Autocrine laminin-5 ligates α6β4 integrin and activates RAC and NFκB to mediate anchorage-independent survival of mammary tumors

Journal of Cell Biology

Volumn 163, Issue 6, 2003, Pages 1397-1407

  Zahir, Nastaran ^a,b   Lakins, Johnathon N ^a   Russell, Alan ^c,d   Ming, WenYu ^e   Chatterjee, Chandrima ^a   Rozenberg, Gabriela I ^a   Marinkovich, M Peter ^c   Weaver, Valerie M ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Cytokinetics Inc   (United States)

^e INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

4 integrin; Apoptosis; GTPase; Mammary epithelial cell; Microenvironment

Indexed keywords

ALPHA6BETA4 INTEGRIN; BETA1 INTEGRIN; BETA4 INTEGRIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KALININ; RAC PROTEIN;

ANCHORAGE INDEPENDENT GROWTH; ARTICLE; AUTOCRINE EFFECT; BASEMENT MEMBRANE; BREAST TUMOR; CELL SURVIVAL; CELL VIABILITY; CYTOPLASM; EPITHELIUM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

AUTOCRINE COMMUNICATION; BASEMENT MEMBRANE; BREAST NEOPLASMS; CARCINOMA; CELL ADHESION; CELL ADHESION MOLECULES; CELL LINE, TUMOR; CELL SURVIVAL; EPIDERMAL GROWTH FACTOR; HUMANS; INTEGRIN ALPHA6BETA4; MAP KINASE SIGNALING SYSTEM; NEOPLASM INVASIVENESS; NF-KAPPA B; PROTEIN STRUCTURE, TERTIARY; RAC GTP-BINDING PROTEINS;

EID: 0347363470     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200302023     Document Type: Article

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