-
1
-
-
0032402903
-
Potassium ion channels and human disease: Phenotypes to drug targets?
-
Curran, M. E. Potassium ion channels and human disease: phenotypes to drug targets? Curr. Opin. Biotechnol. 9, 565-572 (1998).
-
(1998)
Curr. Opin. Biotechnol.
, vol.9
, pp. 565-572
-
-
Curran, M.E.1
-
2
-
-
0031730097
-
Drug target validation and identification of secondary drug target effects using DNA microarrays
-
Marton, M. J. et al. Drug target validation and identification of secondary drug target effects using DNA microarrays. Nature Med. 4, 1293-1301 (1998).
-
(1998)
Nature Med.
, vol.4
, pp. 1293-1301
-
-
Marton, M.J.1
-
3
-
-
0031720889
-
Genomics in the real world
-
Wiley, S. R. Genomics in the real world. Curr. Pharmceut. Des. 4, 417-422 (1998).
-
(1998)
Curr. Pharmceut. Des.
, vol.4
, pp. 417-422
-
-
Wiley, S.R.1
-
4
-
-
0032784646
-
Proteomics: Quantitative and physical mapping of cellular proteins
-
Blackstock, W. P. & Weir, M. P. Proteomics: quantitative and physical mapping of cellular proteins. Trends Biotechnol. 17, 121-127 (1999).
-
(1999)
Trends Biotechnol.
, vol.17
, pp. 121-127
-
-
Blackstock, W.P.1
Weir, M.P.2
-
6
-
-
0032779706
-
Differential gene expression in drug metabolism and toxicology: Practicalities, problems and potential
-
Rockett, J. C., Esdaile, D. J. & Gibson, G. G. Differential gene expression in drug metabolism and toxicology: practicalities, problems and potential. Xenobiotica 29, 655-691 (1999).
-
(1999)
Xenobiotica
, vol.29
, pp. 655-691
-
-
Rockett, J.C.1
Esdaile, D.J.2
Gibson, G.G.3
-
7
-
-
0027936838
-
Apolipoprotein E affects the rate of Alzheimer disease expression: Beta-amyloid burden is a secondary consequence dependent on APOE genotype and duration of disease
-
Roses, A. D. Apolipoprotein E affects the rate of Alzheimer disease expression: beta-amyloid burden is a secondary consequence dependent on APOE genotype and duration of disease. J. Neuropathol. Exp. Neurol. 53, 429-437 (1994).
-
(1994)
J. Neuropathol. Exp. Neurol.
, vol.53
, pp. 429-437
-
-
Roses, A.D.1
-
8
-
-
0033795279
-
Apolipoprotein E and Alzheimer's disease: An update on genetic and functional analyses
-
in the press
-
Saunders, A. M. Apolipoprotein E and Alzheimer's disease: an update on genetic and functional analyses J. Neuropathol. Exp. Neurol. (in the press).
-
J. Neuropathol. Exp. Neurol.
-
-
Saunders, A.M.1
-
9
-
-
0033427722
-
Apolipoprotein E expression by neurons surviving excitotoxic stress
-
Boschert, U., Merlo-Pich, E., Higgins, G., Roses, A. D. & Catsicas, S. Apolipoprotein E expression by neurons surviving excitotoxic stress. Neurobiol. Dis. 6, 508-514 (1999).
-
(1999)
Neurobiol. Dis.
, vol.6
, pp. 508-514
-
-
Boschert, U.1
Merlo-Pich, E.2
Higgins, G.3
Roses, A.D.4
Catsicas, S.5
-
10
-
-
0030175279
-
Human apolipoprotein E2, E3 and E4 isoform-specific transgenic mice: Human-like pattern of neuronal immunoreactivity in central nervous system not observed in wild type mice
-
Xu, P. T. et al. Human apolipoprotein E2, E3 and E4 isoform-specific transgenic mice: human-like pattern of neuronal immunoreactivity in central nervous system not observed in wild type mice. Neurobiol. Dis. 3, 229-245 (1996).
-
(1996)
Neurobiol. Dis.
, vol.3
, pp. 229-245
-
-
Xu, P.T.1
-
11
-
-
0032562645
-
Regionally specific neuronal expression of human APOE gene in transgenic mice
-
Xu, P. T. et al. Regionally specific neuronal expression of human APOE gene in transgenic mice. Neurosci. Lett. 246, 65-68 (1998).
-
(1998)
Neurosci. Lett.
, vol.246
, pp. 65-68
-
-
Xu, P.T.1
-
12
-
-
0344267650
-
Specific regional transcription of apolipoprotein E in human brain neurons
-
Xu, P. T. et al. Specific regional transcription of apolipoprotein E in human brain neurons. Am. J. Pathol. 154, 601-611 (1999).
-
(1999)
Am. J. Pathol.
, vol.154
, pp. 601-611
-
-
Xu, P.T.1
-
13
-
-
0033595261
-
Interleukin-4-dependent production of PPAR-γ ligands in macrophage by 12/15-lipoxygenase
-
Huang, J. T. et al. Interleukin-4-dependent production of PPAR-γ ligands in macrophage by 12/15-lipoxygenase. Nature 400, 378-382 (1999).
-
(1999)
Nature
, vol.400
, pp. 378-382
-
-
Huang, J.T.1
-
14
-
-
0033617520
-
Orphan nuclear receptors: Shifting endocrinology into reverse
-
Kliewer, S. A. Lehmann, J. M. & Wilson, T. M. Orphan nuclear receptors: shifting endocrinology into reverse. Science 284, 757-760 (1999).
-
(1999)
Science
, vol.284
, pp. 757-760
-
-
Kliewer, S.A.1
Lehmann, J.M.2
Wilson, T.M.3
-
15
-
-
0033599038
-
Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension
-
Barroso, I. et al. Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension. Nature 402, 880-883 (1999).
-
(1999)
Nature
, vol.402
, pp. 880-883
-
-
Barroso, I.1
-
16
-
-
0030005627
-
Apolipoprotein E alleles as risk factors in Alzheimer's disease
-
Roses, A. D. Apolipoprotein E alleles as risk factors in Alzheimer's disease. Annu. Rev. Med. 47, 387-400 (1996).
-
(1996)
Annu. Rev. Med.
, vol.47
, pp. 387-400
-
-
Roses, A.D.1
-
17
-
-
0026088977
-
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
-
Goate, A. et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349, 704-706 (1991).
-
(1991)
Nature
, vol.349
, pp. 704-706
-
-
Goate, A.1
-
18
-
-
0029087026
-
Candidate gene for the chromosome I familial Alzheimer's disease locus
-
Levy-Lehad, E. et al. Candidate gene for the chromosome I familial Alzheimer's disease locus. Science 269, 973-977 (1995).
-
(1995)
Science
, vol.269
, pp. 973-977
-
-
Levy-Lehad, E.1
-
19
-
-
0029004341
-
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
-
Sherrington, R. et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375, 754-760 (1995).
-
(1995)
Nature
, vol.375
, pp. 754-760
-
-
Sherrington, R.1
-
20
-
-
0026659436
-
Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis-Dutch type share a decrease in cerebrospinal fluid levels of amyloid beta-protein precursor
-
Van Nostrand, W. E., Wagner, S. L., Haan, J., Bakker, E. & Roos, R. A. Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis-Dutch type share a decrease in cerebrospinal fluid levels of amyloid beta-protein precursor. Ann. Neurol. 32, 215-218 (1992).
-
(1992)
Ann. Neurol.
, vol.32
, pp. 215-218
-
-
Van Nostrand, W.E.1
Wagner, S.L.2
Haan, J.3
Bakker, E.4
Roos, R.A.5
-
22
-
-
0029890317
-
The genetics of asthma
-
Sandford, A., Weir, T. & Pare, P. The genetics of asthma. Am. J. Respir. Crit. Care Med. 153, 1749-1765 (1996).
-
(1996)
Am. J. Respir. Crit. Care Med.
, vol.153
, pp. 1749-1765
-
-
Sandford, A.1
Weir, T.2
Pare, P.3
-
23
-
-
0030854184
-
Genetics of complex disease: Approaches, problems, and solutions
-
Schork, N. J, Genetics of complex disease: approaches, problems, and solutions. Am. J. Respir. Crit. Care Med. 156, S103-S109 (1997).
-
(1997)
Am. J. Respir. Crit. Care Med.
, vol.156
-
-
Schork, N.J.1
-
24
-
-
17344372511
-
A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus
-
Concannon, P. et al. A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus. Nature Genet. 19, 292-296 (1998).
-
(1998)
Nature Genet.
, vol.19
, pp. 292-296
-
-
Concannon, P.1
-
25
-
-
0033010861
-
Genetics of allergy and bronchial hyperresponsiveness
-
Howard, T. D. et al. Genetics of allergy and bronchial hyperresponsiveness. Clin. Exp. Allergy 29(Suppl.), 86-89 (1999).
-
(1999)
Clin. Exp. Allergy
, vol.29
, Issue.SUPPL.
, pp. 86-89
-
-
Howard, T.D.1
-
26
-
-
0032216675
-
Irritable bowel syndrome: Disease definition and symptom description
-
Talley, N. J. Irritable bowel syndrome: disease definition and symptom description. Eur. J. Surg. 583(Suppl.), 24-28 (1998).
-
(1998)
Eur. J. Surg.
, vol.583
, Issue.SUPPL.
, pp. 24-28
-
-
Talley, N.J.1
-
27
-
-
0033609492
-
Recommendations for the management of irritable bowel syndrome in family practice. IBS Consensus Conference Participants
-
Paterson, W. G. et al. Recommendations for the management of irritable bowel syndrome in family practice. IBS Consensus Conference Participants. Can. Med. Assoc. J. 161, 154-160 (1999).
-
(1999)
Can. Med. Assoc. J.
, vol.161
, pp. 154-160
-
-
Paterson, W.1
-
28
-
-
0033134902
-
Additional investigations fail to alter the diagnosis of irritable bowel syndrome in subjects fulfilling the Rome criteria
-
Hamm, L. R. et al. Additional investigations fail to alter the diagnosis of irritable bowel syndrome in subjects fulfilling the Rome criteria. Am. J. Gastroenterol. 94, 1279-1282 (1999).
-
(1999)
Am. J. Gastroenterol.
, vol.94
, pp. 1279-1282
-
-
Hamm, L.R.1
-
29
-
-
0033569516
-
Pharmacogenomics: Translating functional genomics into rational therapeutics
-
Evans W. E. & Relling, M. V. Pharmacogenomics: translating functional genomics into rational therapeutics. Science 286, 487-491 (1999).
-
(1999)
Science
, vol.286
, pp. 487-491
-
-
Evans, W.E.1
Relling, M.V.2
-
30
-
-
0030995879
-
Molecular mechanisms of genetic polymorphisms of drug metabolism
-
Meyer, U. A. & Zanger, U. M. Molecular mechanisms of genetic polymorphisms of drug metabolism. Annu. Rev. Pharmacol. Toxicol. 37, 269-296 (1997).
-
(1997)
Annu. Rev. Pharmacol. Toxicol.
, vol.37
, pp. 269-296
-
-
Meyer, U.A.1
Zanger, U.M.2
-
31
-
-
0030476715
-
Clinical Implications of antidepressant pharmacokinetics and pharmacogenetics
-
Cohen, L. J. & DeVane, C. L. Clinical Implications of antidepressant pharmacokinetics and pharmacogenetics. Ann. Pharmacology 3, 1471-1476 (1998).
-
(1998)
Ann. Pharmacology
, vol.3
, pp. 1471-1476
-
-
Cohen, L.J.1
DeVane, C.L.2
-
32
-
-
0021165503
-
Dropamine pharmacokinetics in Chinese and Caucasian volunteers
-
Rudorfer, M. V., Lane, E. A., Chang, W. H., Zhang, M. & Bower, W. Z. Dropamine pharmacokinetics in Chinese and Caucasian volunteers. Br. J. Clin Pharmacol. 17, 433-440 (1989).
-
(1989)
Br. J. Clin Pharmacol.
, vol.17
, pp. 433-440
-
-
Rudorfer, M.V.1
Lane, E.A.2
Chang, W.H.3
Zhang, M.4
Bower, W.Z.5
-
33
-
-
0003972016
-
-
(ed. Kalow, W.) Churchill Livingstone, Edinburgh
-
Mueller, R. F. & Young, I. D. in Emery's Elements of Medical Genetics (ed. Kalow, W.) 169-175 (Churchill Livingstone, Edinburgh, 1997).
-
(1997)
Emery's Elements of Medical Genetics
, pp. 169-175
-
-
Mueller, R.F.1
Young, I.D.2
-
34
-
-
0007525310
-
Mapping of complex traits by single-nucleotide polymorphisms
-
Zhao, L. P. Aragaki, C., Hsu, L. & Quizoit, F. Mapping of complex traits by single-nucleotide polymorphisms. Am. J. Hum. Genet. 63, 225-240 (1998).
-
(1998)
Am. J. Hum. Genet.
, vol.63
, pp. 225-240
-
-
Zhao, L.P.1
Aragaki, C.2
Hsu, L.3
Quizoit, F.4
-
35
-
-
0032997217
-
The essence of SNPs
-
Brookes, A. J. The essence of SNPs. Gene 234, 177-186 (1999).
-
(1999)
Gene
, vol.234
, pp. 177-186
-
-
Brookes, A.J.1
-
36
-
-
0343846955
-
Determination of ancestral allele for human single-nucleotide polymorphisms using high-density oligonucleotide arrays
-
Hacia, J. G. et al. Determination of ancestral allele for human single-nucleotide polymorphisms using high-density oligonucleotide arrays. Nature Genet. 27, 364-367 (1999).
-
(1999)
Nature Genet.
, vol.27
, pp. 364-367
-
-
Hacia, J.G.1
-
37
-
-
0030860004
-
Polymorphism of the cytochrome P450 CYP2D8 gene is a European population: Characterization of 48 mutations and 53 alleles, their fragnancies and evolution
-
Marez, D. et al. Polymorphism of the cytochrome P450 CYP2D8 gene is a European population: characterization of 48 mutations and 53 alleles, their fragnancies and evolution. Pharmacogenetics 7, 193-202 (1997).
-
(1997)
Pharmacogenetics
, vol.7
, pp. 193-202
-
-
Marez, D.1
-
38
-
-
0343411017
-
-
Foreword The Johns Hopkins University Press, Baltimore
-
McKusick, V. A. Foreword to Mendelian Inheritance in Men 10th edn, vol. 1, xv-xxxvii (The Johns Hopkins University Press, Baltimore, 1992).
-
(1992)
Mendelian Inheritance in Men 10th Edn
, vol.1
-
-
McKusick, V.A.1
-
39
-
-
0032533647
-
4-Mb high-density single nucleotide polymorphism-based map around human APOE
-
Lai, E., Riley, J., Purvis, I. & Roses, A. 4-Mb high-density single nucleotide polymorphism-based map around human APOE. Genomics 54, 31-38 (1998).
-
(1998)
Genomics
, vol.54
, pp. 31-38
-
-
Lai, E.1
Riley, J.2
Purvis, I.3
Roses, A.4
-
40
-
-
0034003082
-
Analysis of association at single nucleotide polymorphisms in the APOE region
-
Martin, E. R. et al. Analysis of association at single nucleotide polymorphisms in the APOE region. Genomics 63, 7-12 (2000).
-
(2000)
Genomics
, vol.63
, pp. 7-12
-
-
Martin, E.R.1
-
41
-
-
0033039497
-
Prospects for whole-genome linkage dimorphism mapping of common diseas genes
-
Kruglyak, L. Prospects for whole-genome linkage dimorphism mapping of common diseas genes. Nature Genet. 22, 139-144 (1999).
-
(1999)
Nature Genet.
, vol.22
, pp. 139-144
-
-
Kruglyak, L.1
-
42
-
-
0033592988
-
Genetic epidemiology of single-nucleotide polymorphisms
-
Collins, A., Lonjou, C. & Morton, N. E. Genetic epidemiology of single-nucleotide polymorphisms. Proc. Natl Acad. Sci. USA, 96, 15173-15177 (1999).
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 15173-15177
-
-
Collins, A.1
Lonjou, C.2
Morton, N.E.3
-
43
-
-
0034602718
-
Predicting the range of linkage disequilibrium
-
Ott, J. Predicting the range of linkage disequilibrium. Proc. Natl Acad. Sci. USA. 97, 2-3 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 2-3
-
-
Ott, J.1
-
44
-
-
0034060781
-
Microsphere-based assay for single-nucleotide polymorphism analysis using single base chain extension
-
Chen, J. et al. Microsphere-based assay for single-nucleotide polymorphism analysis using single base chain extension. Genome Res. 10, 549-557 (2000).
-
(2000)
Genome Res.
, vol.10
, pp. 549-557
-
-
Chen, J.1
-
46
-
-
0034655976
-
Pharmacogenetics and the future of drug development and delivery
-
Roses, A. D. Pharmacogenetics and the future of drug development and delivery. Lancet 355, 1358-1361 (2000).
-
(2000)
Lancet
, vol.355
, pp. 1358-1361
-
-
Roses, A.D.1
-
47
-
-
0033536012
-
Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays
-
Alon, U. et al. Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays. Proc. Natl Acad. Sci. USA 96, 6745-6750 (1999).
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 6745-6750
-
-
Alon, U.1
-
48
-
-
0033984655
-
Clinical trials in the genomic era. Effects of protective genotypes on sample size and duration of trial 2000
-
Bonnie, A., Fijal, M. S., Hall, J. M. & Witte, J. S. Clinical trials in the genomic era. Effects of protective genotypes on sample size and duration of trial 2000. Gastroenterol. Clin. Trials 21, 7-20 (2000).
-
(2000)
Gastroenterol. Clin. Trials
, vol.21
, pp. 7-20
-
-
Bonnie, A.1
Fijal, M.S.2
Hall, J.M.3
Witte, J.S.4
-
49
-
-
0032522873
-
Incidence of adverse drug reactions in hospitalized patients: A meta-analysis of prospective studies
-
Lazarou, J., Pomeranz, B. H. & Corey, P. N. Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. J. Am. Med. Assoc. 279, 1200-1205 (1998).
-
(1998)
J. Am. Med. Assoc.
, vol.279
, pp. 1200-1205
-
-
Lazarou, J.1
Pomeranz, B.H.2
Corey, P.N.3
-
50
-
-
0032542251
-
Making medicines safer - The need for an independent drug safety board
-
Wood, A. J., Stein, C. M. & Woosley, R. Making medicines safer - the need for an independent drug safety board. N. Engl. J. Med. 339, 1851-1854 (1998).
-
(1998)
N. Engl. J. Med.
, vol.339
, pp. 1851-1854
-
-
Wood, A.J.1
Stein, C.M.2
Woosley, R.3
-
51
-
-
0032779530
-
Targets and systems of health care coat control
-
White, J. Targets and systems of health care coat control. J. Health Politics Policy Law 24, 653-696 (1999).
-
(1999)
J. Health Politics Policy Law
, vol.24
, pp. 653-696
-
-
White, J.1
-
52
-
-
0033064813
-
Incorporating clinical outcomes and economic consequences into drug formulary decision: A practical approach
-
Mather, D. B., Sullivan, S. D., Augustein, D., Fullerton, P. & Atherton, D. Incorporating clinical outcomes and economic consequences into drug formulary decision: a practical approach. Am. J. Man. Care 5, 277-285 (1999).
-
(1999)
Am. J. Man. Care
, vol.5
, pp. 277-285
-
-
Mather, D.B.1
Sullivan, S.D.2
Augustein, D.3
Fullerton, P.4
Atherton, D.5
-
53
-
-
0032965722
-
Genetic testing and Alzheimer disease: Recommendations of the Stanford Program in Genomics, Ethics, and Society
-
McConnell, L. M. B. et al. Genetic testing and Alzheimer disease: recommendations of the Stanford Program in Genomics, Ethics, and Society. Genetic Testing 3, 3-12 (1999).
-
(1999)
Genetic Testing
, vol.3
, pp. 3-12
-
-
McConnell, L.M.B.1
-
54
-
-
0031854365
-
Genetic testing for BRCA1 and BRCA2: Recommendations of the Stanford Program in Genomics, Ethics, and Society
-
Breast Cancer Working Group
-
Koenig, B. A., Greely, H. T., McConnell, L. M., Silveberg, H. L. & Raffin, T. A. Genetic testing for BRCA1 and BRCA2: recommendations of the Stanford Program in Genomics, Ethics, and Society. Breast Cancer Working Group. J. Womens Health 7, 531-545 (1992).
-
(1992)
J. Womens Health
, vol.7
, pp. 531-545
-
-
Koenig, B.A.1
Greely, H.T.2
McConnell, L.M.3
Silveberg, H.L.4
Raffin, T.A.5
-
55
-
-
0033037686
-
Drug metabolism polymorphisms as modulators of cancer susceptibility
-
Taningher, M., Malcarne, D., Izzotti, A., Ugolini, D. & Parodi, S. Drug metabolism polymorphisms as modulators of cancer susceptibility. Mutation Res. 436, 227-261 (1999).
-
(1999)
Mutation Res.
, vol.436
, pp. 227-261
-
-
Taningher, M.1
Malcarne, D.2
Izzotti, A.3
Ugolini, D.4
Parodi, S.5
-
56
-
-
15844393893
-
Specificity, sensitivity, and predictive value of apolipoprotein-E genotyping for sporadic Alzheimer's disease
-
Saunders, A. M. et al. Specificity, sensitivity, and predictive value of apolipoprotein-E genotyping for sporadic Alzheimer's disease. Lancet 348, 90-93 (1996).
-
(1996)
Lancet
, vol.348
, pp. 90-93
-
-
Saunders, A.M.1
-
57
-
-
0032545939
-
Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer's disease. Alzheimer's disease Centers Consortium on Apolipoprotein e and Alzheimer's disease
-
Published erratum appears in N. Engl. J. Med. 338, 1325 (1998)
-
Mayeux, R., et al. Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer's disease. Alzheimer's disease Centers Consortium on Apolipoprotein E and Alzheimer's disease. N. Engl. J. Med. 338, 506-511 (1998). [Published erratum appears in N. Engl. J. Med. 338, 1325 (1998).]
-
(1998)
N. Engl. J. Med.
, vol.338
, pp. 506-511
-
-
Mayeux, R.1
-
58
-
-
0030776694
-
Genetic testing for Alzheimer disease. Practical and ethical issues
-
Roses, A. D. Genetic testing for Alzheimer disease. Practical and ethical issues. Arch. Neurol. 54, 1226-1229 (1997).
-
(1997)
Arch. Neurol.
, vol.54
, pp. 1226-1229
-
-
Roses, A.D.1
-
59
-
-
0027984085
-
Apolipoprotein E is a relevant susceptibility gene that affects the rate of expression of Alzheimer's disease
-
Roses, A. D. Apolipoprotein E is a relevant susceptibility gene that affects the rate of expression of Alzheimer's disease. Neurobiol. Aging 15(Suppl 2), S165-S167 (1994).
-
(1994)
Neurobiol. Aging
, vol.15
, Issue.2 SUPPL.
-
-
Roses, A.D.1
|