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Volumn 6, Issue , 2005, Pages 313-330

A science of the individual: Implications for a medical school curriculum

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR; CELL PROTEIN; CHEMOKINE RECEPTOR CCR5; DNA; LOW DENSITY LIPOPROTEIN RECEPTOR; M PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN; RNA;

EID: 25844480621     PISSN: 15278204     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.genom.6.080604.162345     Document Type: Review
Times cited : (33)

References (70)
  • 1
    • 0033624575 scopus 로고    scopus 로고
    • The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
    • Altshuler D, Hirschhorn JN, Klannemark M, Lindgren CM, Vohl M-C, et al. 2000. The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat. Genet. 26:76-81
    • (2000) Nat. Genet. , vol.26 , pp. 76-81
    • Altshuler, D.1    Hirschhorn, J.N.2    Klannemark, M.3    Lindgren, C.M.4    Vohl, M.-C.5
  • 2
    • 0001687389 scopus 로고    scopus 로고
    • The nature and mechanisms of human gene mutations
    • ed. CR Scriver, AL Beaudet, WS Sly, D Valle. New York: McGraw Hill
    • Antonarakis S, Krawczak M, Cooper DN. 2001. The nature and mechanisms of human gene mutations. In The Metabolic and Molecular Bases of Inherited Disease, ed. CR Scriver, AL Beaudet, WS Sly, D Valle, pp. 343-77. New York: McGraw Hill
    • (2001) The Metabolic and Molecular Bases of Inherited Disease , pp. 343-377
    • Antonarakis, S.1    Krawczak, M.2    Cooper, D.N.3
  • 3
    • 11144228603 scopus 로고    scopus 로고
    • Individualized care for patients with cancer - A work in progress
    • Bast RC Jr, Hortobagyi GN. 2004. Individualized care for patients with cancer - A work in progress. N. Engl. J. Med. 351:2865-67
    • (2004) N. Engl. J. Med. , vol.351 , pp. 2865-2867
    • Bast Jr., R.C.1    Hortobagyi, G.N.2
  • 4
    • 0036726605 scopus 로고    scopus 로고
    • Is medical genetics neglecting epigenetics?
    • Beaudet AL. 2002. Is medical genetics neglecting epigenetics? Genet. Med. 4:399-402
    • (2002) Genet. Med. , vol.4 , pp. 399-402
    • Beaudet, A.L.1
  • 5
    • 2642581701 scopus 로고    scopus 로고
    • Predicting disease using genomics
    • Bell J. 2004. Predicting disease using genomics. Nature 429:453-56
    • (2004) Nature , vol.429 , pp. 453-456
    • Bell, J.1
  • 6
    • 2642580889 scopus 로고    scopus 로고
    • Genomes for medicine
    • Bentley DR. 2004. Genomes for medicine. Nature 429:440-45
    • (2004) Nature , vol.429 , pp. 440-445
    • Bentley, D.R.1
  • 7
    • 3242663659 scopus 로고    scopus 로고
    • An integrated epigenetic and genetic approach to common human disease
    • Bjornsson HT, Fallin MD, Feinberg AP. 2004. An integrated epigenetic and genetic approach to common human disease. Trends Genet. 20:350-58
    • (2004) Trends Genet. , vol.20 , pp. 350-358
    • Bjornsson, H.T.1    Fallin, M.D.2    Feinberg, A.P.3
  • 8
    • 0013321009 scopus 로고
    • Familial hypercholesterolemia: Defective binding of pipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3- methylglutaryl coenzyme A reductase assay
    • Brown MS, Goldstein JL. 1974. Familial hypercholesterolemia: defective binding of pipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase assay. Proc. Natl. Acad. Sci. USA 71:788-92
    • (1974) Proc. Natl. Acad. Sci. USA , vol.71 , pp. 788-792
    • Brown, M.S.1    Goldstein, J.L.2
  • 9
    • 0022549920 scopus 로고
    • A receptor-mediated pathway for cholesterol homeostasis
    • Brown MS, Goldstein JL. 1986. A receptor-mediated pathway for cholesterol homeostasis. Science 232:34-47
    • (1986) Science , vol.232 , pp. 34-47
    • Brown, M.S.1    Goldstein, J.L.2
  • 10
    • 9444275411 scopus 로고    scopus 로고
    • Ensuring the appropriate use of genetic tests
    • Burke W, Zimmern RL. 2004. Ensuring the appropriate use of genetic tests. Nat. Rev. (Genet.) 5:955-59
    • (2004) Nat. Rev. (Genet.) , vol.5 , pp. 955-959
    • Burke, W.1    Zimmern, R.L.2
  • 11
    • 2642583283 scopus 로고    scopus 로고
    • Mapping complex disease loci in whole-genome association studies
    • Carlson CS, Eberle MA, Kruglyak L, Nickerson DA. 2004. Mapping complex disease loci in whole-genome association studies. Nature 429:446-52
    • (2004) Nature , vol.429 , pp. 446-452
    • Carlson, C.S.1    Eberle, M.A.2    Kruglyak, L.3    Nickerson, D.A.4
  • 12
    • 0032837669 scopus 로고    scopus 로고
    • Genetics of HIV-1 infection: Chemokine receptor CCR5 polymorphism and its consequences
    • Carrington M, Dean M, Martin MP, O'Brien SJ. 1999. Genetics of HIV-1 infection: chemokine receptor CCR5 polymorphism and its consequences. Hum. Mol. Genet. 8:1939-45
    • (1999) Hum. Mol. Genet. , vol.8 , pp. 1939-1945
    • Carrington, M.1    Dean, M.2    Martin, M.P.3    O'Brien, S.J.4
  • 14
    • 85015054307 scopus 로고    scopus 로고
    • Nature, nurture and human disease
    • Chakravarti A, Little P. 2003. Nature, nurture and human disease. Nature 421:412-14
    • (2003) Nature , vol.421 , pp. 412-414
    • Chakravarti, A.1    Little, P.2
  • 17
    • 2642585738 scopus 로고    scopus 로고
    • The case for a US prospective cohort study of genes and environment
    • Collins FS. 2004. The case for a US prospective cohort study of genes and environment. Nature 429:475-77
    • (2004) Nature , vol.429 , pp. 475-477
    • Collins, F.S.1
  • 20
    • 84968054140 scopus 로고
    • Nothing in biology makes sense except in the light of evolution
    • Dobzhansky T. 1973. Nothing in biology makes sense except in the light of evolution. Am. Biol. Teacher 35:125-29
    • (1973) Am. Biol. Teacher , vol.35 , pp. 125-129
    • Dobzhansky, T.1
  • 21
    • 0033536987 scopus 로고    scopus 로고
    • Susceptibility to otitis media: Strong evidence that genetics plays a role
    • Ehrlich GD, Post JC. 1999. Susceptibility to otitis media: strong evidence that genetics plays a role. JAMA 282:2167-69
    • (1999) JAMA , vol.282 , pp. 2167-2169
    • Ehrlich, G.D.1    Post, J.C.2
  • 22
    • 0037066542 scopus 로고    scopus 로고
    • Intra- and interspecific variation in primate gene expression patterns
    • Enard W, Khaitovich P, Klose J, Zöllner S, Heissig F, et al. 2002. Intra- and interspecific variation in primate gene expression patterns. Science 296:340-43
    • (2002) Science , vol.296 , pp. 340-343
    • Enard, W.1    Khaitovich, P.2    Klose, J.3    Zöllner, S.4    Heissig, F.5
  • 23
    • 2642570170 scopus 로고    scopus 로고
    • Moving towards individualized medicine with pharmacogenomics
    • Evans WE, Relling MV. 2004. Moving towards individualized medicine with pharmacogenomics. Nature 429:464-68
    • (2004) Nature , vol.429 , pp. 464-468
    • Evans, W.E.1    Relling, M.V.2
  • 24
    • 0242524453 scopus 로고    scopus 로고
    • The inherited basis of diabetes mellitus: Implications for the genetic analysis of complex traits
    • Florez JC, Hirschhorn JN, Altshuler D. 2003. The inherited basis of diabetes mellitus: implications for the genetic analysis of complex traits. Annu. Rev. Genomics Hum. Genet. 4:257-91
    • (2003) Annu. Rev. Genomics Hum. Genet. , vol.4 , pp. 257-291
    • Florez, J.C.1    Hirschhorn, J.N.2    Altshuler, D.3
  • 25
    • 3543083373 scopus 로고    scopus 로고
    • Mechanisms of hypertension: The expanding role of aldosterone
    • Freel EM, Connell JM. 2004. Mechanisms of hypertension: the expanding role of aldosterone. J. Am. Soc. Nephrol. 15:1993-2001
    • (2004) J. Am. Soc. Nephrol. , vol.15 , pp. 1993-2001
    • Freel, E.M.1    Connell, J.M.2
  • 27
    • 10444273349 scopus 로고    scopus 로고
    • The role of human major histocompatibility complex (HLA) genes in disease
    • ed. CR Scriver, AL Beaudet, WS Sly, D Valle. New York: McGraw Hill
    • Fugger L, Tisch R, Libau R, van Endert P, McDevitt HO. 2001. The role of human major histocompatibility complex (HLA) genes in disease. In The Metabolic and Molecular Bases of Inherited Disease, ed. CR Scriver, AL Beaudet, WS Sly, D Valle, pp. 311-41. New York: McGraw Hill
    • (2001) The Metabolic and Molecular Bases of Inherited Disease , pp. 311-341
    • Fugger, L.1    Tisch, R.2    Libau, R.3    Van Endert, P.4    McDevitt, H.O.5
  • 28
    • 0037146578 scopus 로고    scopus 로고
    • Finding genes that underlie complex traits
    • Glazier AM, Nadeau JH, Aitman TJ. 2002. Finding genes that underlie complex traits. Science 298:2345-49
    • (2002) Science , vol.298 , pp. 2345-2349
    • Glazier, A.M.1    Nadeau, J.H.2    Aitman, T.J.3
  • 29
    • 0015839023 scopus 로고
    • Hyperlipidemia in coronary heart disease. I. Lipid levels in 500 survivors of myocardial infarction
    • Goldstein JL, Hazzard WR, Schrott HG, Bierman EL, Motulsky AG. 1973. Hyperlipidemia in coronary heart disease. I. Lipid levels in 500 survivors of myocardial infarction. J. Clin. Invest. 52:1533-43
    • (1973) J. Clin. Invest. , vol.52 , pp. 1533-1543
    • Goldstein, J.L.1    Hazzard, W.R.2    Schrott, H.G.3    Bierman, E.L.4    Motulsky, A.G.5
  • 30
    • 0015796295 scopus 로고
    • Hyperlipidemia in coronary heart disease. II. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia
    • Goldstein JL, Schrott HG, Hazzard WR, Bierman EL, Motulsky AG. 1973. Hyperlipidemia in coronary heart disease. II. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia. J. Clin. Invest. 52:1544-68
    • (1973) J. Clin. Invest. , vol.52 , pp. 1544-1568
    • Goldstein, J.L.1    Schrott, H.G.2    Hazzard, W.R.3    Bierman, E.L.4    Motulsky, A.G.5
  • 31
    • 0042166204 scopus 로고    scopus 로고
    • Genomic profiling to promote a healthy lifestyle: Not ready for prime time
    • Haga SB, Khoury MJ, Burke W. 2003. Genomic profiling to promote a healthy lifestyle: not ready for prime time. Nat. Genet. 34:347-50
    • (2003) Nat. Genet. , vol.34 , pp. 347-350
    • Haga, S.B.1    Khoury, M.J.2    Burke, W.3
  • 32
    • 0035978651 scopus 로고    scopus 로고
    • Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
    • Hugot J-P, Chamaillard M, Zouali H, Lesage S, Cézard J-P, et al. 2001. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411:599-603
    • (2001) Nature , vol.411 , pp. 599-603
    • Hugot, J.-P.1    Chamaillard, M.2    Zouali, H.3    Lesage, S.4    Cézard, J.-P.5
  • 33
    • 79959503826 scopus 로고    scopus 로고
    • The international HapMap project
    • 32a. International HapMap Corsortium. 2003. The international HapMap project. Nature 426:789-96
    • (2003) Nature , vol.426 , pp. 789-796
  • 34
    • 7244245762 scopus 로고    scopus 로고
    • Finishing the euchromatic sequence of the human genome
    • International Human Genome Sequencing Consortium. 2004. Finishing the euchromatic sequence of the human genome. Nature 431:931-45
    • (2004) Nature , vol.431 , pp. 931-945
  • 36
    • 0037372003 scopus 로고    scopus 로고
    • Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals
    • Jaenisch R, Bird A. 2003. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat. Genet. 33(Suppl.):245-54
    • (2003) Nat. Genet. , vol.33 , Issue.SUPPL. , pp. 245-254
    • Jaenisch, R.1    Bird, A.2
  • 39
    • 1442357145 scopus 로고    scopus 로고
    • Factor V Leiden and the risk for venous thromboembolism in the adult Danish population
    • Juul K, Tybjaerg-Hansen A, Schnohr P, Nordestgaard BG. 2004. Factor V Leiden and the risk for venous thromboembolism in the adult Danish population. Ann. Intern. Med. 140:330-37
    • (2004) Ann. Intern. Med. , vol.140 , pp. 330-337
    • Juul, K.1    Tybjaerg-Hansen, A.2    Schnohr, P.3    Nordestgaard, B.G.4
  • 40
    • 0038014099 scopus 로고    scopus 로고
    • Integration of genetics into clinical teaching in medical school education
    • Korf BR. 2002. Integration of genetics into clinical teaching in medical school education. Genet. Med. 4:33S-38S
    • (2002) Genet. Med. , vol.4
    • Korf, B.R.1
  • 42
    • 0033863391 scopus 로고    scopus 로고
    • SNPing away at complex diseases: Analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease
    • Martin ER, Lai EH, Gilbert JR, Rogala AR, Afshari AJ, et al. 2000. SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease. Am. J. Hum. Genet. 67:383-94
    • (2000) Am. J. Hum. Genet. , vol.67 , pp. 383-394
    • Martin, E.R.1    Lai, E.H.2    Gilbert, J.R.3    Rogala, A.R.4    Afshari, A.J.5
  • 43
    • 0034944895 scopus 로고    scopus 로고
    • Delayed dark-adaptation and lipofuscin accumulation in abcr+/- mice: Implications for involvement of ABCR in age-related macular degeneration
    • Mata NL, Tzekov RT, Liu X, Weng J, Birch DG, Travis GH. 2001. Delayed dark-adaptation and lipofuscin accumulation in abcr+/- mice: implications for involvement of ABCR in age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 42:1685-90
    • (2001) Invest. Ophthalmol. Vis. Sci. , vol.42 , pp. 1685-1690
    • Mata, N.L.1    Tzekov, R.T.2    Liu, X.3    Weng, J.4    Birch, D.G.5    Travis, G.H.6
  • 44
    • 0000508160 scopus 로고
    • Cause and effect in biology
    • Mayr E. 1961. Cause and effect in biology. Science 134:1501-6
    • (1961) Science , vol.134 , pp. 1501-1506
    • Mayr, E.1
  • 45
    • 0038135191 scopus 로고    scopus 로고
    • Will the genomics revolution revoluntionize psychiatry?
    • Merikangas KR, Risch N. 2003. Will the genomics revolution revoluntionize psychiatry? Am. J. Psychiatry 160:625-35
    • (2003) Am. J. Psychiatry , vol.160 , pp. 625-635
    • Merikangas, K.R.1    Risch, N.2
  • 46
    • 4043128071 scopus 로고    scopus 로고
    • Genetic analysis of genome-wide variation in human gene expression
    • Morley M, Molony CM, Weber TM, Devlin JL, Ewens KG, et al. 2004. Genetic analysis of genome-wide variation in human gene expression. Nature 430:743-47
    • (2004) Nature , vol.430 , pp. 743-747
    • Morley, M.1    Molony, C.M.2    Weber, T.M.3    Devlin, J.L.4    Ewens, K.G.5
  • 47
    • 8344246961 scopus 로고    scopus 로고
    • Genetics of human arterial hypertension
    • Naber CK, Siffert W. 2004. Genetics of human arterial hypertension. Minerva Med. 95:347-56
    • (2004) Minerva Med. , vol.95 , pp. 347-356
    • Naber, C.K.1    Siffert, W.2
  • 48
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
    • Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, et al. 2001. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411:603-6
    • (2001) Nature , vol.411 , pp. 603-606
    • Ogura, Y.1    Bonen, D.K.2    Inohara, N.3    Nicolae, D.L.4    Chen, F.F.5
  • 50
    • 19944422061 scopus 로고    scopus 로고
    • A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
    • Paik S, Shak S, Tang G, Kim C, Baker J, et al. 2004. A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N. Engl. J. Med. 351:2817-26
    • (2004) N. Engl. J. Med. , vol.351 , pp. 2817-2826
    • Paik, S.1    Shak, S.2    Tang, G.3    Kim, C.4    Baker, J.5
  • 51
    • 19944410138 scopus 로고    scopus 로고
    • The chemokine receptor 5 D32 mutation is associated with increased renal survival in patients with IgA nephropathy
    • Panzer U, Schneider A, Steinmetz OM, Wenzel U, Barth P, et al. 2005. The chemokine receptor 5 D32 mutation is associated with increased renal survival in patients with IgA nephropathy. Kidney Int. 67:75-81
    • (2005) Kidney Int. , vol.67 , pp. 75-81
    • Panzer, U.1    Schneider, A.2    Steinmetz, O.M.3    Wenzel, U.4    Barth, P.5
  • 52
    • 2442585704 scopus 로고    scopus 로고
    • Functional variants of OCTN cation transporter genes are associated with Crohn disease
    • Peltekova VD, Wintle RF, Rubin LA, Amos CI, Huang Q, et al. 2004. Functional variants of OCTN cation transporter genes are associated with Crohn disease. Nat. Genet. 36:471-75
    • (2004) Nat. Genet. , vol.36 , pp. 471-475
    • Peltekova, V.D.1    Wintle, R.F.2    Rubin, L.A.3    Amos, C.I.4    Huang, Q.5
  • 53
    • 25844514245 scopus 로고
    • Value of genetics in medicine
    • Penrose LS. 1950. Value of genetics in medicine. Br. Med. J. 2:903-5
    • (1950) Br. Med. J. , vol.2 , pp. 903-905
    • Penrose, L.S.1
  • 54
    • 0041743167 scopus 로고    scopus 로고
    • Monogenic hypercholesterolemia: New insights in pathogenesis and treatment
    • Rader DJ, Cohen J, Hobbs HH. 2003. Monogenic hypercholesterolemia: new insights in pathogenesis and treatment. J. Clin. Invest. 111:1795-803
    • (2003) J. Clin. Invest. , vol.111 , pp. 1795-1803
    • Rader, D.J.1    Cohen, J.2    Hobbs, H.H.3
  • 55
    • 0035451780 scopus 로고    scopus 로고
    • On the allelic spectrum of human disease
    • Reich D, Lander ES. 2001. On the allelic spectrum of human disease. Trends Genet. 17:502-10
    • (2001) Trends Genet. , vol.17 , pp. 502-510
    • Reich, D.1    Lander, E.S.2
  • 56
    • 0344892078 scopus 로고
    • Human genetics as a component of medical school curricula: A report to the American Society of Human Genetics
    • Riccardi VM, Schmickel RD. 1988. Human genetics as a component of medical school curricula: a report to The American Society of Human Genetics. Am. J. Hum. Genet. 43:639-43
    • (1988) Am. J. Hum. Genet. , vol.43 , pp. 639-643
    • Riccardi, V.M.1    Schmickel, R.D.2
  • 57
    • 17744393618 scopus 로고    scopus 로고
    • Mutations in the RNA component of RNase MRP cause a pleiotropic human disease, cartilage-hair hypoplasia
    • Ridanpaa M, van Eenennaam H, Pelin K, Chadwick RB, Johnson C, et al. 2001. Mutations in the RNA component of RNase MRP cause a pleiotropic human disease, cartilage-hair hypoplasia. Cell 104:195-203
    • (2001) Cell , vol.104 , pp. 195-203
    • Ridanpaa, M.1    Van Eenennaam, H.2    Pelin, K.3    Chadwick, R.B.4    Johnson, C.5
  • 58
    • 0034660559 scopus 로고    scopus 로고
    • Searching for genetic determinants in the new millennium
    • Risch NJ. 2000. Searching for genetic determinants in the new millennium. Nature 405:847-56
    • (2000) Nature , vol.405 , pp. 847-856
    • Risch, N.J.1
  • 59
    • 0028931717 scopus 로고
    • High risk of thrombosis in patients homozygous for Factor V Leiden (activated protein C resistance)
    • Rosendaal FR, Koster T, Vandenbroucke JP, Reitsma PH. 1995. High risk of thrombosis in patients homozygous for Factor V Leiden (activated protein C resistance), Blood 85:1504-8
    • (1995) Blood , vol.85 , pp. 1504-1508
    • Rosendaal, F.R.1    Koster, T.2    Vandenbroucke, J.P.3    Reitsma, P.H.4
  • 60
    • 0034660560 scopus 로고    scopus 로고
    • Pharmacogenetics and the practice of medicine
    • Roses AD. 2000. Pharmacogenetics and the practice of medicine. Nature 405:857-65
    • (2000) Nature , vol.405 , pp. 857-865
    • Roses, A.D.1
  • 61
    • 4544246587 scopus 로고    scopus 로고
    • Drug-gene interactions between genetic polymorphisms and antihypertensive therapy
    • Schelleman H, Stricker BH, DeBoer A, Kroon AA, Verschuren MW, et al. 2004. Drug-gene interactions between genetic polymorphisms and antihypertensive therapy. Drugs 64:1801-16
    • (2004) Drugs , vol.64 , pp. 1801-1816
    • Schelleman, H.1    Stricker, B.H.2    Deboer, A.3    Kroon, A.A.4    Verschuren, M.W.5
  • 62
    • 0000134296 scopus 로고    scopus 로고
    • Hyperphenylalaninemia: Phenylalanine hydroxylase deficiency
    • ed. CR Scriver, AL Beaudet, WS Sly, D Valle. New York: McGraw Hill
    • Scriver CR, Kaufman S. 2001. Hyperphenylalaninemia: phenylalanine hydroxylase deficiency. In The Metabolic and Molecular Bases of Inherited Disease, ed. CR Scriver, AL Beaudet, WS Sly, D Valle. pp. 1667-724. New York: McGraw Hill
    • (2001) The Metabolic and Molecular Bases of Inherited Disease , pp. 1667-1724
    • Scriver, C.R.1    Kaufman, S.2
  • 63
    • 0033168957 scopus 로고    scopus 로고
    • Monogenic traits are not simple: Lessons from phenylketonuria
    • Scriver CR, Waters PJ. 1999. Monogenic traits are not simple: lessons from phenylketonuria. Trends Genet. 15:267-72
    • (1999) Trends Genet. , vol.15 , pp. 267-272
    • Scriver, C.R.1    Waters, P.J.2
  • 64
    • 0001926005 scopus 로고
    • The scientific approach to disease: Specific entity and individual sickness
    • ed. AC Crombie. New York: Basic Books
    • Temkin O. 1963. The scientific approach to disease: specific entity and individual sickness. In Scientific Change, ed. AC Crombie, pp. 629-55. New York: Basic Books
    • (1963) Scientific Change , pp. 629-655
    • Temkin, O.1
  • 65
    • 0012119330 scopus 로고    scopus 로고
    • Mutation of Stargardt disease gene (ABCR) in age-related macular degeneration
    • Allikmets R, Shroyer F, Singh N, Seddon JM, Lewis RA, et al. 1997. Mutation of Stargardt disease gene (ABCR) in age-related macular degeneration. Science 277:1805-7
    • (1997) Science , vol.277 , pp. 1805-1807
    • Allikmets, R.1    Shroyer, F.2    Singh, N.3    Seddon, J.M.4    Lewis, R.A.5
  • 66
    • 0242524432 scopus 로고    scopus 로고
    • Patterns of human genetic diversity, implications for human evolutionary history and disease
    • Tishkoff SA, Verrelli BC. 2003. Patterns of human genetic diversity, implications for human evolutionary history and disease. Annu. Rev. Genomics Hum. Genet. 4:293-340
    • (2003) Annu. Rev. Genomics Hum. Genet. , vol.4 , pp. 293-340
    • Tishkoff, S.A.1    Verrelli, B.C.2
  • 67
    • 0036323319 scopus 로고    scopus 로고
    • Genetic analysis of African populations: Human evolution and complex disease
    • Tishkoff SA, Williams SM. 2002. Genetic analysis of African populations: human evolution and complex disease. Nat. Rev. (Genet.) 3:611-21
    • (2002) Nat. Rev. (Genet.) , vol.3 , pp. 611-621
    • Tishkoff, S.A.1    Williams, S.M.2
  • 68
    • 1542374070 scopus 로고    scopus 로고
    • American Society of Human Genetics Presidential Address 2003: Genetics, individuality and medicine in the 21st century
    • Valle D. 2004. American Society of Human Genetics Presidential Address 2003: Genetics, individuality and medicine in the 21st century. Am. J. Hum. Genet. 74:374-81
    • (2004) Am. J. Hum. Genet. , vol.74 , pp. 374-381
    • Valle, D.1
  • 70
    • 34347348571 scopus 로고
    • Genetics and the hierarchy of biological sciences
    • Wright S. 1959. Genetics and the hierarchy of biological sciences. Science 130:959-65
    • (1959) Science , vol.130 , pp. 959-965
    • Wright, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.