Transgenes in the analysis of life span and fitness

American Naturalist

Volumn 154, Issue SUPPL., 1999, Pages

  Tatar, Marc ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

Drosophila melanogaster; Hsp70; Senescence; Superoxide dismutase; Transgenes

Indexed keywords

CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; FITNESS; TRANSGENE;

DROSOPHILA;

EID: 0032863870     PISSN: 00030147     EISSN: None     Source Type: Journal    
DOI: 10.1086/303284     Document Type: Conference Paper

References (73)

1. Basler, K., and G. Struhl. 1994. Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein. Nature (London) 368:208-214.
2. Bernstein, H., and C. Bernstein. 1991. Aging, sex and DNA repair. Academic Press, New York.
3. Charlesworth, B. 1994. Evolution in age-structured populations. 2d ed. Cambridge University Press, Cambridge.
4. Charlesworth, B., and K. A. Hughes. 1996. Age-specific inbreeding depression and components of genetic variance in relation to the evolution of senescence. Proceedings of the National Academy of Sciences of the USA 93:6140-6145.
5. Clark, A. G. 1991. Mutation-selection balance and metabolic control theory. Genetics 129:909-923.
6. Clark, A. G., and R. N. Guadalupe. 1995. Probing the evolution of senescence in Drosophila melanogaster with P element tagging. Genetica 96:225-234.
7. Ezzell, C. 1995. Hot stuff: medical applications of the heatshock protein. Journal of NIH Research 7:42-45.
8. Feder, J. H., J. M. Rossi, J. Solomon, N. Solomon, and S. Lindquist. 1992. The consequences of expressing hsp70 in Drosophila cells at normal temperatures. Genes and Development 6:1402-1413.
9. Feder, M. E. 1999. Engineering candidate genes in studies of adaptation: the heat-shock protein Hsp70 in Drosophila melanogaster. American Naturalist 154(suppl.): S55-S66.
10. Feder, M. E., N. V. Cartano, L. Milos, R. A. Krebs, and S. L. Lindquist. 1997. Effect of engineering Hsp70 copy number on Hsp70 expression and tolerance of ecologically relevant heat shock in larvae and pupae of Drosophila melanogaster. Journal of Experimental Biology 119:1637-1844.
11. Feige, U., R. I. Morimoto, I. Yahara, and B. S. Polla, eds. 1996. Stress-inducible cellular responses. Birkhauser, Basel.
12. Hamilton, W. D. 1966. The moulding of senescence by natural selection. Journal of Theoretical Biology 12: 12-45.
13. Harman, D. 1981. The aging process. Proceedings of the National Academy of Sciences of the USA 78: 7124-7128.
14. Hartl, D. L., D. E. Dykhuizen, and A. M. Dean. 1985. Limits of adaptation: the evolution of selective neutrality. Genetics 111:655-674.
15. Heydari, A. R., T. Takahashi, A. Gutsmann, S. You, and A. Richardson. 1994. Hsp70 and aging. Experientia 50: 1092-1098.
16. Heydari, A. R., S. You, R. Takahashi, A. Gutsmann, K. D. Sarge, and A. Richardson. 1996. Effect of caloric restriction on the expression of the heat shock protein 70 and the activation of heat shock transcription factor 1. Developmental Genetics 18:114-124.
17. Hopfield, J. J. 1974. Kinetic proofreading: a new mechanism for reduction in errors in biosynthetic processes requiring high specificity. Proceedings of the National Academy of Sciences of the USA 182:4135-4139.
18. Hughes, K. A., and B. Charlesworth. 1994. A genetic analysis of senescence in Drosophila. Nature (London) 367:64-66.
19. Jazwinski, S. M. 1996. Longevity, genes, and aging. Science (Washington, D.C.) 273:54-59.
20. Kacser, H., and J. A. Burns. 1973. The control of flux. Symposia of the Society for Experimental Biology 27:65-104.
21. _. 1981. The molecular basis of dominance. Genetics 97:639-666.
22. Kaiser, M., M. Gasser, R. Ackermann, and S. C. Stearns. 1997. P element inserts in transgenic flies: a cautionary tale. Heredity 78:1-11.
23. Khazaeli, A. A., M. Tatar, S. D. Pletcher, and J. W. Curtsinger. 1997. Heat-induced longevity extension in Drosophila. I. Heat treatment, mortality, and thermotolerance. Journal of Gerontology, Biological Sciences 52A: B48-B52.
24. Kirkwood, T. B. L. 1977. Evolution of ageing. Nature (London) 270:301-304.
25. Kirkwood, T. B. L., and M. R. Rose. 1991. Evolution of senescence: late survival sacrificed for reproduction. Philosophical Transactions of the Royal Society of London B, Biological Sciences 332:15-24.
26. Lee, E. T. 1992. Statistical methods for survival data analysis. 2d ed. Wiley, New York.
27. Lithgow, G. J., T. M. White, S. Melov, and T. E. Johnson. 1995. Longevity mutants of Caenorhabditis elegans exhibit increased intrinsic thermotolerance. Proceedings of the National Academy of Sciences of the USA 92: 7540-7544.
28. Lithgow, G. L., and T. B. L. Kirkwood. 1996. Mechanisms and evolution of aging. Science (Washington, D.C.) 273: 80.
29. Lithgow, G. L., T. M. White, D. A. Hinerfeld, and T. E. Johnson. 1994. Thermotolerance of a long-lived mutant of Caenorhabditis elegans. Journal of Gerontology: Biological Sciences 49:B270-B276.
30. Luckinbill, L. S., R. Arking, M. J. Clare, W. C. Cirocco, and S. A. Buck. 1984. Selection for delayed senescence in Drosophila melanogaster. Evolution 38:996-1003.
31. Mackay, T. F. C. 1989. Transposable elements and fitness in Drosophila melanogaster. Genome 31:284-295.
32. Mackay, T. F. C., R. F. Lyman, and M. S. Jackson. 1992. Effects of P element insertions on quantitative traits in Drosophila melanogaster. Genetics 130:315-332.
33. Mackay, W. J., and G. C. Bewley. 1989. The genetics of catalase in Drosophila melanogaster: isolation and characterization of acatalasemic mutants. Genetics 122: 643-652.
34. Makrides, S. C. 1983. Protein synthesis and degeneration during aging and senescence. Biological Review of the Cambridge Philosophical Society 58:343-422.
35. Maynard Smith, J. 1958. The effects of temperature and of egg-laying on the longevity of Drosophila subobscura. Journal of Experimental Biology 35:832-842.
36. Morimoto, R. I., A. Tissieres, and C. Georgopoulos, eds. 1994. The biology of heat shock proteins and molecular chaperones. Cold Spring Laboratory Harbor Press, Cold Spring Harbor, N.Y.
37. Murakarni, S., and T. E. Johnson. 1996. A genetic pathway conferring life extension and resistance to UV stress in Caenorhabditis elegans. Genetics 143:1207-1218.
38. Orr, W. C., and R. S. Sohal. 1992. The effects of catalase gene overexpression on life span and resistance to oxidative stress in transgenic Drosophila melanogaster. Archives of Biochemistry and Biophysics 297:35-41.
39. _. 1993. Effects of Cu-Zn superoxide dismutase overexpression on life span and resistance to oxidative stress in transgenic Drosophila melanogaster. Archives of Biochemistry and Biophysics 301:34-40.
40. _. 1994. Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Science (Washington, D.C.) 263:1128-1130.
41. Orr, W. R., L. Arnold, and R. S. Sohal. 1992. Relationship between catalase activity, life span and some parameters associated with antioxidant defenses in Drosophila melanogaster. Mechanisms of Ageing and Development 63: 287-296.
42. Parsell, D. A., and S. Lindquist. 1994. Heat shock proteins and stress tolerance. Pages 457-493 in R. I. Morimoto, A. Tissieres, and C. Georgopoulos. The biology of heat shock proteins and molecular chaperones. Cold Spring Laboratory Harbor Press, Cold Spring Harbor, N.Y.
43. Phillips, J. P., S. D. Campbell, D. Michaud, M. Carbonneau, and A. J. Hilliker. 1989. Null mutation of copper/ zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity. Proceedings of the National Academy of Sciences of the USA 86:2761-2765.
44. Pletcher, S. D., D. Houle, and J. W. Curtsinger. 1998. Age-specific properties of spontaneous mutations affecting mortality in Drosophila melanogaster. Genetics 148: 287-303.
45. Promislow, D. E. L. 1994. DNA repair and the evolution of longevity: a critical analysis. Journal of Theoretical Biology 170:291-300.
46. Promislow, D. E. L., and M. Tatar. 1998. Mutation and senescence: where genetics and demography meet. Genetica 102/103:299-314.
47. Promislow, D. E. L., M. Tatar, A. A. Khazaeli, and J. W. Curtsinger, 1996. Age-specific patterns of genetic variance in Drosophila melanogaster. I. Mortality. Genetics 143:839-848.
48. Purrington, C. B., and J. Bergelson. 1999. Exploring the physiological basis of costs of herbicide resistance in Arabidopsis thaliana. American Naturalist 154(suppl.): S82-S91.
49. Reiser, K. M. 1990. Nonenzymatic glycation of collagen in aging and diabetes. Proceedings of the Society for Experimental Biology 196:17-29.
50. Resler, A. S., K. Kelly, J. Cantor, A. A. Khazaeli, M. Tatar, and J. W. Curtsinger. 1998. Genetic analysis of extended life span in Drosophila melanogaster. 11. Replication of the backcross test and molecular characterization of the N14 locus. Genetica 104:33-39.
51. Savageau, M. A. 1976. Biochemical systems analysis. Addison-Wesley, Reading, Mass.
52. Schmitt, J., A. C. McCormac, and H. Smith. 1995. A test of the adaptive plasticity hypothesis using transgenic and mutant plants disabled in phytochrome-mediated elongation responses to neighbors. American Naturalist 146:937-953.
53. Seto, N. O., S. Hayashi, and G. M. Tener. 1990. Overexpression of Cu-Zn superoxide dismutase in Drosophila does not affect life span. Proceedings of the National Academy of Sciences of the USA 87:4270-4272.
54. Shepherd, J. C. W., U. Walldord, P. Hug, and W. J. Gehring. 1989. Fruit flies with additional expression of the elongation factor EF-1α live longer. Proceedings of the National Academy of Sciences of the USA 86:7520-7521.
55. Shikama, N., R. Ackermann, and C. Brack. 1994. Protein synthesis elongation factor EE-1α expression and longevity in Drosophila melanogaster. Proceedings of the National Academy of Sciences of the USA 91: 4199-4203.
56. Siegal, M. L., and D. L. Hartl. 1996. Transgene coplacement and high efficiency site-specific recombination with the Cre/loxP system in Drosophila. Genetics 144:715-726.
57. Sohal, R. S., and R. Weindruch. 1996. Oxidative stress, caloric restriction, and aging. Science (Washington, D.C.) 273:59-63.
58. Sokal, R. R., and F. J. Rohlf. 1981. Biometry. 2d ed. W. H. Freeman, New York.
59. Stadtman, E. R. 1992. Protein oxidation and aging. Science (Washington, D.C.) 257:1220-1224.
60. Staveley, B. E., J. P. Phillips, and A. J. Hilliker. 1990. Phenotypic consequences of copper-zinc superoxide dismutase overexpression in Drosophilla melanogaster. Genome 33:867-872.
61. Stearns, S. C., and M. Kaiser. 1993. The effects of enhanced expression of elongation factor EF-1α on lifespan in Drosophila melanogaster. IV. A summary of three experiments. Genetica 91:167-182.
62. _. 1996. Effects on fitness components of P element inserts in Drosophila melanogaster: analysis of trade-offs. Evolution 50:795-806.
63. Stearns, S. C., M. Kaiser, and E. Hillesheim. 1993. Effects on fitness components of enhanced expression of elongation factor EF-1α in Drosophila melanogaster. I. The contrasting approaches of molecular and population biologists. American Naturalist 142:961-993.
64. Struhl, G., and K. Basler. 1993. Organized activity of wingless protein in Drosophila. Cell 72:527-540.
65. Sun, J. and J. Tower. 1999. FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life-span of adult Drosophila melanogaster flies. Molecular and Cellular Biology 19: 216-228.
66. Tatar, M., D. E. L. Promislow, A. A. Khazaeli, and J. W. Curtsinger. 1996. Age-specific patterns of genetic variance in Drosophila melanogaster. II. Fecundity and its genetic covariance with age-specific mortality. Genetics 143:849-858.
67. Tatar, M., A. A. Khazaeli, and J. W. Curtsinger. 1997. Chaperoning extended life. Nature (London) 390:30.
68. Tower, J. 1996. Aging mechanisms in fruit flies. BioEssays 18:799-807.
69. Webster, G. C. 1988. Protein synthesis. Pages 119-128 in F. A. Lints and M. H. Soliman, eds. Drosophila as a model organism for ageing studies. Blackie, Glasgow.
70. Webster, G. C., and S. L. Webster. 1983. Decline in synthesis of elongation factor one (EF-1) precedes the decreased synthesis of total protein in aging Drosophila melanogaster. Mechanisms of Ageing and Development 22:121-128.
71. _. 1984. Specific disappearance of translatable messenger RNA for elongation factor one in aging Drosophila melanogaster. Mechanisms of Ageing and Development 24:335-342.
72. Welte, M. A., J. M. Tetrault, R. P. Dellavalle, and S. L. Lindquist. 1993. A new method for manipulating transgenes: engineering heat tolerance in a complex, multicellular organism. Current Biology 13:842-853.
73. Wheeler, J. C., E. T. Bieschke, and J. Tower. 1995. Muscle-specific expression of Drosophila hsp70 in response to aging and oxidative stress. Proceedings of the National Academy of Sciences of the USA 922:10408-10412.