A new, potent poly(ADP-ribose) polymerase inhibitor improves cardiac and vascular dysfunction associated with advanced aging

Journal of Pharmacology and Experimental Therapeutics

Volumn 311, Issue 2, 2004, Pages 485-491

  Pacher, Pál ^a,b,d   Vaslin, Anne ^a   Benko, Rita ^a,d   Mabley, Jon G ^a   Liaudet, Lucas ^e   Haskó, György ^c,f   Marton, Anita ^a   Bátkai, Sándor ^b   Kollai, Márk ^d   Szabó, Csaba ^a,d,f  

^a INOTEK CORPORATION   (United States)

^b NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^c INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^d SEMMELWEIS UNIVERSITY   (Hungary)

^e LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^f RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; INO 1001; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; NITRIC OXIDE; OXIDIZING AGENT; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; DIABETES MELLITUS; DIASTOLE; DISEASE ASSOCIATION; DRUG POTENCY; ENDOTHELIUM CELL; ENZYME INHIBITION; HEART DISEASE; HEART VENTRICLE REMODELING; HYPERTENSION; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PATHOPHYSIOLOGY; PRESSURE VOLUME CURVE; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SHOCK; SYSTOLE; VASCULAR DISEASE; VASCULAR RING;

AGING; ANIMALS; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; HEART DISEASES; HEART FUNCTION TESTS; INDOLES; MALE; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, INBRED F344; VASCULAR DISEASES; VENTRICULAR REMODELING;

EID: 6344256347     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.069658     Document Type: Article

References (40)

1. Anversa P, Puntillo E, Nikitin P, Olivetti G, Capasso JM, and Sonnenblick EH (1989) Effects of age on mechanical and structural properties of myocardium of Fischer 344 rats. Am J Physiol 256:H1440-H1449.
2. Beckman JS and Koppenol WH (1996) Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Physiol 271:C1424-C1437.
3. Bejma J, Ramires P, and Ji LL (2000) Free radical generation and oxidative stress with ageing and exercise: differential effects in the myocardium and liver. Acta Physiol Scand 169:343-351.
4. Boluyt MO, Converso K, Hwang HS, Mikkor A, and Russell MW (2004) Echocardiographic assessment of age-associated changes in systolic and diastolic function of the female F344 rat heart. J Appl Physiol 96:822-828.
5. Burkart V, Wang ZQ, Radons J, Heller B, Herceg Z, Stingl L, Wagner EF, and Kolb H (1999) Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozotocin. Nat Med 5:314-319.
6. Capasso JM, Palackal T, Olivetti G, and Anversa P (1990) Severe myocardial dysfunction induced by ventricular remodeling in aging rat hearts. Am J Physiol 259:H1086-H1096.
7. Csiszar A, Ungvari Z, Edwards JG, Kaminski P, Wolin MS, Koller A, and Kaley G (2002) Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function. Circ Res 90:1159-1166.
8. Du X, Matsumura T, Edelstein D, Rossetti L, Zsengeller Z, Szabó C, and Brownlee M (2003) Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells. J Clin Investig 112:1049-1057.
9. Eiserich JP, Hristova M, Cross CE, Jones AD, Freeman BA, Halliwell B, and van der Vliet A (1998) Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils. Nature (Lond) 391:393-397.
10. Halliwell B (1997) What nitrates tyrosine? Is nitrotyrosine specific as a biomarker of peroxynitrite formation in vivo? FEBS Lett 411:157-160.
11. Hamilton ML, Van Remmen H, Drake JA, Yang H, Guo ZM, Kewitt K, Walter CA, and Richardson A (2001) Does oxidative damage to DNA increase with age? Proc Natl Acad Sci USA 98:10469-10474.
12. Hatake K, Kakishita E, Wakabayashi I, Sakiyama N, and Hishida S (1990) Effect of aging on endothelium-dependent vascular relaxation of isolated human basilar artery to thrombin and bradykinin. Stroke 21:1039-1043.
13. Higashi Y, Oshima T, Ozono R, Matsuura H, and Kajiyama G (1997) Aging and severity of hypertension attenuate endothelium-dependent renal vascular relaxation in humans. Hypertension 30:252-258.
14. Inoue M and Inoue K (1996) Role of free radicals in and around vascular endothelial cells in the mechanism of aging. Ann NY Acad Sci 786:224-232.
15. Kass DA, Maughan WL, Guo ZM, Kono A, Sunagawa K, and Sagawa K (1987) Comparative influence of load versus inotropic states on indexes of ventricular contractility: experimental and theoretical analysis based on pressure-volume relationships. Circulation 76:1422-1436.
16. Khan TA, Ruel M, Bianchi C, Voisine P, Komjati K, Szabó C, and Sellke FW (2003) Poly(ADP-ribose) polymerase inhibition improves postischemic myocardial function after cardioplegia-cardiopulmonary bypass. J Am Coll Surg 197:270-277.
17. Lakatta EG (2003) Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part III: cellular and molecular clues to heart and arterial aging. Circulation 107:490-497.
18. Little WC (1985) The left ventricular dP/dtmax-end-diastolic volume relation in closed-chest dogs. Circ Res 56:808-815.
19. Murakami K, Enkhbaatar P, Shimoda K, Cox RA, Burke AS, Hawkins HK, Traber LD, Schmalstieg FC, Salzman AL, Mabley JG, et al. (2004) Inhibition of poly (ADP-ribose) polymerase attenuates acute lung injury in an ovine model of sepsis. Shock 21:126-133.
20. Nakano K, Sugawara M, Ishihara K, Kanazawa S, Corin WJ, Denslow S, Biederman RW, and Carabello BA (1990) Myocardial stiffness derived from end-systolic wall stress and logarithm of reciprocal of wall thickness. Contractility index independent of ventricular size. Circulation 82:1352-1361.
21. Navarro A, Gomez C, Lopez-Cepero JM, and Boveris A (2004) Beneficial effects of moderate exercise on mice aging: survival, behavior, oxidative stress, and mitochondrial electron transfer. Am J Physiol Regul Integr Comp Physiol 286:R505-R511.
22. Pacher P, Cziraki A, Mabley JG, Liaudet L, Papp L, and Szabó C (2002a) Role of poly(ADP-ribose) polymerase activation in endotoxin-induced cardiac collapse in rodents. Biochem Pharmacol 64:1785-1791.
23. Pacher P, Liaudet L, Bai P, Mabley JG, Kaminski PM, Virâg L, Deb A, Szabo E, Ungvári Z, Wolin MS, et al. (2003) Potent metalloporphyrin peroxynitrite decomposition catalyst protects against the development of doxorubicin-induced cardiac dysfunction. Circulation 107:896-904.
24. Pacher P, Liaudet L, Bai F, Virág L, Mabley JG, Haskó G, and Szabó C (2002b) Activation of poly(ADP-ribose) polymerase contributes to development of doxorubicin-induced heart failure. J Pharmacol Exp Ther 300:862-867.
25. Pacher P, Liaudet L, Mabley J, Komjati K, and Szabo C (2002c) Pharmacologic inhibition of poly(adenosine diphosphate-ribose) polymerase may represent a novel therapeutic approach in chronic heart failure. J Am Coll Cardiol 40:1006-1016.
26. Pacher P, Liaudet L, Soriano FG, Mabley JG, Szabó E, and Szabó C (2002d) The role of poly(ADP-ribose) polymerase activation in the development of myocardial and endothelial dysfunction in diabetes. Diabetes 51:514-521.
27. Pacher P, Mabley JG, Soriano FG, Liaudet L, Komjati K, and Szabó C (2002e) Endothelial dysfunction in aging animals: the role of poly(ADP-ribose) polymerase activation. Br J Pharmacol 135:1347-1350.
28. Rodriguez-Martinez MA, Alonso MJ, Redondo J, Salaices M, and Marin J (1998) Role of lipid peroxidation and the glutathione-dependent antioxidant system in the impairment of endothelium-dependent relaxations with age. Br J Pharmacol 123: 113-121.
29. Shimoda K, Murakami K, Enkhbaatar P, Traber LD, Cox RA, Hawkins HK, Schmalstieg FC, Komjati K, Mabley JG, Szabó C, et al. (2003) Effect of poly(ADP ribose) synthetase inhibition on burn and smoke inhalation injury in sheep. Am J Physiol Lung Cell Mol Physiol 285:L240-L249.
30. Soriano FG, Pacher P, Mabley J, Liaudet L, and Szabó C (2001a) Rapid reversal of the diabetic endothelial dysfunction by pharmacological inhibition of poly(ADP-Ribose) polymerase. Circ Res 89:684-691.
31. Soriano FG, Virág L, Jagtap P, Szabó E, Mabley JG, Liaudet L, Márton A, Hoyt DG, Murthy KG, Salzman AL, et al. (2001b) Diabetic endothelial dysfunction: the role of poly (ADP-ribose) polymerase activation. Nat Med 7:108-113.
32. Suh JH, Shigeno ET, Morrow JD, Cox B, Rocha AE, Frei B, and Hagen TM (2001) Oxidative stress in the aging rat heart is reversed by dietary supplementation with (R)-(alpha)-lipoic acid. FASEB J 15:700-706.
33. Szabo C, Cuzzocrea S, Zingarelli B, O'Connor M, and Salzman AL (1997) Endothelial dysfunction in a rat model of endotoxic shock. Importance of the activation of poly (ADP-ribose) synthetase by peroxynitrite. J Clin Investig 100:723-735.
34. Szabó G, Liaudet L, Hagl S, and Szabó C (2004a) Poly(ADP-ribose) polymerase activation in the reperfused myocardium. Cardiovasc Res 61:471-480.
35. Szabó G, Soos P, Mandera S, Heger U, Flechtenmacher C, Bahrle S, Seres L, Cziráki A, Gries A, Zsengellér Z, et al. (2004b) INO-1001 a novel poly(ADP-ribose) polymerase (PARP) inhibitor improves cardiac and pulmonary function after crystalloid cardioplegia and extracorporal circulation. Shock 21:426-432.
36. Taddei S, Virdis A, Mattei P, Ghiadoni L, Gennari A, Fasolo CB, Sudano I, and Salvetti A (1995) Aging and endothelial function in normotensive subjects and patients with essential hypertension. Circulation 91:1981-1987.
37. Thiemermann C, Bowes J, Myint FP, and Vane JR (1997) Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle. Proc Natl Acad Sci USA 94:679-683.
38. van der Loo B, Labugger R, Skepper JN, Bachschmid M, Kilo J, Powell JM, Palacios-Callender M, Erusalimsky JD, Quaschning T, Malinski T, et al. (2000) Enhanced peroxynitrite formation is associated with vascular aging. J Exp Med 192:1731-1744.
39. Virág L and Szabó C (2002) The therapeutic potential of poly(ADP-ribose) polymerase inhibitors. Pharmacol Rev 54:375-429.
40. Zingarelli B, Salzman AL, and Szabó C (1998) Genetic disruption of poly (ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion injury. Circ Res 83:85-94.