Targeting poly(ADP-ribosyl)ation: A promising approach in cancer therapy

Trends in Molecular Medicine

Volumn 11, Issue 10, 2005, Pages 456-463

  Haince, Jean François ^a   Rouleau, Michèle ^a   Hendzel, Michael J ^b   Masson, Jean Yves ^a   Poirier, Guy G ^a  

^a LAVAL UNIVERSITY   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXY 2 METHYL 4(3H) QUINAZOLINONE; AG 014699; AG 14361; ALKYLATING AGENT; BRCA1 PROTEIN; BRCA2 PROTEIN; CEP 6800; CISPLATIN; DNA TOPOISOMERASE INHIBITOR; FR 255595; INO 1001; IRINOTECAN; N (5,6 DIHYDRO 6 OXO 2 PHENANTHRIDINYL) 2 DIMETHYLAMINOACETAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; POLY(ADENOSINE DIPHOSPHATE RIBOSE); TEMOZOLOMIDE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; CANCER THERAPY; CLINICAL TRIAL; COLON CARCINOMA; COLORECTAL CANCER; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA STRAND BREAKAGE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LOCALIZATION; GAMMA IRRADIATION; GLIOBLASTOMA; HUMAN; LUNG NON SMALL CELL CANCER; METABOLISM; NONHUMAN; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION;

DNA REPAIR; GENE COMPONENTS; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; INDOLES; MODELS, MOLECULAR; NEOPLASMS; PHENANTHRENES; PIPERAZINES; POLY(ADP-RIBOSE) POLYMERASES; QUINAZOLINES; QUINAZOLINONES; SIGNAL TRANSDUCTION;

EID: 26244461881     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmed.2005.08.003     Document Type: Review

References (68)

1. P. Jagtap, and C. Szabo Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors Nat. Rev. Drug Discov. 4 2005 421 440
2. H.E. Bryant Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase Nature 434 2005 913 917
3. H. Farmer Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy Nature 434 2005 917 921
4. E. Gallmeier, and S.E. Kern Absence of specific cell killing of the BRCA2-deficient human cancer cell line CAPAN1 by Poly(ADP-ribose) polymerase inhibition Cancer Biol. Ther. 4 2005 70 73
5. D. D'Amours Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions Biochem. J. 342 1999 249 268
6. M. Malanga, and F.R. Althaus The role of poly(ADP-ribose) in the DNA damage signaling network Biochem. Cell Biol. 83 2005 354 364
7. T. Lindahl Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks Trends Biochem. Sci. 20 1995 405 411
8. J.C. Ame The PARP superfamily BioEssays 26 2004 882 893
9. M.E. Bonicalzi Poly-ADP-ribosylation in health and disease: Regulation of poly(ADP-ribose) metabolism by poly(ADP-ribose) glycohydrolase: where and when? Cell. Mol. Life Sci. 62 2005 739 750
10. E. Petermann Poly-ADP-ribosylation in health and disease: Importance of poly(ADP-ribose) polymerases in the regulation of DNA-dependent processes Cell. Mol. Life Sci. 62 2005 731 738
11. M. Rouleau Poly(ADP-ribosyl)ated chromatin domains: access granted J. Cell Sci. 117 2004 815 825
12. J.B. Leppard Physical and functional interaction between DNA ligase IIIalpha and poly(ADP-Ribose) polymerase 1 in DNA single-strand break repair Mol. Cell. Biol. 23 2003 5919 5927
13. S.F. El-Khamisy A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage Nucleic Acids Res. 31 2003 5526 5533
14. R. Prasad DNA polymerase beta-mediated long patch base excision repair. Poly(ADP-ribose)polymerase-1 stimulates strand displacement DNA synthesis J. Biol. Chem. 276 2001 32411 32414
15. J.M. Pleschke Poly(ADP-ribose) binds to specific domains in DNA damage checkpoint proteins J. Biol. Chem. 275 2000 40974 40980
16. M.L. Meyer-Ficca Human poly(ADP-ribose) glycohydrolase is expressed in alternative splice variants yielding isoforms that localize to different cell compartments Exp. Cell Res. 297 2004 521 532
17. H. Thomassin Poly(ADP-ribosyl)ation of chromatin in an in-vitro poly(ADP-ribose)-turnover system Biochim. Biophys. Acta 1137 1992 171 181
18. U. Cortes Depletion of the 110-kilodalton isoform of poly(ADP-ribose) glycohydrolase increases sensitivity to genotoxic and endotoxic stress in mice Mol. Cell. Biol. 24 2004 7163 7178
19. D.W. Koh Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality Proc. Natl. Acad. Sci. U. S. A. 101 2004 17699 17704
20. S. Hanai Loss of poly(ADP-ribose) glycohydrolase causes progressive neurodegeneration in Drosophila melanogaster Proc. Natl. Acad. Sci. U. S. A. 101 2004 82 86
21. D. Koh The Road to Survival Goes through PARG Cell Cycle 4 2005 397 399
22. N.S. Patel Mice lacking the 110-kD isoform of poly(ADP-ribose) glycohydrolase are protected against renal ischemia/reperfusion injury J. Am. Soc. Nephrol. 16 2005 712 719
23. C. Arnaudeau DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells J. Mol. Biol. 307 2001 1235 1245
24. A. Tutt, and A. Ashworth The relationship between the roles of BRCA genes in DNA repair and cancer predisposition Trends Mol. Med. 8 2002 571 576
25. M.E. Moynahan Brca1 controls homology-directed DNA repair Mol. Cell 4 1999 511 518
26. T.M. Rudkin, and W.D. Foulkes BRCA2: breaks, mistakes and failed separations Trends Mol. Med. 11 2005 145 148
27. A.A. Davies Role of BRCA2 in control of the RAD51 recombination and DNA repair protein Mol. Cell 7 2001 273 282
28. L. Pellegrini Insights into DNA recombination from the structure of a RAD51-BRCA2 complex Nature 420 2002 287 293
29. Y.G. Yang Ablation of PARP-1 does not interfere with the repair of DNA double-strand breaks, but compromises the reactivation of stalled replication forks Oncogene 23 2004 3872 3882
30. N. Schultz Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination Nucleic Acids Res. 31 2003 4959 4964
31. M.S. Satoh, and T. Lindahl Role of poly(ADP-ribose) formation in DNA repair Nature 356 1992 356 358
32. S. Shall, and G. de Murcia Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model? Mutat. Res. 460 2000 1 15
33. J. Menissier de Murcia Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse EMBO J. 22 2003 2255 2263
34. J.M. de Murcia Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells Proc. Natl. Acad. Sci. U. S. A. 94 1997 7303 7307
35. C. Trucco DNA repair defect in poly(ADP-ribose) polymerase-deficient cell lines Nucleic Acids Res. 26 1998 2644 2649
36. M. Audebert Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining J. Biol. Chem. 279 2004 55117 55126
37. L. Tartier Local DNA damage by proton microbeam irradiation induces poly(ADP-ribose) synthesis in mammalian cells Mutagenesis 18 2003 411 416
38. M.S. Satoh Dual function for poly(ADP-ribose) synthesis in response to DNA strand breakage Biochemistry 33 1994 7099 7106
39. M. Malanga, and F.R. Althaus Poly(ADP-ribose) reactivates stalled DNA topoisomerase I and Induces DNA strand break resealing J. Biol. Chem. 279 2004 5244 5248
40. S.J. Veuger Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair Oncogene 23 2004 7322 7329
41. S.J. Veuger Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1 Cancer Res. 63 2003 6008 6015
42. M. Weinfeld Interaction of DNA-dependent protein kinase and poly(ADP-ribose) polymerase with radiation-induced DNA strand breaks Radiat. Res. 148 1997 22 28
43. T. Ruscetti Stimulation of the DNA-dependent protein kinase by poly(ADP-ribose) polymerase J. Biol. Chem. 273 1998 14461 14467
44. G. Graziani, and C. Szabo Clinical perspectives of PARP inhibitors Pharmacol. Res. 52 2005 109 118
45. C.R. Calabrese Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361 J. Natl. Cancer Inst. 96 2004 56 67
46. L. Tentori Potential clinical applications of poly(ADP-ribose) polymerase (PARP) inhibitors Pharmacol. Res. 45 2002 73 85
47. S. Beneke Poly(ADP-ribosyl)ation inhibitors: promising drug candidates for a wide variety of pathophysiologic conditions Int. J. Cancer 111 2004 813 818
48. M. Masutani Role of poly(ADP-ribose) polymerase in cell-cycle checkpoint mechanisms following gamma-irradiation Biochimie 77 1995 462 465
49. E.L. Jacobson Cell cycle perturbations following DNA damage in the presence of ADP-ribosylation inhibitors Carcinogenesis 6 1985 711 714
50. J. Wesierska-Gadek Increased susceptibility of poly(ADP-ribose) polymerase-1 knockout cells to antitumor triazoloacridone C-1305 is associated with permanent G2 cell cycle arrest Cancer Res. 64 2004 4487 4497
51. L. Tentori Brain distribution and efficacy as chemosensitizer of an oral formulation of PARP-1 inhibitor GPI 15427 in experimental models of CNS tumors Int. J. Oncol. 26 2005 415 422
52. E.R. Plummer Temozolomide pharmacodynamics in patients with metastatic melanoma: dna damage and activity of repair enzymes O6-alkylguanine alkyltransferase and poly(ADP-ribose) polymerase-1 Clin. Cancer Res. 11 2005 3402 3409
53. S.J. Miknyoczki Chemopotentiation of temozolomide, irinotecan, and cisplatin activity by CEP-6800, a poly(ADP-ribose) polymerase inhibitor Mol. Cancer Ther. 2 2003 371 382
54. W.A. Brock Radiosensitization of human and rodent cell lines by INO-1001, a novel inhibitor of poly(ADP-ribose) polymerase Cancer Lett. 205 2004 155 160
55. M. Tsutsumi Increased susceptibility of poly(ADP-ribose) polymerase-1 knockout mice to nitrosamine carcinogenicity Carcinogenesis 22 2001 1 3
56. A. Shibata Parp-1 deficiency causes an increase of deletion mutations and insertions/rearrangements in vivo after treatment with an alkylating agent Oncogene 24 2005 1328 1337
57. C. Morrison Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis Nat. Genet. 17 1997 479 482
58. J.N. Dynek, and S. Smith Resolution of sister telomere association is required for progression through mitosis Science 304 2004 97 100
59. P. Chang Poly(ADP-ribose) is required for spindle assembly and structure Nature 432 2004 645 649
60. M. Katoh Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31 Int. J. Oncol. 23 2003 541 547
61. R.C. Aguiar BAL is a novel risk-related gene in diffuse large B-cell lymphomas that enhances cellular migration Blood 96 2000 4328 4334
62. J. Bartkova DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis Nature 434 2005 864 870
63. J.H. Hoeijmakers Genome maintenance mechanisms for preventing cancer Nature 411 2001 366 374
64. Curtin, N.J. (2003) PARP-1: A new target for cancer treatment. In Cancer Research UK Scientific Yearbook 2002-03, pp. 52-54
65. K.J. Bowman Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064 Br. J. Cancer 78 1998 1269 1277
66. G.E. Abdelkarim Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke Int. J. Mol. Med. 7 2001 255 260
67. P. Pacher A new, potent poly(ADP-ribose) polymerase inhibitor improves cardiac and vascular dysfunction associated with advanced aging J. Pharmacol. Exp. Ther. 311 2004 485 491
68. A. Iwashita Neuroprotective effects of a novel poly(ADP-ribose) polymerase-1 inhibitor, 2-[3-[4-(4-chlorophenyl)-1-piperazinyl] propyl]-4(3H)-quinazolinone (FR255595), in an in vitro model of cell death and in mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease J. Pharmacol. Exp. Ther. 309 2004 1067 1078