S-adenosylmethionine synthesis in Leishmania infantum promastigotes

Cell Biology International

Volumn 23, Issue 8, 1999, Pages 579-583

  Reguera, R M ^a   Perez Pertejo Y ^a   Ordonez C ^a   Cubria J C ^a   Tekwani, B L ^b   Balana Fouce R ^a   Ordonez D ^a  

^a UNIVERSITY OF LEÓN   (Spain)

^b CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Chemotherapy; Leishmania; Polyamines; S adenosylmethionine synthetase; Trypanosomatidae

Indexed keywords

ADENOSINE TRIPHOSPHATE; DIVALENT CATION; MESSENGER RNA; METHIONINE; METHIONINE ADENOSYLTRANSFERASE; POLYAMINE; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE;

ARTICLE; BIOSYNTHESIS; CELL CULTURE; CHEMICAL ANALYSIS; CHEMOTHERAPY; ENZYME SYNTHESIS; GROWTH CURVE; KINETICS; LEISHMANIA INFANTUM; METABOLISM; NONHUMAN; PROMASTIGOTE; QUANTITATIVE ASSAY; TRANSCRIPTION REGULATION; TRYPANOSOMA;

EID: 0343820095     PISSN: 10656995     EISSN: None     Source Type: Journal    
DOI: 10.1006/cbir.1999.0416     Document Type: Article

References (18)

1. Bacchi CJ, Goldberg B, Garofalo-Hannan J, Rattendi D, Lyte P, Yarlett N. Fate of soluble methionine in african trypanosomes: effects of metabolic inhibitors. Biochem J. 309:1995;737-743.
2. Balaña-Fouce R, Cubría JC, Reguera M-R, Ordóñez D. The pharmacology of leishmaniasis. Gen Pharmacol. 30:1998;435-443.
3. Bradford MM. A rapid and sensitive method for quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 72:1976;248-254.
4. Byers TL, Bush TL, McCann PP, Bitonti P. Antitrypanosomal effects of polyamine biosynthesis inhibitors correlate with increases in Trypanosoma brucei S-adenosyl-L-methionine. Biochem J. 274:1991;527-533.
5. De Clercq E. S-Adenosylhomocysteine hydrolase inhibitors as broad spectrum antiviral agents. Biochem Pharmacol. 36:1987;2567-2575.
6. Fairlamb AH, Cerami A. Metabolism and function of trypanothione in the kinetoplastida. Annu Rev Microbiol. 46:1992;695-729.
7. Hanson S, Adelman J, Ullman B. Amplification and molecular cloning of the ornithine decarboxylase gene of Leishmania donovani. J Biol Chem. 267:1992;2350-2359.
8. Kotb M, Geller AM. Methionine adenosyltransferase: structure and function. Pharmacol Ther. 59:1993;125-143.
9. Lawrence F, Robert-Gero M. Distribution of macromolecular methylations in promastigotes of Leishmania donovani and impact of sinefungin. J Eukaryot Microbiol. 40:1993;581-589.
10. Mato JM, Álvarez L, Ortiz P, Pajares MA. S-adenosylmethionine synthesis: molecular mechanism and clinical implications. Pharmacol Ther. 73:1997;265-280.
11. Mukhopadhyay R, Kapoor P, Madhubala R. Antileishmanial effect of a potent S-adenosylmethionine decarboxylase inhibitor: CGP 40215A. Pharmacol Res. 33:1996;67-70.
12. Pajares M-A, Corrales F-J, Durán C, Mato J-M, Álvarez L. How is rat liver S-adenosylmethionine synthetase regulated? FEBS lett. 309:1992;1-4.
13. Pajares MA, Durán C, Corrales F, Pliego M-M, Mato J-M. Modulation of rat liver S-adenosylmethionine synthetase activity by glutathione. J Biol Chem. 267:1992;17,598-17,605.
14. Pajares MA, Durán C, Corrales F, Mato J-M. Protein kinase C phosphorilation of rat liver S-adenosylmethionine synthetase: dissociation and production of an active monomer. Biochem J. 303:1994;949-955.
15. Sambrook KJ, Fritsch EF, Maniatis T. Chapter title. Ford N, Nolank C, Ferguson M. Molecular Cloning: A Laboratory Manual. vol. 1,2,3. 1989;Cold Spring Harbor Laboratory Press, New York.
16. Yarlett N, Quamina A, Bacchi C-J. Protein methylases in Trypanosoma brucei brucei: activities and response to D,L-alpha-difluoromethylornithine. J Gen Microbiol. 137:1991;717-724.
17. Yarlett N, Garofalo J, Goldberg B, Ciminelli MA, Ruggiero V, Sufrin JR, Bacchi CJ. S-adenosylmethionine synthetase in bloodstream Trypanosoma brucei. Biochim Biophys Acta. 1181:1993;68-76.
18. Zappia V, Carteni-Farina M, Galletti P, Della Ragione F, Cacciapuoti G. High-performance liquid chromatographic analysis of adenosyl-sulfur compounds related to polyamine biosynthesis. Methods Enzymol. 94:1983;57-66.