.W. Neitz, and A.I. Louw Comparative properties of a three-dimensional model of Plasmodium falciparum ornithine decarboxylase Proteins 50 2003 464 473
37. L.M. Birkholtz, C. Wrenger, F. Joubert, G.A. Wells, R.D. Walter, and A.I. Louw Parasite-specific inserts in the bifunctional S-adenosylmethionine decarboxylase/ornithine decarboxylase of Plasmodium falciparum modulate catalytic activities and domain interactions Biochemical Journal 377 2004 439 448
38. A.J. Bitonti, J.A. Dumont, and P.P. McCann Characterization of Trypanosoma brucei brucei S-adenosyl-l-methionine decarboxylase and its inhibition by Berenil, pentamidine and methylglyoxal-bis(guanylhydrazone) Biochemical Journal 237 1986 685 689
39. A.J. Bitonti, D.E. Cross-Doersen, and P.P. McCann Effects of α-difluoromethylornithine on protein synthesis and synthesis of the variant-specific glycoprotein (VSG) in Trypanosoma brucei brucei Biochemical Journal 250 1988 295 298
40. A.J. Bitonti, R.J. Baumann, E.T. Jarvi, J.R. McCarthy, and P.P. McCann Antimalarial activity of a 4′,5′-unsaturated 5′- fluoroadenosine mechanism-based inhibitor of S-adenosyl-l-homocysteine hydrolase Biochemical Pharmacology 40 1990 601 606
41. A.J. Bitonti, T.L. Byers, T.L. Bush, P.J. Casara, C.J. Bacchi, A.B. Clarkson jr, P.P. McCann, and A. Sjoerdsma Cure of Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense infections in mice with an irreversible inhibitor of S-adenosylmethionine decarboxylase Antimicrobial Agents and Chemotherapy 34 1990 1485 1490
42. H.J. Blom, G.H. Boers, J.P. van den Elzen, W.A. Gahl, and A. Tangerman Transamination of methionine in humans Clinical Sciences (London) 76 1989 43 49
43. J.M. Bollinger jr, D.S. Kwon, G.W. Huisman, R. Kolter, and C.T. Walsh Glutathionylspermidine metabolism in Escherichia coli. Purification, cloning, overproduction, and characterization of a bifunctional glutathionylspermidine synthetase/amidase Journal of Biological Chemistry 270 1995 14031 14041
44. P. Bonnarme, C. Lapadatescu, M. Yvon, and H.E. Spinnler l-Methionine degradation potentialities of cheese-ripening microorganisms Journal of Dairy Research 68 2001 663 674
45. D. Bordo, and P. Bork The rhodanese/Cdc25 phosphatase superfamily. Sequence-structure-function relations EMBO Reports 3 2002 741 746
46. A.E. Braunstein, E.V. Goryachenkova, E.A. Tolosa, I.H. Willhardt, and L.L. Yefremova Specificity and some other properties of liver serine sulphydrase: evidence for its identity with cystathionine β-synthase Biochimica et Biophysica Acta 242 1971 247 260
47. Z. Brener Biology of Trypanosoma cruzi Annual Review of Microbiology 27 1973 347 382
48. D.M. Brown, J.A. Upcroft, and P. Upcroft Cysteine is the major low-molecular weight thiol in Giardia duodenalis Molecular and Biochemical Parasitology 61 1993 155 158
49. I. Bruchhaus, and E. Tannich Induction of the iron-containing superoxide dismutase in Entamoeba histolytica by a superoxide anion-generating system or by iron chelation Molecular and Biochemical Parasitology 67 1994 281 288
50. I. Bruchhaus, and E. Tannich Analysis of the genomic sequence encoding the 29-kDa cysteine-rich protein of Entamoeba histolytica Tropical Medicine and Parasitology 44 1993 116 118
51. I. Bruchhaus, S. Richter, and E. Tannich Recombinant expression and biochemical characterization of an NADPH:flavin oxidoreductase from Entamoeba histolytica Biochemical Journal 330 1998 1217 1221
52. R. Brun, and M. Schonenberger Cultivation and in vitro cloning of procyclic culture forms of Trypanosoma brucei in a semi-defined medium Acta Tropica 36 1979 289 292
53. R. Brun, Y. Buhler, U. Sandmeier, R. Kaminsky, C.J. Bacchi, D. Rattendi, S. Lane, S.L. Croft, D. Snowdon, V. Yardley, G. Caravatti, J. Frei, J. Stanek, and H. Mett In vitro trypanocidal activities of new S-adenosylmethionine decarboxylase inhibitors Antimicrobial Agents and Chemotherapy 40 1996 1442 1447
54. E. Burton, and W. Sakami Methionine synthesis (yeast) Methods in Enzymology 17B 1971 388 392
55. E.G. Burton, and R.L. Metzenberg Regulation of methionine biosynthesis in Neurospora crassa Archives of Biochemistry and Biophysics 168 1975 219 229
56. T.L. Byers, T.L. Bush, P.P. McCann, and A.J. Bitonti Antitrypanosomal effects of polyamine biosynthesis inhibitors correlate with increases in Trypanosoma brucei brucei S-adenosyl-l-methionine Biochemical Journal 274 1991 527 533
57. C.R. Byrne, R.S. Monroe, K.A. Ward, and N.M. Kredich DNA sequences of the cysK regions of Salmonella typhimurium and Escherichia coli and linkage of the cysK regions to ptsH Journal of Bacteriology 170 1988 3150 3157
58. G.L. Cantoni Biological methylation: selected aspects Annual Review of Biochemistry 44 1975 435 451
59. R.A. Casero jr, and P.M. Woster Terminally alkylated polyamine analogues as chemotherapeutic agents Journal of Medicinal Chemistry 44 2001 1 26
60. M. Ceccon, P. Giusti, L. Facci, G. Borin, M. Imbesi, M. Floreani, and S.D. Skaper Intracellular glutathione levels determine cerebellar granule neuron sensitivity to excitotoxic injury by kainic acid Brain Research 862 2000 83 89
61. Chalmers, R.A., Tracey, B.M., Mistry, J., Griffiths, K.D., Green, A. and Winterborn, M.H. (1984). l-Glyceric aciduria (primary hyperoxaluria type 2) in siblings in two unrelated families. Journal of Inheritable Metabolic Diseases 7, supplement 2, 133-134.
62. J. Chen, X. Huang, Y. Liu, G. Dai, and W. Chen Detoxicating enzymes of Entamoeba histolytica and their detoxifying roles Chinese Medical Journal 109 1996 792 794
63. K.S. Chen, and H.A. Lardy Pathway of gluconeogenesis from d- and l-glycerate in rat hepatocytes Archives of Biochemistry and Biophysics 265 1988 433 440
64. G.P. Cheung, J.P. Cotropia, and H.J. Sallach The effects of dietary protein on the hepatic enzymes of serine metabolism in the rabbit Archives of Biochemistry and Biophysics 129 1969 672 682
65. P.K. Chiang, and G.L. Cantoni Activation of methionine for transmethylation. Purification of the S-adenosylmethionine synthetase of bakers' yeast and its separation into two forms Journal of Biological Chemistry 252 1977 4506 4513
66. P.K. Chiang, M.E. Chamberlin, D. Nicholson, S. Soubes, X. Su, G. Subramanian, D.E. Lanar, S.T. Prigge, J.P. Scovill, L.H. Miller, and J.Y. Chou Molecular characterization of Plasmodium falciparum S-adenosylmethionine synthetase Biochemical Journal 344 1999 571 576
67. C.G. Clark, and A.J. Roger Direct evidence for secondary loss of mitochondria in Entamoeba histolytica Proceedings of the National Academy of Sciences of the USA 92 1995 6518 6521
68. P. Cochat, and M.O. Rolland Primary hyperoxalurias J. Fernandes J.M. Saudubray G. Van der Berghe Inborn Metabolic Diseases 2002 Springer-Verlag Berlin 446 452
69. Cody, G.D., Boctor, N.Z., Filley, T.R., Hazen, R.M., Scott, J.H., Sharma, A. and Yoder, H.S., jr (2000). Primordial carbonylated iron-sulfur compounds and the synthesis of pyruvate. Science 289, 1337-1340.
70. G.H. Coombs, and J.C. Mottram Trifluoromethionine, a prodrug designed against methionine γ-lyase-containing pathogens, has efficacy in vitro and in vivo against Trichomonas vaginalis Antimicrobial Agents and Chemotherapy 45 2001 1743 1745
71. A.J. Cooper Biochemistry of sulfur-containing amino acids Annual Review of Biochemistry 52 1983 187 222
72. J.L. Cooper, and A. Meister Isolation and properties of highly purified glutamine transaminase Biochemistry 11 1972 661 671
73. R. Cooper, A.R. de Jesus, and G.A. Cross Deletion of an immunodominant Trypanosoma cruzi surface glycoprotein disrupts flagellum-cell adhesion Journal of Cell Biology 122 1993 149 156
74. A.F. Cowman The molecular basis of resistance to the sulfones, sulfonamides, and dihydrofolate reductase inhibitors I.W. Sherman Malaria Parasite Biology, Pathogenesis, and Protection 1998 ASM Press Washington, DC 317 330
75. K.A. Creedon, P.K. Rathod, and T.E. Wellems Plasmodium falciparum S-adenosylhomocysteine hydrolase. cDNA identification, predicted protein sequence, and expression in Escherichia coli Journal of Biological Chemistry 269 1994 16364 16370
76. B. Das, R. Gupta, and R. Madhubala Combined action of inhibitors of S-adenosylmethionine decarboxylase with an antimalarial drug, chloroquine, on Plasmodium falciparum Journal of Eukaryotic Microbiology 44 1997 12 17
77. A. De Bree, W.M. Verschuren, D. Kromhout, L.I. Mennen, and H.J. Blom Homocysteine and coronary heart disease: the importance of a distinction between low and high risk subjects International Journal of Epidemiology 31 2002 1268 1272
78. T.J. De Koning, K. Snell, M. Duran, R. Berger, B.T. Poll-The, and R. Surtees l-Serine in disease and development Biochemical Journal 371 2003 653 661
79. J. De La Rosa, J. Ostrowski, M.M. Hryniewicz, N.M. Kredich, M. Kotb, H.L. LeGros jr, M. Valentine, and A.M. Geller Chromosomal localization and catalytic properties of the recombinant α subunit of human lymphocyte methionine adenosyltransferase Journal of Biological Chemistry 270 1995 21860 21868
80. E.J. Devor, and R. Waziri A familial/genetic study of plasma serine and glycine concentrations Biology of Psychiatry 34 1993 221 225
81. B. Dias, and B. Weimer Purification and characterization of l-methionine γ-lyase from Brevibacterium linens BL2 Applied Environmental Microbiology 64 1998 3327 3331
82. C.J. Doelman, and A. Bast Oxygen radicals in lung pathology Free Radical Biology of Medicine 9 1990 381 400
83. R. Dringen, L. Kussmaul, J.M. Gutterer, J. Hirrlinger, and B. Hamprecht The glutathione system of peroxide detoxification is less efficient in neurons than in astroglial cells Journal of Neurochemistry 72 1999 2523 2530
84. J.A. Duerre Preparation and properties of S-adenosyl-l-homocysteine, S-adenosyl-l-homocysteine sulfoxide and S-ribosyl-l-homocysteine Archives of Biochemistry and Biophysics 96 1962 70 76
85. M. Duszenko, M.A. Ferguson, G.S. Lamont, M.R. Rifkin, and G.A. Cross Cysteine eliminates the feeder cell requirement for cultivation of Trypanosoma brucei bloodstream forms in vitro Journal of Experimental Medicine 162 1985 1256 1263
86. M. Duszenko, K. Muhlstadt, and A. Broder Cysteine is an essential growth factor for Trypanosoma brucei bloodstream forms Molecular and Biochemical Parasitology 50 1992 269 273
87. M.R. Edwards, F.V. Gilroy, B.M. Jimenez, and W.J. O'Sullivan Alanine is a major end product of metabolism by Giardia lamblia: a proton nuclear magnetic resonance study Molecular and Biochemical Parasitology 37 1989 19 26
88. A.C. Eliot, and J.F. Kirsch Pyridoxal phosphate enzymes: mechanistic, structural, and evolutionary considerations Annual Review of Biochemistry 73 2004 383 415
89. K.E. Ellis, B. Clough, J.W. Saldanha, and R.J. Wilson Nifs and Sufs in malaria Molecular Microbiology 41 2001 973 981
90. N. Esaki, and K. Soda l-Methionine γ-lyase from Pseudomonas putida and Aeromonas Methods in Enzymology 143 1987 459 465
91. R.C. Fahey, G.L. Newton, B. Arrick, T. Overdank-Bogart, and S.B. Aley Entamoeba histolytica: a eukaryote without glutathione metabolism Science 224 1984 70 72
92. Fairlamb, A.H. (1989). Novel biochemical pathways in parasitic protozoa. Parasitology 99, supplement, S93-S112.
93. A.H. Fairlamb, and A. Cerami Metabolism and functions of trypanothione in the Kinetoplastida Annual Review of Microbiology 46 1992 695 729
94. Fairlamb, A.H. and Henderson, G.B. (1987). Metabolism of trypanothione and glutathionylspermidine in trypanosomatids. In: Host-Parasite Cellular and Molecular Interactions in Protozoal Infections (K.P. Chang and D. Snary, eds). Vol. H11, pp. 29-40. Berlin: Springer-Verlag/NATO ASI Series.
95. A.H. Fairlamb, and S.A. LeQuesne Polyamine metabolism in trypanosomes G. Hide J.C. Mottram G.H. Coombs P.H. Holmes Trypanosomiasis and Leishmaniasis: Biology and Control vol. 9 1997 CAB International Wallingford, UK 149 161
96. A.H. Fairlamb, P. Blackburn, P. Ulrich, B.T. Chait, and A. Cerami Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids Science 227 1985 1485 1487
97. A.H. Fairlamb, G.B. Henderson, C.J. Bacchi, and A. Cerami In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma brucei Molecular and Biochemical Parasitology 24 1987 185 191
98. N.G. Faleev, M.V. Troitskaya, E.A. Paskonova, M.B. Saporovslaya, and V.M. Belikov l-Methionine γ-lyase in Citrobacter intermedius cells: stereochemical requirements with respect to the thiol structure Enzymes and Microbial Technology 19 1996 590 593
99. H.J. Fallon, E.J. Hackney, and W.L. Byrne Serine biosynthesis in rat liver. Regulation of enzyme concentration by dietary factors Journal of Biological Chemistry 241 1966 4157 4167
100. D.A. Fell, and K. Snell Control analysis of mammalian serine biosynthesis. Feedback inhibition on the final step Biochemical Journal 256 1988 97 101
101. A.J. Ferro, A. Barrett, and S.K. Shapiro Kinetic properties and the effect of substrate analogues on 5′-methylthioadenosine nucleosidase from Escherichia coli Biochimica et Biophysica Acta 438 1976 487 494
102. A.J. Ferro, A. Barrett, and S.K. Shapiro 5-Methylthioribose kinase. A new enzyme involved in the formation of methionine from 5-methylthioribose Journal of Biological Chemistry 253 1978 6021 6025
103. J. Field, B. Rosenthal, and J. Samuelson Early lateral transfer of genes encoding malic enzyme acetyl-CoA synthetase and alcohol dehydrogenases from anaerobic prokaryotes to Entamoeba histolytica Molecular Microbiology 38 2000 446 455
104. J.D. Finkelstein Methionine metabolism in mammals: the biochemical basis for homocysteinuria Metabolism 23 1974 387 398
105. J.D. Finkelstein, and J.J. Martin Methionine metabolism in mammals. Adaptation to methionine excess Journal of Biological Chemistry 261 1986 1582 1587
106. J.D. Finkelstein, W. Kyle, and B.J. Harris Methionine metabolism in mammals. Regulation of homocysteine methyltransferases in rat tissue Archives of Biochemistry and Biophysics 146 1971 84 92
107. J.D. Finkelstein, W.E. Kyle, and B.J. Harris Methionine metabolism in mammals: regulatory effects of S-adenosylhomocysteine Archives of Biochemistry and Biophysics 165 1974 774 779
108. L. Flohe, H.J. Hecht, and P. Steinert Glutathione and trypanothione in parasitic hydroperoxide metabolism Free Radical Biology and Medicine 27 1999 966 984
109. M. Fontecave, E. Mulliez, and S. Ollagnier-de-Choudens Adenosylmethionine as a source of 5′-deoxyadenosyl radicals Current Opinion Chemical Biology 5 2001 506 511
110. P.C. Fu, V. Zic, and K. Ozimy Studies of ethylene-forming system in rat liver extract Biochimica et Biophysica Acta 585 1979 427 434
111. T.F. Fu, J.P. Rife, and V. Schirch The role of serine hydroxymethyltransferase isozymes in one-carbon metabolism in MCF-7 cells as determined by (13)C NMR Archives of Biochemistry and Biophysics 393 2001 42 50
112. E.S. Furfine, and R.H. Abeles Intermediates in the conversion of 5′-S-methylthioadenosine to methionine in Klebsiella pneumoniae Journal of Biological Chemistry 263 1988 9598 9606
113. M.J. Gardner, N. Hall, E. Fung, O. White, M. Berriman, R.W. Hyman, J.M. Carlton, A. Pain, K.E. Nelson, S. Bowman, I.T. Paulsen, K. James, J.A. Eisen, K. Rutherford, S.L. Salzberg, A. Craig, S. Kyes, M.S. Chan, V. Nene, S.J. Shallom, B. Suh, J. Peterson, S. Angiuoli, M. Pertea, J. Allen, J. Selengut, D. Haft, M.W. Mather, A.B. Vaidya, D.M. Martin, A.H. Fairlamb, M.J. Fraunholz, D.S. Roos, S.A. Ralph, G.I. McFadden, L.M. Cummings, G.M. Subramanian, C. Mungall, J.C. Venter, D.J. Carucci, S.L. Hoffman, C. Newbold, R.W. Davis, C.M. Fraser, and B. Barrel Genome sequence of the human malaria parasite Plasmodium falciparum Nature 419 2002 498 511
114. C.R. Gentry-Weeks, J.M. Keith, and J. Thompson Toxicity of Bordetella avium β-cystathionase toward MC3T3-E1 osteogenic cells Journal of Biological Chemistry 268 1993 7298 7314
115. E. Ghadirian, S.D. Somerfield, and P.A. Kongshavn Susceptibility of Entamoeba histolytica to oxidants Infection and Immunity 51 1986 263 267
116. L.Y. Ghoda, T.M. Savarese, C.H. Northup, R.E. Parks jr, J. Garofalo, L. Katz, B.B. Ellenbogen, and C.J. Bacchi Substrate specificities of 5′-deoxy-5′-methylthioadenosine phosphorylase from Trypanosoma brucei brucei and mammalian cells Molecular and Biochemical Parasitology 27 1988 109 118
117. C.F. Giafi, and G. Rumsby Kinetic analysis and tissue distribution of human d-glycerate dehydrogenase/glyoxylate reductase and its relevance to the diagnosis of primary hyperoxaluria type 2 Annals of Clinical Biochemistry 35 1998 104 109
118. F.D. Gillin, and L.S. Diamond Attachment and short-term maintenance of motility and viability of Entamoeba histolytica in a defined medium Journal of Protozoology 27 1980 220 225
119. F.D. Gillin, and L.S. Diamond Attachment of Entamoeba histolytica to glass in a defined maintenance medium: specific requirement for cysteine and ascorbic acid Journal of Protozoology 27 1980 474 478
120. F.D. Gillin, and L.S. Diamond Entamoeba histolytica and Giardia lamblia: effects of cysteine and oxygen tension on trophozoite attachment to glass and survival in culture media Experimental Parasitology 52 1981 9 17
121. F.D. Gillin, and L.S. Diamond Entamoeba histolytica and Giardia lamblia: growth responses to reducing agents Experimental Parasitology 51 1981 382 391
122. F.D. Gillin, and L.S. Diamond Inhibition of clonal growth of Giardia lamblia and Entamoeba histolytica by metronidazole, quinacrine, and other antimicrobial agents Journal of Antimicrobial Chemotherapy 8 1981 305 316
123. F.D. Gillin, and D.S. Reiner Attachment of the flagellate Giardia lamblia: role of reducing agents, serum, temperature, and ionic composition Molecular and Cellular Biology 2 1982 369 377
124. F.D. Gillin, D.S. Reiner, R.B. Levy, and P.A. Henkart Thiol groups on the surface of anaerobic parasitic protozoa Molecular and Biochemical Parasitology 13 1984 1 12
125. J. Giovanelli Sulfur amino acids of plants: an overview Methods in Enzymology 143 1987 419 426
126. B. Goldberg, N. Yarlett, J. Sufrin, D. Lloyd, and C.J. Bacchi A unique transporter of S-adenosylmethionine in African trypanosomes FASEB Journal 11 1997 256 260
127. B. Goldberg, D. Rattendi, D. Lloyd, J.R. Sufrin, and C.J. Bacchi Effects of intermediates of methionine metabolism and nucleoside analogs on S-adenosylmethionine transport by Trypanosoma brucei brucei and a drug-resistant Trypanosoma brucei rhodesiense Biochemical Pharmacology 56 1998 95 103
128. B. Goldberg, D. Rattendi, D. Lloyd, N. Yarlett, and C.J. Bacchi Kinetics of S-adenosylmethionine cellular transport and protein methylation in Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense Archives of Biochemistry and Biophysics 364 1999 13 18
129. B. Goldberg, D. Rattendi, D. Lloyd, N. Yarlett, and C.J. Bacchi Kinetics of methionine transport and metabolism by Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense Archives of Biochemistry and Biophysics 377 2000 49 57
130. J.C. Gonzalez, R.V. Banerjee, S. Huang, J.S. Sumner, and R.G. Matthews Comparison of cobalamin-independent and cobalamin-dependent methionine synthases from Escherichia coli: two solutions to the same chemical problem Biochemistry 31 1992 6045 6056
131. J.M. Greenler, J.S. Sloan, B.W. Schwartz, and W.M. Becker Isolation, characterization and sequence analysis of a full-length cDNA clone encoding NADH-dependent hydroxypyruvate reductase from cucumber Plant Molecular Biology 13 1989 139 150
132. O.W. Griffith Mammalian sulfur amino acid metabolism: an overview Methods in Enzymology 143 1987 366 376
133. R.F. Grimble, and G.K. Grimble Immunonutrition: role of sulfur amino acids, related amino acids, and polyamines Nutrition 14 1998 605 610
134. J.L. Guan, J.E. Trevithick, and R.O. Hynes Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein Cell Regulation 2 1991 951 964
135. R.W. Guynn, D.K. Merrill, and K. Lund The reactions of the phosphorylated pathway of l-serine biosynthesis: thermodynamic relationships in rat liver in vivo Archives of Biochemistry and Biophysics 245 1986 204 211
136. T.R. Hall, R. Wallin, G.D. Reinhart, and S.M. Hutson Branched chain aminotransferase isoenzymes. Purification and characterization of the rat brain isoenzyme Journal of Biological Chemistry 268 1993 3092 3098
137. Q. Han, M. Lenz, Y. Tan, M. Xu, X. Sun, X. Tan, L. Tang, D. Miljkovic, and R.M. Hoffman High expression, purification, and properties of recombinant homocysteine α-, γ-lyase Protein Expression and Purification 14 1998 267 274
138. S. Hariharan, J. Ajioka, and J. Swindle Stable transformation of Trypanosoma cruzi: inactivation of the PUB12.5 polyubiquitin gene by targeted gene disruption Molecular and Biochemical Parasitology 57 1993 15 30
139. O. Heby, S.C. Roberts, and B. Ullman Polyamine biosynthetic enzymes as drug targets in parasitic protozoa Biochemical Society Transactions 31 2003 415 419
140. J. Heilbronn, J. Wilson, and B.J. Berger Tyrosine aminotransferase catalyzes the final step of methionine recycling in Klebsiella pneumoniae Journal of Bacteriology 181 1999 1739 1747
141. R. Hell, C. Bork, N. Bogdanova, I. Frolov, and R. Hauschild Isolation and characterization of two cDNAs encoding for compartment specific isoforms of O-acetylserine (thiol) lyase from Arabidopsis thaliana FEBS Letters 351 1994 257 262
142. D.M. Henderson, S. Hanson, T. Allen, K. Wilson, D.E. Coulter-Karis, M.L. Greenberg, M.S. Hershfield, and B. Ullman Cloning of the gene encoding Leishmania donovani S-adenosylhomocysteine hydrolase, a potential target for antiparasitic chemotherapy Molecular and Biochemical Parasitology 53 1992 169 183
143. K. Herbig, E.P. Chiang, L.R. Lee, J. Hills, B. Shane, and P.J. Stover Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and S-adenosylmethionine biosynthesis Journal of Biological Chemistry 277 2002 38381 38389
144. R.A. Hillary, and A.E. Pegg Decarboxylases involved in polyamine biosynthesis and their inactivation by nitric oxide Biochimica et Biophysica Acta 1647 2003 161 166
145. H. Hirsch, and D.M. Greenberg Studies on phosphoserine aminotransferase of sheep brain Journal of Biological Chemistry 242 1967 2283 2287
146. C.L. Ho, and K. Saito Molecular biology of the plastidic phosphorylated serine biosynthetic pathway in Arabidopsis thaliana Amino Acids 20 2001 243 259
147. C.L. Ho, M. Noji, M. Saito, M. Yamazaki, and K. Saito Molecular characterization of plastidic phosphoserine aminotransferase in serine biosynthesis from Arabidopsis Plant Journal 16 1998 443 452
148. C.L. Ho, M. Noji, and K. Saito Plastidic pathway of serine biosynthesis. Molecular cloning and expression of 3-phosphoserine phosphatase from Arabidopsis thaliana Journal of Biological Chemistry 274 1999 11007 11012
149. C.L. Ho, M. Noji, M. Saito, and K. Saito Regulation of serine biosynthesis in Arabidopsis. Crucial role of plastidic 3-phosphoglycerate dehydrogenase in non-photosynthetic tissues Journal of Biological Chemistry 274 1999 397 402
150. D.R. Hoffman, J.A. Haning, and W.E. Cornatzer Microsomal phosphatidylethanolamine methyltransferase: inhibition by S-adenosylhomocysteine Lipids 16 1981 561 567
151. D.W. Horne, R.S. Holloway, and C. Wagner Transport of S-adenosylmethionine in isolated rat liver mitochondria Archives of Biochemistry and Biophysics 343 1997 201 206
152. F. Ikegami, M. Kamiya, Y.H. Kuo, F. Lambein, and I. Murakoshi Enzymatic synthesis of two isoxazolylalanine isomers by cysteine synthases in Lathyrus species Biological Pharmaceutical Bulletins 19 1996 1214 1215
153. S. Ito, T. Nakamura, and Y. Eguchi Purification and characterization of methioninase from Pseudomonas putida Journal of Biochemistry (Tokyo) 79 1976 1263 1272
154. Y. Izumi, T. Yoshida, H. Kanzaki, S. Toki, S.S. Miyazaki, and H. Yamada Purification and characterization of hydroxypyruvate reductase from a serine-producing methylotroph, Hyphomicrobium methylovorum GM2 European Journal of Biochemistry 190 1990 279 284
155. J. Jaeken, M. Detheux, L. Van Maldergem, M. Foulon, H. Carchon, and E. Van Schaftingen 3-Phosphoglycerate dehydrogenase deficiency: an inborn error of serine biosynthesis Archives of Disease in Childhood 74 1996 542 545
156. J. Jaeken, M. Detheux, L. Van Maldergem, J.P. Frijns, P. Alliet, M. Foulon, H. Carchon, and E. Van Schaftingen 3-Phosphoglycerate dehydrogenase deficiency and 3-phosphoserine phosphatase deficiency: inborn errors of serine biosynthesis Journal of Inheritable Metabolic Diseases 19 1996 223 226
157. C.J. Janse, T. Ponnudurai, A.H. Lensen, J.H. Meuwissen, J. Ramesar, M. Van der Ploeg, and J.P. Overdulve DNA synthesis in gametocytes of Plasmodium falciparum Parasitology 96 1988 1 7
158. E.L. Jarroll, P. Manning, A. Berrada, D. Hare, and D.G. Lindmark Biochemistry and metabolism of Giardia Journal of Protozoology 36 1989 190 197
159. A.E. Kaiser, A.M. Gottwald, C.S. Wiersch, W.A. Maier, and H.M. Seitz Spermidine metabolism in parasitic protozoa. A comparison to the situation in prokaryotes, viruses, plants and fungi Folia Parasitologia (Praha) 50 2003 3 18
160. M.M. Kaplan, and M. Flavin Cystathionine γ-synthetase of
161. E. Karvonen, L. Kauppinen, T. Partanen, and H. Poso Irreversible inhibition of putrescine-stimulated S-adenosyl-l-methionine decarboxylase by Berenil and pentamidine Biochemical Journal 231 1985 165 169
162. L.N. Kinch, J.R. Scott, B. Ullman, and M.A. Phillips Cloning and kinetic characterization of the Trypanosoma cruzi S-adenosylmethionine decarboxylase Molecular and Biochemical Parasitology 101 1999 1 11
163. Kitade, Y., Kozaki, A., Miwa, T., Nakanishi, M., and Yatome, C. (2000). Synthesis of carbocyclic nucleosides and their SAH hydrolase inhibitory activities. Nucleic Acids Symposium Series no. 44, 111-112.
164. Kitade, Y., Kojima, H., Zulfiqur, F., Yabe, S., Yamagiwa, D., Ito, Y., Nakanishi, M., Ueno, Y., Kim, H.S. and Wataya, Y. (2003). Synthesis of carbocyclic and acyclic nucleosides possessing 2-fluoroadenine derivatives and their inhibitory activities against Plasmodium falciparum SAH hydrolase. Nucleic Acids Research, supplement 3, 5-6.
165. L.W. Klomp, T.J. de Koning, H.E. Malingre, E.A. van Beurden, M. Brink, F.L. Opdam, M. Duran, J. Jaeken, M. Pineda, L. Van Maldergem, B.T. Poll-The, I.E. van den Berg, and R. Berger Molecular characterization of 3-phosphoglycerate dehydrogenase deficiency: a neurometabolic disorder associated with reduced l-serine biosynthesis American Journal of Human Genetics 67 2000 1389 1399
166. L.A. Knodler, M.R. Edwards, and P.J. Schofield The intracellular amino acid pools of Giardia intestinalis, Trichomonas vaginalis, and Crithidia luciliae Experimental Parasitology 79 1994 117 125
167. W.E. Knox, A. Herzfeld, and J. Hudson Phosphoserine phosphatase distribution in normal and neoplastic rat tissues Archives of Biochemistry and Biophysics 132 1969 397 403
168. N. Kohashi, K. Yamaguchi, Y. Hosokawa, Y. Kori, O. Fujii, and I. Ueda Dietary control of cysteine dioxygenase in rat liver Journal of Biochemistry (Tokyo) 84 1978 159 168
169. Kojima, H., Yamaguchi, T., Kozaki, A., Nakanishi, M., Ueno, Y. and Kitade, Y. (2002). Synthesis of noraristeromycin analogues possessing SAH hydrolase inhibitory activity for the development of antimalaria agents. Nucleic Acids Research, supplement 2, 141-142.
170. M. Kotb, and A.M. Geller Methionine adenosyltransferase: structure and function Pharmacological Therapy 59 1993 125 143
171. M. Kotb, and N.M. Kredich S-adenosylmethionine synthetase from human lymphocytes. Purification and characterization Journal of Biological Chemistry 260 1985 3923 3930
172. J.P. Kraus, M. Janosik, V. Kozich, R. Mandell, V. Shih, M.P. Sperandeo, G. Sebastio, R. de Franchis, G. Andria, L.A. Kluijtmans, H. Blom, G.H. Boers, R.B. Gordon, P. Kamoun, M.Y. Tsai, W.D. Kruger, H.G. Koch, T. Ohura, and M. Gaustadnes Cystathionine β-synthase mutations in homocysteinuria Human Mutations 13 1999 362 375
173. T. Krause, K. Luersen, C. Wrenger, T.W. Gilberger, S. Muller, and R.D. Walter The ornithine decarboxylase domain of the bifunctional ornithine decarboxylase/S-adenosylmethionine decarboxylase of Plasmodium falciparum: recombinant expression and catalytic properties of two different constructs Biochemical Journal 352 2000 287 292
174. Krauth-Siegel, R.L.and Inhoff, O. (2003). Parasite-specific trypanothione reductase as a drug target molecule. Parasitology Research 90, supplement 2, S77-S85.
175. N.M. Kredich, and G.M. Tomkins The enzymic synthesis of l-cysteine in Escherichia coli and Salmonella typhimurium Journal of Biological Chemistry 241 1966 4955 4965
176. Kredich, N.M., Hulanicka, M.D. and Hallquist, S.G. (1979). Synthesis of l-cysteine in Salmonella typhimurium. Ciba Foundation Symposium 72, 87-99.
177. W. Kreis, and C. Hession Isolation and purification of l-methionine-α-deamino-γ-mercaptomethane-lyase (l-methioninase) from Clostridium sporogenes Cancer Research 33 1973 1862 1865
178. J. Krungkrai, H.K. Webster, and Y. Yuthavong Characterization of cobalamin-dependent methionine synthase purified from the human malarial parasite, Plasmodium falciparum Parasitology Research 75 1989 512 517
179. M.J. LaGier, J. Tachezy, F. Stejskal, K. Kutisova, and J.S. Keithly Mitochondrial-type iron-sulfur cluster biosynthesis genes (IscS and IscU) in the apicomplexan Cryptosporidium parvum Microbiology 149 2003 3519 3530
180. H. Lancero, J. Niu, and P.W. Johnson Exposure of periodontal ligament cells to methyl mercaptan reduces intracellular pH and inhibits cell migration Journal of Dental Research 75 1996 1994 2002
181. C. Larsson, and E. Albertsson Enzymes related to serine synthesis in spinach chloroplasts Physiologia Plantarum 45 1979 7 10
182. F. Lawrence, T. Derbecourt, and M. Robert-Gero Proton-ATPase activities involved in the uptake of an S-adenosylmethionine analogue Molecular and Biochemical Parasitology 92 1998 99 109
183. H.L. LeGros jr, A.B. Halim, A.M. Geller, and M. Kotb Cloning, expression, and functional characterization of the β regulatory subunit of human methionine adenosyltransferase (MAT II) Journal of Biological Chemistry 275 2000 2359 2366
184. T. Leustek, M.N. Martin, J.A. Bick, and J.P. Davies Pathways and regulation of sulfur metabolism revealed through molecular and genetic studies Annual Review of Plant Physiology and Plant Molecular Biology 51 2000 141 165
185. H.B. Lin, R. Falchetto, P.J. Mosca, J. Shabanowitz, D.F. Hunt, and J.L. Hamlin Mimosine targets serine hydroxymethyltransferase Journal of Biological Chemistry 271 1996 2548 2556
186. B.C. Lockwood, and G.H. Coombs Purification and characterization of methionine γ-lyase from Trichomonas vaginalis Biochemical Journal 279 1991 675 682
187. B. Loftus, I. Anderson, R. Davies, U.C.M. Alismark, J. Samuelson, P. Amedeo, P. Roncaglia, M. Berriman, R.P. Hirt, B.J. Mann, T. Nozaki, B. Suh, M. Pop, M. Duchene, J. Ackers, E. Tannich, M. Leippe, M. Hofer, I. Bruchhaus, U. Willhoeft, A. Bhattacharya, T. Chillingworth, C. Churcher, Z. Hance, B. Harris, D. Harris, K. Jagels, S. Moule, K. Mungall, D. Ormond, R. Squares, S. Whitehead, N. Guill, C. Gilchrist, S.E. Stroup, S. Bhattacharya, A. Lohia, P.G. Foster, T. Sicheritz-Ponten, C. Weber, U. Singh, C. Mukherjee, W.A.J. Petri, C.G. Clark, T.M. Embley, B. Barrell, C.M. Fraser, and N. Hall The genome of the protist parasite Entamoeba histolytica Nature 433 2005 865 868
188. H.D. Lujan, and T.E. Nash The uptake and metabolism of cysteine by Giardia lamblia trophozoites Journal of Eukaryotic Microbiology 41 1994 169 175
189. S.C. Lu S-adenosylmethionine International Journal of Biochemistry and Cell Biology 32 2000 391 395
190. G.X. Luo, and P.M. Horowitz The sulfurtransferase activity and structure of rhodanese are affected by site-directed replacement of Arg-186 or Lys-249 Journal of Biological Chemistry 269 1994 8220 8225
191. Z. Mai, S. Ghosh, M. Frisardi, B. Rosenthal, R. Rogers, and J. Samuelson Hsp60 is targeted to a cryptic mitochondrion-derived organelle ('crypton') in the microaerophilic protozoan parasite Entamoeba histolytica Molecular and Cellular Biology 19 1999 2198 2205
192. K.S. Marchitto, and A.J. Ferro The metabolism of 5′- methylthioadenosine and 5-methylthioribose 1-phosphate in Saccharomyces cerevisiae Journal of General Microbiology 131 1985 2153 2164
193. L.J. Marton, and A.E. Pegg Polyamines as targets for therapeutic intervention Annual Review of Pharmacology and Toxicology 35 1995 55 91
194. A. Maruyama, K. Ishizawa, T. Takagi, and Y. Esashi Cytosolic β-cyanoalanine synthase activity attributed to cysteine synthases in cocklebur seeds. Purification and characterization of cytosolic cysteine synthases Plant Cell Physiology 39 1998 671 680
195. Mato, J.M., Corrales, F., Martin-Duce, A., Ortiz, P., Pajares, M.A. and Cabrero, C. (1990). Mechanisms and consequences of the impaired trans-sulphuration pathway in liver disease: Part I. Biochemical implications. Drugs 40, supplement 3, 58-64.
196. A.E. McKie, T. Edlind, J. Walker, J.C. Mottram, and G.H. Coombs The primitive protozoon Trichomonas vaginalis contains two methionine γ-lyase genes that encode members of the γ-family of pyridoxal 5′-phosphate-dependent enzymes Journal of Biological Chemistry 273 1998 5549 5556
197. J. McLaughlin, and S. Aley The biochemistry and functional morphology of the Entamoeba Journal of Protozoology 32 1985 221 240
198. R.K. Mehlotra Antioxidant defense mechanisms in parasitic protozoa Critical Reviews in Microbiology 22 1996 295 314
199. P.K. Mehta, and P. Christen The molecular evolution of pyridoxal-5′-phosphate-dependent enzymes Advances in Enzymology and Related Areas of Molecular Biology 74 1998 129 184
200. A. Meister, and M.E. Anderson Glutathione Annual Review of Biochemistry 52 1983 711 760
201. Merali, S., Vargas, D., Franklin, M. and Clarkson, A.B., jr (2000). S-adenosylmethionine and Pneumocystis carinii. Journal of Biological Chemistry 275, 14958-14963.
202. J.W. Miller Homocysteine and Alzheimer's disease Nutrition Review 57 1999 126 129
203. R.L. Miller, and D.P. Toorchen MTA phosphorylase in protozoa: a potential target for chemotherapeutic attack Advances in Experimental Medicine and Biology 250 1988 211 218
204. J. Mingorance, L. Alvarez, M.A. Pajares, and J.M. Mato Recombinant rat liver S-adenosyl-l-methionine synthetase tetramers and dimers are in equilibrium International Journal of Biochemistry and Cell Biology 29 1997 485 491
205. L. Minotto, G.A. Ko, M.R. Edwards, and A.S. Bagnara Trichomonas vaginalis: expression and characterisation of recombinant S- adenosylhomocysteinase Experimental Parasitology 90 1998 175 180
206. H. Motoshima, K. Inagaki, T. Kumasaka, M. Furuichi, H. Inoue, T. Tamura, N. Esaki, K. Soda, N. Tanaka, M. Yamamoto, and H. Tanaka Crystal structure of the pyridoxal 5′-phosphate dependent l-methionine γ-lyase from Pseudomonas putida Journal of Biochemistry (Tokyo) 128 2000 349 354
207. S.H. Mudd, and J.R. Poole Labile methyl balances for normal humans on various dietary regimens Metabolism 24 1975 721 735
208. Mudd, S.H., Skovby, F., Levy, H.L., Pettigrew, K.D., Wilcken, B., Pyeritz, R.E., Andria, G., Boers, G.H., Bromberg, I.L., Cerone, R., et al. (1985). The natural history of homocysteinuria due to cystathionine β-synthase deficiency. American Journal of Human Genetics 37, 1-31.
209. M. Muller Energy metabolism of protozoa without mitochondria Annual Review of Microbiology 42 1988 465 488
210. M. Muller Energy metabolism of ancestral eukaryotes: a hypothesis based on the biochemistry of amitochondriate parasitic protists Biosystems 28 1992 33 40
211. S. Muller, A. Da'dara, K. Luersen, C. Wrenger, R. Das Gupta, R. Madhubala, and R.D. Walter In the human malaria parasite Plasmodium falciparum, polyamines are synthesized by a bifunctional ornithine decarboxylase, S-adenosylmethionine decarboxylase Journal of Biological Chemistry 275 2000 8097 8102
212. S. Muller, G.H. Coombs, and R.D. Walter Targeting polyamines of parasitic protozoa in chemotherapy Trends in Parasitology 17 2001 242 249
213. S. Muller, E. Liebau, R.D. Walter, and R.L. Krauth-Siegel Thiol-based redox metabolism of protozoan parasites Trends in Parasitology 19 2003 320 328
214. J.T. Murphy, and K.D. Spence Transport of S-adenosylmethionine in Saccharomyces cerevisiae Journal of Bacteriology 109 1972 499 504
215. R.W. Myers, J.W. Wray, S. Fish, and R.H. Abeles Purification and characterization of an enzyme involved in oxidative carbon-carbon bond cleavage reactions in the methionine salvage pathway of Klebsiella pneumoniae Journal of Biological Chemistry 268 1993 24785 24791
216. S. Nagai, and M. Flavin Acetylhomoserine. An intermediate in the fungal biosynthesis of methionine Journal of Biological Chemistry 242 1967 3884 3895
217. T. Nakamura, Y. Kon, H. Iwahashi, and Y. Eguchi Evidence that thiosulfate assimilation by Salmonella typhimurium is catalyzed by cysteine synthase B Journal of Bacteriology 156 1983 656 662
218. M. Nakanishi, A. Iwata, C. Yatome, and Y. Kitade Purification and properties of recombinant Plasmodium falciparum S-adenosyl-l-homocysteine hydrolase Journal of Biochemistry (Tokyo) 129 2001 101 105
219. K. Nakayama, S. Awata, J. Zhang, H. Ebinuma, T. Mariyama, and H. Kodama Contents of sulfur amino acids and cystathionine β-synthase, and γ-lyase activities in various tissues from Agkistroden blomhoffi (mamushi) Physiological Chemistry and Physical Medicine NMR 32 2000 21 26
220. T. Nakayama, N. Esaki, K. Sugie, T.T. Beresov, H. Tanaka, and K. Soda Purification of bacterial l-methionine γ-lyase Analytical Biochemistry 138 1984 421 424
221. D.L. Nandi, P.M. Horowitz, and J. Westley Rhodanese as a thioredoxin oxidase International Journal of Biochemistry and Cell Biology 32 2000 465 473
222. W. Ng, and J. Tonzetich Effect of hydrogen sulfide and methyl mercaptan on the permeability of oral mucosa Journal of Dental Research 63 1984 994 997
223. N. Nirmalan, P. Wang, P.F. Sims, and J.E. Hyde Transcriptional analysis of genes encoding enzymes of the folate pathway in the human malaria parasite Plasmodium falciparum Molecular Microbiology 46 2002 179 190
224. S. Nishimura, Y. Taya, Y. Kuchino, and Z. Oashi Enzymatic synthesis of 3-(3-amino-3-carboxypropyl)uridine in Escherichia coli phenylalanine transfer RNA: transfer of the 3-amino-acid-3-carboxypropyl group from S-adenosylmethionine Biochemical and Biophysical Research Communications 57 1974 702 708
225. J.E. Nixon, A. Wang, J. Field, H.G. Morrison, A.G. McArthur, M.L. Sogin, B.J. Loftus, and J. Samuelson Evidence for lateral transfer of genes encoding ferredoxins, nitroreductases, NADH oxidase, and alcohol dehydrogenase 3 from anaerobic prokaryotes to Giardia lamblia and Entamoeba histolytica Eukaryotic Cell 1 2002 181 190
226. G. Noctor, A.C. Arisi, L. Jouanin, and C.H. Foyer Manipulation of glutathione and amino acid biosynthesis in the chloroplast Plant Physiology 118 1998 471 482
227. M. Noji, and K. Saito Molecular and biochemical analysis of serine acetyltransferase and cysteine synthase towards sulfur metabolic engineering in plants Amino Acids 22 2002 231 243
228. M. Noji, I. Murakoshi, and K. Saito Molecular cloning of a cysteine synthase cDNA from Citrullus vulgaris (watermelon) by genetic complementation in an E. coli Cys-auxotroph Molecular and General Genetics 244 1994 57 66
229. M. Noji, K. Inoue, N. Kimura, A. Gouda, and K. Saito Isoform-dependent differences in feedback regulation and subcellular localization of serine acetyltransferase involved in cysteine biosynthesis from Arabidopsis thaliana Journal of Biological Chemistry 273 1998 32739 32745
230. T. Nozaki, T. Asai, S. Kobayashi, F. Ikegami, M. Noji, K. Saito, and T. Takeuchi Molecular cloning and characterization of the genes encoding two isoforms of cysteine synthase in the enteric protozoan parasite Entamoeba histolytica Molecular and Biochemical Parasitology 97 1998 33 44
231. T. Nozaki, T. Asai, L.B. Sanchez, S. Kobayashi, M. Nakazawa, and T. Takeuchi Characterization of the gene encoding serine acetyltransferase, a regulated enzyme of cysteine biosynthesis from the protist parasites Entamoeba histolytica and Entamoeba dispar. Regulation and possible function of the cysteine biosynthetic pathway in Entamoeba Journal of Biological Chemistry 274 1999 32445 32452
232. T. Nozaki, M. Tokoro, M. Imada, Y. Saito, Y. Abe, Y. Shigeta, and T. Takeuchi Cloning and biochemical characterization of genes encoding two isozymes of cysteine synthase from Entamoeba dispar Molecular and Biochemical Parasitology 107 2000 129 133
233. T. Nozaki, Y. Shigeta, Y. Saito-Nakano, M. Imada, and W.D. Kruger Characterization of transsulfuration and cysteine biosynthetic pathways in the protozoan hemoflagellate, Trypanosoma cruzi. Isolation and molecular characterization of cystathionine β-synthase and serine acetyltransferase from Trypanosoma Journal of Biological Chemistry 276 2001 6516 6523
234. N. Ogasawara, S. Nakai, and H. Yoshikawa Systematic sequencing of the 180 kilobase region of the Bacillus subtilis chromosome containing the replication origin DNA Research 1 1994 1 14
235. J.W. Olson, J.N. Agar, M.K. Johnson, and R.J. Maier Characterization of the NifU and NifS Fe-S cluster formation proteins essential for viability in Helicobacter pylori Biochemistry 39 2000 16213 16219
236. R.N. Ondarza, A. Iturbe, G. Hurtado, E. Tamayo, M. Ondarza, and E. Hernandez Entamoeba histolytica: a eukaryote with trypanothione metabolism instead of glutathione metabolism Biotechnology and Applied Biochemistry 30 1999 47 52
237. B. Ono, K. Kijima, N. Ishii, T. Kawato, A. Matsuda, A. Paszewski, and S. Shinoda Regulation of sulphate assimilation in Saccharomyces cerevisiae Yeast 12 1996 1153 1162
238. J. Ostrowski, G. Jagura-Burdzy, and N.M. Kredich DNA sequences of the cysB regions of Salmonella typhimurium and Escherichia coli Journal of Biological Chemistry 262 1987 5999 6005
239. B.L. Parsons, and A.K. Mattoo Wound-regulated accumulation of specific transcripts in tomato fruit: interactions with fruit development, ethylene and light Plant Molecular Biology 17 1991 453 464
240. R.B. Parsons, R.H. Waring, A.C. Williams, and D.B. Ramsden Cysteine dioxygenase: regional localisation of protein and mRNA in rat brain Journal of Neuroscience Research 65 2001 78 84
241. A.E. Pegg Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy Cancer Research 48 1988 759 774
242. A.E. Pegg, and H.G. Williams-Ashman On the role of S-adenosyl-l- methionine in the biosynthesis of spermidine by rat prostate Journal of Biological Chemistry 244 1969 682 693
243. L. Pepplinkhuizen, J. Bruinvels, W. Blom, and P. Moleman Schizophrenia-like psychosis caused by a metabolic disorder Lancet 1 1980 454 456
244. Y. Perez-Pertejo, R.M. Reguera, H. Villa, C. Garcia-Estrada, R. Balana-Fouce, M.A. Pajares, and D. Ordonez Leishmania donovani methionine adenosyltransferase. Role of cysteine residues in the recombinant enzyme European Journal of Biochemistry 270 2003 28 35
245. K. Persson, L. Aslund, B. Grahn, J. Hanke, and O. Heby Trypanosoma cruzi has not lost its S-adenosylmethionine decarboxylase: characterization of the gene and the encoded enzyme Biochemical Journal 333 1998 527 537
246. M.A. Phelouzat, M. Basselin, F. Lawrence, and M. Robert-Gero Sinefungin shares AdoMet-uptake system to enter Leishmania donovani promastigotes Biochemical Journal 305 1995 133 137
247. R. Picton, M.C. Eggo, G.A. Merrill, M.J. Langman, and S. Singh Mucosal protection against sulphide: importance of the enzyme rhodanese Gut 50 2002 201 205
248. N. Pieniazek, P.P. Stepien, and A. Paszewski An Aspergillus nidulans mutant lacking cystathionine β-synthase: identity of l-serine sulfhydrylase with cystathionine β-synthase and its distinctness from O-acetyl-l-serine sulfhydrylase Biochimica et Biophysica Acta 297 1973 37 47
249. H. Poso, P. Hannonen, J.J. Himberg, and J. Janne Adenosylmethionine decarboxylase from various organisms: relation of the putrescine activation of the enzyme to the ability of the organism to synthesize spermine Biochemical and Biophysical Research Communications 68 1976 227 234
250. S. Rahlfs, R.H. Schirmer, and K. Becker The thioredoxin system of Plasmodium falciparum and other parasites Cellular and Molecular Life Sciences 59 2002 1024 1041
251. S. Rathaur, and R.D. Walter Plasmodium falciparum: S-adenosyl-l- methionine decarboxylase Experimental Parasitology 63 1987 227 232
252. P.K. Rathod, N.P. Leffers, and R.D. Young Molecular targets of 5-fluoroorotate in the human malaria parasite, Plasmodium falciparum Antimicrobial Agents and Chemotherapy 36 1992 704 711
253. L.G. Ratkay, J.D. Waterfield, and J. Tonzetich Stimulation of enzyme and cytokine production by methyl mercaptan in human gingival fibroblast and monocyte cell cultures Archives of Oral Biology 40 1995 337 344
254. S. Ravanel, B. Gakiere, D. Job, and R. Douce The specific features of methionine biosynthesis and metabolism in plants Proceedings of the National Academy of Sciences of the USA 95 1998 7805 7812
255. P.A. Rea, Z.S. Li, Y.P. Lu, Y.M. Drozdowicz, and E. Martinoia From vacuolar Gs-X pumps to multispecific Abc transporters Annual Review of Plant Physiology and Plant Molecular Biology 49 1998 727 760
256. R.E. Reeves Metabolism of Entamoeba histolytica Schaudinn, 1903 Advances in Parasitology 23 1984 105 142
257. R.E. Reeves, L.G. Warren, B. Susskind, and H.S. Lo An energy-conserving pyruvate-to-acetate pathway in Entamoeba histolytica. Pyruvate synthase and a new acetate thiokinase Journal of Biological Chemistry 252 1977 726 731
258. R.E. Reeves, J.D. Guthrie, and P. Lobelle-Rich Entamoeba histolytica: isolation of ferredoxin Experimental Parasitology 49 1980 83 88
259. R.M. Reguera, Y. Perez-Pertejo, C. Ordonez, J.C. Cubria, B.L. Tekwani, R. Balana-Fouce, and D. Ordonez S-adenosylmethionine synthesis in Leishmania infantum promastigotes Cell Biology International 23 1999 579 583
260. R.M. Reguera, R. Balana-Fouce, Y. Perez-Pertejo, F.J. Fernandez, C. Garcia-Estrada, J.C. Cubria, C. Ordonez, and D. Ordonez Cloning expression and characterization of methionine adenosyltransferase in Leishmania infantum promastigotes Journal of Biological Chemistry 277 2002 3158 3167
261. S.B. Renwick, K. Snell, and U. Baumann The crystal structure of human cytosolic serine hydroxymethyltransferase: a target for cancer chemotherapy Structure 6 1998 1105 1116
262. M.K. Riscoe, A.J. Ferro, and J.H. Fitchen Analogs of 5-methylthioribose, a novel class of antiprotozoal agents Antimicrobial Agents and Chemotherapy 32 1988 1904 1906
263. M.K. Riscoe, A.J. Ferro, and J.H. Fitchen Methionine recycling as a target for antiprotozoal drug development Parasitology Today 5 1989 330 333
264. S.C. Roberts, J. Scott, J.E. Gasteier, Y. Jiang, B. Brooks, A. Jardim, N.S. Carter, O. Heby, and B. Ullman S-adenosylmethionine decarboxylase from Leishmania donovani. Molecular, genetic, and biochemical characterization of null mutants and overproducers Journal of Biological Chemistry 277 2002 5902 5909
265. M.A. Rodriguez, M.E. Hidalgo, T. Sanchez, and E. Orozco Cloning and characterization of the Entamoeba histolytica pyruvate:ferredoxin oxidoreductase gene Molecular and Biochemical Parasitology 78 1996 273 277
266. S. Romer, A. d'Harlingue, B. Camara, R. Schantz, and M. Kuntz Cysteine synthase from Capsicum annuum chromoplasts. Characterization and cDNA cloning of an up-regulated enzyme during fruit development Journal of Biological Chemistry 267 1992 17966 17970
267. I.Y. Rosenblum, D.H. Antkowiak, H.J. Sallach, L.E. Flanders, and L.A. Fahien Purification and regulatory properties of beef liver d-glycerate dehydrogenase Archives of Biochemistry and Biophysics 144 1971 375 383
268. E.V. Rowsell, K. Snell, J.A. Carnie, and A.H. Al-Tai Liver-l-alanine- glyoxylate and l-serine-pyruvate aminotransferase activities: an apparent association with gluconeogenesis Biochemical Journal 115 1969 1071 1073
269. P. Ruenwongsa, M. Luanvararat, and W.J. O'Sullivan Serine hydroxymethyltransferase from pyrimethamine-sensitive and -resistant strains of Plasmodium chabaudi Molecular and Biochemical Parasitology 33 1989 265 271
270. K. Saito, N. Miura, M. Yamazaki, H. Hirano, and I. Murakoshi Molecular cloning and bacterial expression of cDNA encoding a plant cysteine synthase Proceedings of the National Academy of Sciences of the USA 89 1992 8078 8082
271. K. Saito, K. Tatsuguchi, I. Murakoshi, and H. Hirano cDNA cloning and expression of cysteine synthase B localized in chloroplasts of Spinacia oleracea FEBS Letters 324 1993 247 252
272. K. Saito, H. Yokoyama, M. Noji, and I. Murakoshi Molecular cloning and characterization of a plant serine acetyltransferase playing a regulatory role in cysteine biosynthesis from watermelon Journal of Biological Chemistry 270 1995 16321 16326
273. K. Saito, Y. Takagi, H.C. Ling, H. Takahashi, and M. Noji Molecular cloning, characterization and expression of cDNA encoding phosphoserine aminotransferase involved in phosphorylated pathway of serine biosynthesis from spinach Plant Molecular Biology 33 1997 359 366
274. R. Sanchez-Fernandez, M. Fricker, L.B. Corben, N.S. White, N. Sheard, C.J. Leaver, M. Van Montagu, D. Inze, and M.J. May Cell proliferation and hair tip growth in the Arabidopsis root are under mechanistically different forms of redox control Proceedings of the National Academy of Sciences of the USA 94 1997 2745 2750
275. R. Saski, and L.I. Pizer Regulatory properties of purified 3-phosphoglycerate dehydrogenase from Bacillus subtilis European Journal of Biochemistry 51 1975 415 427
276. M. Schwartz, and S.K. Shapiro The mechanism of utilization of thiomethyladenosine in the biosynthesis of methionine Journal of Bacteriology 67 1954 98 102
277. F. Seeber Biogenesis of iron-sulphur clusters in amitochondriate and apicomplexan protists International Journal for Parasitology 32 2002 1207 1217
278. A. Sekowska, H.F. Kung, and A. Danchin Sulfur metabolism in Escherichia coli and related bacteria: facts and fiction Journal of Molecular Microbiology and Biotechnology 2 2000 145 177
279. I.W. Sherman Biochemistry of Plasmodium (malarial parasites) Microbiology Reviews 43 1979 453 495
280. S. Shuto, N. Minakawa, S. Niizuma, H.S. Kim, Y. Wataya, and A. Matsuda New neplanocin analogues. 12. Alternative synthesis and antimalarial effect of (6′R)-6′-C-methylneplanocin A, a potent AdoHcy hydrolase inhibitor Journal of Medicinal Chemistry 45 2002 748 751
281. A. Sjoerdsma, and P.J. Schechter Chemotherapeutic implications of polyamine biosynthesis inhibition Clinical Pharmacology and Therapy 35 1984 287 300
282. J. Slapeta, F. Stejskal, and J.S. Keithly Characterization of S-adenosylmethionine synthetase in Cryptosporidium parvum (Apicomplexa) FEMS Microbiology Letters 225 2003 271 277
283. J.C. Slaughter, and D.D. Davies Inhibition of 3-phosphoglycerate dehydrogenase by l-serine Biochemical Journal 109 1968 749 755
284. L.J. Smeijsters, N.M. Zijlstra, E. de Vries, F.F. Franssen, C.J. Janse, and J.P. Overdulve The effect of S-9-(3-hydroxy-2-phosphonylmethoxypropyl) adenine on nuclear and organellar DNA synthesis in erythrocytic schizogony in malaria Molecular and Biochemical Parasitology 67 1994 115 124
285. K. Smith, A. Borges, M.R. Ariyanayagam, and A.H. Fairlamb Glutathionylspermidine metabolism in Escherichia coli Biochemical Journal 312 1995 465 469
286. K. Snell Enzymes of serine metabolism in normal, developing and neoplastic rat tissues Advances in Enzyme Regulation 22 1984 325 400
287. K. Snell The duality of pathways for serine biosynthesis is a fallacy Trends in Biochemical Sciences 11 1986 241 243
288. K. Snell, and D.A. Fell Metabolic control analysis of mammalian serine metabolism Advances in Enzyme Regulation 30 1990 13 32
289. K. Snell, Y. Natsumeda, J.N. Eble, J.L. Glover, and G. Weber Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma British Journal of Cancer 57 1988 87 90
290. K. Soda Microbial sulfur amino acids: an overview Methods in Enzymology 143 1987 453 459
291. C. Steegborn, T. Clausen, P. Sondermann, U. Jacob, M. Worbs, S. Marinkovic, R. Huber, and M.C. Wahl Kinetics and inhibition of recombinant human cystathionine γ-lyase. Toward the rational control of transsulfuration Journal of Biological Chemistry 274 1999 12675 12684
292. R.D. Steele, and N.J. Benevenga The metabolism of 3-methylthiopropionate in rat liver homogenates Journal of Biological Chemistry 254 1979 8885 8890
293. D.J. Steenkamp Trypanosomal antioxidants and emerging aspects of redox regulation in the trypanosomatids Antioxidative Redox Signaling 4 2002 105 121
294. R.F. Steiger, and E. Steiger Cultivation of Leishmania donovani and Leishmania braziliensis in defined media: nutritional requirements Journal of Protozoology 24 1977 437 441
295. P.P. Stepien, and N.J. Pieniazek The use of the l-serine sulfhydrylase assay for the estimation of cystathionine β-synthase Analytical Biochemistry 54 1973 294 299
296. M.H. Stipanuk Metabolism of sulfur-containing amino acids Annual Review of Nutrition 6 1986 179 209
297. M.H. Stipanuk Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteine Annual Review of Nutrition 24 2004 539 577
298. G. Stramentinoli Pharmacologic aspects of S-adenosylmethionine. Pharmacokinetics and pharmacodynamics American Journal of Medicine 83 1987 35 42
299. J.R. Sufrin, S.R. Meshnick, A.J. Spiess, J. Garofalo-Hannan, X.Q. Pan, and C.J. Bacchi Methionine recycling pathways and antimalarial drug design Antimicrobial Agents and Chemotherapy 39 1995 2511 2515
300. E. Sugimoto, and L.I. Pizer The mechanism of end product inhibition of serine biosynthesis. I. Purification and kinetics of phosphoglycerate dehydrogenase Journal of Biological Chemistry 243 1968 2081 2089
301. H. Sun, J. Gao, D.A. Ferrington, H. Biesiada, T.D. Williams, and T.C. Squier Repair of oxidized calmodulin by methionine sulfoxide reductase restores ability to activate the plasma membrane Ca-ATPase Biochemistry 38 1999 105 112
302. C.W. Tabor, and H. Tabor Polyamines Annual Review of Biochemistry 53 1984 749 790
303. J. Tachezy, L.B. Sanchez, and M. Muller Mitochondrial type iron-sulfur cluster assembly in the amitochondriate eukaryotes Trichomonas vaginalis and Giardia intestinalis, as indicated by the phylogeny of IscS Molecular Biology and Evolution 18 2001 1919 1928
304. H. Tachibana, S. Ihara, S. Kobayashi, Y. Kaneda, T. Takeuchi, and Y. Watanabe Differences in genomic DNA sequences between pathogenic and nonpathogenic isolates of Entamoeba histolytica identified by polymerase chain reaction Journal of Clinical Microbiology 10 1991 2234 2239
305. K. Tada, S. Kure, M. Takayanagi, A. Kume, and K. Narisawa Non-ketotic hyperglycinemia: a life-threatening disorder in the neonate Early Human Development 29 1992 75 81
306. T. Takeuchi, E.C. Weinbach, M. Gottlieb, and L.S. Diamond Mechanism of l-serine oxidation in Entamoeba histolytica Comparative Biochemical Physiology [B] 62 1979 281 285
307. F. Takusagawa, S. Kamitori, and G.D. Markham Structure and function of S-adenosylmethionine synthetase: crystal structures of S-adenosylmethionine synthetase with ADP, BrADP, and PPi at 28 angstroms resolution Biochemistry 35 1996 2586 2596
308. E.M. Tamayo, A. Iturbe, E. Hernandez, G. Hurtado, X.M.M. Gutierrez, J.L. Rosales, M. Woolery, and R.N. Ondarza Trypanothione reductase from the human parasite Entamoeba histolytica: a new drug target Biotechnology and Applied Biochemistry 41 2005 105 115
309. B.L. Tekwani, C.J. Bacchi, and A.E. Pegg Putrescine activated S-adenosylmethionine decarboxylase from Trypanosoma brucei brucei Molecular and Cellular Biochemistry 117 1992 53 61
310. B.L. Tekwani, C.J. Bacchi, J.A. Secrist III, and A.E. Pegg Irreversible inhibition of S-adenosylmethionine decarboxylase of Trypanosoma brucei brucei by S-adenosylmethionine analogues Biochemical Pharmacology 44 1992 905 911
311. D. Thomas, and Y. Surdin-Kerjan Metabolism of sulfur amino acids in Saccharomyces cerevisiae Microbiology and Molecular Biology Reviews 61 1997 503 532
312. K.W. Thong, and G.H. Coombs l-Serine sulphydrase activity in trichomonads IRCS Medical Science 13 1985 495 496
313. K.W. Thong, and G.H. Coombs Trichomonas species: homocysteine desulphurase and serine sulphydrase activities Experimental Parasitology 63 1987 143 151
314. K.W. Thong, G.H. Coombs, and B.E. Sanderson S-adenosylhomocysteine hydrolase activity in Trichomonas vaginalis and other trichomonads Molecular and Biochemical Parasitology 17 1985 35 44
315. K.W. Thong, G.H. Coombs, and B.E. Sanderson S-adenosylmethionine and transmethylation reactions in trichomonads Parasitology Research 73 1987 193 198
316. K.W. Thong, G.H. Coombs, and B.E. Sanderson l-Methionine catabolism in trichomonads Molecular and Biochemical Parasitology 23 1987 223 231
317. M. Tokoro, T. Asai, S. Kobayashi, T. Takeuchi, and T. Nozaki Identification and characterization of two isoenzymes of methionine γ-lyase from Entamoeba histolytica: a key enzyme of sulfur-amino acid degradation in an anaerobic parasitic protist that lacks forward and reverse trans-sulfuration pathways Journal of Biological Chemistry 278 2003 42717 42727
318. B.E. Torian, B.M. Flores, V.L. Stroeher, F.S. Hagen, and W.E. Stamm cDNA sequence analysis of 29-kDa cysteine-rich surface antigen of pathogenic Entamoeba histolytica Proceedings of the National Academy of Sciences of the USA 87 1990 6358 6362
319. J. Tovar, A. Fischer, and C.G. Clark The mitosome, a novel organelle related to mitochondria in the amitochondrial parasite Entamoeba histolytica Molecular Microbiology 32 1999 1013 1021
320. J. Tovar, G. Leon-Avila, L.B. Sanchez, R. Sutak, J. Tachezy, M. Van Der Giezen, M. Hernandez, M. Muller, and J.M. Lucocq Mitochondrial remnant organelles of Giardia function in iron-sulphur protein maturation Nature 426 2003 172 176
321. D.M. Townsend, K.D. Tew, and H. Tapiero Sulfur containing amino acids and human disease Biomedical Pharmacotherapy 58 2004 47 55
322. P.C. Trackman, and R.H. Abeles Methionine synthesis from 5′-S-methylthioadenosine. Resolution of enzyme activities and identification of 1-phospho-5-S methylthioribulose Journal of Biological Chemistry 258 1983 6717 6720
323. W. Trager, M. Robert-Gero, and E. Lederer Antimalarial activity of S-isobutyl adenosine against Plasmodium falciparum in culture FEBS Letters 85 1978 264 266
324. W. Trager, M. Tershakovec, P.K. Chiang, and G.L. Cantoni Plasmodium falciparum: antimalarial activity in culture of sinefungin and other methylation inhibitors Experimental Parasitology 50 1980 83 89
325. A.M. Tucker, H.H. Winkler, L.O. Driskell, and D.O. Wood S-adenosylmethionine transport in Rickettsia prowazekii Journal of Bacteriology 185 2003 3031 3035
326. J.F. Turrens Oxidative stress and antioxidant defenses: a target for the treatment of diseases caused by parasitic protozoa Molecular Aspects of Medicine 25 2004 211 220
327. J.A. Upcroft, and P. Upcroft Keto-acid oxidoreductases in the anaerobic protozoa Journal of Eukaryotic Microbiology 46 1999 447 449
328. J. Uren Cystathionine β-lyase from Escherichia coli Methods in Enzymology 143 1987 483 486
329. D. Van der Straeten, L. Van Wiemeersch, H.M. Goodman, and M. Van Montagu Cloning and sequence of two different cDNAs encoding 1-aminocyclopropane-1- carboxylate synthase in tomato Proceedings of the National Academy of Sciences of the USA 87 1990 4859 4863
330. S. Van Nieuwenhove, P.J. Schechter, J. Declercq, G. Bone, J. Burke, and A. Sjoerdsma Treatment of gambiense sleeping sickness in the Sudan with oral DFMO (dl-α-difluoromethylornithine), an inhibitor of ornithine decarboxylase; first field trial Transactions of the Royal Society of Tropical Medicine and Hygiene 79 1985 692 698
331. E. Van Schaftingen, J.P. Draye, and F. Van Hoof Coenzyme specificity of mammalian liver d-glycerate dehydrogenase European Journal of Biochemistry 186 1989 355 359
332. V.D. Vigneaud A Trail of Research 1952 Cornell University Press Ithaca, NY
333. S.K. Wadman, M. Duran, D. Ketting, L. Bruinvis, P.K. De Bree, J.P. Kamerling, G.J. Gerwig, J.F. Vliegenthart, H. Przyrembel, K. Becker, and H.J. Bremer d-Glyceric acidemia in a patient with chronic metabolic acidosis Clinica Chimica Acta 71 1976 477 484
334. D.S. Wald, M. Law, and J.K. Morris Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis British Medical Journal 325 2002 1202
335. J. Walker, and J. Barrett Parasite sulphur amino acid metabolism International Journal for Parasitology 27 1997 883 897
336. R.D. Walker, and J.A. Duerre S-adenosylhomocysteine metabolism in various species Canadian Journal of Biochemistry 53 1975 312 319
337. D.A. Walsh, and H.J. Sallach Purification and properties of chicken liver d-3-phosphoglycerate dehydrogenase Biochemistry 4 1965 1076 1085
338. C.C. Wang Molecular mechanisms and therapeutic approaches to the treatment of African trypanosomiasis Annual Review of Pharmacology and Toxicology 35 1995 93 127
339. W. Wang, H.S. Cho, R. Kim, J. Jancarik, H. Yokota, H.H. Nguyen, I.V. Grigoriev, D.E. Wemmer, and S.H. Kim Structural characterization of the reaction pathway in phosphoserine phosphatase: crystallographic 'snapshots' of intermediate states Journal of Molecular Biology 319 2002 421 431
340. R. Waziri, R. Wilson, and A.D. Sherman Plasma serine to cysteine ratio as a biological marker for psychosis British Journal of Psychiatry 143 1983 69 73
341. R. Waziri, J. Wilcox, A.D. Sherman, and J. Mott Serine metabolism and psychosis Psychiatry Research 12 1984 121 136
342. B. Weimer, K. Seefeldt, and B. Dias Sulfur metabolism in bacteria associated with cheese Antonie Van Leeuwenhoek 76 1999 247 261
343. E.C. Weinbach, and L.S. Diamond Entamoeba histolytica. I. Aerobic metabolism Experimental Parasitology 35 1974 232 243
344. E.C. Weinbach, T. Takeuchi, C. Elwood Claggett, F. Inohue, H. Kon, and L.S. Diamond Role of iron-sulfur proteins in the electron transport system of Entamoeba histolytica Archivos de Investigacion de Medicina (Mexico) 11 1980 75 81
345. J.M. Whaun, G.A. Miura, N.D. Brown, R.K. Gordon, and P.K. Chiang Antimalarial activity of neplanocin A with perturbations in the metabolism of purines, polyamines and S-adenosylmethionine Journal of Pharmacological and Experimental Therapy 236 1986 277 283
346. C.D. Whitfield, E.J. Steers jr, and H. Weisbach Purification and properties of 5-methyltetrahydropteroyltriglutamate-homocysteine transmethylase Journal of Biological Chemistry 245 1970 390 401
347. Wilson, R.J., Rangachari, K., Saldanha, J.W., Rickman, L., Buxton, R.S. and Eccleston, J.F. (2003). Parasite plastids: maintenance and functions. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 358, 155-162; discussion 162-164.
348. J.W. Wray, and R.H. Abeles A bacterial enzyme that catalyzes formation of carbon monoxide Journal of Biological Chemistry 268 1993 21466 21469
349. J.W. Wray, and R.H. Abeles The methionine salvage pathway in Klebsiella pneumoniae and rat liver. Identification and characterization of two novel dioxygenases Journal of Biological Chemistry 270 1995 3147 3153
350. P.S. Wright, T.L. Byers, D.E. Cross-Doersen, P.P. McCann, and A.J. Bitonti Irreversible inhibition of S-adenosylmethionine decarboxylase in Plasmodium falciparum-infected erythrocytes: growth inhibition in vitro Biochemical Pharmacology 41 1991 1713 1718
351. U. Wullner, J. Seyfried, P. Groscurth, S. Beinroth, S. Winter, M. Gleichmann, M. Heneka, P. Loschmann, J.B. Schulz, M. Weller, and T. Klockgether Glutathione depletion and neuronal cell death: the role of reactive oxygen intermediates and mitochondrial function Brain Research 826 1999 53 62
352. H.H. Xue, M. Fujie, T. Sakaguchi, T. Oda, H. Ogawa, N.M. Kneer, H.A. Lardy, and A. Ichiyama Flux of the l-serine metabolism in rat liver. The predominant contribution of serine dehydratase Journal of Biological Chemistry 274 1999 16020 16027
353. H.H. Xue, T. Sakaguchi, M. Fujie, H. Ogawa, and A. Ichiyama Flux of the l-serine metabolism in rabbit, human, and dog livers. Substantial contributions of both mitochondrial and peroxisomal serine:pyruvate/alanine:glyoxylate aminotransferase Journal of Biological Chemistry 274 1999 16028 16033
354. M.A. Yakubu, S. Majumder, and F. Kierszenbaum Inhibition of S-adenosyl-l-methionine (AdoMet) decarboxylase by the decarboxylated AdoMet analog 5′-([(Z)-4-amino-2-butenyl]methylamino)-5′-deoxyadenosine (MDL 73811) decreases the capacities of Trypanosoma cruzi to infect and multiply within a mammalian host cell Journal of Parasitology 79 1993 525 532
355. K. Yamaguchi, and Y. Hosokawa Cysteine dioxygenase Methods in Enzymology 143 1987 395 403
356. N. Yarlett, and C.J. Bacchi Effect of dl-α-difluoromethylornithine on methionine cycle intermediates in Trypanosoma brucei brucei Molecular and Biochemical Parasitology 27 1988 1 10
357. N. Yarlett, and C.J. Bacchi Effect of dl-α-difluoromethylornithine on polyamine synthesis and interconversion in Trichomonas vaginalis grown in a semi-defined medium Molecular and Biochemical Parasitology 31 1988 1 9
358. N. Yarlett, and C.J. Bacchi Parasite polyamine metabolism: targets for chemotherapy Biochemical Society Transactions 22 1994 875 879
359. N. Yarlett, B. Goldberg, M.A. Moharrami, and C.J. Bacchi Inhibition of Trichomonas vaginalis ornithine decarboxylase by amino acid analogs Biochemical Pharmacology 44 1992 243 250
360. N. Yarlett, J. Garofalo, B. Goldberg, M.A. Ciminelli, V. Ruggiero, J.R. Sufrin, and C.J. Bacchi S-adenosylmethionine synthetase in bloodstream Trypanosoma brucei Biochimica et Biophysica Acta 1181 1993 68 76
361. Y.B. Yu, D.O. Adams, and S.F. Yang 1-Aminocyclopropanecarboxylate synthase, a key enzyme in ethylene biosynthesis Archives of Biochemistry and Biophysics 198 1979 280 286
362. Zanin, V.A., Lukina, V.I., and Berezov, T.T. (1989). [Isolation, various physico-chemical and catalytic properties of l-methionine-γ-lyase from Pseudomonas taetrolens.] Voprosy Meditsinskoi Khimii 35, 84-89. [In Russian; English Summary.]