Keto-acid oxidoreductases in the anaerobic protozoa

Journal of Eukaryotic Microbiology

Volumn 46, Issue 4, 1999, Pages 447-449

  Upcroft, Jacqueline A ^a   Upcroft, Peter ^a  

^a ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

Author keywords

Alternative oxoacid oxidoreductases; Entamoeba; Ferredoxin; Giardia; Metronidazole resistance; Pyruvate:ferredoxin oxidoreductase; Trichomonas

Indexed keywords

MICROBIAL ACTIVITY; PYRUVATE SYNTHASE;

ENTAMOEBA HISTOLYTICA; GIARDIA DUODENALIS; TRICHOMONAS VAGINALIS;

EID: 0033166964     PISSN: 10665234     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1550-7408.1999.tb04628.x     Document Type: Conference Paper

References (20)

1. Altman, F. P. 1981. Some aspects of the use of tetrazolium salts in quantitative histochemistry. Acta Histochemica, 24, (Suppl.):221-230.
2. Bradley, P. J., Lahti, C. J., Plümper, E. & Johnson, P. J. 1997. Targeting and translocation of proteins into the hydrogenosome of the protist Trichomonas: similarities with mitochondrial protein import. EMBO J., 16:3484-3493.
3. Brown, D. M., Upcroft, J. A., Edwards, M. R. & Upcroft, P. 1998. Anaerobic bacterial metabolism in the ancient eukaryote Giardia duodenalis. Int. J. Parasitol., 28:149-164.
4. Brown, D., Upcroft, J. A., Dodd, H. N., Chen, N. & Upcroft, P. 1999. Alternative 2-keto acid oxidoreductase activities in Trichomonas vaginalis. Mol. Biochem. Parasitol., 98:203-214.
5. Cammack, R. 1996. Iron and sulfur in the origin and evolution of biological energy conversion systems. In: Baltscheffsky, H. (ed.), Origin and Evolution of Biological Energy Conversion. VCH Publishers, New York. p. 43-49.
6. Edwards, D. I. 1993. Nitroimidazole drugs - action and resistance mechanisms. I. Mechanisms of action. J. Antimicrob. Chemother., 31: 9-20.
7. Johnson, P. J., d'Oliveira, C. E., Gorrel, T. E. & Müller, M. 1990. Molecular analysis of the hydrogenosomal ferredoxin of the anaerobic protist Trichomonas vaginalis. Proc. Natl. Acad. Sci. USA., 87:6097-6101.
8. Keeling, P. J. & Doolittle, W. F. 1997. Evidence that eukaryotic triosephosphate isomerase is of alpha-proteobacterial origin. Proc. Natl. Acad. Sci. USA, 94:1270-1275.
9. Kerscher, L. & Oesterhelt, D. 1982. Pyruvate:ferredoxin oxidoreductase - new findings on an ancient enzyme. Trends Biochem. Sci., 7: 371-374.
10. Kletzin, A. & Adams, M. W. W. 1996. Molecular and phylogenetic characterization of pyruvate and 2-ketoisovalerate ferredoxin oxidoreductases from Pyrococcus furiosus and pyruvate ferredoxin oxidoreductase-from Thermotoga maritima. J. Bacteriol., 178:248-257.
11. Kulda, J., Tachezy, J. & Erkasovová, A. 1993. In vitro induced anaerobic resistance to metronidzole in Trichomonas vaginalis. J. Euk. Microbiol., 40:262-269.
12. Ma, K., Hutchins, A., Sung, S-J, S. & Adams, M. W. W. 1997. Pyruvate ferredoxin oxidoreductase from the hyperthermophilic archaeon, Pyrococcus furiosus, functions as a CoA-dependent pyruvate decarboxylase. Proc. Natl. Acad. Sci. USA, 94:9608-9613.
13. Mai, X. & Adams, M. W. W. 1996. Characterization of a fourth type of 2-keto-acid-oxidizing enzyme from a hyperthermophile archaeon: 2-ketoglutarate ferredoxin oxidoreductase from Thermococcus litoralis. J. Bacteriol., 178:5890-5896.
14. Roger, A. J., Svard, S. G., Tovar, J., Clark, C. G., Smith, M. W., Gillin, F. D. & Sogin, M. L. 1998. A mitochondrial-like chaperonin 60 gene in Giardia lamblia: evidence that diplomonads once harboured an endosymbiont related to the progenitor of mitochondria. Proc. Natl. Acad. Sci. USA. 95:229-234.
15. Samarawickrema, N. A., Brown, D. M., Upcroft, J. A., Thammapalerd, N. & Upcroft. P. 1997. Involvement of superoxide dismutase and pyruvate: ferredoxin oxidoreductase in mechanisms of metronidazole resistance in Entamoeba histolytica. J. Antimicrob. Chemother., 40: 833-840.
16. Townson, S. M., Upcroft, J. A. & Upcroft, P. 1996. Characterisation and purification of pyruvate:ferredoxin oxidoreductase from Giardia duodenalis. Mol. Biochem. Parasitol..: xx-xx.
17. Townson, S. M., Hanson, G. R., Upcroft, J. A. & Upcroft, P. 1994. A purified ferredoxin from Giardia duodenalis. Eur. J. Biochem., 220: 439-446.
18. Townson, S. M., Laqua, H., Upcroft, P., Boreham, P. F. L. & Upcroft, J. A. 1992. Induction of metronidazole and furazolidone resistance in Giardia. Trans. R. Soc. Trop. Med., Hyg., 86:521-522.
19. Vogel, G. 1997. Searching for living relics of the cells early days. Science, 277:1604.
20. Zhang, Q., Iwasaki, T., Wakagi, T. & Oshima, T. 1996. 2-Oxoacid:ferredoxin oxidoreductase from the thermoacidophilic archaeon. Sulfolobus sp. Strain 7. J. Biochem., 120:587-599.