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Volumn 30, Issue 1, 2005, Pages 71-88

Introduction to the background, principles, and state of the art in suicide gene therapy

Author keywords

Bystander effect; Enzymes for GDEPT; GDEPT; Imaging; Prodrugs; Suicide gene therapy

Indexed keywords

CELLS; DRUG PRODUCTS; ENZYMES; IMAGING TECHNIQUES; IMMUNOLOGY; TUMORS;

EID: 25444474137     PISSN: 10736085     EISSN: None     Source Type: Journal    
DOI: 10.1385/mb:30:1:071     Document Type: Review
Times cited : (82)

References (89)
  • 1
    • 0029815716 scopus 로고    scopus 로고
    • Gene-directed enzyme prodrug therapy with a mustard prodrug/ carboxypeptidase G2 combination
    • Marais, R., Spooner, R. A., Light, Y., Martin, J., and Springer, C. J. (1996) Gene-directed enzyme prodrug therapy with a mustard prodrug/ carboxypeptidase G2 combination. Cancer Res. 56, 4735-4742.
    • (1996) Cancer Res. , vol.56 , pp. 4735-4742
    • Marais, R.1    Spooner, R.A.2    Light, Y.3    Martin, J.4    Springer, C.J.5
  • 2
    • 0029609610 scopus 로고
    • Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954
    • Bridgewater, G., Springer, C. J., Knox, R., Minton, N., Michael, P., and Collins, M. (1995) Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954. Eur. J. Cancer 31A, 2362-2370.
    • (1995) Eur. J. Cancer , vol.31 A , pp. 2362-2370
    • Bridgewater, G.1    Springer, C.J.2    Knox, R.3    Minton, N.4    Michael, P.5    Collins, M.6
  • 3
    • 0029637158 scopus 로고
    • VDEPT; an enzyme/prodrug gene therapy approach for the treatment of metastatic colorectal cancer
    • Huber, B. E., Richards, C. A., and Austin, E. A. (1995) VDEPT; an enzyme/prodrug gene therapy approach for the treatment of metastatic colorectal cancer. Adv. Drug Delivery Rev. 17, 279-292.
    • (1995) Adv. Drug Delivery Rev. , vol.17 , pp. 279-292
    • Huber, B.E.1    Richards, C.A.2    Austin, E.A.3
  • 4
    • 0035038479 scopus 로고    scopus 로고
    • Genetic prodrug activation therapy (GPAT) in two rat prostate models generates an immune bystander effect and can be monitored by magnetic resonance techniques
    • Eaton, J. L., Perry, M. J. A., Todryk, S. M., et al. (2001) Genetic prodrug activation therapy (GPAT) in two rat prostate models generates an immune bystander effect and can be monitored by magnetic resonance techniques. Gene Ther. 8, 557-567.
    • (2001) Gene Ther. , vol.8 , pp. 557-567
    • Eaton, J.L.1    Perry, M.J.A.2    Todryk, S.M.3
  • 5
    • 0034022622 scopus 로고    scopus 로고
    • Gene-delivery from replication-selective viruses: Arming guided missiles in the war against cancer
    • Hermiston, T. (2000) Gene-delivery from replication-selective viruses: arming guided missiles in the war against cancer. J. Clin. Invest. 105, 1169-1172.
    • (2000) J. Clin. Invest. , vol.105 , pp. 1169-1172
    • Hermiston, T.1
  • 6
    • 0031025998 scopus 로고    scopus 로고
    • Gene therapy for cancer: What have we done and where are we going?
    • Roth, J. A. and Cristiano, R. G. (1997) Gene therapy for cancer: what have we done and where are we going? J. Natl. Cancer Inst. 89, 21-30.
    • (1997) J. Natl. Cancer Inst. , vol.89 , pp. 21-30
    • Roth, J.A.1    Cristiano, R.G.2
  • 8
    • 0032879929 scopus 로고    scopus 로고
    • Patent property of prodrug involving gene therapy (1996-1999)
    • Springer, C. J. and Niculescu-Duvaz, I. (1999) Patent property of prodrug involving gene therapy (1996-1999). Exp. Opin. Ther. Patents 9, 1381-1388.
    • (1999) Exp. Opin. Ther. Patents , vol.9 , pp. 1381-1388
    • Springer, C.J.1    Niculescu-Duvaz, I.2
  • 10
    • 0032535405 scopus 로고    scopus 로고
    • Adeno-associated virus-mediated delivery of antiangiogenic factors as an antitumor stratergy
    • Nguyen, J. T., Wu, P., Clouse, M. E., Hlatky, L., and Terwilliger, E. F. (1998) Adeno-associated virus-mediated delivery of antiangiogenic factors as an antitumor stratergy. Cancer Res. 58, 5673-5677.
    • (1998) Cancer Res. , vol.58 , pp. 5673-5677
    • Nguyen, J.T.1    Wu, P.2    Clouse, M.E.3    Hlatky, L.4    Terwilliger, E.F.5
  • 11
    • 0031770243 scopus 로고    scopus 로고
    • Viral vectors for gene therapy
    • Robbins, P. D. and Ghivizzani, S. C. (1998) Viral vectors for gene therapy. Pharm. Ther. 80, 35-47.
    • (1998) Pharm. Ther. , vol.80 , pp. 35-47
    • Robbins, P.D.1    Ghivizzani, S.C.2
  • 12
    • 0033088695 scopus 로고    scopus 로고
    • Development and application of adenoviral vectors for gene therapy of cancer
    • Zhang, W. W. (1999) Development and application of adenoviral vectors for gene therapy of cancer. Cancer Gene Ther. 7, 113-138.
    • (1999) Cancer Gene Ther. , vol.7 , pp. 113-138
    • Zhang, W.W.1
  • 14
    • 0034490393 scopus 로고    scopus 로고
    • Toward the optimal vector for prostate cancer gene therapy; a CaPCURE meeting report
    • Roth, M. G. and Curiel, D. T. (2000) Toward the optimal vector for prostate cancer gene therapy; a CaPCURE meeting report. Cancer Gene Ther. 7, 1507-1510.
    • (2000) Cancer Gene Ther. , vol.7 , pp. 1507-1510
    • Roth, M.G.1    Curiel, D.T.2
  • 15
    • 0035134629 scopus 로고    scopus 로고
    • Clinical research results with di 1520 (ONYX-015), a replication selective adenovirus for the treatment of cancer: What have we learned?
    • Kirn, D. (2001) Clinical research results with dI 1520 (ONYX-015), a replication selective adenovirus for the treatment of cancer: what have we learned? Gene Ther. 8, 89-98.
    • (2001) Gene Ther. , vol.8 , pp. 89-98
    • Kirn, D.1
  • 16
    • 0032479769 scopus 로고    scopus 로고
    • Cationic liposomes for gene therapy
    • Miller, A. D. (1998) Cationic liposomes for gene therapy. Angew. Chem. Int. Ed. 37, 1768-1785.
    • (1998) Angew. Chem. Int. Ed. , vol.37 , pp. 1768-1785
    • Miller, A.D.1
  • 17
    • 0034997403 scopus 로고    scopus 로고
    • Non-viral vectors in cancer gene therapy: Principles and progress
    • Schatzlein, A. G. (2001) Non-viral vectors in cancer gene therapy: principles and progress. Anti-Cancer Drug Des. 12, 275-304.
    • (2001) Anti-Cancer Drug Des. , vol.12 , pp. 275-304
    • Schatzlein, A.G.1
  • 18
    • 0034105702 scopus 로고    scopus 로고
    • Prodrug-activating systems in suicide gene therapy
    • Springer, C. J. and Niculescu-Duvaz, I. (2000) Prodrug-activating systems in suicide gene therapy. J. Clin. Investig. 105, 1161-1167.
    • (2000) J. Clin. Investig. , vol.105 , pp. 1161-1167
    • Springer, C.J.1    Niculescu-Duvaz, I.2
  • 20
    • 0033900009 scopus 로고    scopus 로고
    • Bystander effect in herpes simplex virus-thymidine kinase/ganciclovir cancer gene therapy: Role of gap-junctional intercellular communications
    • Mesnil, M. and Yamasachi, H. (2000) Bystander effect in herpes simplex virus-thymidine kinase/ganciclovir cancer gene therapy: role of gap-junctional intercellular communications. Cancer Res. 60, 3989-3999.
    • (2000) Cancer Res. , vol.60 , pp. 3989-3999
    • Mesnil, M.1    Yamasachi, H.2
  • 21
    • 0031956262 scopus 로고    scopus 로고
    • The design of selectively-activated anti-cancer prodrugs for use in antibody-directed and gene-directed enzyme prodrugs therapies
    • Denny, W. A. and Wilson, W. R. (1998) The design of selectively-activated anti-cancer prodrugs for use in antibody-directed and gene-directed enzyme prodrugs therapies. J. Pharm. Pharmacol. 50, 387-394.
    • (1998) J. Pharm. Pharmacol. , vol.50 , pp. 387-394
    • Denny, W.A.1    Wilson, W.R.2
  • 23
    • 2342467196 scopus 로고    scopus 로고
    • Gene-directed enzyme prodrug therapy
    • (Baguley, B., ed.). Academic, New York
    • Springer, C. J. and Niculescu-Duvaz, I. (2002) Gene-directed enzyme prodrug therapy. In: Anticancer Drug Development (Baguley, B., ed.). Academic, New York, pp. 137-135.
    • (2002) Anticancer Drug Development , pp. 137-1135
    • Springer, C.J.1    Niculescu-Duvaz, I.2
  • 24
    • 0031437780 scopus 로고    scopus 로고
    • A cell surface tethered enzyme improves efficiency in gene-directed enzyme prodrug therapy
    • Marais, R., Spooner, R. A., Stribbling, S. M., Light, Y., Martin, J., and Springer, C. J. (1997) A cell surface tethered enzyme improves efficiency in gene-directed enzyme prodrug therapy. Nature Biotechnol. 15, 1373-1377.
    • (1997) Nature Biotechnol. , vol.15 , pp. 1373-1377
    • Marais, R.1    Spooner, R.A.2    Stribbling, S.M.3    Light, Y.4    Martin, J.5    Springer, C.J.6
  • 25
    • 0035100085 scopus 로고    scopus 로고
    • Human prostate carcinoma cells as target for herpes simplex virus thymidine kinase-mediated suicide gene therapy
    • Loimas, S., Toppinen, M.-R., Visakorpi, T., Janne, J., and Wahlfors, D. (2001) Human prostate carcinoma cells as target for herpes simplex virus thymidine kinase-mediated suicide gene therapy. Cancer Gene Ther. 8, 137-144.
    • (2001) Cancer Gene Ther. , vol.8 , pp. 137-144
    • Loimas, S.1    Toppinen, M.-R.2    Visakorpi, T.3    Janne, J.4    Wahlfors, D.5
  • 26
    • 0034490547 scopus 로고    scopus 로고
    • Combined suicide and granulocyte-macrophage colony-stimulating factor gene therapy induces complete tumor regression and generates antitumor immunity
    • Jones, R. K., Pope, I. M., Kinsella, A. R., Watson, A. J. M., and Christmas, S. E. (2000) Combined suicide and granulocyte-macrophage colony-stimulating factor gene therapy induces complete tumor regression and generates antitumor immunity. Cancer Gene Ther. 7, 1519-1528.
    • (2000) Cancer Gene Ther. , vol.7 , pp. 1519-1528
    • Jones, R.K.1    Pope, I.M.2    Kinsella, A.R.3    Watson, A.J.M.4    Christmas, S.E.5
  • 27
    • 0034072458 scopus 로고    scopus 로고
    • Bystander-mediated regression of osteosarcoma via retroviral transfer of the herpes simplex virus thymidine kinase and human interleukin-2 genes
    • Walling, H. W., Swarthout, G. T., and Culver, K. W. (2000) Bystander-mediated regression of osteosarcoma via retroviral transfer of the herpes simplex virus thymidine kinase and human interleukin-2 genes. Cancer Gene Ther. 7, 187-196.
    • (2000) Cancer Gene Ther. , vol.7 , pp. 187-196
    • Walling, H.W.1    Swarthout, G.T.2    Culver, K.W.3
  • 28
    • 0033920755 scopus 로고    scopus 로고
    • Transduction of human pancreatic tumor cells with vesicular stomatitis virus G-pseudotyped retroviral vectors containing a herpes simplex virus thymidine kinase mutant gene enhances bystander effects and sensitivity to ganciclovir
    • Howard, B. D., Boenicke, L., Schniewind, B., Henne-Bruns, D., and Kalthoff, H. (2000) Transduction of human pancreatic tumor cells with vesicular stomatitis virus G-pseudotyped retroviral vectors containing a herpes simplex virus thymidine kinase mutant gene enhances bystander effects and sensitivity to ganciclovir. Cancer Gene Ther. 7, 927-938.
    • (2000) Cancer Gene Ther. , vol.7 , pp. 927-938
    • Howard, B.D.1    Boenicke, L.2    Schniewind, B.3    Henne-Bruns, D.4    Kalthoff, H.5
  • 29
    • 0034128036 scopus 로고    scopus 로고
    • Herpes simplex virus thymidine kinase gene therapy in experimental rat BT4C glioma model: Effect of the percentage of thymidine kinase-positive glioma cells on treatment effect, survival time, and tissue reac¬≠tions
    • Sandmair, A.-M., Turunen, M., Tyynela, K., et al. (2000) Herpes simplex virus thymidine kinase gene therapy in experimental rat BT4C glioma model: effect of the percentage of thymidine kinase-positive glioma cells on treatment effect, survival time, and tissue reac¬≠tions. Cancer Gene Ther. 7, 413-421.
    • (2000) Cancer Gene Ther. , vol.7 , pp. 413-421
    • Sandmair, A.-M.1    Turunen, M.2    Tyynela, K.3
  • 30
    • 0033980574 scopus 로고    scopus 로고
    • Purified herpes simplex thymidine kinase retroviral particles. II. Influence of clinical parameters and bystander killing mechanisms
    • Kruse, C. A., Lamb, C., Hogan, S., Russell Smiley, W., Kleinschmidt-DeMasters, B., and Burrows, F. G. (2000) Purified herpes simplex thymidine kinase retroviral particles. II. Influence of clinical parameters and bystander killing mechanisms. Cancer Gene Ther. 7, 118-127.
    • (2000) Cancer Gene Ther. , vol.7 , pp. 118-127
    • Kruse, C.A.1    Lamb, C.2    Hogan, S.3    Russell Smiley, W.4    Kleinschmidt-DeMasters, B.5    Burrows, F.G.6
  • 31
    • 0034922609 scopus 로고    scopus 로고
    • E-5-(2-bromovinyl)-2′-deoxyuridine potentiates ganciclovir-mediated cytotoxicity on herpes simplex virus-thymidine kinase-expressing cells
    • Hamel, W., Zirkel, D., Mehdorn, H. M., Westphal, M., and Israel, M. A. (2001) E-5-(2-bromovinyl)-2′-deoxyuridine potentiates ganciclovir-mediated cytotoxicity on herpes simplex virus-thymidine kinase-expressing cells. Cancer Gene Ther. 8, 388-396.
    • (2001) Cancer Gene Ther. , vol.8 , pp. 388-396
    • Hamel, W.1    Zirkel, D.2    Mehdorn, H.M.3    Westphal, M.4    Israel, M.A.5
  • 32
    • 0034033272 scopus 로고    scopus 로고
    • Comparative in vitro and in vivo cytotoxic activity of (E)-5-(2-bromovinyl)-2′-deoxyuridine (BVDU) and its arabinosyl derivative, (E)-5-(2-bromovinyl)-1-β-D-arabinofuranosyluracil (BVaraU), against tumor cells expressing either the Varicella zoster or the Herpes simplex virus thymidine kinase
    • Grignet-Debrus, C., Cool, V., Baudson, N., et al. (2000) Comparative in vitro and in vivo cytotoxic activity of (E)-5-(2-bromovinyl)-2′- deoxyuridine (BVDU) and its arabinosyl derivative, (E)-5-(2-bromovinyl)-1- β-D-arabinofuranosyluracil (BVaraU), against tumor cells expressing either the Varicella zoster or the Herpes simplex virus thymidine kinase. Cancer Gene Ther. 7, 215-223.
    • (2000) Cancer Gene Ther. , vol.7 , pp. 215-223
    • Grignet-Debrus, C.1    Cool, V.2    Baudson, N.3
  • 33
    • 0034660858 scopus 로고    scopus 로고
    • In vivo cancer gene therapy by adenovirus-mediated transfer of a bifunctional yeast cytosine deaminase/uracil phosphoribosyltransferase fusion gene
    • Erbs, P., Regulier, E., Kintz, J., et al. (2000) In vivo cancer gene therapy by adenovirus-mediated transfer of a bifunctional yeast cytosine deaminase/uracil phosphoribosyltransferase fusion gene. Cancer Res. 60, 3813-3822.
    • (2000) Cancer Res. , vol.60 , pp. 3813-3822
    • Erbs, P.1    Regulier, E.2    Kintz, J.3
  • 34
    • 0033950759 scopus 로고    scopus 로고
    • Cytosine deaminase suicide gene therapy for peritoneal carcinomatosis
    • Bentires-Alj, M., Helin, A.-C., Lechanteur, C., et al. (2000) Cytosine deaminase suicide gene therapy for peritoneal carcinomatosis. Cancer Gene Ther. 7, 20-26.
    • (2000) Cancer Gene Ther. , vol.7 , pp. 20-26
    • Bentires-Alj, M.1    Helin, A.-C.2    Lechanteur, C.3
  • 35
    • 0035399802 scopus 로고    scopus 로고
    • Appropriate subcellular location of prodrug-activating enzymes has important consequences for suicide gene therapy
    • Spooner, R. A., Maycroft, K. A., Paterson, H., Friedlos, F., Springer, C. J., and Marais, R. (2001) Appropriate subcellular location of prodrug-activating enzymes has important consequences for suicide gene therapy. Int. J. Cancer 93, 123-130.
    • (2001) Int. J. Cancer , vol.93 , pp. 123-130
    • Spooner, R.A.1    Maycroft, K.A.2    Paterson, H.3    Friedlos, F.4    Springer, C.J.5    Marais, R.6
  • 36
    • 0033981131 scopus 로고    scopus 로고
    • The nitroreductase/CB1954 combination in Epstein-Barr virus-positive B cell lines: Induction of bystander killing in vitro and in vivo
    • Westphal, E.-M., Ge, J., Catchpole, J. R., Ford, M., and Kennedy, S. C. (2000) The nitroreductase/CB1954 combination in Epstein-Barr virus-positive B cell lines: induction of bystander killing in vitro and in vivo. Cancer Gene Ther. 7, 97-106.
    • (2000) Cancer Gene Ther. , vol.7 , pp. 97-106
    • Westphal, E.-M.1    Ge, J.2    Catchpole, J.R.3    Ford, M.4    Kennedy, S.C.5
  • 38
    • 0034947012 scopus 로고    scopus 로고
    • Cell surface display of a lysosomal enzyme for extra-cellular gene-directed enzyme prodrug therapy
    • Heine, D., Muller, R., and Brusselbach, S. (2001) Cell surface display of a lysosomal enzyme for extra-cellular gene-directed enzyme prodrug therapy. Gene Ther. 8, 1005-1010.
    • (2001) Gene Ther. , vol.8 , pp. 1005-1010
    • Heine, D.1    Muller, R.2    Brusselbach, S.3
  • 39
    • 0033961881 scopus 로고    scopus 로고
    • Expression of endogenously activated secreted or cell surface carboxypeptidase A sensitizes tumor cells to methotrexate-_-peptide prodrugs
    • Hamstra, D. A., Page, M., Maybaum, J., and Rehemtulla, A. (2000) Expression of endogenously activated secreted or cell surface carboxypeptidase A sensitizes tumor cells to methotrexate-_-peptide prodrugs. Cancer Res. 60, 657-665.
    • (2000) Cancer Res. , vol.60 , pp. 657-665
    • Hamstra, D.A.1    Page, M.2    Maybaum, J.3    Rehemtulla, A.4
  • 40
    • 0034688260 scopus 로고    scopus 로고
    • Regressions of established breast cancer xenografts by carboxypeptidase G2 suicide gene therapy and the prodrug CMDA are due to a bystander effect
    • Stribbling, S. M., Friedlos, F., Martin, J., et al. (2000) Regressions of established breast cancer xenografts by carboxypeptidase G2 suicide gene therapy and the prodrug CMDA are due to a bystander effect. Hum. Gene Ther. 11, 285-292.
    • (2000) Hum. Gene Ther. , vol.11 , pp. 285-292
    • Stribbling, S.M.1    Friedlos, F.2    Martin, J.3
  • 41
    • 0033664464 scopus 로고    scopus 로고
    • Development of a novel enzyme/prodrug combination for gene therapy of cancer: Horseradish per-oxidase/indole-3-acetic acid
    • Greco, O., Folkes, L. K., Wardman, P., Tozer, G. M., and Dachs, G. U. (2000) Development of a novel enzyme/prodrug combination for gene therapy of cancer: horseradish per-oxidase/indole-3-acetic acid. Cancer Gene Ther. 7, 1414-1420.
    • (2000) Cancer Gene Ther. , vol.7 , pp. 1414-1420
    • Greco, O.1    Folkes, L.K.2    Wardman, P.3    Tozer, G.M.4    Dachs, G.U.5
  • 42
    • 0034541169 scopus 로고    scopus 로고
    • Tyrosinase mutants are capable of prodrug activation in transfected non-melanotic cells
    • Simonova, M., Wall, A., Weissleder, R., and Bogdanov, A. (2000). Tyrosinase mutants are capable of prodrug activation in transfected non-melanotic cells. Cancer Res. 60, 6656-6662.
    • (2000) Cancer Res. , vol.60 , pp. 6656-6662
    • Simonova, M.1    Wall, A.2    Weissleder, R.3    Bogdanov, A.4
  • 43
    • 0034087221 scopus 로고    scopus 로고
    • Expression of Escherichia coli uracil phosphoribosyltransferase gene in murine colon carcinoma cells augments the antitumoral effect of 5-fluorouracil and induces protective immunity
    • Kawamura, K., Tasaki, K., Hamada, H., Takenaga, K., Sakiyama, S., and Tagawa, M. (2000) Expression of Escherichia coli uracil phosphoribosyltransferase gene in murine colon carcinoma cells augments the antitumoral effect of 5-fluorouracil and induces protective immunity. Cancer Gene Ther. 7, 637-643.
    • (2000) Cancer Gene Ther. , vol.7 , pp. 637-643
    • Kawamura, K.1    Tasaki, K.2    Hamada, H.3    Takenaga, K.4    Sakiyama, S.5    Tagawa, M.6
  • 44
    • 0035875466 scopus 로고    scopus 로고
    • Fluoropyrimidine sensitivity of human MCF-7 breast cancer cells stably transfected with human uridine phosphorylase
    • Cuq, P., Rouquet, C., Evrard, A., Ciccolini, J., Vian, L., and Cano, J.-P. (2001) Fluoropyrimidine sensitivity of human MCF-7 breast cancer cells stably transfected with human uridine phosphorylase. Br. J. Cancer 84, 1677-1680.
    • (2001) Br. J. Cancer , vol.84 , pp. 1677-1680
    • Cuq, P.1    Rouquet, C.2    Evrard, A.3    Ciccolini, J.4    Vian, L.5    Cano, J.-P.6
  • 45
    • 0033993506 scopus 로고    scopus 로고
    • Secreted human _-glucuronidase: A novel tool for gene-directed enzyme prodrug therapy
    • Weyel, D., Sedlacek, H. H., Muller, R., and Brusselbach, S. (2000) Secreted human _-glucuronidase: a novel tool for gene-directed enzyme prodrug therapy. Gene Ther. 7, 224-231.
    • (2000) Gene Ther. , vol.7 , pp. 224-231
    • Weyel, D.1    Sedlacek, H.H.2    Muller, R.3    Brusselbach, S.4
  • 46
    • 0029883624 scopus 로고    scopus 로고
    • Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy
    • Black, M. E., Newcomb, T. G., Wilson, H. M., and Loeb, L. A. (1996) Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy. Proc. Natl. Acad. Sci. USA 93, 3525-3529.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 3525-3529
    • Black, M.E.1    Newcomb, T.G.2    Wilson, H.M.3    Loeb, L.A.4
  • 47
    • 0035300565 scopus 로고    scopus 로고
    • Herpes simplex virus-1 thymidine kinase mutants created by semi-random sequence mutagenesis improve prodrug-mediated tumor cell killing
    • Black, M., Kokoris, M. S., and Sabo, P. (2001) Herpes simplex virus-1 thymidine kinase mutants created by semi-random sequence mutagenesis improve prodrug-mediated tumor cell killing. Cancer Res. 61, 3022-3026.
    • (2001) Cancer Res. , vol.61 , pp. 3022-3026
    • Black, M.1    Kokoris, M.S.2    Sabo, P.3
  • 48
    • 26244435639 scopus 로고    scopus 로고
    • Enzymes Combinations for Destroying Proliferative Cells, US Patent W09735024, Rhone-Poulenc Roerer, p. 1-61
    • Blanche, F., Cameron, B., Couder, M., and Crouzet, J. (1997). Enzymes Combinations for Destroying Proliferative Cells, US Patent W09735024, Rhone-Poulenc Roerer, p. 1-61.
    • (1997)
    • Blanche, F.1    Cameron, B.2    Couder, M.3    Crouzet, J.4
  • 49
    • 0030810198 scopus 로고    scopus 로고
    • Potentiation of cytochrome P450/cyclo-phosphamide-based cancer gene therapy by coexpression of the P450 reductase gene
    • Chen, L., Yu, L. J., and Waxman, D. J. (1997) Potentiation of cytochrome P450/cyclo-phosphamide-based cancer gene therapy by coexpression of the P450 reductase gene. Cancer Res. 57, 4830-4837.
    • (1997) Cancer Res. , vol.57 , pp. 4830-4837
    • Chen, L.1    Yu, L.J.2    Waxman, D.J.3
  • 50
    • 0040717056 scopus 로고    scopus 로고
    • Ganciclovir-mediated cell killing and bystander effect is enhanced in cells with two copies of the herpes simplex virus thymidine kinase
    • Kim, Y. G., Bi, W., Feliciano, E. S., Drake, R. R., and Stambrook, P. J. (2000) Ganciclovir-mediated cell killing and bystander effect is enhanced in cells with two copies of the herpes simplex virus thymidine kinase. Cancer Gene Ther. 7, 240-246.
    • (2000) Cancer Gene Ther. , vol.7 , pp. 240-246
    • Kim, Y.G.1    Bi, W.2    Feliciano, E.S.3    Drake, R.R.4    Stambrook, P.J.5
  • 51
    • 0034115137 scopus 로고    scopus 로고
    • Combined chemotherapy of murine mammary tumors by local activation of the prodrug ifosfamide and 5-fluorocytosine
    • Kammertoens, T., Gelbmann, W., Karle, P., et al. (2000) Combined chemotherapy of murine mammary tumors by local activation of the prodrug ifosfamide and 5-fluorocytosine. Cancer Gene Ther. 7, 629-636.
    • (2000) Cancer Gene Ther. , vol.7 , pp. 629-636
    • Kammertoens, T.1    Gelbmann, W.2    Karle, P.3
  • 52
    • 0033984339 scopus 로고    scopus 로고
    • Double suicide gene therapy augments the antitumor activity of a replication-competent lytic adenovirus through enhanced cytotoxicity and radiosensitization
    • Rogulski, K. R., Wing, M. S., Paielli, D. L., Gilbert, J. D., Kim J. H., and Freytag, S. O. (2000) Double suicide gene therapy augments the antitumor activity of a replication-competent lytic adenovirus through enhanced cytotoxicity and radiosensitization. Hum. Gene Ther. 11, 67-76.
    • (2000) Hum. Gene Ther. , vol.11 , pp. 67-76
    • Rogulski, K.R.1    Wing, M.S.2    Paielli, D.L.3    Gilbert, J.D.4    Kim, J.H.5    Freytag, S.O.6
  • 53
    • 0035076462 scopus 로고    scopus 로고
    • Combination suicide/cytokine gene therapy as adjuvants to a defective herpes simplex virus-based cancer vaccine
    • Toda, M., Martuza, R. L., and Rabkin, S. D. (2001) Combination suicide/cytokine gene therapy as adjuvants to a defective herpes simplex virus-based cancer vaccine. Gene Ther. 8, 332-339.
    • (2001) Gene Ther. , vol.8 , pp. 332-339
    • Toda, M.1    Martuza, R.L.2    Rabkin, S.D.3
  • 54
    • 0034034314 scopus 로고    scopus 로고
    • Use of a herpes thymidine kinase/neomycin phosphotransferase chimeric gene for metabolic suicide gene therapy
    • Candotti, F., Agbaria, R., Mullen, C. A., et al. (2000) Use of a herpes thymidine kinase/neomycin phosphotransferase chimeric gene for metabolic suicide gene therapy. Cancer Gene Ther. 7, 574-580.
    • (2000) Cancer Gene Ther. , vol.7 , pp. 574-580
    • Candotti, F.1    Agbaria, R.2    Mullen, C.A.3
  • 55
    • 0033974798 scopus 로고    scopus 로고
    • Comparison of the genotoxic and apoptosis-inducing properties of ganciclovir and penciclovir in Chinese hamster ovary cells transfected with the thymidine kinase gene of herpes simplex virus-1: Implication for gene therapeutic approaches
    • Thust, R., Tomicic, M., Klocking, R., Voutilainen, N., Wutzler, P., and Kaina, B. (2000) Comparison of the genotoxic and apoptosis-inducing properties of ganciclovir and penciclovir in Chinese hamster ovary cells transfected with the thymidine kinase gene of herpes simplex virus-1: implication for gene therapeutic approaches. Cancer Gene Ther. 7, 107-117.
    • (2000) Cancer Gene Ther. , vol.7 , pp. 107-117
    • Thust, R.1    Tomicic, M.2    Klocking, R.3    Voutilainen, N.4    Wutzler, P.5    Kaina, B.6
  • 56
    • 0034039073 scopus 로고    scopus 로고
    • Avoidance of bone marrow suppression using A-5021 as a nucleoside analog for retrovirus-mediated herpes simplex virus type I thymidine kinase gene therapy
    • Hasegawa, Y., Nishiyama, Y., Imaizumi, K., et al. (2000) Avoidance of bone marrow suppression using A-5021 as a nucleoside analog for retrovirus-mediated herpes simplex virus type I thymidine kinase gene therapy. Cancer Gene Ther. 7, 557-562.
    • (2000) Cancer Gene Ther. , vol.7 , pp. 557-562
    • Hasegawa, Y.1    Nishiyama, Y.2    Imaizumi, K.3
  • 57
    • 0033951472 scopus 로고    scopus 로고
    • Potentiation of ganciclovir toxicity in the herpes simplex virus thymidine kinase/ganciclovir administration system by ponicidin
    • Hayashi, K., Hayashi, T., Sun, H.-D., and Takeda, I. (2000) Potentiation of ganciclovir toxicity in the herpes simplex virus thymidine kinase/ganciclovir administration system by ponicidin. Cancer Gene Ther. 7, 45-42.
    • (2000) Cancer Gene Ther. , vol.7 , pp. 45-142
    • Hayashi, K.1    Hayashi, T.2    Sun, H.-D.3    Takeda, I.4
  • 58
    • 0034085228 scopus 로고    scopus 로고
    • Two-drug combinations that increase apoptosis and modulate Bak and Bcl-XL expression in human colon tumor cell lines transduced with herpes simplex virus thymidine kinase
    • McMasters, R. A., Wilbert, T. N., Jones, K. E., et al. (2000) Two-drug combinations that increase apoptosis and modulate Bak and Bcl-XL expression in human colon tumor cell lines transduced with herpes simplex virus thymidine kinase. Cancer Gene Ther. 7, 563-573.
    • (2000) Cancer Gene Ther. , vol.7 , pp. 563-573
    • McMasters, R.A.1    Wilbert, T.N.2    Jones, K.E.3
  • 59
    • 0032169967 scopus 로고    scopus 로고
    • Superior cytotoxicity with gancyclovir compared with acyclovir and 1-β-D-arabinofuranosylthymine in herpes simplex virus-thymidine kinase-expressing-cells: A novel paradigm for cell killing
    • Rubsam, L. Z., Davidson, L., and Shewach, D. S. (1998) Superior cytotoxicity with gancyclovir compared with acyclovir and 1-β-D- arabinofuranosylthymine in herpes simplex virus-thymidine kinase-expressing- cells: a novel paradigm for cell killing. Cancer Res. 58, 3873-3882.
    • (1998) Cancer Res. , vol.58 , pp. 3873-3882
    • Rubsam, L.Z.1    Davidson, L.2    Shewach, D.S.3
  • 60
    • 0034654516 scopus 로고    scopus 로고
    • Synergistic enhancement of herpes simplex virus thymidine kinase/ganciclovir mediated cytotoxicity by hydroxyurea
    • Boucher, P. D., Ostruszka, L. J., and Shewach, D. S. (2000) Synergistic enhancement of herpes simplex virus thymidine kinase/ganciclovir mediated cytotoxicity by hydroxyurea. Cancer Res. 60, 1631-1636.
    • (2000) Cancer Res. , vol.60 , pp. 1631-1636
    • Boucher, P.D.1    Ostruszka, L.J.2    Shewach, D.S.3
  • 61
    • 0033943812 scopus 로고    scopus 로고
    • Impact of liver P450 reductase suppression on cyclophosphamide activation, pharmacokinetics and antitumoral activity in a cytochrom P450-based cancer gene therapy model
    • Huang, Z., Raychowdhury, K., and Waxman, D. J. (2000) Impact of liver P450 reductase suppression on cyclophosphamide activation, pharmacokinetics and antitumoral activity in a cytochrom P450-based cancer gene therapy model. Cancer Gene Ther. 7, 1034-1042.
    • (2000) Cancer Gene Ther. , vol.7 , pp. 1034-1042
    • Huang, Z.1    Raychowdhury, K.2    Waxman, D.J.3
  • 62
    • 0034660849 scopus 로고    scopus 로고
    • Combination of the bioreductive drug tirapazamine with the chemotherapeutic prodrug cyclophosphamide for P450/P450-reductase-based cancer gene therapy
    • Jounaidi, Y. and Waxman, D. J. (2000) Combination of the bioreductive drug tirapazamine with the chemotherapeutic prodrug cyclophosphamide for P450/P450-reductase-based cancer gene therapy. Cancer Res. 60, 3761-3769.
    • (2000) Cancer Res. , vol.60 , pp. 3761-3769
    • Jounaidi, Y.1    Waxman, D.J.2
  • 63
    • 0035138403 scopus 로고    scopus 로고
    • Usefulness of repeated intratumoral gene transfer using hemagglutinating virus of Japan-liposome method for cytosine deaminase suicide gene therapy
    • Kanyama, H., Tomita, N., Yamano, T., et al. (2001) Usefulness of repeated intratumoral gene transfer using hemagglutinating virus of Japan-liposome method for cytosine deaminase suicide gene therapy. Cancer Res. 61, 14-18.
    • (2001) Cancer Res. , vol.61 , pp. 14-18
    • Kanyama, H.1    Tomita, N.2    Yamano, T.3
  • 64
    • 0035360868 scopus 로고    scopus 로고
    • Frequent, moderate dose cyclophosphamide administration improves the efficacy of cytochrome P-450/cytochrome P-450 reductase based cancer gene therapy
    • Jounaidi, Y. and Waxman, D. J. (2001) Frequent, moderate dose cyclophosphamide administration improves the efficacy of cytochrome P-450/cytochrome P-450 reductase based cancer gene therapy. Cancer Res. 61, 4437-4444.
    • (2001) Cancer Res. , vol.61 , pp. 4437-4444
    • Jounaidi, Y.1    Waxman, D.J.2
  • 65
    • 0034077052 scopus 로고    scopus 로고
    • Radiosensitization of rat glioma with bromodeoxycytidine and adenovirus expressing herpes simplex virus-thymidine kinase delivered by slow, rate-controlled positive pressure infusion
    • Brust, D., Feden, J., Farnsworth, J., Amir, C., Broaddus, W. C., and Valerie, K. (2000) Radiosensitization of rat glioma with bromodeoxycytidine and adenovirus expressing herpes simplex virus-thymidine kinase delivered by slow, rate-controlled positive pressure infusion. Cancer Gene Ther. 7, 778-788.
    • (2000) Cancer Gene Ther. , vol.7 , pp. 778-788
    • Brust, D.1    Feden, J.2    Farnsworth, J.3    Amir, C.4    Broaddus, W.C.5    Valerie, K.6
  • 66
    • 0033935125 scopus 로고    scopus 로고
    • Improved radiosensitization of rat glioma cells with adenovirus-expressed mutant herpes simplex virus-thymidine kinase in combination with acyclovir
    • Valerie, K., Brust, D., Farnsworth, J., et al. (2000) Improved radiosensitization of rat glioma cells with adenovirus-expressed mutant herpes simplex virus-thymidine kinase in combination with acyclovir. Cancer Gene Ther. 7, 879-884.
    • (2000) Cancer Gene Ther. , vol.7 , pp. 879-884
    • Valerie, K.1    Brust, D.2    Farnsworth, J.3
  • 67
    • 0035121644 scopus 로고    scopus 로고
    • Substantially improved in vivo radiosensitization of rat glioma with mutant HSV-TK and acyclovir
    • Valerie, K., Hawkins, W., Farnsworth, J., et al. (2001) Substantially improved in vivo radiosensitization of rat glioma with mutant HSV-TK and acyclovir. Cancer Gene Ther. 8, 3-8.
    • (2001) Cancer Gene Ther. , vol.8 , pp. 3-8
    • Valerie, K.1    Hawkins, W.2    Farnsworth, J.3
  • 68
    • 2442745332 scopus 로고    scopus 로고
    • Regression of hepatocelluar carcinoma in vitro and in vivo by radiosensitising suicide gene therapy under the inducible and spatial control of radiation
    • Kawashita, Y., Ohtsuru, A., Kaneda, Y., et al. (1999) Regression of hepatocelluar carcinoma in vitro and in vivo by radiosensitising suicide gene therapy under the inducible and spatial control of radiation. Hum. Gene Ther. 10, 1509-1519.
    • (1999) Hum. Gene Ther. , vol.10 , pp. 1509-1519
    • Kawashita, Y.1    Ohtsuru, A.2    Kaneda, Y.3
  • 69
    • 0035013495 scopus 로고    scopus 로고
    • Increasing specificity of anti-tumour therapy: Cytotoxic proteins delivery by non-pathogenic Clostridia under regulation of radio-induced promoter
    • Nuyts, S., Theys, J., Landuyt, W., Van Mellaert, L., Lambin, P., and Anne, J. (2001) Increasing specificity of anti-tumour therapy: cytotoxic proteins delivery by non-pathogenic Clostridia under regulation of radio-induced promoter. Anticancer Res. 21, 857-862.
    • (2001) Anticancer Res. , vol.21 , pp. 857-862
    • Nuyts, S.1    Theys, J.2    Landuyt, W.3    Van Mellaert, L.4    Lambin, P.5    Anne, J.6
  • 70
    • 0035014279 scopus 로고    scopus 로고
    • The use of radiation-induced bacterial promoters in anaerobic-conditions: A means to control gene expression in Clostridium-mediated gene therapy
    • Nuyts, S., Van Mellaert, L., Theys, J., Landuyt, W., Lambin, P., and Anne, J. (2001) The use of radiation-induced bacterial promoters in anaerobic-conditions: a means to control gene expression in Clostridium-mediated gene therapy. Radiat. Res. 155, 716-723.
    • (2001) Radiat. Res. , vol.155 , pp. 716-723
    • Nuyts, S.1    Van Mellaert, L.2    Theys, J.3    Landuyt, W.4    Lambin, P.5    Anne, J.6
  • 71
    • 0034102736 scopus 로고    scopus 로고
    • Enhanced green fluorescent proteinfusion proteins of herpes simplex virus type 1 thymidine kinase and cytochrome P450 4B1: Applications for prodrug-activating gene therapy
    • Steffens, S., Frank, S., Fisher, U., et al. (2000) Enhanced green fluorescent proteinfusion proteins of herpes simplex virus type 1 thymidine kinase and cytochrome P450 4B1: applications for prodrug-activating gene therapy. Cancer Gene Ther. 7, 806-812.
    • (2000) Cancer Gene Ther. , vol.7 , pp. 806-812
    • Steffens, S.1    Frank, S.2    Fisher, U.3
  • 72
    • 9544242826 scopus 로고    scopus 로고
    • Noninvasive imaging of herpes simplex virus thymidine kinase gene transfer and expression: A potential method for monitoring clinical gene therapy
    • Tjuvajev, J.G., Finn, R., Watanabe, K., et al. (1996) Noninvasive imaging of herpes simplex virus thymidine kinase gene transfer and expression: a potential method for monitoring clinical gene therapy. Cancer Res. 56, 4087-4095.
    • (1996) Cancer Res. , vol.56 , pp. 4087-4095
    • Tjuvajev, J.G.1    Finn, R.2    Watanabe, K.3
  • 73
    • 17144471900 scopus 로고    scopus 로고
    • Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography
    • Tjuvajev, J.G., Avril, N., Oku, T., et al. (1998) Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography. Cancer Res. 58, 4333-4341.
    • (1998) Cancer Res. , vol.58 , pp. 4333-4341
    • Tjuvajev, J.G.1    Avril, N.2    Oku, T.3
  • 74
    • 0034785946 scopus 로고    scopus 로고
    • Direct correlation between positron emission tomographic images of two reporter genes delivered by two distinct adenoviral vectors
    • Yagoubi, S. S., Wu, L., Liang, Q., et al. (2001) Direct correlation between positron emission tomographic images of two reporter genes delivered by two distinct adenoviral vectors. Gene Ther. 8, 1072-1080.
    • (2001) Gene Ther. , vol.8 , pp. 1072-1080
    • Yagoubi, S.S.1    Wu, L.2    Liang, Q.3
  • 75
    • 0035024462 scopus 로고    scopus 로고
    • 124/ 125I]FIAU for imaging herpes simplex virus type 1 thymidine kinase gene expression
    • 124/ 125I]FIAU for imaging herpes simplex virus type 1 thymidine kinase gene expression. Eur. J. Nucl. Med 28, 721-729.
    • (2001) Eur. J. Nucl. Med. , vol.28 , pp. 721-729
    • Brust, P.1    Haubner, R.2    Friedrich, A.3
  • 76
    • 0028108469 scopus 로고
    • Metabolism of 5-fluorocytidine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: Significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase
    • Huber, B. F., Austin, E. A., Richards, C. A., Davis, S. T., and Good, S. S. (1994) Metabolism of 5-fluorocytidine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase. Proc. Natl. Acad. Sci. USA 91, 8302-8306.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 8302-8306
    • Huber, B.F.1    Austin, E.A.2    Richards, C.A.3    Davis, S.T.4    Good, S.S.5
  • 78
    • 0030916131 scopus 로고    scopus 로고
    • Protection of herpes simplex virus thymidine kinase-transduced cells fromganciclovir-mediated cytotoxicityby bystander cells: The good Samaritan effect
    • Wygoda, M. R., Wilson, M. R., Davis, M. A., Trosko, J. E., Rehemtulla, A., and Lawrence, T. S. (1997) Protection of herpes simplex virus thymidine kinase-transduced cells fromganciclovir-mediated cytotoxicityby bystander cells: the good Samaritan effect. Cancer Res. 57, 1699-1703.
    • (1997) Cancer Res. , vol.57 , pp. 1699-1703
    • Wygoda, M.R.1    Wilson, M.R.2    Davis, M.A.3    Trosko, J.E.4    Rehemtulla, A.5    Lawrence, T.S.6
  • 80
    • 0032213438 scopus 로고    scopus 로고
    • Enhancement of the herpes simplex virus thymidine kinase/ganciclovir bystander effect and its antitumor efficacy in vivo by pharmacologic manipulation of gap junctions
    • Touraine, R. L., Vahanian, N., Ramsey, W. J., and Blaese, R. M. (1998) Enhancement of the herpes simplex virus thymidine kinase/ganciclovir bystander effect and its antitumor efficacy in vivo by pharmacologic manipulation of gap junctions. Hum. Gene Ther. 9, 2385-2391.
    • (1998) Hum. Gene Ther. , vol.9 , pp. 2385-2391
    • Touraine, R.L.1    Vahanian, N.2    Ramsey, W.J.3    Blaese, R.M.4
  • 81
    • 0032440742 scopus 로고    scopus 로고
    • The bystander effect in the HSVtk/ganciclovir system and its relation to gap junctional communication
    • Touraine, R. L., Ishii-Morita, H., Ramsey, W. J., and Blaese, R. M. (1998) The bystander effect in the HSVtk/ganciclovir system and its relation to gap junctional communication. Gene Ther. 5, 1705-1711.
    • (1998) Gene Ther. , vol.5 , pp. 1705-1711
    • Touraine, R.L.1    Ishii-Morita, H.2    Ramsey, W.J.3    Blaese, R.M.4
  • 82
    • 0033669748 scopus 로고    scopus 로고
    • The role of cellular- and prodrug-associated factors in the bystander effect induced by the Varicella zoster and Herpes simplex viral thymidine kinases in suicide gene therapy
    • Grignet-Debrus, C., Cool, V., Baudson, N., Velu, T., and Calberg-Bacq, C.-M. (2000) The role of cellular- and prodrug-associated factors in the bystander effect induced by the Varicella zoster and Herpes simplex viral thymidine kinases in suicide gene therapy. Cancer Gene Ther. 7, 1456-1468.
    • (2000) Cancer Gene Ther. , vol.7 , pp. 1456-1468
    • Grignet-Debrus, C.1    Cool, V.2    Baudson, N.3    Velu, T.4    Calberg-Bacq, C.-M.5
  • 83
    • 0029112774 scopus 로고
    • Gene therapy of hepatoma: Bystander effect s and non-apoptotic cell death induced by thymidine kinase and ganciclovir
    • Kaneko, Y. and Tsukamoto, A. (1995) Gene therapy of hepatoma: bystander effect s and non-apoptotic cell death induced by thymidine kinase and ganciclovir. Cancer Lett. 96, 105-110.
    • (1995) Cancer Lett. , vol.96 , pp. 105-110
    • Kaneko, Y.1    Tsukamoto, A.2
  • 85
    • 0035106088 scopus 로고    scopus 로고
    • Immune-dependent distant bystander effect after adenovirus-mediated suicide gene transfer in a rat model of liver colorectal metastasis
    • Agard, C., Ligeza, C., Dupas, B., et al. (2001) Immune-dependent distant bystander effect after adenovirus-mediated suicide gene transfer in a rat model of liver colorectal metastasis. Cancer Gene Ther. 8, 128-136.
    • (2001) Cancer Gene Ther. , vol.8 , pp. 128-136
    • Agard, C.1    Ligeza, C.2    Dupas, B.3
  • 86
    • 0033914768 scopus 로고    scopus 로고
    • Efficacy of herpes simplex virus thymidine kinase in combination with cytokine gene therapy in an experimental metastatic breast cancer model
    • Majumdar, A., Zolotorev, A., Samuel, S., et al. (2000) Efficacy of herpes simplex virus thymidine kinase in combination with cytokine gene therapy in an experimental metastatic breast cancer model. Cancer Gene Ther. 7, 1086-1099.
    • (2000) Cancer Gene Ther. , vol.7 , pp. 1086-1099
    • Majumdar, A.1    Zolotorev, A.2    Samuel, S.3
  • 87
    • 0034032940 scopus 로고    scopus 로고
    • Enhanced antitumoral effect of adenovirus-mediated cytosine deaminase gene therapy by induction of antigen-presenting cells through stem cell factor/granulocyte macrophage colony-stimu-lating factor gene transfer
    • Cao, X., Huang, X., Ju, D.W., Zhang, W.P., Hamada, H., and Wang, J. (2000) Enhanced antitumoral effect of adenovirus-mediated cytosine deaminase gene therapy by induction of antigen-presenting cells through stem cell factor/granulocyte macrophage colony-stimu-lating factor gene transfer. Cancer Gene Ther. 7, 177-186.
    • (2000) Cancer Gene Ther. , vol.7 , pp. 177-186
    • Cao, X.1    Huang, X.2    Ju, D.W.3    Zhang, W.P.4    Hamada, H.5    Wang, J.6
  • 88
    • 0033918251 scopus 로고    scopus 로고
    • Absence of in vitro or in vivo bystander effects in a thymidine kinase-transduced murine T-lymphoma
    • Rivas, C., Chandler, P., Melo, J. V., Simpson, E., and Apperley, J. F. (2000) Absence of in vitro or in vivo bystander effects in a thymidine kinase-transduced murine T-lymphoma. Cancer Gene Ther. 7, 954-962.
    • (2000) Cancer Gene Ther. , vol.7 , pp. 954-962
    • Rivas, C.1    Chandler, P.2    Melo, J.V.3    Simpson, E.4    Apperley, J.F.5
  • 89
    • 0035049257 scopus 로고    scopus 로고
    • Necrotic, rather than apoptotic death caused by cytochrome P450-activated ifosfamide
    • Karle, P., Renner, M., Salmons, B., and Gunzburg, W. H. (2001) Necrotic, rather than apoptotic death caused by cytochrome P450-activated ifosfamide. Cancer Gene Ther. 8, 220-230.
    • (2001) Cancer Gene Ther. , vol.8 , pp. 220-230
    • Karle, P.1    Renner, M.2    Salmons, B.3    Gunzburg, W.H.4


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