Benefits and risks of pharmacological treatments for essential tremor

Drug Safety

Volumn 26, Issue 7, 2003, Pages 461-481

  Lyons, Kelly E ^a   Pahwa, Rajesh ^a,k   Comella, Cynthia L ^b   Eisa, Mahmood S ^c   Elble, Rodger J ^d   Fahn, Stanley ^e   Jankovic, Joseph ^f   Juncos, Jorge L ^g   Koller, William C ^h   Ondo, William G ^f   Sethi, Kapil D ⁱ   Stern, Matthew B ^c   Tanner, Caroline M ^j   Tintner, Ron ^f   Watts, Ray L ^g  

^a UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^b RUSH UNIVERSITY MEDICAL CENTER   (United States)

^c PENNSYLVANIA HOSPITAL   (United States)

^d SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e Och Spine at New York Presbyterian Hospitals   (United States)

^f BAYLOR COLLEGE OF MEDICINE   (United States)

^g EMORY UNIVERSITY   (United States)

^h MOUNT SINAI MEDICAL CENTER   (United States)

ⁱ MEDICAL COLLEGE OF GEORGIA   (United States)

^j PARKINSON S INSTITUTE   (United States)

^k UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; ACETAZOLAMIDE; ALPRAZOLAM; AROTINOLOL; ATENOLOL; BENZODIAZEPINE DERIVATIVE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BOTULINUM TOXIN A; CALCIUM CHANNEL BLOCKING AGENT; CARBONATE DEHYDRATASE INHIBITOR; CLONAZEPAM; CLONIDINE; CLOZAPINE; DIAZEPAM; GABAPENTIN; ISONIAZID; LORAZEPAM; METHAZOLAMIDE; METOPROLOL; MIRTAZAPINE; NADOLOL; NIMODIPINE; PHENOBARBITAL; PINDOLOL; PRIMIDONE; PROPRANOLOL; SPIRENDOLOL; TIMOLOL; TOPIRAMATE; UNINDEXED DRUG;

ABDOMINAL PAIN; AGRANULOCYTOSIS; ALOPECIA; AMNESIA; ANOREXIA; ANXIETY; ATAXIA; BRADYCARDIA; BRAIN DEPTH STIMULATION; CLINICAL TRIAL; CONFUSION; CONSTIPATION; DEPRESSION; DIARRHEA; DISABILITY; DISORIENTATION; DROWSINESS; DRY EYE; DRY SKIN; DYSPHAGIA; EPIGASTRIC PAIN; ESSENTIAL TREMOR; FATIGUE; FEVER; GAIT DISORDER; GAMMA KNIFE RADIOSURGERY; HALLUCINATION; HEADACHE; HEART PALPITATION; HEARTBURN; HUMAN; HYPOTENSION; IMPOTENCE; INSOMNIA; LETHARGY; LIVER TOXICITY; MUSCLE WEAKNESS; NAUSEA; NERVOUSNESS; NEUROTOXICITY; PARESTHESIA; PERIPHERAL NEUROPATHY; POLYURIA; PRIORITY JOURNAL; RASH; REVIEW; RISK BENEFIT ANALYSIS; SIDE EFFECT; SOMNOLENCE; STRESS; SYNCOPE; TASTE DISORDER; THALAMOTOMY; THALAMUS; TINNITUS; VERTIGO; VIVID DREAM; VOMITING; WEIGHT GAIN;

ADRENERGIC AGONISTS; ANTICONVULSANTS; CLINICAL TRIALS; ELECTRIC STIMULATION THERAPY; ESSENTIAL TREMOR; HUMANS; NEUROMUSCULAR AGENTS; PRIMIDONE; RISK ASSESSMENT;

EID: 0037902473     PISSN: 01145916     EISSN: None     Source Type: Journal    
DOI: 10.2165/00002018-200326070-00003     Document Type: Review

References (140)

1. Lou JS, Jankovic J. Essential tremor: clinical correlates in 350 patients. Neurology 1991; 41:234-8
2. Louis ED, Ottman R, Hauser WA. How common is the most common adult movement disorder? estimates of the prevalence of essential tremor throughout the world. Mov Disord 1998; 13:5-10
3. Elble RJ. Diagnostic criteria for essential tremor and differential diagnosis. Neurology 2000; 54:S2-6
4. Deuschl G, Bain P, Brin M. Consensus statement of the Movement Disorder Society on Tremor. Ad Hoc Scientific Committee. Mov Disord 1998; 13:2-23
5. Findley LJ. Classification of tremors. J Clin Neurophysiol 1996; 13:122-32
6. Marshall J. Tremor. In: Vinken PJ, Bruyn GW, editors. Handbook of clinical neurology. Vol 6. Amsterdam: North-Holland Publishing Co, 1968: 809-25
7. Winkler GF, Young RR. Efficacy of chronic propranolol therapy in action tremors of the familial, senile or essential varieties. N Engl J Med 1974; 290:984-8
8. Sevitt I. The effect of adrenergic beta-receptor blocking drugs on tremor. Practitioner 1971; 207:677-8
9. Winkler GF, Young RR. The control of essential tremor by propranolol. Trans Am Neurol Assoc 1971; 96:66-8
10. Tolosa ES, Loewenson RB. Essential tremor: treatment with propranolol. Neurology 1975; 25:1041-4
11. Murray TJ. Long-term therapy of essential tremor with propranol. Can Med Assoc J 1976; 115:892-4
12. Dupont E, Hansen HJ, Dalby MA. Treatment of benign essential tremor with propranolol: a controlled clinical trial. Acta Neurol Scand 1973; 69:75-84
13. Teräväinen H, Fogelholm R, Larsen A. Effect of propranolol on essential tremor. Neurology 1976; 26:27-30
14. Sweet RD, Blumberg J, Lee JE, et al. Propranolol treatment of essential tremor. Neurology 1974; 24:64-7
15. Calzetti S, Findley LJ, Gresty MA, et al. Effect of a single dose of propranolol on essential tremor: a double-blind controlled study. Ann Neurol 1983; 13:165-71
16. Calzetti S, Findley LJ, Perucca E, et al. The response of essential tremor to propranolol: evaluation of clinical variables governing the efficacy of prolonged administration. J Neurol Neurosurg Psychiatry 1983; 46:393-8
17. Koller WC. Dose-response relationship of propranolol in essential tremor. Arch Neurol 1986; 35:42-3
18. Koller WC. Long-acting propranolol in essential tremor. Neurology 1985; 36:108-10
19. Cleeves L, Findley L. Propranolol and propranolol-LA in essential tremor: a double-blind comparative study. J Neurol Neurosurg Psychiatry 1988; 51: 379-81
20. Physician's Desk Reference. 57th Edition. Thompson PDR; Montvale (NJ), 2003
21. Young RR. Essential-familial tremor and other action tremors. Semin Neurol 1982; 2:386-91
22. Koller WC, Royse V. Time course of a single oral dose of propranolol in essential tremor. Neurology 1985; 35:1494-9
23. Jefferson D, Jenner P, Marsden CD. Beta-adrenoreceptor antagonists in essential tremor. J Neurol Neurosurg Psychiatry 1979; 42:904-9
24. Huttunen J, Teräväinen H, Larsen A. Beta-adrenoreceptor antagonist in essential tremor [brief report]. Lancet 1984; II: 857
25. Britt CR, Peters BH. Metoprolol for essential tremor [brief report]. N Engl J Med 1979; 301: 331
26. Ljung O. Treatment of essential tremor with metoprolol [brief report]. N Engl J Med 1979; 301: 1005
27. Newman RP, Jacobs L. Metoprolol in essential tremor. Arch Neurol 1980; 37: 596-7
28. Riley T, Pleet AB. Metoprolol tartrate for essential tremor [brief report]. N Engl J Med 1979; 301: 663
29. Turnbull DM, Shaw DA. Metoprolol in essential tremor. Lancet 1980; I: 95
30. Calzetti S, Findley LJ, Gresty MA, et al. Metoprolol and propranolol in essential tremor: a double-blind controlled study. J. Neurol Neurosurg Psychiatry 1981; 44: 814-9
31. Koller WC, Biary N. Metoprolol compared to propranolol in the treatment of essential tremor. Arch Neurol 1984; 41: 171-2
32. Koller WC. Nadolol in the treatment of essential tremor. Neurology 1983; 33: 1074-5
33. Dietrichson P, Espen E. Effects of timolol and atenolol on benign essential tremor: placebo-controlled studies based on quantitative tremor recordings. J Neurol Neurosurg Psychiatry 1981; 44: 677-83
34. Teräväinen H, Larsen A, Fogelheim R. Comparison between the effects of pindolol and propranolol on essential tremor. Neurology 1977; 27: 439-43
35. Koller WC, Larsen L, Potempa K. Pindolol-induced tremor. Clin Neuropharmacol 1987; 10: 449-60
36. Kuroda Y, Kakigi R, Shilasaki H. Treatment of essential tremor with arotinolol. Neurology 1988; 38: 650-1
37. O'Brien MD, Upton AR, Toseland PA. Benign familial tremor treated with primidone. BMJ 1981; 282: 178-80
38. Chakrabarti A, Pearce JMS: Essential tremor: response to primidone [brief report]. J Neurol Neurosurg Psychiatry 1981; 44: 650
39. Findley LJ, Cleeves L, Calzetti S. Primidone in essential tremor of the hands and head: a double-blind controlled clinical study. J Neurol Neurosurg Psychiatry 1985; 481: 911-5
40. Koller WC, Royse V. Efficacy of primidone in essential tremor. Neurology 1986; 36: 121-4
41. Calzetti S, Findley L, Risani F, et al. Phenyethylmalonamide in essential tremor. J Neurol Neurosurg Psychiatry 1981; 44: 932-4
42. Findley LJ, Calzetti S. Double-blind controlled study of primidone in essential tremor: preliminary results. BMJ 1982; 285: 608
43. Gorman WP, Cooper R, Pocock P, et al. A comparison of primidone, propranolol, and placebo in essential tremor using quantitative analysis. J Neurol Neurosurg Psychiatry 1986; 491: 64-8
44. Crystal HA. Duration of effectiveness of primidone in essential tremor. Neurology 1986; 36: 1543
45. Shale H, Fahn S. Response to essential tremor to treatment with primidone [abstract]. Neurology 1987; 37: 123
46. Sasso E, Perucca E, Fava N, et al. Primidone in the long-term treatment of essential tremor: a prospective study with computerized quantitative analysis. Clin Neuropharmacol 1990; 13: 67-76
47. Huber SJ, Paulson GW. Efficacy of alprazolam for essential tremor. Neurology 1988; 38 (2): 241-3
48. Gunal DI, Afsar N, Bekiroglu N, et al. New alternative agents in essential tremor therapy; double-blind placebo-controlled study of alprazolam and acetazolamide. Neurol Sci 2000; 21: 315-7
49. Thompson C, Lang A, Parkes JD, et al. A double-blind trial of clonazepam in benign essential tremor. Clin Neuropharmacol 1984; 7: 83-8
50. Biary N, Koller W. Kinetic predominant essential tremor: successful treatment with clonazepam. Neurology 1987; 37: 471-4
51. Heilman KM. Orthostatic tremor. Arch Neurol 1984; 41: 880-1
52. McManis PG, Sharbrough FW. Orthostatic tremor: clinical and electrophysiologic characteristics. Muscle Nerve 1993; 16: 1254-60
53. Burrows GT, King RB. Gabapentin in essential tremor [abstract]. Neurology 1995; 45 Suppl. 4: A187-188
54. Adler CH. Effectiveness of gabapentin in various movement disorders [abstract]. Mov Disord 1996; 11 Suppl. 1: 251
55. Merren MD. Gabapentin for treatment of pain and tremor: a large case series. South Med J 1998; 91: 739-44
56. Gironell A, Barbanoj M, Kulisevsky, J, et al. A randomized placebo controlled comparative trial of gabapentin and propranolol in essential tremor. Arch Neurol 1999; 56 (4): 475-80
57. Ondo WG, Hunter C, Schwartz K, et al. High dose gabapentin for essential tremor: a double-blind, placebo-controlled, crossover trial. Mov Disord 2000; 15: 678-82
58. Pahwa R, Lyons K, Hubble J, et al. Double-blind controlled trial of gabapentin in essential tremor. Mov Disord 1998; 13: 465-7
59. Gee NS, Brown JP, Dissanayake VUK, et al. The novel anticonvulsant drug, gabapentin (Neurontin), binds to the a2δ subunit of a calcium channel. J Biol Chem 1996; 271: 5768-76
60. Schumacher TB, Beck H, Steinhauser C, et al. Effects of phenytoin, carbamazepine, and gabapentin on calcium channels in hippocampal granule cells from patients with temporal lobe epilepsy. Epilepsia 1998; 39: 355-63
61. Kelly KM. Gabapentin. Neuropsychobiology 1998; 38: 139-44
62. Taylor CP, Gee NS, Su TZ, et al. A summary of mechanistic hypotheses of gabapentin pharmacology. Epilepsy Res 1998; 29: 233-49
63. Goa KL, Sorkin EM. Gabapentin. Drugs 1993; 46: 409-27
64. Connor GS. Topiramate as a novel treatment for essential tremor [abstract]. Mov Disord 1999; 14: 908
65. Connor GS. A randomized double-blind placebo controlled trial of topiramate treatment for essential tremor. Neurology 2002; 59: 132-4
66. Glauser TA. Topiramate. Epilepsia 1999; 40 Suppl. 5: S71-80
67. Kawasaki H, Tancredi V, D'Arcangelo G, et al. Multiple actions of the novel anticonvulsant drug topiramate in the rat subiculum in vitro. Brain Res 1998; 807: 125-34
68. Petroff OA, Hyder F, Mattson RH, et al. Topiramate increases brain GABA, homocarnosine, and pyrrolidinone in patients with epilepsy. Neurology 1999; 52: 473-8
69. Montecucco C, Shiavo G, Rossetto O. The mechanism of action of tetanus and botulinum neurotoxins. Arch Toxicol Suppl 1996; 18: 342-54
70. Catsicas S, Grenningloh G, Pcij EM. Nerve-terminal proteins: to fuse to learn. Trends Neurosci 1994; 17: 368-73
71. Jost WH, Kohl A. Botulinum toxin: evidence-based medicine criteria in rare conditions. J Neurol 2000; 248 Suppl. 1: I39-44
72. Jankovic J, Schwartz K. Botulinum toxin treatment of tremors. Neurology 1991; 41: 1185-8
73. Jankovic J, Schwartz K, Clemence W, et al. A randomized, double-blind, placebo-controlled study to evaluate botulinum toxin type A in essential hand tremor. Mov Disord 1996; 11: 250-6
74. Brin MF, Lyons KE, Doucette J, et al. A randomized, double masked, controlled trial of botulinum toxin type A in essential hand tremor. Neurology 2001; 56: 1523-8
75. Pacchetti C, Mancini F, Bulgheroni M, et al. Botulinum toxin treatment for functional disability induced by essential tremor. Neurol Sci 2000; 21: 349-53
76. Trosch RM, Pullman SL. Botulinum toxin A injections for the treatment of hand tremors. Movement Dis 1994; 9: 601-9
77. Henderson JM, Ghika JA, Van Melle G, et al. Botulinum toxin A in non-dystonic tremors. Eur Neurol 1996; 36: 29-35
78. Wissel J, Masuhr F, Schelosky L, et al. Quantitative assessment of botulinum toxin treatment in 43 patients with head tremor. Mov Disord 1997; 12: 722-6
79. Pahwa R, Busenbark K, Swanson-Hyland EF, et al. Botulinum toxin treatment of essential head tremor. Neurology 1995; 45: 822-4
80. Blitzer A, Brin MF, Stewart C, et al. Abductor laryngeal dystonia: a series treated with botulinum toxin. Laryngoscope 1992; 102: 163-7
81. Hertegard S, Granqvist S, Lindestad PA. Botulinum toxin injections for essential voice tremor. Ann Otol Rhinol Laryngol 2000; 109: 204-9
82. Warrick P. The treatment of essential voice tremor with botulinum toxin A: a longitudinal case report. J Voice 2000; 14: 410-21
83. Warrick P. Botulinum toxin for essential tremor of the voice with multiple anatomical sites of tremor: a crossover design study of unilateral versus unilateral injection. Laryngoscope 2000: 110: 1266-374
84. Cho JW, Chu K, Jeon BS. Case of essential palatal tremor: atypical features and remarkable benefit from botulinum toxin injection. Mov Disord 2001; 16: 779-82
85. Bakar M, Zarifoglu M, Bora I, et al. Treatment of trembling chin with botulinum toxin. Mov Disord 1998; 13: 845-6
86. Koller WC, Hristova A, Brin M. Pharmacologic treatment of essential tremor. Neurology 2000; 54 Suppl. 4: S30-8
87. Muenter MD, Daube JR, Caviness JN, et al. Treatment of essential tremor with methazolamide. Mayo Clinic Proc 1991; 66: 991-7
88. Busenbark K, Pahwa R, Hubble J, et al. The effect of acetazolamide on essential tremor: an open-label trial. Neurology 1992; 42: 1394-13495
89. Busenbark K, Pahwa R, Hubble J, et al. Double-blind controlled study of methazolamide in the treatment of essential tremor. Neurology 1993; 43: 104-1047
90. Baruzzi A, Procaceranti G, Martinelle P. Phenobarbital and propranolol in essential tremor: a double-blind controlled clinical trial. Neurology 1983; 33: 296-300
91. Findley LJ, Cleeves L. Phenobarbital in essential tremor. Neurology 1985; 35: 1784-7
92. Sasso E, Perucca E, Calzetti S. Double-blind comparison of primidone and phenobarbital in essential tremor. Neurology 1988; 38: 808-10
93. Topaktas S, Onur R, Dalkara T. Calcium channel blockers and essential tremor. Eur Neurol 1987; 27: 114-9
94. Garcia-Ruiz PJ, Garcia de Yenebes Prous J, Jimenez-Jimenez J. Effect of nicardipine on essential tremor: brief report. Clin Neuropharmacol 1993; 16: 456-9
95. Jimenez-Jimenez FJ, Garcia-Ruiz PJ, Cabrera-Valdivia F. Nicardipine versus propranolol in essential tremor. Acta Neurol (Napoli) 1994; 16 (4): 184-8
96. Biary N, Bahou Y, Sofi MA, et al. The effect of nimodipine on essential tremor. Neurology 1995; 45: 1523-5
97. Hallett M, Ravits J, Dubinsky RM, et al. A double-blind trial of isoniazid for essential tremor and other action tremors. Mov Disord 1991; 6 (3): 253-6
98. Caccia MR, Mangoni A. Clonidine in essential tremor: preliminary observations from an open trial. J Neurol 1985; 232: 55-7
99. Koller WC, Herbster G, Cone S. Clonidine in the treatment of essential tremor. Mov Disord 1986; 1: 235-7
100. Caccia MR, Osio M, Galimberti V, et al. Propranolol, clonidine, urapidil and trazodone infusion in essential tremor: a double-blind crossover trial. Acta Neurol Scand 1989; 79 (5): 379-83
101. Pakkenberg H, Pakkenberg B. Clozapine in the treatment of tremor. Acta Neurol Scand 1986; 73: 295-7
102. Ceravolo R, Salvetti S, Piccini P, et al. Acute and chronic effects of clozapine in essential tremor. Mov Disord 1999: 14 (3): 468-72
103. Pact V, Giduz T. Mirtazapine treats resting tremor, essential tremor, and levodopa induced dyskinesias [clinical/scientific note]. Neurology 1999; 53: 1154
104. Ertan S, Koksal A, Ozekmekci S. Clinical efficacy of mirtazapine in essential tremor [abstract P557]. Mov Disord 2000; 15 (S3): 102
105. Lyons KE, Pahwa R. A double-blind, placebo-controlled, pilot study of mirtazapine in essential tremor [abstract]. Neurology 2002; 58 Suppl. 3: A254
106. Laitinen L. Stereotaxic treatment of hereditary tremor. Acta Neurol Scand 1965; 41: 74-9
107. Blacker HM, Bertrand C, Martinez N, et al. Hypotonia accompanying the neurosurgical relief of essential tremor. J Nerv Ment Dis 1968; 147: 49-55
108. Bertrand C, Hardy J, Molina-Negro P, et al. Tremor of attitude. Confin Neurol 1969; 31: 37-41
109. van Manen J. Stereotaxic operations in cases of hereditary and intention tremor. Acta Neurochir (Wien) 1974; Suppl. 21: 49-55
110. Ohye C, Hirai T, Miyazaki M, et al. Vim thalamotomy for the treatment of various kinds of tremor. Appl Neurophysiol 1982; 45: 275-80
111. Nagaseki Y, Shibazaki T, Hirai T, et al. Long-term follow-up results of selective VIM-thalamotomy. J Neurosurg 1986; 65: 296-302
112. Mohadjer M, Goerke H, Milios E, et al. Long-term results of stereotaxy in the treatment of essential tremor. Stereotact Funct Neurosurg 1990; 55: 125-9
113. Goldman MS, Kelly PJ. Symptomatic and functional outcome of stereotactic ventralis lateralis thalamotomy for intention tremor. J Neurosurg 1992; 77: 223-9
114. Jankovic J, Cardoso F, Grossman RG, et al. Outcome after stereotactic thalamotomy for parkinsonian, essential, and other types of tremor. Neurosurgery 1995; 37: 680-6
115. Tasker RR. Movement disorders. In: Apuzzo MLJ, editor. Brain surgery complication avoidance and management. New York: Churchill Livingstone, 1993: 1509
116. Activa tremor control therapy reference guide. Minneapolis: Medtronics, 1997
117. Benabid AL, Pollak P, Gervason C, et al. Long-term suppression of tremor by chronic stimulation of the ventral intermediate thalamic nucleus. Lancet 1991; 337: 403-6
118. Blond S, Caparros-Lefebvre D, Parker F, et al. Control of tremor and involuntary movement disorders by chronic stereotactic stimulation of the ventral intermediate thalamic nucleus. J Neurosurg 1992; 77: 62-8
119. Benabid AL, Pollak P, Seigneuret E, et al. Chronic VIM thalamic stimulation in Parkinson's disease, essential tremor and extra-pyramidal dyskinesias. Acta Neurochir Suppl (Wien) 1993; 58: 39-44
120. Alesch F, Pinter MM, Helscher RJ, et al. Stimulation of the ventra intermediate thalamic nucleus in tremor dominated Parkinson's disease and essential tremor. Acta Neurochir (Wien) 1995; 136: 75-81
121. Benabid AL, Pollak P, Gao D, et al. Chronic electrical stimulation of the ventralis intermedius nucleus of the thalamus as a treatment of movement disorders. J Neurosurg 1996; 84: 203-14.
122. Hubble JP, Busenbark KL, Wilkinson S, et al. Deep brain stimulation for essential tremor. Neurology 1996; 46: 1150-3
123. Koller W, Pahwa R, Busenbark K, et al. High-frequency unilateral thalamic stimulation in the treatment of essential and parkinsonian tremor. Ann Neurol 1997; 42: 292-9
124. Ondo W, Jankovic J, Schwartz K, et al. Unilateral thalamic deep brain stimulation for refractory essential tremor and Parkinson's disease tremor. Neurology 1998; 51: 1063-9
125. Koller WC, Lyons KE, Wilkinson SB, et al. Long-term safety and efficacy of unilateral deep brain stimulation of the thalamus in essential tremor. Mov Disord 2001; 16: 464-8
126. Pahwa R, Lyons KE, Wilkinson SB, et al. Bilateral thalamic stimulation for essential tremor. Neurology 1998; 50 Suppl. 4: A19
127. Carpenter MA, Pahwa R, Miyawaki KL, et al. Reduction in voice tremor under thalamic stimulation. Neurology 1998; 50: 796-8
128. Koller WC, Lyons KE, Wilkinson SB, et al. Efficacy of unilateral deep brain stimulation of the VIM nucleus of the thalamus for essential head tremor. Mov Disord 1999; 14: 847-50
129. Obwegeser AA, Uitti RJ, Turk MF, et al. Thalamic stimulation for the treatment of midline tremors in essential tremor patients. Neurology 2000; 54: 2342-4
130. Tasker RR. Deep brain stimulation is preferable to thalamotomy for tremor suppression. Surg Neurol 1998; 49: 145-53
131. Schuurman PR, Bosch DA, Bossuyt PM, et al. A comparison of continuous thalamic stimulation and thalamotomy for suppression of severe tremor. N Engl J Med 2000; 342: 461-8
132. Pahwa R, Lyons KE, Wilkinson SB, et al. Comparison of thalamotomy to deep brain stimulation of the thalamus in essential tremor. Mov Disord 2001; 16: 140-3
133. Young RF, Jacques S, Mark R, et al. Gamma knife thalamotomy for treatment of tremor: long-term results. J Neurosurg 2000; 93 Suppl. 3: 128-35
134. Niranjan A, Kondziolka D, Baser S, et al. Functional outcomes after gamma knife thalamotomy for essential tremor and MS-related tremor. Neurology 2000; 55: 443-6
135. Siderowf A, Gollump SM, Stern MB, et al. Emergence of complex involuntary movements after gamma knife radiosurgery for essential tremor. Mov Disord 2001; 16: 965-7
136. Deuschl G, Koster B, Lucking CH, et al. Diagnostic and pathophysiological aspects of psychogenic tremors. Mov Disord 1998; 13: 294-302
137. Lundervold DA, Belwood MF, Craney JL, et al. Reduction of tremor severity and disability following behavioral relaxation training. J Behav Ther & Exp Psychiat 1999; 30: 119-35
138. Bilodeau M, Keen DA, Sweeney PJ, et al. Strength training can improve steadiness in persons with essential tremor. Muscle Nerve 2000; 23: 771-8
139. Lundervold DA, Poppen R. Biobehavioral rehabilitation for older adults with essential tremor. Gerontologist 1995; 35: 556-9
140. Chung W, Poppen R, Lundervold DA. Behavioral relaxation training for tremor disorders in older adults. Biofeedback Self Regul 1995; 20: 123-35