Increased expression of geminin stimulates the growth of mammary epithelial cells and is a frequent event in human tumors

Journal of Cellular Physiology

Volumn 202, Issue 1, 2005, Pages 215-222

  Montanari, Micaela ^a,b   Boninsegna, Alma ^a   Faraglia, Beatrice ^a   Coco, Claudio ^a   Giordano, Antonio ^b   Cittadini, Achille ^a   Sgambato, Alessandro ^a,c  

^a CATHOLIC UNIVERSITY   (Italy)

^b Temple University   (United States)

^c CATHOLIC UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; GEMININ; MESSENGER RNA;

ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CANCER CELL; CANCER CELL CULTURE; CARCINOGENESIS; CELL GROWTH; COLORECTAL CANCER; CONTROLLED STUDY; EPITHELIUM CELL; GENE OVEREXPRESSION; GROWTH REGULATION; HISTOGENESIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CELL; WESTERN BLOTTING;

BREAST NEOPLASMS; CARCINOMA; CELL CYCLE PROTEINS; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; DNA REPLICATION; DNA, COMPLEMENTARY; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, CDC; HUMANS; MAMMARY GLANDS, HUMAN; RECTAL NEOPLASMS; RNA, MESSENGER; TRANSFECTION; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION;

EUKARYOTA;

EID: 10044298303     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.20120     Document Type: Article

References (21)

1. Bell SP. 2002. The origin recognition complex: From simple origins to complex functions. Genes Dev 16:659-672.
2. Hansel DE, Rahman A, Hidalgo M, Thuluvath PJ, Lillemoe KD, Shulick R, Ku JL, Park JG, Miyazaki K, Ashfaq R, Wistuba II, Varma R, Hawthorne L, Geradts J, Argani P, Maitra A. 2003. Identification of novel cellular targets in biliary tract cancers using global gene expression technology. Am J Pathol 163:217-229.
3. Kulartz M, Kreitz S, Hiller E, Damoc EC, Przybylski M, Knippers R. 2003. Expression and phosphorylation of the replication regulator protein geminin. Biochem Biophys Res Commun 305:412-420.
4. Lygerou Z, Nurse P. 2000. Cell cycle. License withheld - Geminin blocks DNA replication. Science 290:2271-2273.
5. Madine M, Laskey R. 2001. Geminin bans replication licence. Nat Cell Biol 3:E49-E50.
6. McGarry TJ. 2002. Geminin deficiency causes a Chk1-dependent G2 arrest in Xenopus. Mol Biol Cell 13:3662-3671.
7. McGarry TJ, Kirschner MW. 1998. Geminin, an inhibitor of DNA replication, is degraded during mitosis. Cell 93:1043-1053.
8. Mihaylov IS, Kondo T, Jones L, Ryzhikov S, Tanaka J, Zheng J, Higa LA, Minamino N, Cooley L, Zhang H. 2002. Control of DNA replication and chromosome ploidy by geminin and cyclin A. Mol Cell Biol 22:1868-1880.
9. Nishitani H, Lygerou Z. 2002. Control of DNA replication licensing in a cell cycle. Genes Cells 7:523-534.
10. Nishitani H, Taraviras S, Lygerou Z, Nishimoto T. 2001. The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase. J Biol Chem 276:44905-44911.
11. Sgambato A, Han EK-H, Zhou P, Schieren I, Weinstein IB. 1996. Overexpression of cyclin E in the HC11 mouse mammary cell line is associated with growth inhibition and increased expression of p27Kip1. Cancer Res 56:1389-1399.
12. Sgambato A, Zhang Y-J, Ciaparrone M, Soh J-W, Cittadini A, Santella RM, Weinstein IB. 1998a. Overexpression of p27kip1 inhibits the growth of both normal and transformed human mammary epithelial cells. Cancer Res 58:3448-3454.
13. Sgambato A, Flamini G, Cittadini A, Weinstein IB. 1998b. Abnormalities in cell cycle control in cancer an their clinical implications. Tumori 84:421-433.
14. Shreeram S, Sparks A, Lane DP, Blow JJ. 2002. Cell type-specific responses of human cells to inhibition of replication licensing. Oncogene 21:6624-6632.
15. Soule Hd, Maloney TM, Wolman SR, WD Peterson J, Brenz R, McGrath CM, Russo J, Pauly RJ, Jones RF, Brooks SC. 1990. Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10. Cancer Res 50:6075-6086.
16. Sun W, Hola M, Pedley K, Tada S, Blow JJ, Todorov IT, Kearsey SE, Brooks RF. 2000. The replication capacity of intact mammalian nuclei in Xenopus egg extracts declines with quiescence, but the residual DNA synthesis is independent of Xenopus MCM proteins. J Cell Sci 113(Pt. 4):683-695.
17. Tada S, Li A, Maiorano D, Mechali M, Blow JJ. 2001. Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin. Nat Cell Biol 3:107-113.
18. Wohlschlegel JA, Dwyer BT, Dhar SK, Cvetic C, Walter JC, Dutta A. 2000. Inhibition of eukaryotic DNA replication by geminin binding to Cdt1. Science 290:2309-2312.
19. Wohlschlegel JA, Kutok JL, Weng AP, Dutta A. 2002. Expression of geminin as a marker of cell proliferation in normal tissues and malignancies. Am J Pathol 161:267-273.
20. Yanagi K, Mizuno T, You Z, Hanaoka F. 2002. Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a novel intrinsic Cdt1 DNA binding activity. J Biol Chem 277:40871-40880.
21. Yoshida K, Oyaizu N, Dutta A, Inoue I. 2004. The destruction box of human Geminin is critical for proliferation and tumor growth in human colon cancer cells. Oncogene 23:58-70.