Effects of free fatty acids on gluconeogenesis and glycogenolysis

Life Sciences

Volumn 72, Issue 9, 2003, Pages 977-988

  Boden, Guenther ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

FFA; Gluconeogenesis; Glycogenolysis; Insulin; Type 2 diabetes

Indexed keywords

AMINO ACID; C PEPTIDE; DEUTERIUM OXIDE; FATTY ACID; GLUCONIC ACID; GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLUCOSE 6 PHOSPHATE; GLYCEROL; GLYCOGEN; INSULIN; KETONE BODY; LACTIC ACID; LIPID; NICOTINIC ACID; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PYRUVIC ACID;

AUTOREGULATION; CARBOHYDRATE ANALYSIS; CARBON NUCLEAR MAGNETIC RESONANCE; CENTRAL NERVOUS SYSTEM; DIABETES MELLITUS; DIET RESTRICTION; FATTY ACID BLOOD LEVEL; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE UTILIZATION; GLYCOGENOLYSIS; HEPARINIZATION; HORMONAL REGULATION; HORMONE ACTION; HUMAN; HYPERGLYCEMIA; HYPERINSULINEMIA; INSULIN DEFICIENCY; INSULIN RELEASE; INSULIN RESISTANCE; LIVER; METHODOLOGY; NON INSULIN DEPENDENT DIABETES MELLITUS; PROTEIN BLOOD LEVEL; QUANTITATIVE ASSAY; REGULATORY MECHANISM; SHORT SURVEY; STARVATION;

DIABETES MELLITUS, TYPE 2; FASTING; FATTY ACIDS, NONESTERIFIED; GLUCONEOGENESIS; GLYCOGEN; HUMANS; INSULIN; INSULIN RESISTANCE;

EID: 0037449380     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(02)02350-0     Document Type: Short Survey

References (37)

1. Bergman R.N. Non-esterified fatty acids and the liver: why is insulin secreted into the portal vein? Diabetologia. 43:2000;946-952.
2. Bevilacqua S., Buzzigoli G., Bonadonna R., Brandi S., Oleggini M., Boni C., Geloni M., Ferrannini E. Operation of Randle's cycle in patients with NIDDM. Diabetes. 39:1990;383-389.
3. Boden G. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes. 46:1997;3-10.
4. Boden G., Chen X. Effects of fatty acids and ketone bodies on basal insulin secretion in type 2 diabetes. Diabetes. 48:1999;577-583.
5. Boden G., Chen X., Capulong E., Mozzoli M. Effects of free fatty acids on gluconeo-genesis and autoregulation of glucose production in type 2 diabetes. Diabetes. 50:2001;810-816.
6. Boden G., Chen X., Iqbal N. Acute lowering of plasma fatty acids lowers basal insulin secretion in diabetic and nondiabetic subjects. Diabetes. 47:1998;1609-1612.
7. Boden G., Chen X., Rosner J.et al. Effects of a 48-h fat infusion on insulin secretion and glucose utilization. Diabetes. 44:1995;1239-1242.
8. Boden G., Chen X., Ruiz J., White J.V., Rossetti L. Mechanisms of fatty acid-induced inhibition of glucose uptake. J Clin Invest. 93:1994;2438-2446.
9. Boden G., Chen X., Stein T.P. Gluconeogenesis in moderately and severely hypergly-cemic patients with type 2 diabetes mellitus. Am J Physiol. 280:2001;E23-E30.
10. Boden G., Cheung P., Stein T.P., Kresge K., Mozzzoli M. FFA cause hepatic insulin resistance by inhibiting insulin suppression of glycogenolysis. Am J Physiol. 283:2002;E12-E19.
11. Boden G., Jadali F. Effects of lipid on basal carbohydrate metabolism in normal men. Diabetes. 40:1991;686-692.
12. Cahill G.F. Jr. Starvation in man. N Engl J Med. 282:1970;668-675.
13. Chen X., Iqbal N., Boden G. The effects of free fatty acids on gluconeogenesis and glycogenolysis in normal subjects. J Clin Invest. 103:1999;365-372.
14. Cimbala M.A., Lamers W.H., Nelson K., Monahan J.E., Yoo-Warren H., Hanson R.W. Rapid changes in the concentration of phosphoenolpyruvate carboxykinase gene transcription: the dominant role of insulin. J Biol Chem. 257:1982;7629-7636.
15. Clore J.N., Glickman P.S., Nestler J.E., Blackard W.G. In vivo evidence for hepatic autoregulation during FFA-stimulated gluconeogenesis in normal humans. Am J Physiol. 261:1991;E524-E429.
16. Crespin S.R., Greenough W.B., Steinberg D. Stimulation of insulin secretion by long-chain free fatty acids. J Clin Invest. 52:1973;1979-1984.
17. Edgerton D.S., Carin S., Emshwiller M., Neal D., Chandramouli V., Schumann W.C., Landau B.R., Rossetti L., Cherrington A.D. Small increases in insulin inhibit hepatic glucose production solely caused by an effect of glycogen metabolism. Diabetes. 50:2001;1872-1882.
18. Fanelli C., Calderone S., Epifano L., DeVincenzo A., Modarelli F., Pampanelli S., Perriello G., DeFeo P., Brunetti P., Gerich J.E., Bolli G.B. Demonstration of a critical role for free fatty acids in mediating counterregulatory stimulation of gluconeogenesis and suppression of glucose utilization in humans. J Clin Invest. 92:1993;1617-1622.
19. Ferrannini E., Barrett E., Bevilacqua S., DeFronzo R. Effect of fatty acids on glucose production and utilization in man. J Clin Invest. 72:1983;1737-1747.
20. Gastaldelli A., Baldi S., Pettiti M., Toschi E., Camastra S., Natali A., Landau B.R., Ferrannini E. Influence of obesity and type 2 diabetes on gluconeogenesis and glucose output in humans. Diabetes. 49:2000;1367-1373.
21. Gastaldelli A., Toschi E., Pettiti M., Frascerra S., Quinones-Galvan A., Sironi A.M., Natali A., Ferrannini E. Effect of physiological hyperinsulinemia on gluconeogenesis in nondiabetic subjects and in type 2 diabetic patients. Diabetes. 50:2001;1807-1812.
22. Hanson R.W., Reshef L. Regulation of phosphoenolpyruvate carboxykinase mRNA in rat liver and kidney: effects of insulin and cyclic AMP. Annu Rev Biochem. 66:1997;581-611.
23. Hellerstein M.K., Neese R.A., Linfoot P., Christiansen M., Turner S., Letscher A. Hepatic gluconeogenic fluxes and glycogen turnover during fasting in humans. A stable isotope study. J Clin Invest. 100:1997;1305-1319.
24. Jensen T., Nurjhan N., Consoli A., Gerich J.E. Failure of substrate-induced gluconeo-genesis to increase overall glucose appearance in normal humans: demonstration of hepatic autoregulation without a change in plasma glucose concentration. J Clin Invest. 86:1990;489-497.
25. Jomain-Baum M., Hanson R.W. Regulation of hepatic gluconeogenesis in the guinea pig by fatty acids and ammonia. J Biol Chem. 250:1975;8978-8985.
26. Katz J. Determination of gluconeogenesis in vivo with 14C-labeled substrates. Am J Physiol Regulatory Intergrative Comp Physiol. 248:1985;R391-R399.
27. Katz J., Tayek J.A. Gluconeogenesis and the Cori cycle in 12-, 20-, and 40-h-fasted humans. Am J Physiol. 275:1998;E537-E542.
28. Landau B.R. Methods for measuring glycogen cycling. Am J Physiol. 281:2001;E413.
29. Landau B.R., Wahren J., Chandramouli V., Schumann W.C., Ekberg K., Kalhan S.C. Contributions of gluconeogenesis to glucose production in the fasted state. J Clin Invest. 98:1996;378-385.
30. Magnusson I., Rothman D.L., Katz L.D., Shulman R.G., Shulman G.I. Increased rate of gluconeogenesis in type II diabetes mellitus. J Clin Invest. 90:1992;1323-1327.
31. Roden M., Stingl H., Chandramouli V., Schumann W.C., Hofer A., Landau B.R., Nowotny P., Waldhausl W., Shulman G.I. Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans. Diabetes. 49:2000;701-707.
32. 13C NMR. Science. 254:1991;573-576.
33. Saloranta C., Koivisto V., Widen E., Falholt K., DeFronzo R., Harkonen M., Groop L. Contribution of muscle and liver to glucose-fatty acid cycle in humans. Am J Physiol. 264:1993;E599-E605.
34. Santomauro A., Boden G., Silva M.et al. Overnight lowering of free fatty acids with acipimox improves insulin resistance and glucose tolerance in obese diabetic and non-diabetic subjects. Diabetes. 48:1999;1836-1841.
35. Sasaki K., Cripe T.P., Koch S.R., Andreone T.L., Petersen D.D., Beale E.G., Granner D.K. Multi-hormonal regulation of phosphoenolpyruvate carboxykinase gene transcription: the dominant role of insulin. J Biol Chem. 259:1984;15242-15251.
36. Shah P., Vella A., Basu A., Basu R., Adkins A., Schwenk W.F., Johnson C.M., Nair K.S., Jensen M.D., Rizza R.A. Effects of free fatty acids and glycerol on splanchnic glucose metabolism and insulin extraction in nondiabetic humans. Diabetes. 51:2002;301-310.
37. Wajngot A., Chandramouli V., Schumann W.C., Ekberg K., Jones P.K., Efendic S., Landau B.R. Quantitative contributions of gluconeogenesis to glucose production during fasting in type 2 diabetes mellitus. Metabolism. 50:2001;47-52.