Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 10, 2005, Pages 3679-3684

  Luo, Bing Hao ^a   Carman, Christopher V ^a   Takagi, Junichi ^b   Springer, Timothy A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2 INTEGRIN; BETA3 INTEGRIN; INTEGRIN; LEUCINE; MEMBRANE PROTEIN; TETRAMER;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CONTROLLED STUDY; DIMERIZATION; GENE MUTATION; HUMAN; HUMAN CELL; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN CONFORMATION; SCANNING ELECTRON MICROSCOPY;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL MEMBRANE; CHO CELLS; CRICETINAE; DIMERIZATION; DISULFIDES; LIGANDS; MOLECULAR SEQUENCE DATA; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEIN STRUCTURE, SECONDARY;

CRICETINAE; CRICETULUS GRISEUS;

EID: 14844346910     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0409440102     Document Type: Article

References (37)

1. Hynes, R. O. (2002) Cell 110, 673-687.
2. Liddington, R. C. & Ginsberg, M. H. (2002) J. Cell Biol. 158, 833-839.
3. Carman, C. V. & Springer, T. A. (2003) Curr. Opin. Cell Biol. 15, 547-556.
4. Takagi, J. & Springer, T. A. (2002) Immunol. Rev. 186, 141-163.
5. Takagi, J., Petre, B. M., Walz, T. & Springer, T. A. (2002) Cell 110, 599-611.
6. Kim, M., Carman, C. V. & Springer, T. A. (2003) Science 301, 1720-1725.
7. Vinogradova, O., Velyvis, A., Velyviene, A., Hu, B., Haas, T. A., Plow, E. F. & Qin, J. (2002) Cell 110, 587-597.
8. Luo, B.-H., Springer, T. A. & Takagi, J. (2004) PLoS Biol. 2, 776-786.
9. Xiao, T., Takagi, J., Wang, J.-h., Coller, B. S. & Springer, T. A. (2004) Nature 432, 59-67.
10. Bazroni, G. & Hemler, M. E. (1998) Trends Biochem. Sci. 23, 30-34.
11. Li, R., Mitra, N., Gratkowski, H., Vilaire, G., Litvinov, S. V., Nagasami, C., Weisel, J. W., Lear. J. D., DeGrado, W. F. & Bennett, J. S. (2003) Science 300, 795-798.
12. Hogg, N., Henderson, R., Leitinger, B., McDowall, A., Porter, J. & Stanley, P. (2002) Immunol. Rev. 186, 164-171.
13. van Kooyk, Y., van Vliet, S. J. & Figdor, C. G. (1999) J. Biol. Chem. 274, 26869-26877.
14. Constantin, G., Majeed, M., Giagulli, C., Piccib, L., Kim, J. Y., Butcher, E. C. & Laudanna, C. (2000) Immunity 13, 759-769.
15. Plancon, S., Morel-Kopp, M. C., Schaffner-Reckinger, E., Chen, P. & Kieffer, N. (2001) Biochem. J. 357, 529-536.
16. Laukaitis, C. M., Webb, D. J., Donais, K. & Horwitz, A. F. (2001) J. Cell Biol. 153, 1427-1440.
17. Ballestrem, C., Hinz, B., Imhof, B. A. & Wehrle-Haller, B. (2001) J. Cell Biol. 155, 1319-1332.
18. Giannone, G., Dubin-Thaler, B. J., Dobereiner, H.-G., Kieffer, N., Bresnick, A. R. & Sheetz, M. P. (2004) Cell 116, 431-443.
19. Loftus, J. C. & Albrecht, R. M. (1984) J. Cell Biol. 99, 822-829.
20. Isenberg, W. M., McEver, R. P., Phillips, D. R., Shuman, M. A. & Bainton, D. F. (1987) J. Cell Biol. 104, 1655-1663.
21. Oliver, J. A. & Albrecht, R. M. (1987) Scanning Microsc. 1, 745-756.
22. Buensuceso, C., De Virgilio, M. & Shattil, S. J. (2003) J. Biol. Chem. 278, 15217-15224.
23. Kim, M., Carman, C. V., Yang, W., Salas, A. & Springer, T. A. (2004) J. Cell Biol. 167, 1241-1253.
24. Li, R., Babu, C. R., Lear, J. D., Wand, A. J., Bennett, J. S. & Degrado, W. F. (2001) Proc. Natl. Acad. Sci. USA 98, 12462-12467.
25. Li, R., Gorelik, R., Nanda, V., Law, P. B., Lear, J. D., DeGrado, W. F. & Bennett, J. S. (2004) J. Biol. Chem. 279, 26666-26673.
26. DuBridge, R. B., Tang, P., Hsia, H. C., Leong, P. M., Miller, J. H. & Calos, M. P. (1987) Mol. Cell. Biol. 7, 379-387.
27. Abrams, C., Deng, Y. J., Steiner, B., O'Toole, T. & Shattil, S. J. (1994) J. Biol. Chem. 269, 18781-18788.
28. Tokuhira, M., Handa, M., Kamata, T., Oda, A., Katayama, M., Tomiyama, Y., Murata, M., Kawai, Y., Watanabe, K. & Ikeda, Y. (1996) Thromb. Haemostasis 76, 1038-1046.
29. Petruzzelli, L., Huang, C. & Springer, T. A. (1995) in Leucocyte Typing V: White Cell Differentiation Antigens, eds. Schlossman, S. F., Boumsell, L., Gilks, W., Harlan, J., Kishimoto, T., Morimoto, C., Ritz, J., Shaw, S., Silverstein, R., Springer, T., et al. (Oxford Univ. Press, New York), pp. 1586-1587.
30. Du, X., Gu, M., Weisel, J. W., Nagaswami, C., Bennett, J. S., Bowditch, R. & Ginsberg, M. H. (1993) J. Biol. Chem. 268, 23087-23092.
31. Loftus, J. C., Plow, E. F., Frelinger, A. L. d., D'Souza, S. E., Dixon, D., Lacy, J., Sorge, J. & Ginsberg, M. H. (1987) Proc. Natl. Acad. Sci. USA 84, 7114-7118.
32. Jennings, L. K. & White, M. M. (1998) Am. Heart J. 135, S179-S183.
33. Luo, B.-H., Springer, T. A. & Takagi, J. (2003) Proc. Natl. Acad. Sci. USA 100, 2403-2408.
34. Lemmon, M. A., Flanagan, J. M., Treutlein, H. R., Zhang, J. & Engelman, D. M. (1992) Biochemistry 31, 12719-12725.
35. Luo, B.-H., Strokovich, K., Walz, T., Springer, T. A. & Takagi, J. (2004) J. Biol. Chem. 279, 27466-27471.
36. Hughes, P. E., Diaz-Gonzalez, F., Leong, L., Wu, C., McDonald, J. A., Shattil, S. J. & Ginsberg, M. H. (1996) J. Biol. Chem. 271, 6571-6574.
37. Kucik, D. F., Dustin, M. L., Miller, J. M. & Brown, E. J. (1996) J. Clin. Invest. 97, 2139-2144.