Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways

Molecules and Cells

Volumn 17, Issue 2, 2004, Pages 188-202

  Lee, Jung Weon ^a   Juliano, Rudy ^b  

^a Seoul National University   (South Korea)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Actin; Cell adhesion; Erk; FAK; GTPases; Integrins; Receptors; Signaling

Indexed keywords

CADHERIN; CELL ADHESION MOLECULE; CELL RECEPTOR; GROWTH FACTOR RECEPTOR; IMMUNOGLOBULIN; INTEGRIN; MEMBRANE PROTEIN; SCLEROPROTEIN; SELECTIN; SYNDECAN; ACTIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN;

APOPTOSIS; CELL ADHESION; CELL DIFFERENTIATION; CELL INTERACTION; CELL MIGRATION; CELL PROLIFERATION; CELL SPREADING; EMBRYO DEVELOPMENT; EXTRACELLULAR MATRIX; GENE INDUCTION; HUMAN; METASTASIS; MITOGENESIS; PROTEIN BINDING; PROTEIN FAMILY; RECEPTOR BINDING; REVIEW; SIGNAL TRANSDUCTION; TUMOR CELL; WOUND HEALING; ANIMAL; ENZYME ACTIVATION; METABOLISM; PHYSIOLOGY;

ACTINS; ANIMALS; CELL ADHESION; ENZYME ACTIVATION; EXTRACELLULAR MATRIX PROTEINS; HUMANS; INTEGRINS; RECEPTORS, GROWTH FACTOR; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION;

EID: 3442879850     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (174)

1. Abbi, S. and Guan, J. L. (2002) Focal adhesion kinase: protein interactions and cellular functions. Histol. Histopathol. 17, 1163-1171.
2. Abbi, S., Ueda, H., Zheng, C., Cooper, L. A., Zhao, J., Christopber, R., and Guan, J. L. (2002) Regulation of focal adhesion kinase by a novel protein inhibitor FIP200. Mol. Biol. Cell 13, 3178-3191.
3. Albanese, C., Johnson, J., Watanabe, G., Eklund, N., Vu, D., Arnold, A., and Pestell, R. G. (1995) Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions. J. Biol. Chem. 270, 23589-23597.
4. Almeida, E. A., Ilic, D., Han, Q., Hauck, C. R., Jin, F., Kawakatsu, H., Schlaepfer, D. D., and Damsky, C. H. (2000) Matrix survival signaling: from fibronectin via focal adhesion kinase to c-jun-terminal kinase. J. Cell Biol. 149, 741-754.
5. Angers-Loustau, A., Cote, J. F., Charest, A., Dowbenko, D., Spencer, S., Lasky, L. A., and Tremblay, M. L. (1999) Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts. J. Cell Biol. 144, 1019-1031.
6. Aplin, A. E., Short, S. M., and Juliano, R. L. (1999) Anchorage-dependent regulation of the mitogen-activated protein kinase cascade by growth factors is supported by a variety of integrin alpha chains. J. Biol. Chem. 274, 31223-31228.
7. Aplin, A. E., Stewart, S. A., Assoian, R. K., and Juliano, R. L. (2001) Integrin-mediated adhesion regulates ERK nuclear translocation and phosphorylation of Elk-1. J. Cell Biol. 153, 273-282.
8. Balasenthil, S., Sahin, A. A., Barnes, C. J., Wang, R. A., Pestell, R. G., Vadlamudi, R. K., and Kumar, R. (2004) p21-activated kinase-1 signaling mediates cyclin D1 expression in mammary epithelial and cancer cells. J. Biol. Chem. 279, 1422-1428.
9. Ballestrem, C., Hinz, B., Imhof, B. A., and Wehrle-Haller, B. (2001) Marching at the front and dragging behind: differential alphaVbeta3-integrin turnover regulates focal adhesion behavior. J. Cell Biol. 155, 1319-1332.
10. Barberis, L., Wary, K. K., Fiucci, G., Liu, F., Hirsch, E., Brancaccio, M., Altruda, F., Tarone, G., and Giancotti, F. G. (2000) Distinct roles of the adaptor protein Shc and focal adhesion kinase in integrin signaling to ERK. J. Biol. Chem. 275, 36532-36540.
11. Barclay, A. N. (2003) Membrane proteins with immunoglobulin-like domains - a master superfamily of interaction molecules. Semin. Immunol. 15, 215-223.
12. Bellanger, J. M., Astier, C., Sardet, C., Ohta, Y., Stossel, T. P., and Debant, A. (2000) The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin. Nat. Cell Biol. 2, 888-892.
13. Bishop, A. L. and Hall, A. (2000) Rho GTPases and their effector proteins. Biochem. J. 348 Pt 2, 241-255.
14. Brakebusch, C. and Fassler, R. (2003) The integrin-actin connection, an eternal love affair. EMBO J. 22, 2324-2333.
15. Braun, A., Bordoy, R., Stanchi, F., Moser, M., Kostka, G. G., Ehler, E., Brandau, O., and Fassler, R. (2003) PINCH2 is a new five LIM domain protein, homologous to PINCHand localized to focal adhesions. Exp. Cell Res. 284, 239-250.
16. Brummendorf, T. and Lemmon, V. (2001) Immunoglobulin superfamily receptors: cis-interactions, intracellular adapters and alternative splicing regulate adhesion. Curr. Opin. Cell Biol. 13, 611-618.
17. Buensuceso, C. S. and O'Toole, T. E. (2000) The association of CRKII with C3G can be regulated by integrins and defines a novel means to regulate the mitogen-activated protein kinases. J. Biol. Chem. 275, 13118-13125.
18. Burridge, K. and Chrzanowska-Wodnicka, M. (1996) Focal adhesions, contractility, and signaling. Ann. Rev. Cell Dev. Biol. 12, 463-518.
19. Calalb, M. B., Zhang, X., Polte, T. R., and Hanks, S. K. (1996) Focal adhesion kinase tyrosine-861 is a major site of phosphorylation by Src. Biochem. Biophys. Res. Commun. 228, 662-668.
20. Calderwood, D. A., Huttenlocher, A., Kiosses, W. B., Rose, D. M., Woodside, D. G., Schwartz, M. A., and Ginsberg, M. H. (2001) Increased filamin binding to beta-integrin cytoplasmic domains inhibits cell migration. Nat. Cell Biol. 3, 1060-1068.
21. Carragher, N. O., Westhoff, M. A., Fincham, V. J., Schaller, M. D., and Frame, M. C. (2003) A novel role for FAK as a protease-targeting adaptor protein: regulation by p42 ERK and Src. Curr. Biol. 13, 1442-1450.
22. Chaudhary, A., King, W. G., Mattaliano, M. D., Frost, J. A., Diaz, B., Morrison, D. K., Cobb, M. H., Marshall, M. S., and Brugge, J. S. (2000) Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338. Curr. Biol. 10, 551-554.
23. Chen, H. C., Appeddu, P. A., Parsons, J. T., Hildebrand, J. D., Schaller, M. D., and Guan, J. L. (1995) Interaction of focal adhesion kinase with cytoskeletal protein talin. J. Biol. Chem. 270, 16995-16999.
24. Chen, Q., Lin, T. H., Der, C. J., and Juliano, R. L. (1996) Integrin-mediated activation of MEK and mitogen-activated protein kinase is independent of Ras [corrected] [published erratum appears in J. Biol. Chem. 1996 Sep 6;271(36):22280]. J. Biol. Chem. 271, 18122-18127.
25. Chen, J., Baskerville, C., Han, Q., Pan, Z. K., and Huang, S. (2001) Alpha(v) integrin, p38 mitogen-activated protein kinase, and urokinase plasminogen activator are functionally linked in invasive breast cancer cells. J. Biol. Chem. 276, 47901-47905.
26. Clark, E. A. and Hynes, R. O. (1996) Ras activation is necessary for integrin-mediated activation of extracellular signal-regulated kinase 2 and cytosolic phospholipase A2 but not for cytoskeletal organization. J. Biol. Chem. 271, 14814-14818.
27. Comoglio, P. M., Boccaccio, C., and Trusolino, L. (2003) Interactions between growth factor receptors and adhesion molecules: breaking the rules. Curr. Opin. Cell Biol. 15, 565-571.
28. Coppolino, M. G. and Dedhar, S. (2000) Bi-directional signal transduction by integrin receptors. Int. J. Biochem. Cell Biol. 32, 171-188,
29. Cotteret, S. and Chernoff, J. (2002) The evolutionary history of effectors downstream of Cdc42 and Rac. Genome Biol. 3, REVIEWS0002.
30. Cuevas, B. D., Abell, A. N., Witowsky, J. A., Yujiri, T., Johnson, N. L., Kesavan, K., Ware, M., Jones, P. L., Weed, S. A., De-Biasi, R. L., Oka, Y., Tyler, K. L., and Johnson, G. L. (2003) MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblasts. EMBO J. 22, 3346-3355.
31. Danen, E. H. and Yamada, K. M. (2001) Fibronectin, integrins, and growth control. J. Cell Physiol. 189, 1-13.
32. Danen, E. H., Sonneveld, P., Sonnenberg, A., and Yamada, K. M. (2000) Dual stimulation of Ras/mitogen-activated protein kinase and RhoA by cell adhesion to fibronectin supports growth factor-stimulated cell cycle progression. J. Cell Biol. 151, 1413-1422.
33. Danen, E. H., Sonneveld, P., Brakebusch, C., Fassler, R., and Sonnenberg, A. (2002) The fibronectin-binding integrins alpha5beta1 and alphavbeta3 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis. J. Cell Biol. 159, 1071-1086.
34. Dedhar, S. (2000) Cell-substrate interactions and signaling through ILK. Curr. Opin. Cell Biol. 12, 250-256.
35. Del Pozo, M. A., Kiosses, W. B., Alderson, N. B., Meller, N., Hahn, K. M., and Schwartz, M. A. (2002) Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI. Nat. Cell Biol. 4, 232-239.
36. Delcommenne, M., Tan, C., Gray, V., Rue, L., Woodgett, J., and Dedhar, S. (1998) Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proc. Natl. Acad. Sci. USA 95, 11211-11216.
37. DeMali, K. A., Balciunaite, E., and Kazlauskas, A. (1999) Integrins enhance platelet-derived growth factor (PDGF)-dependent responses by altering the signal relay enzymes that are recruited to the PDGF beta receptor. J. Biol. Chem. 274, 19551-19558.
38. DeMali, K. A., Barlow, C. A., and Burridge, K. (2002) Recruitment of the Arp2/3 complex to vinculin: coupling membrane protrusion to matrix adhesion. J. Cell Biol. 159, 881-891.
39. DeMali, K. A., Wennerberg, K., and Burridge, K. (2003) Integrin signaling to the actin cytoskeleton. Curr. Opin. Cell Biol. 15, 572-582.
40. Eliceiri, B. P. (2001) Integrin and growth factor receptor crosstalk. Circ. Res. 89, 1104-1110.
41. Eliceiri, B. P., Puente, X. S., Hood, J. D., Stupack, D. G., Schlaeffer, D. D., Huang, X. Z., Sheppard, D., and Cheresh, D. A. (2002) Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling. J. Cell Biol. 157, 149-160.
42. Etienne-Manneville, S. and Hall, A. (2002) Rho GTPases in cell biology. Nature 420, 629-635.
43. Frame, M. C. and Brunton, V. G. (2002) Advances in Rho-dependent actin regulation and oncogenic transformation. Curr. Opin. Genet. Dev. 12, 36-43.
44. Frisch, S., Vuori, K., Ruoslahti, E., and Chan-Hui, P. (1996a) Control of adhesion-dependent cell survival by focal adhesion kinase. J. Cell Biol. 134, 793-799.
45. Gabarra-Niecko, V., Keely, P. J., and Schaller, M. D. (2002) Characterization of an activated mutant of focal adhesion kinase: 'SuperFAK'. Biochem. J. 365, 591-603.
46. Giancotti, F. G. (2000) Complexity and specificity of integrin signalling [news]. Nat. Cell Biol. 2, E13-14.
47. Giancotti, F. G. and Ruoslahti, E. (1999) Integrin signaling. Science 285, 1028-1032.
48. Giancotti, F. G. and Tarone G. (2003) Positional control of cell fate through joint integrin/receptor protein kinase signaling. Annu. Rev. Cell Dev. Biol. 19, 173-206.
49. Gilmore, A. P. and Burridge, K. (1996) Molecular mechanisms for focal adhesion assembly through regulation of protein-protein interactions. Structure 4, 647-651.
50. Gilmore, A. and Romer, L. (1996) Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation. Mol. Biol. Cell 7, 1209-1224.
51. Hall, A. (1998) Rho GTPases and the actin cytoskeleton. Science 279, 509-514.
52. Hansen, L. K. and Albrecht, J. H. (1999) Regulation of the hepatocyte cell cycle by type I collagen matrix: role of cyclin D1. J. Cell Sci. 112 (Pt 17), 2971-2981.
53. Hildebrand, J. D., Schaller, M. D., and Parsons, J. T. (1995) Paxillin, a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase. Mol. Biol. Cell 6, 637-647.
54. Hood, J. D., Frausto, R., Kiosses, W. B., Schwartz, M. A., and Cheresh, D. A. (2003) Differential av integrin-mediated Ras-ERK signaling during two pathways of angiogenesis. J. Cell Biol. 162, 933-943.
55. Horwitz, A., Duggan, K., Buck, C., Beckerle, M. C., and Burridge, K. (1986) Interaction of plasma membrane fibronectin receptor with talin-a transmembrane linkage. Nature 320, 531-533.
56. Howe, A. K. and Juliano, R. L. (1998) Distinct mechanisms mediate the initial and sustained phases of integrin-mediated activation of the Raf/MEK/MAPK cascade. J. Biol. Chem. 273, 27268-27274.
57. Howe, A. K., Aplin, A. E., and Juliano, R. L. (2002) Anchorage-dependent ERK signaling - mechanisms and consequences. Curr. Opin. Genet. Dev. 12, 30-35.
58. Hsia, D. A., Mitra, S. K., Hauck, C. R., Streblow, D. N., Nelson, J. A., Ilic, D., Huang, S., Li, E., Nemerow, G. R., Leng, J., Spencer, K. S., Cheresh, D. A., and Schlaepfer, D. D. (2003) Differential regulation of cell motility and invasion by FAK. J. Cell Biol. 160, 753-767.
59. Huang, S. and Ingber, D. E. (2002) A discrete cell cycle check-point in late G(1) that is cytoskeleton-dependent and MAP kinase (Erk)-independent. Exp. Cell Res. 275, 255-264.
60. Huang, C., Rajfur, Z., Borchers, C., Schaller, M. D., and Jacobson, K. (2003) JNK phosphorylates paxillin and regulates cell migration. Nature 424, 219-223.
61. Hunger-Glaser, I., Salazar, E. P., Sinnett-Smith, J., and Rozengurt, E. (2003) Bombesin, lysophosphatidic acid, and epidermal growth factor rapidly stimulate focal adhesion kinase phosphorylation at Ser-910: requirement for ERK activation. J. Biol. Chem. 278, 22631-22643.
62. Hynes, R. O. (2002a) Integrins: bidirectional, allosteric signaling machines. Cell 110, 673-687.
63. Hynes, R. O. (2002b) A reevaluation of integrins as regulators of angiogenesis. Nat. Med. 8, 918-921.
64. Hynes, R. O. and Lander, A. D. (1992) Contact and adhesive specificities in the associations, migrations, and targeting of cells and axons. Cell 68, 303-322.
65. Igishi, T., Fukuhara, S., Patel, V., Katz, B. Z., Yamada, K. M., and Gutkind, J. S. (1999) Divergent signaling pathways link focal adhesion kinase to mitogen-activated protein kinase cascades. Evidence for a role of paxillin in c-Jun NH(2)-terminal kinase activation. J. Biol. Chem. 274, 30738-30746.
66. Illario, M., Cavallo, A. L., Bayer, K. U., Di Matola, T., Fenzi, G., Rossi, G., and Vitale, M. (2003) Calcium/calmodulin-dependent protein kinase II binds to Raf-1 and modulates integrin-stimulated ERK activation. J. Biol. Chem. 278, 45101-45108.
67. Ivankovic-Dikic, I., Gronroos, E., Blaukat, A., Barth, B. U., and Dikic, I. (2000) Pyk2 and FAK regulate neurite outgrowth induced by growth factors and integrins. Nat. Cell Biol. 2, 574-581.
68. Ivaska, J., Reunanen, H., Westermarck, J., Koivisto, L., Kahari, V. M., and Heino, J. (1999) Integrin alpha2beta1 mediates isoform-specific activation of p38 and upregulation of collagen gene transcription by a mechanism involving the alpha2 cytoplasmic tail. J. Cell Biol. 147, 401-416.
69. Izaguirre, G., Aguirre, L., Hu, Y. P., Lee, H. Y., Schlaepfer, D. D., Aneskievich, B. J., and Haimovich, B. (2001) The cytoskeletal/non-muscle isoform of alpha-actinin is phosphorylated on its actin-binding domain by the focal adhesion kinase. J. Biol. Chem. 276, 28676-28685.
70. Joyce, J. G., Tung, J. S., Przysiecki, C. T., Cook, J. C., Lehman, E. D., Sands, J. A., Jansen, K. U., Keller, P. M. (1999) The L1 major capsid protein of human papillomavirus type 11 recombinant virus-like particles interacts with heparin and cell-surface glycosaminoglycans on human keratinocytes. J. Biol. Chem. 274, 5810-5822.
71. Juliano, R. L. (2002) Signal transduction by cell adhesion receptors and the cytoskeleton: functions of integrins, cadherins, selectins, and immunoglobulin-superfamily members. Annu. Rev. Pharmacol. Toxicol. 42, 283-323.
72. Katz, B. Z., Romer, L., Miyamoto, S., Volberg, T., Matsumoto, K., Cukierman, E., Geiger, B., and Yamada, K. M. (2003) Targeting membrane-localized focal adhesion kinase to focal adhesions: roles of tyrosine phosphorylation and SRC family kinases. J. Biol. Chem. 278, 29115-29120.
73. King, W. G., Mattaliano, M. D., Chan, T. O., Tsichlis, P. N., and Brugge, J. S. (1997) Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation. Mol. Cell. Biol. 17, 4406-4418.
74. Klekotka, P. A., Santoro, S. A., Wang, H., and Zutter, M. M. (2001) Specific residues within the alpha 2 integrin subunit cytoplasmic domain regulate migration and cell cycle progression via distinct MAPK pathways. J. Biol. Chem. 276, 32353-32361.
75. Kornberg, L., Earp, H. S., Turner, C., Prokop, C., and Juliano, R. L. (1991) Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta1 integrins. Proc. Natl. Acad. Sci. USA 88, 8392-8396.
76. Laukaitis, C. M., Webb, D. J., Donais, K., and Horwitz, A. F. (2001) Differential dynamics of alpha5 integrin, paxillin, and alpha-actinin during formation and disassembly of adhesions in migrating cells. J. Cell Biol. 153, 1427-1440.
77. Lavoie, J. N., L'Allemain, G., Brunet, A., Muller, R., and Pouyssegur, J. (1996) Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway. J. Biol. Chem. 271, 20608-20616.
78. Le Gall, M., Grall, D., Chambard, J. C., Pouyssegur, J., and Van Obberghen-Schilling, E. (1998) An anchorage-dependent signal distinct from p42/44 MAP kinase activation is required for cell cycle progression. Oncogene 17, 1271-1277.
79. Lee, J. W. and Juliano, R. L. (2000) α5β1 integrin protects intestinal epithelial cells from apoptosis through a phosphatidylinositol 3-kinase and protein kinase B- dependent pathway. Mol. Biol. Cell 11, 1973-1987.
80. Lee, J. W. and Juliano, R. L. (2002) The alpha5beta1 integrin selectively enhances epidermal growth factor signaling to the phosphatidylinositol-3-kinase/Akt pathway in intestinal epithelial cells. Biochim. Biophys. Acta 1542, 23-31.
81. Leyton, L., Schneider, P., Labra, C. V., Ruegg, C., Hetz, C. A., Quest, A. F., and Bron, C. (2001) Thy-1 binds to integrin beta(3) on astrocytes and triggers formation of focal contact sites. Curr. Biol. 11, 1028-1038.
82. Liddington, R. C. and Ginsberg, M. H. (2002) Integrin activation takes shape. J. Cell Biol. 158, 833-839.
83. Lin, T., Chen, Q., Howe, A., and Juliano, R. (1997a) Cell anchorage permits efficient signal transduction between Ras and its downstream kinases. J. Biol. Chem. 272, 8849-8852.
84. Lin, T. H., Aplin, A. E., Shen, Y., Chen, Q., Schaller, M., Romer, L., Aukhil, I., and Juliano, R. L. (1997b) Integrin-mediated activation of MAP kinase is independent of FAK: evidence for dual integrin signaling pathways in fibroblasts. J. Cell Biol. 136, 1385-1395.
85. Liu, F., Sells, M. A., and Chernoff, J. (1998) Protein tyrosine phosphatase 1B negatively regulates integrin signaling. Curr. Biol. 8, 173-176.
86. Lynch, D. K., Ellis, C. A., Edwards, P. A., and Hiles, I. D. (1999) Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism. Oncogene 18, 8024-8032.
87. Malliri, A. and Collard, J. G. (2003) Role of Rho-family proteins in cell adhesion and cancer. Curr. Opin. Cell Biol. 15, 583-589.
88. Mariotti, A., Kedeshian, P. A., Dans, M., Curatola, A. M., Gagnoux-Palacios, L., and Giancotti, F. G. (2001) EGF-R signaling through Fyn kinase disrupts the function of integrin alpha6beta4 at hemidesmosomes: role in epithelial cell migration and carcinoma invasion. J. Cell Biol. 155, 447-458.
89. Mettouchi, A., Klein, S., Guo, W., Lopez-Lago, M., Lemichez, E., Westwick, J. K., and Giancotti, F. G. (2001) Integrin-specific activation of Rac controls progression through the G(1) phase of the-cell cycle. Mol. Cell 8, 115-127.
90. Miao, H., Li, S., Hu, Y. L., Yuan, S., Zhao, Y., Chen, B. P., Puzon-McLaughlin, W., Tarui, T., Shyy, J. Y., Takada, Y., Usami, S., and Chien, S. (2002) Differential regulation of Rho GTPases by beta1 and beta3 integrins: the role of an extracellular domain of integrin in intracellular signaling. J. Cell Sci. 115, 2199-2206.
91. Mira, J. P., Benard, V., Groffen, J., Sanders, L. C., and Knaus, U. G. (2000) Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway. Proc. Natl. Acad. Sci. USA 97, 185-189.
92. Miranti, C. K., Ohno, S., and Brugge, J. S. (1999) Protein kinase C regulates integrin-induced activation of the extracellular regulated kinase pathway upstream of Shc. J. Biol. Chem. 274, 10571-10581.
93. Mishima, M., Kaitna, S., and Glotzer, M. (2002) Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity. Dev. Cell 2, 41-54.
94. Miyamoto, S., Teramoto, H., Gutkind, J., and Yamada, K. (1996) Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinas activation: roles of integrin aggregation and occupancy of receptors. J. Cell Biol. 135, 1633-1642.
95. Moghal, N. and Sternberg, P. W. (1999) Multiple positive and negative regulators of signaling by the EGF-receptor. Curr. Opin. Cell Biol. 11, 190-196.
96. Moon, S. Y. and Zheng, Y. (2003) Rho GTPase-activating proteins in cell regulation. Trends Cell Biol. 13, 13-22.
97. Moro, L., Venturino, M., Bozzo, C., Silengo, L., Altruda, F., Beguinot, L., Tarone, G., and Defilippi, P. (1998) Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion-dependent cell survival. EMBO J. 17, 6622-6632.
98. Cas and leads to phosphorylation of specific EGF receptor tyrosines. J. Biol. Chem. 277, 9405-9414.
99. Naranatt, P. P., Akula, S. M., Zien, C. A., Krishnan, H. H., and Chandran, B. (2003) Kaposi's sarcoma-associated herpesvirus induces the phosphatidylinositol 3-kinase-PKC-zeta-MEK-ERK signaling pathway in target cells early during infection: implications for infectivity. J. Virol. 77, 1524-1539.
100. Nikolopoulos, S. N. and Turner, C. E. (2000) Actopaxin, a new focal adhesion protein that binds paxillin LD motifs and actin and regulates cell adhesion. J. Cell Biol. 151, 1435-1448.
101. Nikolopoulos, S. N. and Turner, C. E. (2001) Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization to focal adhesions. J. Biol. Chem. 13, 13.
102. Nikolopoulos, S. N. and Turner, C. E. (2002) Molecular dissection of actopaxin-integrin-linked kinase-Paxillin interactions and their role in subcellular localization. J. Biol. Chem. 277, 1568-1575.
103. Novak, A., Hsu, S. C., Leung-Hagesteijn, C., Radeva, G., Papkoff, J., Montesano, R., Roskelley, C., Grosschedl, R., and Dedhar, S. (1998) Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways. Proc. Natl. Acad. Sci. USA 95, 4374-4379.
104. Nowakowski, J., Cronin, C. N., McRee, D. E., Knuth, M. W., Nelson, C. G., Pavletich, N. P., Rogers, J., Sang, B. C., Scheibe, D. N., Swanson, R. V., and Thompson, D. A. (2002) Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography. Structure (Camb) 10, 1659-1667.
105. Obermeier, A., Ahmed, S., Manser, E., Yen, S. C., Hall, C., and Lim, L. (1998) PAK promotes morphological changes by acting upstream of Rac. EMBO J. 17, 4328-4339.
106. O'Connor, K. L., Nguyen, B. K., and Mercurio, A. M. (2000) RhoA function in lamellae formation and migration is regulated by the alpha6beta4 integrin and cAMP metabolism. J. Cell Biol. 148, 253-258.
107. Oktay, M., Wary, K. K., Dans, M., Birge, R. B., and Giancotti, F. G. (1999) Integrin-mediated activation of focal adhesion kinase is required for signaling to Jun NH2-terminal kinase and progression through the G1 phase of the cell cycle. J. Cell Biol. 145, 1461-1469.
108. Olayioye, M. A., Neve, R. M., Lane, H. A., and Hynes, N. E. (2000) The ErbB signaling network: receptor heterodimerization in development and cancer. EMBO J. 19, 3159-3167.
109. Olski, T. M., Noegel, A. A., and Korenbaum, E. (2001) Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily. J. Cell Sci. 114, 525-538.
110. Page, K., Li, J., Hodge, J. A., Liu, P. T., Vanden Hoek, T. L., Becker, L. B., Pestell, R. G., Rosner, M. R., and Hershenson, M. B. (1999) Characterization of a Rac1 signaling pathway to cyclin D(1) expression in airway smooth muscle cells. J. Biol. Chem. 274, 22065-22071.
111. Panicker, A. K., Buhusi, M., Thelen, K., and Maness, P. F. (2003) Cellular signalling mechanisms of neural cell adhesion molecules. Front. Biosci. 8, d900-911.
112. Pardee, A. B. (1989) G1 events and regulation of cell proliferation. Science 246, 603-608.
113. Persad, S., Attwell, S., Gray, V., Mawji, N., Deng, J. T., Leung, D., Yan, J., Sanghera, J., Walsh, M. P., and Dedhar, S. (2001) Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase. Critical roles for kinase activity and amino acids arginine 211 and serine 343. J. Biol. Chem. 276, 27462-27469.
114. Cas. Proc. Natl. Acad. Sci. USA 92, 10678-10682.
115. Pozzi, A. and Zent, R. (2003) Integrins: sensors of extracellular matrix and modulators of cell function. Nephron. Exp. Nephrol. 94, e77-84.
116. Ren, X. D., Kiosses, W. B., and Schwartz, M. A. (1999) Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton. EMBO J. 18, 578-585.
117. Renshaw, M. W., Toksoz, D., and Schwartz, M. A. (1996) Involvement of the small GTPase Rho in integrin-mediated activation of mitogen-activated protein kinase. J. Biol. Chem. 271, 21691-21694.
118. Renshaw, M. W., Ren, X. D., and Schwartz, M. A. (1997) Growth factor activation of MAP kinase requires cell adhesion. EMBO J. 16, 5592-5599.
119. Renshaw, M. W., Price, L. S., and Schwartz, M. A. (1999) Focal adhesion kinase mediates the integrin signaling requirement for growth factor activation of MAP kinase. J. Cell Biol. 147, 611-618.
120. Ridley, A. J. (2001) Rho GTPases and cell migration. J. Cell Sci. 114, 2713-2722.
121. Riese, D. J. 2nd and Stern, D. F. (1998) Specificity within the EGF family/ErbB receptor family signaling network. Bioessays 20, 41-48.
122. Rigacci, S., Rovida, E., Sbarba, P. D., and Berti, A. (2002) Low Mr phosphotyrosine protein phosphatase associates and dephosphorylates p125 focal adhesion kinase, interfering with cell motility and spreading. J. Biol. Chem. 277, 41631-41636.
123. Roovers, K. and Assoian, R. K. (2000) Integrating the MAP kinase signal into the G1 phase cell cycle machinery. Bioessays 22, 818-826.
124. Roovers, K. and Assoian, R. K. (2003) Effects of rho kinase and actin stress fibers on sustained extracellular signal-regulated kinase activity and activation of G(1) phase cyclin-dependent kinases. Mol. Cell. Biol. 23, 4283-4294.
125. Roovers, K., Davey, G., Zhu, X., Bottazzi, M. E., and Assoian, R. K. (1999) Alpha5beta1 integrin controls cyclin D1 expression by sustaining mitogen-activated protein kinase activity in growth factor-treated cells. Mol. Biol. Cell 10, 3197-3204.
126. Sakai, T., Li, S., Docheva, D., Grashoff, C., Sakai, K., Kostka, G., Braun, A., Pfeifer, A., Yurchenco, P. D., and Fassler, R. (2003) Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation. Genes Dev. 17, 926-940.
127. Saoncella, S., Echtermeyer, F., Denhez, F., Nowlen, J. K., Mosher, D. F., Robinson, S. D., Hynes, R. O., and Goetinck, P. F. (1999) Syndecan-4 signals cooperatively with integrins in a Rho dependent manner in the assembly of focal adhesions and actin stress fibers. Proc. Natl. Acad. Sci. USA 96, 2805-2810.
128. Schaller, M. D. (1996) The focal adhesion kinase. J. Endocrinol. 150, 1-7.
129. Schaller, M. D. (2001) Biochemical signals and biological responses elicited by the focal adhesion kinase. Biochim. Biophys. Acta 1540, 1-21.
130. Schaller, M. D. and Parsons, J. T. (1994) Focal adhesion kinase and associated proteins. Curr. Opin. Cell Biol. 6, 705-710.
131. Schaller, M., Borgman, C., Cobb, B. S., Vines, R. R., Reynolds, A. B., and Parsons, J. T. (1992) pp125FAK, a structurally distinctive protein-kinase associated with focal adhesions. Proc. Natl. Acad. Sci. USA 89, 5192-5196.
132. Schaller, M. D., Otey, C. A., Hildebrand, J. D., and Parsons, J. T. (1995) Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains. J. Cell Biol. 130, 1181-1187.
133. Schlaepfer, D. D., Hanks, S. K., Hunter, T., and van der Geer, P. (1994) Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature 372, 786-791.
134. Schlaepfer, D. D., Hauck, C. R., and Sieg, D. J. (1999) Signaling through focal adhesion kinase. Prog. Biophys. Mol. Biol. 71, 435-478.
135. Schlaepfer, D. D., Jones, K. C., and Hunter, T. (1998) Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events. Mol. Cell. Biol. 18, 2571-2585.
136. Schlessinger, J. (2002) Ligand-induced, receptor-mediated dimerization and activation of EGF receptor. Cell 110, 669-672.
137. Schneller, M., Vuori, K., and Ruoslahti, E. (1997) Alphavbeta3 integrin associates with activated insulin and PDGFb receptors and potentiates the biological activity of PDGF. EMBO J. 16, 5600-5607.
138. Schoenwaelder, S. M. and Burridge, K. (1999) Bidirectional signaling between the cytoskeleton and integrins. Curr. Opin. Cell Biol. 11, 274-286.
139. Schwartz, M. A. and Ginsberg, M. H. (2002) Networks and crosstalk: integrin signalling spreads. Nat. Cell Biol. 4, E65-68.
140. Shen, T. L. and Guan, J. L. (2001) Differential regulation of cell migration and cell cycle progression by FAK complexes with Src, PI3K, Grb7 and Grb2 in focal contacts. FEBS Lett. 499, 176-181.
141. Shen, Y. and Schaller, M. D. (1999) Focal adhesion targeting: the critical determinant of FAK regulation and substrate phosphorylation. Mol. Biol. Cell 10, 2507-2518.
142. Shen, T. L., Han, D. C., and Guan, J. L. (2002) Association of Grb7 with phosphoinositides and its role in the regulation of cell migration. J. Biol. Chem. 277, 29069-29077.
143. Sherr, C. J. (1994) G1 phase progression: cycling on cue. Cell 79, 551-555.
144. Sieg, D. J., Hauck, C. R., Ilic, D., Klingbeil, C. K., Schaefer, E., Damsky, C. H., and Schlaepfer, D. D. (2000) FAK integrates growth-factor and integrin signals to promote cell migration. Nat. Cell Biol. 2, 249-256.
145. Sordella, R., Classon, M., Hu, K. Q., Matheson, S. F., Brouns, M. R., Fine, B., Zhang, L., Takami, H., Yamada, Y., and Settleman, J. (2002) Modulation of CREB activity by the Rho GTPase regulates cell and organism size during mouse embryonic development. Dev. Cell 2, 553-565.
146. Steimle, P. A., Hoffert, J. D., Adey, N. B., and Craig, S. W. (1999) Polyphosphoinositides inhibit the interaction of vinculin with actin filaments. J. Biol. Chem. 274, 18414-18420.
147. Sundberg, C. and Rubin, K. (1996) Stimulation of b1 integrins on fibroblasts induces PDGF independent tyrosine phosphorylation of PDGF b-receptors. J. Cell Biol. 132, 741-752.
148. Tadokoro, S., Shattil, S. J., Eto, K., Tai, V., Liddington, R. C., de Pereda, J. M., Ginsberg, M. H., and Calderwood, D. A. (2003) Talin binding to integrin beta tails: a final common step in integrin activation. Science 302, 103-106.
149. Tahiliani, P. D., Singh, L., Auer, K. L., and LaFlamme, S. E. (1997) The role of conserved amino acid motifs within the integrin beta3 cytoplasmic domain in triggering focal adhesion kinase phosphorylation. J. Biol. Chem. 272, 7892-7898.
150. Takenawa, T. and Miki, H. (2001) WASP and WAVE family proteins: key molecules for rapid rearrangement of cortical actin filaments and cell movement. J. Cell Sci. 114, 1801-1809.
151. Takino, T., Yoshioka, K., Miyamori, H., Yamada, K. M., and Sato, H. (2002) A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine-phosphorylated. Oncogene 21, 6488-6497.
152. Tamura, M., Gu, J., Matsumoto, K., Aota, S., Parsons, R., and Yamada, K. M. (1998) Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science 280, 1614-1617.
153. Tanaka, S., Ouchi, T., and Hanafusa, H. (1997) Downstream of Crk adaptor signaling pathway: activation of Jun kinase by v-Crk through the guanine nucleotide exchange protein C3G. Proc. Natl. Acad. Sci. USA 94, 2356-2361.
154. Toker, A. and Newton, A. C. (2000) Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site. J. Biol. Chem. 275, 8271-8274.
155. Trusolino, L., Bertotti, A., and Comoglio, P. M. (2001) A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth. Cell 107, 643-654.
156. Tu, Y., Li, F., and Wu, C. (1998) Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways. Mol. Biol. Cell 9, 3367-3382.
157. Tu, Y., Huang, Y., Zhang, Y., Hua, Y., and Wu, C. (2001) A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading. J. Cell Biol. 153, 585-598.
158. Vadlamudi, R. K., Adam, L., Nguyen, D., Santos, M., and Kumar, R. (2002) Differential regulation of components of the focal adhesion complex by heregulin: role of phosphatase SHP-2. J. Cell Physiol. 190, 189-199.
159. Vuori, K. and Ruoslahti, E. (1999) Connections count in cell migration [news]. Nat. Cell Biol. 1, E85-87.
160. Vuori, K., Hirai, H., Aizawa, S., and Ruoslahti, E. (1996) Induction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases. Mol. Cell. Biol. 16, 2606-2613.
161. Wang, R., Kobayashi, R., and Bishop, J. M. (1996) Cellular adherence elicits ligand-independent activation of the Met cell-surface receptor. Proc. Natl. Acad. Sci. USA 93, 8425-8430.
162. Wang, J. F., Zhang, X. F., and Groopman, J. E. (2001) Stimulation of beta 1 integrin induces tyrosine phosphorylation of vascular endothelial growth factor receptor-3 and modulates cell migration. J. Biol. Chem. 276, 41950-41957.
163. Wary, K. K., Mariotti, A., Zurzolo, C., and Giancotti, F. G. (1998) A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth. Cell 94, 625-634.
164. Weaver, A. M., Heuser, J. E., Karginov, A. V., Lee, W. L., Parsons, J. T., and Cooper, J. A. (2002) Interaction of cortactin and N-WASP with Arp2/3 complex. Curr. Biol. 12, 1270-1278.
165. Wehrle-Haller, B. and Imhof, B. A. (2003) Integrin-dependent pathologies. J. Pathol. 200, 481-487.
166. Welsh, C. F., Roovers, K., Villanueva, J., Liu, Y., Schwartz, M. A., and Assoian, R. K. (2001) Timing of cyclin D1 expression within G1 phase is controlled by Rho. Nat. Cell Biol. 3, 950-957.
167. White, D. E., Cardiff, R. D., Dedhar, S., and Muller, W. J. (2001) Mammary epithelial-specific expression of the integrin-linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice. Oncogene 20, 7064-7072.
168. Wisdom, R., Johnson, R. S., and Moore, C. (1999) c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms. EMBO J. 18, 188-197.
169. Yamada, K. M. and Even-Ram, S. (2002) Integrin regulation of growth factor receptors. Nat. Cell Biol. 4, E75-76.
170. Yamaji, S., Suzuki, A., Sugiyama, Y., Koide, Y., Yoshida, M., Kanamori, H., Mohri, H., Ohno, S., and Ishigatsubo, Y. (2001) A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction. J. Cell Biol. 153, 1251-1264.
171. Yu, D. H., Qu, C. K., Henegariu, O., Lu, X., and Feng, G. S. (1998) Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion. J. Biol. Chem. 273, 21125-21131.
172. Zang, M., Hayne, C., and Luo, Z. (2002) Interaction between active Pak1 and Raf-1 is necessary for phosphorylation and activation of Raf-1. J. Biol. Chem. 277, 4395-4405.
173. Zhang, Y., Chen, K., Tu, Y., Velyvis, A., Yang, Y., Qin, J., and Wu, C. (2002) Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites. J. Cell Sci. 115, 4777-4786.
174. Zhao, J. H., Reiske, H., and Guan, J. L. (1998) Regulation of the cell cycle by focal adhesion kinase. J. Cell Biol. 143, 1997-2008.