Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with a bis-sulfonamide - Two heads are better than one?

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 16, 2003, Pages 2759-2763

  Casini, Angela ^a   Abbate, Francesco ^a   Scozzafava, Andrea ^a   Supuran, Claudiu T ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 SULFAMOYLPHENYLCARBOXAMIDOETHYL)BENZENESULFONAMIDE; AMIDE; AMINO ACID; ANTIGLAUCOMA AGENT; BENZENESULFONAMIDE DERIVATIVE; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE INHIBITOR; HUMAN ISOZYME 2; ISOENZYME; SULFONAMIDE; SULFONAMIDE ZINC; UNCLASSIFIED DRUG; WATER; ZINC ION;

ARTICLE; CRYSTAL STRUCTURE; DRUG BINDING; DRUG STRUCTURE; HYDROGEN BOND; HYDROPHOBICITY; IONIZATION; OPTICAL RESOLUTION; X RAY CRYSTALLOGRAPHY;

EID: 0038149006     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00508-0     Document Type: Article

References (17)

1. Mincione F., Starnotti M., Menabuoni L., Scozzafava A., Casini A., Supuran C.T. Bioorg. Med. Chem. Lett. 11:2001;1787.
2. Supuran C.T., Scozzafava A., Casini A. Med. Res. Rev. 23:2003;146.
3. Supuran C.T., Scozzafava A. Exp. Opin. Ther. Patents. 12:2002;217.
4. Supuran C.T., Scozzafava A. Curr. Med. Chem. Imm., Endoc. Metab. Agents. 1:2001;61.
5. Supuran C.T., Scozzafava A. Exp. Opin. Ther. Patents. 10:2000;575.
6. Casini A., Scozzafava A., Mincione F., Menabuoni L., Supuran C.T. J. Enz. Inhib. Med. Chem. 17:2002;333.
7. Abbate F., Supuran C.T., Scozzafava A., Orioli P., Stubbs M., Klebe G. J. Med. Chem. 45:2002;3583.
8. Hakansson K., Carlsson M., Svensson L.A., Liljas A. J. Mol. Biol. 227:1992;1192.
9. Supuran, C. T. In Carbonic Anhydrase and Modulation of Physiologic and Pathologic Processes in the Organism, Puscas, I. Ed., Helicon Press, Timisoara, 1994, p 29.
10. Scozzafava A., Menabuoni L., Mincione F., Supuran C.T. J. Med. Chem. 45:2002;1466.
11. Sheldrick, G.M. SHELX97; University of Göttingen: Göttingen, Germany, 1997.
12. Jones T.A., Cowan S.W., Kjeldgaard M. Acta Crystallogr. A47:1991;110.
13. free of 0.25). The final number of water molecules was 112.
14. Casini A., Antel J., Abbate F., Scozzafava A., David S., Waldeck H., Schäfer S., Supuran C.T. Bioorg. Med. Chem. Lett. 13:2003;841.
15. (a) Kim C.Y., Chandra P.P., Jain A., Christianson D.W. J. Am. Chem. Soc. 123:2001;9620
16. (b) Gruneberg S., Wendt B., Klebe G. Angew. Chem. Int. Ed. 40:2001;389.
17. Abbate, F., Casini, A., Scozzafava, A.; Supuran, C.T. J. Enzyme Inhib. Med. Chem. 2003, 18, in press.