Modulation of cell cycle components by epigenetic and genetic events

Seminars in Oncology

Volumn 32, Issue 5, 2005, Pages 452-457

  Macaluso, Marcella ^a,b,c   Montanari, Micaela ^a,d   Cinti, Caterina ^a,e   Giordano, Antonio ^a,c  

^a Temple University   (United States)

^b UNIVERSITY OF PALERMO   (Italy)

^c UNIVERSITY OF SIENA   (Italy)

^d CATHOLIC UNIVERSITY   (Italy)

^e CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P107; PROTEIN P130; PROTEIN P53; RETINOBLASTOMA PROTEIN;

CELL CYCLE; CELL PROLIFERATION; DNA DAMAGE; EPIGENETICS; GENE FREQUENCY; GENE MUTATION; GENE TARGETING; HUMAN; MOLECULAR DYNAMICS; PRIORITY JOURNAL; REVIEW; TUMOR CELL;

EID: 25844504743     PISSN: 00937754     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.seminoncol.2005.07.009     Document Type: Article

References (104)

1. M. Montanari, A. Boninsegna, B. Faraglia Increased expression of geminin stimulates the growth of mammary epithelial cells and is a frequent event in human tumors J Cell Physiol 202 2005 215 222
2. U. Galderisi, F.P. Jori, A. Giordano Cell cycle regulation and neural differentiation Oncogene 22 2003 5208 5219
3. M. Macaluso, M.G. Paggi, A. Giordano Genetic and epigenetic alterations as hallmarks of the intricate road to cancer Oncogene 22 2003 6472 6478
4. M. Macaluso, A. Giordano How does DNA methylation mark the fate of cells? Tumori 90 2004 367 372
5. M. Esteller Cancer epigenetics DNA methylation and chromatin alteration in human cancer Adv Exp Med Biol 532 2003 39 49
6. P.A. Jones, S.B. Baylin The fundamental role of epigenetic event in cancer Nat Rev Genet 3 2002 415 428
7. A.J. Giaccia, M. Kastan The complexity of p53 modulation Emerging patterns from divergent signals Genes Dev 12 1998 2973 2983
8. D. Gan, M. Macaluso, C. Cinti How does a normal human cell become a cancer cell? J Exp Clin Cancer Res 22 2003 509 515
9. C.J. Sherr, F. McCormick The RB and p53 pathways in cancer Cancer Cell 2 2002 103 112
10. M. Macaluso, G. Russo, C. Cinti Ras family genes An interesting link between cell cycle and cancer J Cell Physiol 192 2002 125 130
11. L. Yamasaki Role of the RB tumor suppressor in cancer Cancer Treat Res 115 2003 209 239
12. C.L. Stewart, A.M. Soria, P.A. Hamel Integration of the pRB and p53 cell cycle control pathways J Neurooncol 51 2001 183 204
13. P. Stiegler, A. Giordano The family of retinoblastoma proteins Crit Rev Eukaryot Gene Expr 11 2001 59 76
14. M.V. Frolov, N.J. Dyson Molecular mechanisms of E2F-dependent activation and pRb-mediated repression J Cell Sci 117 2004 2173 2181
15. M.G. Paggi, A. Giordano Who is the boss in the retinoblastoma familiy? The point of view of pRb2/p1b, the little brother Cancer Res 61 2001 4651 4654
16. R. Ferreira, L. Magnaghi-Jaulin, P. Robin The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase Proc Natl Acad Sci U S A 95 1998 10493 10498
17. P. Stiegler, A. De Luca, L. Bagella The COOH-terminal region of pRb2/p130 binds to histone deacetylase 1 (HDAC1), enhancing transcriptional repression of the E2F-dependent cyclin A promoter Cancer Res 58 1998 5049 5052
18. L. Vandel, E. Nicolas, O. Vaute Transcriptional repression by the retinoblastoma protein through the recruitment of a histone methyltransferase Mol Cell Biol 21 2001 6484 6494
19. D. La Sala, M. Macaluso, C. Trimarchi Triggering of p73-dependent apoptosis in osteosarcoma is under control of E2Fs-pRb2/p130 complexes Oncogene 22 2003 3518 3529
20. M. Macaluso, C. Cinti, G. Russo pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-α in breast cancer Oncogene 22 2003 3511 3517
21. K. Helin Deregulation of cell proliferation by E2F transcription factors Curr Opin Genet Dev 8 1998 28 35
22. J.M. Trimarchi, J.A. Lees Sibling rivalry in the E2F family Nat Rev Mol Cell Biol 3 2002 11 20
23. B.T. Spike, K.F. Macleod The Rb tumor suppressor in stress responses and hematopoietic homeostasis Cell Cycle 4 2005 42 45
24. T. Quentin, C. Henke, M. Korabiowska Altered mRNA expression of the Rb and p16 tumor suppressor genes and of CDK4 in transitional cell carcinomas of the urinary bladder associated with tumor progression Anticancer Res 24 2004 1011 1023
25. A. Semczuk, R. Miturski, D. Skomra Expression of the cell-cycle regulatory proteins (pRb, cyclin D1, p16INK4A and cdk4) in human endometrial cancer Correlation with clinicopathological features Arch Gynecol Obstet 269 2004 104 110
26. D.E. Quelle, F. Zindy, R.A. Ashmund Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest Cell 83 1995 993 1000
27. G. Dominguez, J. Javier Silva, J.M. Garcia Prevalence of aberrant methylation of p14ARF over p16INK4a in some human primary tumors Mutat Res 530 2003 9 17
28. M. Ruas, G. Peters The p16INK4a/CDKN2A tumor suppressor and its relatives Biochim Biophys Acta 1378 1998 F115 F177
29. A. Semczuk, J.A. Jakowicki Alterations of pRb1-cyclin D1-cdk4/6-p16(INK4A) pathway in endometrial carcinogenesis Cancer Lett 203 2004 1 12
30. G. Konopka, A. Bonni Signaling pathways regulating gliomagenesis Curr Mol Med 3 2003 73 84
31. J.Y. Wang, L. Del Valle, Peruzzi Poliomaviruses and cancer - Interplay between viral proteins and signal transduction pathways J Exp Clin Cancer Res 23 2004 373 384
32. H.S. Zhang, A.A. Postigo, D.C. Dean Active transcritional repression by pRb-E2F complex mediates G1 arrest triggered by p16INK4a, TGF beta, and contact inhibition Cell 97 1999 53 61
33. M. Serrano, G.J. Hannon, D. Beach A new regulatory motif in cellcycle control causing specific inhibition of cyclin D/CDK4 Nature 366 1993 704 707
34. M.B. Beasley, S. Lantuejoul, S. Abbondanzo The P16/cyclin D1/Rb pathway in neuroendocrine tumors of the lung Hum Pathol 34 2003 136 142
35. Y. Zhang, Y. Xiong, W.G. Yarbrough ARF promotes MDM2 degradation and stabilizes p53. ARF-INK4ka locus deletion impairs both the Rb and p53 tumor suppression pathways Cell 92 1998 725 734
36. P. Cairns, Y. Poladcik TJ Eby Frequency of homozygous deletion at p16/CDKN2 in primary human tumors Nat Genet 11 1995 210 212
37. J. Jen, J.W. Harper, S.H. Bigner Deletion of p16 and p15 genes in brain tumors Cancer Res 54 1994 6353 6358
38. M. Ohta, H. Nagai, M. Shimizu Rarity of somatic and germline mutiations of the cyclin-dependent kinase 4 ihnibitor gene, CDK4I, in melanoma Cancer Res 54 1994 5269 5272
39. S.N. Wagner, C. Wagner, L. Briedigkeit Homozygous deletion of the p16INK4a and the p15INK4b tumour suppressor genes in a subset of human sporadic cutaneous malignant melanoma Br J Dermatol 138 1998 13 21
40. I.M. Bachmann, O. Straume, L.A. Akslen Altered expression of cell cycle regulators cyclin D1, p14, p16, CDK4 and Rb in nodular melanomas Oncology 25 2004 1559 1565
41. M. Esteller Dormant hypermethylated tumour suppressor genes questions and answers J Pathol 205 2005 172 180
42. S. Lee, K.S. Hwang, H.J. Lee Aberrant CpG island hypermethylation of multiple genes in colorectal neoplasia Lab Invest 84 2004 884 893
43. D.J. Simpson, A.M. McNicol, D.C. Murray Molecular pathology shows p16 methylation in nonadenomatous pituitaries from patients with Cushing's disease Clin Cancer Res 10 2004 1780 1788
44. Y. Shu, D. Wang, R. Tanaka Anthracotic index and DNA methylation status of sputum contents can be used for identifying the population at risk of lung carcinoma Cancer 102 2004 348 354
45. J. Wang, J.J. Lee, L. Wang Value of p16INK4a and RASSF1A promoter hypermethylation in prognosis of patients with resectable non-small cell lung cancer Clin Cancer Res 10 2004 6119 6125
46. S. Toyooka, M. Suzuki, R. Maruyama The relationship between aberrant methylation and survival in non-small-cell lung cancers Br J Cancer 91 2004 771 774
47. T. Shimamoto, J.H. Ohyashiki, T. Hirano.Hypermethylation of E-cadherin gene is frequent and independent of p16INK4A methylation in non-small cell lung cancer Potential prognostic implication Oncol Rep 12 2004 389 395
48. H. Kim, Y.M. Kwon, J.S. Kim Tumor-specific methylation in bronchial lavage for the early detection of non-small-cell lung cancer J Clin Oncol 22 2004 2363 2370
49. J. Yokota, T. Kohno Molecular footprints of human lung cancer progression Cancer Sci 95 2004 197 204
50. E. Brambilla, S. Gazzeri, D. Moro Alterations of Rb pathway (Rb-p16INK4-cyclin D1) in preinvasive bronchial lesions Clin Cancer Res i 5 1999 243 250
51. A.D. Vinci, L. Perdelli, B. Banelli p16(INK4a) promoter methylation and protein expression in breast fibroadenoma and carcinoma Int J Cancer 114 2004 414 421
52. M. Ruas, S. Brookes, N.Q. McDonald Functional evaluation of tumour- specific variants of p16INK4a/CDKN2A Correlation with protein structure information Oncogene 18 1999 5423 5434
53. L. Xu, D. Sgroi, C.J. Sterner Mutational analysis of CDKN2 (MTS1/p16ink4) in human breast carcinomas Cancer Res 54 1994 5262 5264
54. A. Kamb, N.A. Gruis, J. Weaver-Feldhaus A cell cycle regulator potentially involved in genesis of many tumor types Science 264 1994 436 440
55. J. Silva, J.M. Silva, G. Dominguez Concomitant expression of p16INK4a and p14ARF in primary breast cancer and analysis of inactivation mechanisms J Pathol 199 2003 289 297
56. T.D. Tlsty, Y.G. Crawford, C.R. Holst Genetic and epigenetic changes in mammary epithelial cells may mimic early events in carcinogenesis J Mammary Gland Biol Neoplasia 9 2004 263 274
57. U. Lehmann, F. Langer, H. Feist Quantitative assessment of promoter hypermethylation during breast cancer development Am J Pathol 160 2002 605 612
58. J. Geradts, P.A. Wilson High frequency of aberrant p16(INK4A) expression in human breast cancer Am J Pathol 149 1996 15 18
59. R. Emig, A. Magener, V. Ehemann Aberrant cytoplasmic expression of the p16 protein in breast cancer is associated with accelerated tumor proliferation Br J Cancer 78 1998 1661 1668
60. E.A. Dublin, N.K. Patel, C.E. Gillett Retinoblastoma and p16 proteins in mammary carcinoma Their relationship to cyclin D1 and histopathological parameters Int J Cancer 79 1998 71 75
61. S. Han, S.H. Ahn, K. Park P16INK4a protein expression is associated with poor survival of the breast cancer patients after CMF chemotherapy Breast Cancer Res Treat 70 2001 205 212
62. C.R. Holst, G.J. Nuovo, M. Esteller Methylation of p16 (INK4a) promoters occurs in vivo in histologically normal human mammary epithelia Cancer Res 63 2003 1596 1601
63. J.M. McCloud, R. Sivakumar, A. Greenhough p16INK4a polymorphism Associations with tumour progression in patients with sporadic colorectal cancer Int J Oncol 25 2004 1447 1452
64. S. Kamoshida, H. Matsuoka, T. Ishikawa Immunohistochemical evaluation of thymidylate synthase (TS) and p16INK4a in advanced colorectal cancer Implication of TS expression in 5-FU-based adjuvant chemotherapy Jpn J Clin Oncol 34 2004 594 601
65. X. Cui, Y. Shirai, T. Wakai expression of pRb and p16(INK4), alone or in combination, indicates poor outcome after resection in patients with colorectal carcinoma Hum Pathol 35 2004 1189 1195
66. S. Mittnacht Control of pRb phosphorylation Curr Opin Genet Dev 8 1998 21 27
67. P.D. Adams Regulation of the retinoblastoma tumor suppressor protein by cyclin/cdks Biochim Biophys Acta 1471 2001 M123 M133
68. M. von Willebrand, E. Zacksenhaus, E. Cheng The tyrphostin AG1024 accelerates the degradation of phosphorylated form of retinoblastoma protein (pRb) and restores pRb tumor suppressive function in melanoma cells Cancer Res 63 2003 1420 1429
69. M. Fu, C. Wang, Z. Li Cyclin D1 normal and abnormal functions Endocrinology 145 2004 5439 5447
70. O. Tetsu, F. McCormick Proliferation of cancer cells despite CDK2 inhibition Cancer Cell 3 2003 233 245
71. Q. Zhou, J. Wulfkuhle, T. Ouatas Cyclin D1 overexpression in a model of human breast premalignancy Preferential stimulation of anchorage-independent but not anchorage-dependent growth is associated with increased cdk2 activity Breast Cancer Res Treat 59 2000 27 39
72. M.G. Peters, C. Vidal Mdel, L. Gimenez Prognostic value of cell cycle regulator molecules in surgically resected stage I and II breast cancer Oncol Rep 12 2004 1143 1150
73. L. Lin, D. Hicks, B. Xu Expression profile and molecular genetic regulation of cyclin D1 expression in epithelioid sarcoma Mod Pathol 18 2005 705 709
74. Q. Yu, Y. Geng, P. Sicinski Specific protection against breast cancers by cyclin D1 ablation Nature 411 2001 1017 1021
75. K. Kozar, M.A. Ciemerych, V.I. Rebel Mouse development and cell proliferation in the absence of D-cyclins Cell 118 2004 477 491
76. I. Chu, K. Blackwell, S. Chen The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer Cancer Res 65 2005 18 25
77. R.S. Muraoka, A.E. Lenferink, B. Law ErbB2/Neu-induced, cyclin D1-dependent transformation is accelerated in p27-haploinsufficient mammary epithelial cells but impaired in p27-null cells Mol Cell Biol 22 2002 2204 2219
78. K.H. Vousden, C. Prives P53 and prognosis New insights and further complexity Cell 120 2005 7 10
79. A. Russo, M. Migliavacca, I. Zanna Gatekeepers and Caretakers Encyclopedia of the Human Genome 2003 Nature Publishing Group New York, NY
80. H.F. Ding, D.E. Fisher Induction of apoptosis in cancer New therapeutic opportunities Ann Med 34 2002 451 469
81. S.W. Lowe, E. Cepero, G. Evan Intrinsic tumour suppression Nature 432 2004 307 315
82. A.J. Munro, S. Lain, D.P. Lane P53 abnormalities and outcomes in colorectal cancer A systematic review Br J Cancer 92 2005 434 444
83. L. Xin p53 A heavily dictated dictator of life and death Curr Opin Genet Dev 15 2005 27 33
84. C.J. Sherr Principles of tumor suppression Cell 116 2004 235 246
85. C.J. Sherr Cancer cell cycles revisited Cancer Res 60 2000 3689 3695
86. M.G. Moule, C.H. Collins, F. McCormick Role for PP2A in ARF signaling to p53 Proc Natl Acad Sci U S A 39 2004 14063 14066
87. S.W. Lowe, E. Cepero, G. Evan Intrinsic tumour suppression Nature 432 2004 307 315
88. ARF links the tumor suppressor RB and p53 Nature 395 1998 124 125
89. A. Chytil, M. Waltner-Law, R. West Construction of a cyclin D1-Cdk2 fusion protein to model the biological functions of cyclin D1-Cdk2 complexes J Biol Chem 279 2004 47688 47698
90. D.J. Mazzatti, Y.J. Lee, C.E. Helt p53 modulates radiation sensitivity independent of p21 transcriptional activation Am J Clin Oncol 28 2005 43 50
91. Y. Huang, M.J. Corbley, Z. Tang Down-regulation of p21WAF1 promotes apoptosis in senescent human fibroblasts involvement of retinoblastoma protein phosphorylation and delay of cellular aging J Cell Physiol 201 2004 483 491
92. G. Fulci, M. Labuhn, D. Mayer p53 mutations and ink4-arf deletion appear to be two mutually exclusive events in human glioblastoma Oncogene 19 2000 3816 3822
93. E.W. Newcomb, M. Alonso, T. Sung Incidence of the p14/ARF gene deletion in high grade adult and pediatric astrocytomas Hum Pathol 31 2000 115 119
94. S. Sarkar, K.P. Julicher, M.S. Burger Different combinations of genetic/epigenetic alterations inactive p53 and pRb pathways in invasive human bladder cancers Cancer Res 60 2000 3862 3872
95. J.A. Randerson-Moor, M. Harland, S. Williams A germline deletion of p14(ARF) but not CDKN2A in a melanoma-neural system tumour syndrome family Hum Mol Genet 10 2001 55 62
96. S. Zheng, P. Chen, McMillan Correlations of partial and extensive methylation at the p14 (ARF) locus with reduced mRNA expression in colorectal cancer cell lines and clinicopathological features in primary tumors Carcinogenesis 21 2000 2057 2064
97. S. Zochbauer-Muller, J.D. Minna, A.F. Gazdar Aberrant DNA methylation in lung cancer Oncologist 7 2002 451 456
98. CIP/WAF1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblasts Mol Cell Biol 23 2003 2859 2870
99. L. Burke, D.B. Flieder, D.G. Guinee Prognostic implications of molecular and immunohistochemical profiles of the Rb and p53 cell cycle regulatory pathways in primary non-small cell lung carcinoma Clin Cancer Res 11 2005 232 241
100. G.-Z. Li, M.S. Eller, K. Hanna Signaling pathway requirements for induction of senescence by telomere homolog oligonucleotides Exp Cell Res 301 2004 189 200
101. G. Konopka, A. Bonni Signaling pathways regulating gliomagenesis Curr Mol Med 3 2003 73 84
102. L. Yamasaki, M. Pagano Cell cycle, proteolysis and cancer Curr Opin Cell Biol 16 2004 623 628
103. C.L. Stewart, A.M. Soria, P.A. Hamel Integration of the pRB and p53 cell cycle control pathways J Neurooncol 51 2001 183 204
104. E. Surmacz, M. Bartucci Role of estrogen receptor alpha in modulating IGF-1 receptor signaling and function in breast cancer J Exp Clin Cancer Res 23 2004 385 394