In vivo activity of 11β-hydroxysteroid dehydrogenase type 1 and free fatty acid-induced insulin resistance

Clinical Endocrinology

Volumn 63, Issue 4, 2005, Pages 442-449

  Mai, Knut ^a,b   Kullmann, V ^a,b   Bobbert, T ^a,b   Maser Gluth, C ^d   Mohlig M ^a,b   Bahr V ^a,b   Pfeiffer, A F H ^a   Spranger, J ^a,b   Diederich, S ^a,b,c  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^c Endokrinologikum Berlin   (Germany)

^d UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; 11BETA HYDROXYSTEROID DEHYDROGENASE TYPE 1; CORTICOTROPIN; CORTISONE ACETATE; FATTY ACID; HYDROCORTISONE; INSULIN; STEROID; UNCLASSIFIED DRUG; CORTISONE; DIAGNOSTIC AGENT; DRUG DERIVATIVE; GLUCOSE; LIPID; TETRAHYDROCORTISOL;

ARTICLE; ENZYME ACTIVITY; GLUCOSE INFUSION; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; INSULIN RESISTANCE; MALE; NORMAL HUMAN; PRIORITY JOURNAL; STATISTICAL ANALYSIS; ADULT; BLOOD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYMOLOGY; LIVER; METABOLISM; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; URINE;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ADRENOCORTICOTROPIC HORMONE; ADULT; CORTISONE; ENZYME ACTIVATION; FATTY ACIDS, NONESTERIFIED; GLUCOSE; HUMANS; HYDROCORTISONE; INSULIN; INSULIN RESISTANCE; LIPIDS; LIVER; MALE; PROSPECTIVE STUDIES; TETRAHYDROCORTISOL;

EID: 26644435979     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2005.02362.x     Document Type: Article

References (75)

1. Reaven, G.M. & Hoffman, B.B. ( 1987) A role for insulin in the aetiology and course of hypertension? Lancet, 2, 435-437.
2. DeFronzo, R.A. & Ferrannini, E. (1991) Insulin resistance. A multi-faceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care, 14, 173-194.
3. Friedman, T.C., Mastorakos, G., Newman, T.D., Mullen, N.M., Horton, E.G., Costello, R., Papadopoulos, N.M. & Chrousos, G.P. (1996) Carbohydrate and lipid metabolism in endogenous hypercortisolism: shared features with metabolic syndrome X and NIDDM. Endocrine Journal, 43, 645-655.
4. Krakoff, L.R. (1988) Glucocorticoid excess syndromes causing hypertension. Cardiology Clinics, 6, 537-545.
5. Imai, Y., Abe, K., Sasaki, S., Minami, N., Nihei, M., Munukata, M., Murakami, O., Matsue, K., Sekino, H. & Miura, Y. (1988) Altered circadian blood pressure rhythm in patients with Cushing's syndrome. Hypertension, 12, 11-19.
6. Nosadini, R., Del Prato, P.S., Tiengo, A., Valerio, A., Muggeo, M., Opocher, G., Mantero, F., Duner, E., Marescotti, C., Mollo, F. & Belloni, E (1983) Insulin resistance in Cushing's syndrome. Journal of Clinical Endocrinology and Metabolism, 57, 529-536.
7. Olefsky, J.M. & Kimmerling, G. (1976) Effects of glucocorticoids on carbohydrate metabolism. American Journal of Medical Science, 271, 202-210.
8. Perley, M. & Kipnis, D.M. (1966) Effect of glucocorticoids on plasma insulin. New England Journal of Medicine, 274, 1237-1241.
9. Yoon, J.C., Puigserver, P., Chen, G., Donovan, J., Wu, Z., Rhee, J., Adelmant, G., Stafford, J., Kahn, C.R., Granner, D.K., Newgard, C.B. & Spiegelman, B.M. (2001) Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature, 413, 131-138.
10. Hanson, R.W. & Reshef, L. (1997) Regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression. Annual Reviews of Biochemistry, 66, 581-611.
11. Friedman, J.E., Yun, J.S., Patel, Y.M., McGrane, M.M. & Hanson, R.W. (1993) Glucocorticoids regulate the induction of phosphoenolpyruvate carboxykinase (GTP) gene transcription during diabetes. Journal of Biological Chemistry, 268, 12952-12957.
12. Dimitriadis, G., Leighton, B., Parry-Billings, M., Sasson, S., Young, M., Krause, U., Bevan, S., Piva, T., Wegener, G. & Newsholme, E.A. (1997) Effects of glucocorticoid excess on the sensitivity of glucose transport and metabolism to insulin in rat skeletal muscle. Biochemical Journal, 321, 707-712.
13. Stewart, P.M., Boulton, A., Kumar, S., Clark, P.M.S. & Shackleton, C.H.L. (1999) Cortisol metabolism in human obesity: impaired cortisone to cortisol conversion in subjects with central adiposity. Journal of Clinical Endocrinology and Metabolism, 84, 1022-1027.
14. Glass, A.R., Burman, K.D., Dahms, W.T. & Boehm, T.M. (1981) Endocrine function in human obesity. Metabolism, 30, 89-104.
15. Andrews, R.C., Herlihy, O., Livingstone, D.E., Andrew, R. & Walker, B.R. (2002) Abnormal cortisol metabolism and tissue sensitivity to cortisol in patients with glucose intolerance. Journal of Clinical Endocrinology and Metabolism, 87, 5587-5593.
16. Rask, E., Walker, B.R., Soderberg, S., Livingstone, D.E., Eliasson, M., Johnson, O., Andrew, R. & Olsson, T. (2002) Tissue-specific changes in peripheral cortisol metabolism in obese women: increased adipose 11beta-hydroxysteroid dehydrogenase type 1 activity. Journal of Clinical Endocrinology and Metabolism, 87, 3330-3336.
17. Stewart, P.M. & Krozowski, Z.S. (1999) 11 Beta-hydroxysteroid dehydrogenase. Vitamins and Hormones, 57, 249-324.
18. Bahr, V., Pfeiffer, A.F. & Diederich, S. (2002) The metabolic syndrome X and peripheral cortisol synthesis. Experimental and Clinical Endocrinology and Diabetes, 110, 313-318.
19. Kotelevtsev, Y., Holmes, M.C., Burchell, A., Houston, P.M., Schmoll, D., Jamieson, P., Best, R., Brown, R., Edwards, C.R., Seckl, J.R. & Mullins, J.J. (1997) 11Beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress. Proceedings of the National Academy of Sciences of the United States of America, 94, 14924-14929.
20. Bujalska, I.J., Kumar, S. & Stewart, P.M. (1997) Does central obesity reflect 'Cushing's disease of the omentum'? Lancet, 349, 1210-1213.
21. Alberts, P., Engblom, L., Edling, N., Forsgren, M., Klingstrom, G., Larsson, C., Ronquist-Nii, Y., Ohman, B. & Abrahmsen, L. (2002) Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice. Diabetologia, 45, 1528-1532.
22. Alberts, P., Nilsson, C., Selen, G., Engblom, L.O., Edling, N.H., Norling, S., Klingstrom, G., Larsson, C., Forsgren, M., Ashkzari, M., Nilsson, C.E., Fiedler, M., Bergqvist, E., Ohman, B., Bjorkstrand, E. & Abrahmsen, L.B. (2003) Selective inhibition of 11 {beta}-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains. Endocrinology, 144, 4755-4762.
23. Golay, A., Swislocki, A.L., Chen, Y.D., Jaspan, J.B. & Reaven, G.M. (1986) Effect of obesity on ambient plasma glucose, free fatty acid, insulin, growth hormone, and glucagon concentrations. Journal of Clinical Endocrinology and Metabolism, 63, 481-484.
24. Guo, Z., Hensrud, D.D., Johnson, C.M. & Jensen, M.D. (1999) Regional postprandial fatty acid metabolism in different obesity phenotypes. Diabetes, 48, 1586-1592.
25. Bavenholm, P.N., Kuhl, J., Pigon, J., Saha, A.K., Ruderman, N.B. & Efendic, S. (2003) Insulin resistance in type 2 diabetes: association with truncal obesity, impaired fitness, and atypical malonyl coenzyme A regulation. Journal of Clinical Endocrinology and Metabolism, 88, 82-87.
26. Boden, G., Chen, X., Ruiz, J., White, J.V. & Rossetti, L. (1994) Mechanisms of fatty acid-induced inhibition of glucose uptake. Journal of Clinical Investigation, 93, 2438-2446.
27. Boden, G. (1998) Free fatty acids (FFA), a link between obesity and insulin resistance. Frontiers in Bioscience, 3, D169-D175.
28. Lam, T.K., Yoshii, H., Haber, C.A., Bogdanovic, E., Lam, L., Fantus, I.G. & Giacca, A. (2002) Free fatty acid-induced hepatic insulin resistance: a potential role for protein kinase C-delta. American Journal of Physiology. Endocrinology and Metabolism, 283, E682-E691.
29. Lam, T.K.W.G. & Giacca, A. (2003) Free fatty acids increase basal hepatic glucose production and induce hepatic insulin resistance at different sites. American Journal of Physiology. Endocrinology and Metabolism, 284, E281-E290.
30. Chen, X., Iqbal, N. & Boden, G. (1999) The effects of free fatty acids on gluconeogenesis and glycogenolysis in normal subjects. Journal of Clinical Investigation, 103, 365-372.
31. Stingl, H., Krssak, M., Krebs, M., Bischof, M.G., Nowotny, P., Furnsinn, C., Shulman, G.I., Waldhausl, W. & Roden, M. (2001) Lipid-dependent control of hepatic glycogen stores in healthy humans. Diabetologia, 44, 48-54.
32. Boden, G., Jadali, F., White, J., Liang, Y., Mozzoli, M., Chen, X., Coleman, E. & Smith, C. (1991) Effects of fat on insulin-stimulated carbohydrate metabolism in normal men. Journal of Clinical Investigation, 88, 960-966.
33. Boden, G. & Jadali, F. (1991) Effects of lipid on basal carbohydrate metabolism in normal men. Diabetes, 40, 686-692.
34. Boden, G., Chen, X., Rosner, J. & Barton, M. (1995) Effects of a 48-h fat infusion on insulin secretion and glucose utilization. Diabetes, 44, 1239-1242.
35. Boden, G. (2003) Effects of free fatty acids on gluconeogenesis and glycogenolysis. Life Sciences, 72, 977-988.
36. Baron, A.D., Brechtel, G. & Edelman, S.V. (1989) Effects of free fatty acids and ketone bodies on in vivo non-insulin-mediated glucose utilization and production in humans. Metabolism, 38, 1056-1061.
37. Ferrannini, E., Barrett, E.J., Bevilacqua, S. & Defronzo, R.A. (1983) Effect of fatty acids on glucose production and utilization in man. Journal of Clinical Investigation, 72, 1737-1747.
38. Pelkonen, R., Miettinen, T.A., Taskinen, M.R. & Nikkila, E.A. (1968) Effect of acute elevation of plasma glycerol, triglyceride and FFA levels on glucose utilization and plasma insulin. Diabetes, 17, 76-82.
39. Felber, J.P. & Vannotti, A. (1964) Effects of fat infusion on glucose tolerance and insulin plasma levels. Medicina Experimentalis. International Journal of Experimental Medicine, 10, 153-156.
40. Roden, M., Stingl, H., Chandramouli, V., Schumann, W.C., Hoter, A., Landau, B.R., Nowotny, P., Waldhausl, W. & Shulman, G.I. (2000) Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans. Diabetes, 49, 701-707.
41. Boden, G. (2002) Interaction between free fatty acids and glucose metabolism. Current Opinions in Clinical Nutrition and Metabolic Care, 5, 545-549.
42. Antras-Ferry, J., Robin, P., Robin, D. & Forest, C. (1995) Fatty acids and fibrates are potent inducers of transcription of the phosphenolpyruvate carboxykinase gene in adipocytes. European Journal of Biochemistry, 234, 390-396.
43. Massillon, D., Barzilai, N., Hawkins, M., Prus-Wertheimer, D. & Rossetti, L. (1997) Induction of hepatic glucose-6-phosphatase gene expression by lipid infusion. Diabetes, 46, 153-157.
44. Bays, H., Mandarino, L. & Defronzo, R.A. (2004) Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach. Journal of Clinical Endocrinology and Metabolism, 89, 463-478.
45. Morton, N.M., Holmes, M.C., Fievet, C., Staels, B., Tailleux, A., Mullins, J.J. & Seckl, J.R. (2001) Improved lipid and lipoprotein profile, hepatic insulin sensitivity and glucose tolerance in 11β-hydroxysteroid dehydrogenase type 1 null mice. Journal of Biological Chemistry, 276, 41293-41300.
46. Walker, B.R., Connacher, A.A., Lindsay, R.M., Webb, D.J. & Edwards, C.R.W. (1995) Carbenoxolone increases hepatic insulin sensitivity in man: a novel role for 11-oxosteroid reductase in enhancing glucocorticoid receptor activation. Journal of Clinical Endocrinology and Metabolism, 80, 3155-3159.
47. American Diabetes Association (2003) Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care, 26 (Suppl. 1), S5-S20.
48. Defronzo, R.A., Tobin, J.D. & Andres, R. (1979) Glucose clamp technique: a method for quantifying insulin secretion and resistance. American Journal of Physiology, 237, E214-E223.
49. Stewart, P.M., Wallace, A.M., Atherden, S.M., Shearing, C.H. & Edwards, C.R. (1990) Mineralocorticoid activity of carbenoxolone: contrasting effects of carbenoxolone and liquorice on 11beta-hydroxysteroid dehydrogenase activity in man. Clinical Science (Colchester), 78, 49-54.
50. Palermo, M., Shackleton, C.H.L., Mantero, F. & Stewart, P.M. (1996) Urinary free cortisone and the assessment of 11β-hydroxysteroid dehydrogenase activity in man. Clinical Endocrinology, 45, 605-611.
51. Best, R. & Walker, B.R. (1997) Additional value of measurement of urinary cortisone and unconjugated cortisol metabolites in assessing the activity of 11β-hydroxysteroid dehydrogenase in vivo. Clinical Endocrinology, 47, 231-236.
52. Andrew, R., Phillips, D.I. & Walker, B.R. (1998) Obesity and gender influence cortisol secretion and metabolism in man. Journal of Clinical Endocrinology and Metabolism, 83, 1806-1809.
53. Ulick, S., Tedde, R. & Wang, J.Z. (1992) Defective ring A reduction of cortisol as the major metabolic error in the syndrome of apparent mineralocorticoid excess. Journal of Clinical Endocrinology and Metabolism, 74, 593-599.
54. Westerbacka, J., Yki-Jarvinen, H., Vehkavaara, S., Hakkinen, A.M., Andrew, R., Wake, D.J., Seckl, J.R. & Walker, B.R. (2003) Body fat distribution and cortisol metabolism in healthy men: enhanced 5beta-reductase and lower cortisol/cortisone metabolite ratios in men with fatty liver. Journal of Clinical Endocrinology and Metabolism, 88, 4924-4931.
55. Maser-Gluth, C., Reincke, M., Allolio, B. & Schulze, E. (2000) Metabolism of glucocorticoids and mineralocorticoids in patients with adrenal incidentalomas. European Journal of Clinical Investigation, 30, 83-86.
56. Dimitriou, T., Maser-Gluth, C. & Remer, T. (2003) Adrenocortical activity in healthy children is associated with fat mass. American Journal of Clinical Nutrition, 77, 731-736.
57. Defronzo, R.A., Gunnarsson, R., Bjorkman, O., Olsson, M. & Wahren, J. (1985) Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus. Journal of Clinical Investigation, 76, 149-155.
58. Kruszynska, Y.T., Olefsky, J.M. & Prias, J.P. (2003) Effect of obesity on susceptibility to fatty acid-induced peripheral tissue insulin resistance. Metabolism, 52, 233-238.
59. Li, L. & Yang, G.Y. (2004) Effect of hepatic glucose production on acute insulin resistance induced by lipid-infusion in awake rats. World Journal of Gastroenterology, 10, 3208-3211.
60. Rask, E., Olsson, T., Soderberg, S., Andrew, R., Livingstone, D.E., Johnson, O. & Walker, B.R. (2001) Tissue-specific dysregulation of cortisol metabolism in human obesity. Journal of Clinical Endocrinology and Metabolism, 86, 1418-1421.
61. Masuzaki, H., Paterson, J., Shinyama, H., Morton, N.M., Mullins, J.J., Seckl, J.R. & Flier, J.S. (2001) A transgenic model of visceral obesity and the metabolic syndrome. Science, 294, 2166-2170.
62. Masuzaki, H., Yamamoto, H., Kenyon, C.J., Elmquist, J.K., Morton, N.M., Paterson, J.M., Shinyama, H., Sharp, M.G., Fleming, S., Mullins, J.J., Seckl, J.R. & Flier, J.S. (2003) Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice. Journal of Clinical Investigation, 112, 83-90.
63. Paterson, J.M., Morton, N.M., Fievet, C., Kenyon, C.J., Holmes, M.C., Staels, B., Seckl, J.R. & Mullins, J.J. (2004) Metabolic syndrome without obesity: hepatic overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America, 101, 7088-7093.
64. Livingstone, D.E.W., Jones, G.C., Smith, K., Jamieson, P.M., Andrew, R., Kenyon, C.J. & Walker, B.R. (2000) Understanding the role of glucocorticoids in obesity: tissue-specific alterations of corticosterone metabolism in obese Zucker rats. Endocrinology, 141, 560-563.
65. Tomlinson, J.W., Moore, J.S., Clark, P.M., Holder, G., Shakespeare, L. & Stewart, P.M. (2004) Weight loss increases 11beta-hydroxysteroid dehydrogenase type 1 expression in human adipose tissue. Journal of Clinical Endocrinology and Metabolism, 89, 2711-2716.
66. Paulmyer-Lacroix, O., Boullu, S., Oliver, C., Alessi, M.C. & Grino, M. (2002) Expression of the mRNA coding for 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue from obese patients: an in situ hybridization study. Journal of Clinical Endocrinology and Metabolism, 87, 2701-2705.
67. Lindsay, R.S., Wake, D.J., Nair, S., Bunt, J., Livingstone, D.E., Permana, P.A., Tataranni, P.A. & Walker, B.R. (2003) Subcutaneous adipose 11beta-hydroxysteroid dehydrogenase type 1 activity and messenger ribonucleic acid levels are associated with adiposity and insulinemia in Pima Indians and Caucasians. Journal of Clinical Endocrinology and Metabolism, 88, 2738-2744.
68. Engeli, S., Bohnke, J., Feldpausch, M., Gorzelniak, K., Heintze, U., Janke, J., Luft, F.C. & Sharma, A.M. (2004) Regulation of 11beta-HSD genes in human adipose tissue: influence of central obesity and weight loss. Obesity Research, 12, 9-17.
69. Hermanowski-Vosatka, A., Gerhold, D., Mundt, S.S., Loving, V.A., Lu, M., Chen, Y., Elbrecht, A., Wu, M., Doebber, T., Kelly, L., Milot, D., Guo, Q., Wang, P.R., Ippolito, M., Chao, Y.S., Wright, S.D. & Thieringer, R. (2000) PPARalpha agonists reduce 11beta-hydroxysteroid dehydrogenase type 1 in the liver. Biochemical and Biophysical Research Communications, 279, 330-336.
70. Kliewer, S.A., Sundseth, S.S., Jones, S.A., Brown, P.J., Wisely, G.B., Koble, C.S., Devchand, P., Wahli, W., Willson, T.M., Lenhard, J.M. & Lehmann, J.M. (1997) Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma. Proceedings of the National Academy of Sciences of the United States of America, 94, 4318-4323.
71. Bisschop, P.H., Ackermans, M.T., Endert, E., Ruiter, A.F., Meijer, A.J., Kuipers, F., Sauerwein, H.P. & Romijn, J.A. (2002) The effect of carbohydrate and fat variation in euenergetic diets on postabsorptive free fatty acid release. British Journal of Nutrition, 87, 555-559.
72. Morton, N.M., Ramage, L. & Seckl, J.R. (2004) Down-regulation of adipose 11beta-hydroxysteroid dehydrogenase type 1 by high-fat feeding in mice: a potential adaptive mechanism counteracting metabolic disease. Endocrinology, 145, 2707-2712.
73. Livingstone, D.E., Kenyon, C.J. & Walker, B.R. (2000) Mechanisms of dysregulation of 11beta-hydroxysteroid dehydrogenase type 1 in obese Zucker rats. Journal of Endocrinology, 167, 533-539.
74. Walker, B.R. (2000) How will we know if 11beta-hydroxysteroid dehydrogenases are important in common diseases. Clinical Endocrinology, 52, 401-402.
75. Quinkler, M., Troeger, H., Eigendorff, E., Maser-Gluth, C., Stiglic, A., Oelkers, W., Bahr, V. & Diederich, S. (2003) Enhanced 11beta-hydroxysteroid dehydrogenase type 1 activity in stress adaptation in the guinea pig. Journal of Endocrinology, 176, 185-192.