p53 modulates radiation sensitivity independent of p21 transcriptional activation

American Journal of Clinical Oncology: Cancer Clinical Trials

Volumn 28, Issue 1, 2005, Pages 43-50

  Mazzatti, Dawn J ^a   Lee, Yi Jang ^a   Helt, Christopher E ^a   O'Reilly, Michael A ^a   Keng, Peter C ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

Cell cycle arrest; G1 phase; p21; p53; Radiation sensitivity; Radiosensitivity

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; ONCOPROTEIN; PROTEIN P21; PROTEIN P53;

APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL DEATH; CONTROLLED STUDY; HUMAN; HUMAN CELL; IONIZING RADIATION; LUNG CARCINOMA; METAPHASE CHROMOSOME; MITOSIS INHIBITION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; RADIOSENSITIVITY; TRANSCRIPTION INITIATION; WILD TYPE;

APOPTOSIS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA DAMAGE; GENES, P53; HUMANS; INTERPHASE; PHENOTYPE; RADIATION TOLERANCE; RADIATION, IONIZING; TRANS-ACTIVATION (GENETICS); TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 13444259333     PISSN: 02773732     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.coc.0000139484.51715.5a     Document Type: Article

References (30)

1. Bristow RG, Brail L, Jang A, et al. p53-mediated radioresistance does not correlate with metastatic potential in tumorigenic rat embryo cell lines following oncogene transfection. Int J Radiat Oncol Biol Phys. 1996;34:341-355.
2. Bristow RG, Benchimol S, Hill RP. The p53 gene as a modifier of intrinsic radiosensitivity: implications for radiotherapy. Radiother Oncol. 1996;40:197-223.
3. Buchhop S, Gibson MK, Wang XW, et al. Interaction of p53 with the human Rad51 protein. Nucleic Acids Res. 1997;25:3868-3874.
4. Pardo FS, Su M, Borek C, et al. Transfection of rat embryo cells with mutant p53 increases the intrinsic radiation resistance. Radiat Res. 1994;140:180-185.
5. Aldridge DR, Radford IR. Explaining differences in sensitivity to killing by ionizing radiation between human lymphoid cell lines. Cancer Res. 1998;58:2817-2824.
6. Servomaa K, Kiuru A, Grenman R, et al. p53 mutations associated with increased sensitivity to ionizing radiation in human head and neck cancer cell lines. Cell Prolif. 1996;29:219-230.
7. Yount GL, Afshar G, Ries S, et al. Transcriptional activation of TRADD mediates p53-independent radiation-induced apoptosis of glioma cells. Oncogene. 2001;20:2826-2835.
8. Humar B, Muller H, Scott RJ. Elevated frequency of p53-independent apoptosis after irradiation increases levels of DNA breaks in ataxia telangiectasia lymphoblasts. Int J Radiat Biol. 1997;72:257-269.
9. Gudkov AV, Komarova EA. The role of p53 in determining sensitivity to radiotherapy. Nat Rev Cancer. 2003;3:117-129.
10. Banin S, Moyal L, Shieh S, et al. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science. 1998;281:1674-1677.
11. Bache M, Pigorsch S, Dunst J, et al. Loss of G2/M arrest correlates with radiosensitization in two human sarcoma cell lines with mutant p53. Int J Cancer. 2001;96:110-117.
12. Little JB. Failla Memorial Lecture. Changing views of cellular radiosensitivity. Radiat Res. 1994;140:299-311.
13. Levine AJ. p53, the cellular gatekeeper for growth and division. Cell. 1997;88:323-331.
14. Harper JW, Adami GR, Wei N, et al. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell. 1993;75:805-816.
15. Waldman T, Zhang Y, Dillehay L, et al. Cell-cycle arrest versus cell death in cancer therapy. Nat Med. 1997;3:1034-1036.
16. Strathdee CA, McLeod MR, Hall JR. Efficient control of tetracycline-responsive gene expression from an autoregulated bi-directional expression vector. Gene. 1999;229:21-29.
17. Helt CE, Staversky RJ, Lee YJ, et al. The CDK and PCNA domains on p21 Cip1 both function to inhibit G1/S progression during hyperoxia. Am J Physiol Lung Cell Mol Physiol. In press.
18. Murphy M, Mabruk MJ, Lenane P, et al. Comparison of the expression of p53, p21, Bax and the induction of apoptosis between patients with basal cell carcinoma and normal controls in response to ultraviolet irradiation. J Clin Pathol. 2002;55:829-833.
19. Komarova EA, Christov K, Faerman AI, et al. Different impact of p53 and p21 on the radiation response of mouse tissues. Oncogene. 2000;19:3791-3798.
20. Joseph B, Lewensohn R, Zhivotovsky B. Role of apoptosis in the response of lung carcinomas to anti-cancer treatment. Ann N Y Acad Sci. 2000;926:204-216.
21. Swisher SG, Roth JA, Komaki R, et al. Induction of p53-regulated genes and tumor regression in lung cancer patients after intratumoral delivery of adenoviral p53 (INGN 201) and radiation therapy. Clin Cancer Res. 2003;9:93-101.
22. Offer H, Wolkowicz R, Matas D, et al. Direct involvement of p53 in the base excision repair pathway of the DNA repair machinery. FEBS Lett. 1999;450:197-204.
23. Offer H, Milyavsky M, Erez N, et al. Structural and functional involvement of p53 in BER in vitro and in vivo. Oncogene. 2001;20:581-589.
24. Brown KD, Lataxes TA, Shangary S, et al. Ionizing radiation exposure results in up-regulation of Ku70 via a p53/ataxia-telangiectasia-mutated protein-dependent mechanism. J Biol Chem. 2000;275:6651-6656.
25. Tang W, Willers H, Powell SN. p53 directly enhances rejoining of DNA double-strand breaks with cohesive ends in gamma-irradiated mouse fibroblasts. Cancer Res. 1999;59:2562-2565.
26. Okorokov AL, Warnock L, Milner J. Effect of wild-type, S15D and R175H p53 proteins on DNA end joining in vitro: potential mechanism of DNA double-strand break repair modulation. Carcinogenesis. 2002;23:549-557.
27. Lu X, Lozano G, Donehower LA. Activities of wildtype and mutant p53 in suppression of homologous recombination as measured by a retroviral vector system. Mutat Res. 2003;522:69-83.
28. Boehden GS, Akyuz N, Roemer K, et al. p53 mutated in the transactivation domain retains regulatory functions in homology-directed double-strand break repair. Oncogene. 2003;22:4111-4117.
29. Willers H, McCarthy EE, Wu B, et al. Dissociation of p53-mediated suppression of homologous recombination from G1/S cell cycle checkpoint control. Oncogene. 2000;19:632-639.
30. Saintigny Y, Rouillard D, Chaput B, et al. Mutant p53 proteins stimulate spontaneous and radiation-induced intrachromosomal homologous recombination independently of the alteration of the transactivation activity and of the G1 checkpoint. Oncogene. 1999;18:3553-3563.